University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Tara Sigdel, PhD

Tara Sigdel, PhD

Assistant Professor, Department of Surgery, UCSF

Cancer Center Program Memberships

Affiliate Member

Research Summary

My research is driven by two major factors. First, there is an unprecedented pressure to deliver new and improved diagnostic and treatment options to patients. Second, due to improved understanding of biological intricacies with ever improving molecular assays have placed us in a much better position to look for disease specific biomarkers that once validated can be used in the clinics in order to provide timely and accurate assessment of health status of patients.

Education

Tribhuvan University, Nepal, B.Sc., 08/87-07/89, Biology/Chemistry
Tribhuvan University, Nepal, M.Sc., 07/90-08/92, Chemistry
Miami University, Oxford, OH & Stanford University, Ph.D., 08/00-09/05, Biochemistry
Stanford University, Postdoctoral Training, 11/05-06/09, Biomarker Discovery in Organ Transplantation


Professional Experience

  • 1992-1993
    Research Assistant, Research Laboratory for Agricultural Biotechnology and Biochemistry
  • 1993-1994
    Lecturer, Tribhuvan University, Kathmandu, Nepal
  • 1995-2000
    Chemistry Faculty, Chemistry Dept, Budhanilkantha School, Kathmandu, Nepal
  • 1999-2000
    Chair, Chemistry Dept., Budhanilkantha School, Kathmandu, Nepal
  • 2000-2003
    Teaching Associate, Miami University, Oxford, OH
  • 2004-2005
    Graduate Research Assistant, Miami University, Oxford, OH
  • 2005-2009
    Postdoctoral Fellow, Stanford University, Stanford, CA
  • 2009-2011
    Research Associate, Stanford University, Stanford, CA
  • 2012-2014
    Associate Scientist, California Pacific Medical Center, San Francisco, CA
  • 2014-present
    Assistant Professor, University of California San Francisco, San Francisco, CA

Honors & Awards

  • 2007-2008
    Recipient of Deans Fellowship 2007-2008, Stanford University
  • 2008-2009
    Recipient of Pediatric Research Fund – CHRP Award
  • 2008
    Helena Anna Henzl Gabor Award to attend XXII International Congress of The Transplantation Society, Sydney, Australia
  • 2009-2010
    Recipient of Pediatric Research Fund – CHRP Award
  • 2009-2010
    Awarded with Transplant and Tissue Engineering Center of Excellence (COE) grant to work
    as a postdoctoral fellow on the development of a novel non-Invasive urinary proteomic panel for monitoring transplant health.

