Marc A. Shuman, MD

Professor, Departments of Medicine and Urology, UCSF

shuman@medicine.ucsf.edu

Phone: (415) 476-2125 (voice)
Box 1270, UCSF
San Francisco, CA 94143-1270

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Education

University of Wisconsin, Madison Madison, WI, B.S., 1962, Philosophy/Chemistry
University of PA, Philadelphia Philadelphia, PA, Biology
Thomas Jefferson Medical College Philadelphia, PA, M.D., 1967, Medicine

Professional Experience

• 1967-1968
  Intern, Pennsylvania Hospital, Philadelphia
• 1968-1969
  Junior Assistant Resident, Hospital of the University of Pennsylvania, Philadelphia
• 1971-1972
  Senior Resident, Department of Medicine, Hospital of the University of Pennsylvania, Phila.
• 1972-1973
  Clinical Fellow, Division of Hematology-Oncology, Washington University, St. Louis, MO
• 1973-1976
  Postdoctoral Fellow, Division of Hematology-Oncology, Washington University, St. Louis, MO
• 1976-1981
  Assistant Professor of Medicine, University of California, San Francisco
• 1981-1986
  Associate Professor of Medicine, University of California, San Francisco
• 1986-present
  Professor of Medicine, University of California, San Francisco
• 1989-present
  Chief of Hematology, Division of Hematology-Oncology, UCSF
• 1992-1996
  Interim Director, Cancer Research Institute, UCSF
• 1996-2004
  Associate Director, Cancer Research Institute, UCSF
• 1997-2000
  Chief of Oncology, Division of Hematology-Oncology, UCSF
• 1997-2007
  Associate Director for Program Development, UCSF Helen Diller Family Comprehensive Cancer Center
• 1997-2007
  Director, Prostate Cancer Program, UCSF Helen Diller Family Comprehensive Cancer Center
• 1997-present
  Executive Committee, UCSF Helen Diller Family Comprehensive Cancer Center
• 1999-present
  Professor of Urology, University of California, San Francisco
• 2005-present
  Clinical Director, California Institute for Quantitative Biomedical Research (QB3), San Francisco, CA

Honors & Awards

• 1980
  Elected to American Society of Clinical Investigation
• 1981
  Awarded Research Career Development Award, National Institutes of Health
• 1989
  Elected to Association of American Physicians