Selected Publications

  1. Sigdel TK, Nicora CD, Qian WJ, Sarwal MM. Optimization for Peptide Sample Preparation for Urine Peptidomics. Methods Mol Biol. 2018 Apr 06.
    View on PubMed
  2. Pineda S, Sigdel TK, Chen J, Jackson AM, Sirota M, Sarwal MM. Corrigendum: Novel Non-Histocompatibility Antigen Mismatched Variants Improve the Ability to Predict Antibody-Mediated Rejection Risk in Kidney Transplant. Front Immunol. 2018; 9:107.
    View on PubMed
  3. Pineda S, Sigdel TK, Chen J, Jackson AM, Sirota M, Sarwal MM. Novel Non-Histocompatibility Antigen Mismatched Variants Improve the Ability to Predict Antibody-Mediated Rejection Risk in Kidney Transplant. Front Immunol. 2017; 8:1687.
    View on PubMed
  4. Towfighi P, Shaw J, Sigdel T. Fractionation of Soluble Proteins Using DEAE-Sepharose, SP-Sepharose, and Phenyl Sepharose Chromatographies for Proteomics. Methods Mol Biol. 2017 Dec 02.
    View on PubMed
  5. Sigdel TK, Sarwal MM. Discovery of Immune Reactive Human Proteins by High-Density Protein Arrays and Customized Validation of Potential Biomarkers by ELISA. Methods Mol Biol. 2017 Nov 08.
    View on PubMed
  6. Gao Y, Wang H, Nicora CD, Shi T, Smith RD, Sigdel TK, Sarwal MM, Camp DG, Qian WJ. LC-SRM-Based Targeted Quantification of Urinary Protein Biomarkers. Methods Mol Biol. 2017 Nov 08.
    View on PubMed
  7. Roedder S, Sigdel T, Hsieh SC, Cheeseman J, Metes D, Macedo C, Reed EF, Gritsch HA, Zeevi A, Shapiro R, Kirk AD, Sarwal MM. Expression of Mitochondrial-Encoded Genes in Blood Differentiate Acute Renal Allograft Rejection. Front Med (Lausanne). 2017; 4:185.
    View on PubMed
  8. Chandran S, Tang Q, Sarwal M, Laszik ZG, Putnam AL, Lee K, Leung J, Nguyen V, Sigdel T, Tavares EC, Yang JYC, Hellerstein M, Fitch M, Bluestone JA, Vincenti F. Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants. Am J Transplant. 2017 Nov; 17(11):2945-2954.
    View on PubMed
  9. Sigdel TK, Sarwal MM. Assessment of Circulating Protein Signatures for Kidney Transplantation in Pediatric Recipients. Front Med (Lausanne). 2017; 4:80.
    View on PubMed
  10. Crespo E, Roedder S, Sigdel T, Hsieh SC, Luque S, Cruzado JM, Tran TQ, Grinyó JM, Sarwal MM, Bestard O. Molecular and Functional Noninvasive Immune Monitoring in the ESCAPE Study for Prediction of Subclinical Renal Allograft Rejection. Transplantation. 2017 06; 101(6):1400-1409.
    View on PubMed
  11. Pidala J, Sigdel TK, Wang A, Hsieh S, Inamoto Y, Martin PJ, Flowers ME, Hansen JA, Lee SJ, Sarwal MM. A combined biomarker and clinical panel for chronic graft versus host disease diagnosis. J Pathol Clin Res. 2017 Jan; 3(1):3-16.
    View on PubMed
  12. Sigdel TK, Bestard O, Salomonis N, Hsieh SC, Torras J, Naesens M, Tran TQ, Roedder S, Sarwal MM. Intragraft Antiviral-Specific Gene Expression as a Distinctive Transcriptional Signature for Studies in Polyomavirus-Associated Nephropathy. Transplantation. 2016 10; 100(10):2062-70.
    View on PubMed
  13. Nasr M, Sigdel T, Sarwal M. Advances in diagnostics for transplant rejection. Expert Rev Mol Diagn. 2016 10; 16(10):1121-1132.
    View on PubMed
  14. Yang JY, Sigdel TK, Sarwal MM. Self-antigens and rejection: a proteomic analysis. Curr Opin Organ Transplant. 2016 Aug; 21(4):362-7.
    View on PubMed
  15. Sigdel TK, Gao Y, He J, Wang A, Nicora CD, Fillmore TL, Shi T, Webb-Robertson BJ, Smith RD, Qian WJ, Salvatierra O, Camp DG, Sarwal MM. Mining the human urine proteome for monitoring renal transplant injury. Kidney Int. 2016 06; 89(6):1244-52.
    View on PubMed
  16. Wei C, Sigdel TK, Sarwal MM, Reiser J. Circulating CD40 autoantibody and suPAR synergy drives glomerular injury. Ann Transl Med. 2015 Nov; 3(19):300.
    View on PubMed
  17. Sigdel TK, Bestard O, Tran TQ, Hsieh SC, Roedder S, Damm I, Vincenti F, Sarwal MM. A Computational Gene Expression Score for Predicting Immune Injury in Renal Allografts. PLoS One. 2015; 10(9):e0138133.
    View on PubMed
  18. Vitalone MJ, Sigdel TK, Salomonis N, Sarwal RD, Hsieh SC, Sarwal MM. Transcriptional Perturbations in Graft Rejection. Transplantation. 2015 Sep; 99(9):1882-93.
    View on PubMed
  19. Sigdel TK, Ng YW, Lee S, Nicora CD, Qian WJ, Smith RD, Camp DG, Sarwal MM. Perturbations in the urinary exosome in transplant rejection. Front Med (Lausanne). 2014; 1:57.
    View on PubMed
  20. Woo SH, Sigdel TK, Dinh VT, Vu MT, Sarwal MM, Lafayette RA. Mapping novel immunogenic epitopes in IgA nephropathy. Clin J Am Soc Nephrol. 2015 Mar 06; 10(3):372-81.
    View on PubMed

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