Selected Publications

1. Rubenstein JL, Li J, Chen L, Advani R, Drappatz J, Gerstner E, Batchelor T, Krouwer H, Hwang J, Auerback G, Kadoch C, Lowell C, Munster P, Cha S, Shuman MA, Damon LE. Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma. Blood. 2013 Jan 31; 121(5):745-51.
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2. Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY. Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev. 2012 Aug 15; 26(16):1780-96.
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3. Wieduwilt MJ, Valles F, Issa S, Behler CM, Hwang J, McDermott M, Treseler P, O'Brien J, Shuman MA, Cha S, Damon LE, Rubenstein JL. Immunochemotherapy with intensive consolidation for primary CNS lymphoma: a pilot study and prognostic assessment by diffusion-weighted MRI. Clin Cancer Res. 2012 Feb 15; 18(4):1146-55.
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4. Huang V, Place RF, Portnoy V, Wang J, Qi Z, Jia Z, Yu A, Shuman M, Yu J, Li LC. Upregulation of Cyclin B1 by miRNA and its implications in cancer. Nucleic Acids Res. 2012 Feb; 40(4):1695-707.
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5. Sun C, Su KH, Valentine J, Rosa-Bauza YT, Ellman JA, Elboudwarej O, Mukherjee B, Craik CS, Shuman MA, Chen FF, Zhang X. Time-resolved single-step protease activity quantification using nanoplasmonic resonator sensors. ACS Nano. 2010 Feb 23; 4(2):978-84.
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6. So AY, de la Fuente E, Walter P, Shuman M, Bernales S. The unfolded protein response during prostate cancer development. Cancer Metastasis Rev. 2009 Jun; 28(1-2):219-23.
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7. Kadoch C, Dinca EB, Voicu R, Chen L, Nguyen D, Parikh S, Karrim J, Shuman MA, Lowell CA, Treseler PA, James CD, Rubenstein JL. Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model. Clin Cancer Res. 2009 Mar 15; 15(6):1989-97.
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8. Rubenstein JL, Shen A, Batchelor TT, Kadoch C, Treseler P, Shuman MA. Differential gene expression in central nervous system lymphoma. Blood. 2009 Jan 1; 113(1):266-7; author reply 267-8.
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9. Roy S, Josephson SA, Fridlyand J, Karch J, Kadoch C, Karrim J, Damon L, Treseler P, Kunwar S, Shuman MA, Jones T, Becker CH, Schulman H, Rubenstein JL. Protein biomarker identification in the CSF of patients with CNS lymphoma. J Clin Oncol. 2008 Jan 1; 26(1):96-105.
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10. Rubenstein JL, Fridlyand J, Abrey L, Shen A, Karch J, Wang E, Issa S, Damon L, Prados M, McDermott M, O'Brien J, Haqq C, Shuman M. Phase I study of intraventricular administration of rituximab in patients with recurrent CNS and intraocular lymphoma. J Clin Oncol. 2007 Apr 10; 25(11):1350-6.
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11. Chan JM, Feraco A, Shuman M, Hernández-Díaz S. The epidemiology of prostate cancer--with a focus on nonsteroidal anti-inflammatory drugs. Hematol Oncol Clin North Am. 2006 Aug; 20(4):797-809.
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12. Rubenstein JL, Fridlyand J, Shen A, Aldape K, Ginzinger D, Batchelor T, Treseler P, Berger M, McDermott M, Prados M, Karch J, Okada C, Hyun W, Parikh S, Haqq C, Shuman M. Gene expression and angiotropism in primary CNS lymphoma. Blood. 2006 May 1; 107(9):3716-23.
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13. Tindall D, Horne FM, Hruszkewycz A, Mohla S, Shuman M, Wang Z, Kantoff P. Symposium on androgen action in prostate cancer. Cancer Res. 2004 Oct 1; 64(19):7178-80.
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14. Reddy JC, Shuman MA, Aster RH. Quinine/quinidine-induced thrombocytopenia: a great imitator. Arch Intern Med. 2004 Jan 26; 164(2):218-20.
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15. Bhatt AS, Takeuchi T, Ylstra B, Ginzinger D, Albertson D, Shuman MA, Craik CS. Quantitation of membrane type serine protease 1 (MT-SP1) in transformed and normal cells. Biol Chem. 2003 Feb; 384(2):257-66.
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16. Bok RA, Hansell EJ, Nguyen TP, Greenberg NM, McKerrow JH, Shuman MA. Patterns of protease production during prostate cancer progression: proteomic evidence for cascades in a transgenic model. Prostate Cancer Prostatic Dis. 2003; 6(4):272-80.
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17. Rubenstein JL, Combs D, Rosenberg J, Levy A, McDermott M, Damon L, Ignoffo R, Aldape K, Shen A, Lee D, Grillo-Lopez A, Shuman MA. Rituximab therapy for CNS lymphomas: targeting the leptomeningeal compartment. Blood. 2003 Jan 15; 101(2):466-8.
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18. Rubenstein J, Fischbein N, Aldape K, Burton E, Shuman M. Hemorrhage and VEGF expression in a case of primary CNS lymphoma. J Neurooncol. 2002 May; 58(1):53-6.
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19. Elfman F, Bok R, Conn M, Shuman M, Cunha G. Urokinase plasminogen activator amino-terminal peptides inhibit development of the rat ventral prostate. Differentiation. 2001 Dec; 69(2-3):108-20.
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20. Bok RA, Halabi S, Fei DT, Rodriquez CR, Hayes DF, Vogelzang NJ, Kantoff P, Shuman MA, Small EJ. Vascular endothelial growth factor and basic fibroblast growth factor urine levels as predictors of outcome in hormone-refractory prostate cancer patients: a cancer and leukemia group B study. Cancer Res. 2001 Mar 15; 61(6):2533-6.
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