University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
James F. Smith, MD

James F. Smith, MD

Assistant Professor, Department of Urology, UCSF

Research Summary

Dr. Smith is Director of the UCSF Male Reproductive Health practice dedicated to providing outstanding reproductive clinical care, conducting cutting edge research, and improving access to reproductive care. His research program is dedicated to helping men and boys with cancer become fathers after surviving cancer treatment. He and his partners conduct basic science investigations of sperm physiology, sperm stem cells, and semen physiology; translational research focused on fertility restoration by means of testicular and stem cell transplantation; and clinical research into reproductive effects of targeted cancer therapies such as tyrosine kinase inhibitors and MTOR inhibitors., Clinically, Dr. Smith treats men with fertility problems, need for fertility preservation, erectile dysfunction, orchalgia, and hypogonadism in the Center for Reproductive Health. Dr. Smith specializes in the use of minimally invasive vasectomy, microsurgical vasovasostomy, vasoepididymostomy, sperm retrieval techniques, spermatic cord denervation, and varicocelectomy.

Selected Publications

  1. Salomo K, Smith JF, Feild TS, Samain MS, Bond L, Davidson C, Zimmers J, Neinhuis C, Wanke S. The Emergence of Earliest Angiosperms may be Earlier than Fossil Evidence Indicates. Syst Bot. 2017 Dec; 42(4):607-619.
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  2. Gilbert K, Nangia AK, Dupree JM, Smith JF, Mehta A. Fertility preservation for men with testicular cancer: Is sperm cryopreservation cost effective in the era of assisted reproductive technology? Urol Oncol. 2018 Mar; 36(3):92.e1-92.e9.
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  3. Hall J, Ralph EC, Shanker S, Wang H, Byrnes LJ, Horst R, Wong J, Brault A, Dumlao D, Smith JF, Dakin LA, Schmitt DC, Trujillo J, Vincent F, Griffor M, Aulabaugh AE. The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition. Protein Sci. 2017 Dec; 26(12):2367-2380.
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  4. Ramstein JJ, Tsai KK, Smith JF. Tyrosine Kinase Inhibitors and Male Reproductive Health. Clin Pharmacol Ther. 2017 Nov; 102(5):754-756.
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  5. Swallow JG, Kim JJ, Maloney JM, Chen D, Smith JF, Bishop SR, Tuller HL, Van Vliet KJ. Dynamic chemical expansion of thin-film non-stoichiometric oxides at extreme temperatures. Nat Mater. 2017 Jul; 16(7):749-754.
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  6. Ho JR, Hoffman JR, Aghajanova L, Smith JF, Cardenas M, Herndon CN. Demographic analysis of a low resource, socioculturally diverse urban community presenting for infertility care in a United States public hospital. Contracept Reprod Med. 2017; 2:17.
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  7. Smith JF. Maternal fetal medicine. Curr Opin Obstet Gynecol. 2017 Apr; 29(2):65.
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  8. Reynolds NK, Smith ME, Tretter ED, Gause J, Heeney D, Cafaro MJ, Smith JF, Novak SJ, Bourland WA, White MM. Resolving relationships at the animal-fungal divergence: A molecular phylogenetic study of the protist trichomycetes (Ichthyosporea, Eccrinida). Mol Phylogenet Evol. 2017 04; 109:447-464.
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  9. Neidleman JA, Chen JC, Kohgadai N, Müller JA, Laustsen A, Thavachelvam K, Jang KS, Stürzel CM, Jones JJ, Ochsenbauer C, Chitre A, Somsouk M, Garcia MM, Smith JF, Greenblatt RM, Münch J, Jakobsen MR, Giudice LC, Greene WC, Roan NR. Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells. PLoS Pathog. 2017 Feb; 13(2):e1006163.
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  10. Selvaraj V, Hour S, Gunasekar P, Gray C, Smith JF. Escitalopram-Induced Amenorrhea and False Positive Urine Pregnancy Test. Korean J Fam Med. 2017 Jan; 38(1):40-42.
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  11. Hussein AA, Yango P, Ezz Y, Smith JF, Tran ND. Fertility preservation options for prepubertal boys facing gonadotoxic therapies. Minerva Ginecol. 2016 Dec; 68(6):668-74.
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  12. Smith JF, Clark JL, Amaya-Márquez M, Marín-Gómez OH. Resolving incongruence: Species of hybrid origin in Columnea (Gesneriaceae). Mol Phylogenet Evol. 2017 01; 106:228-240.
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  13. Winkelman WD, Katz PP, Smith JF, Rowen TS. The Sexual Impact of Infertility Among Women Seeking Fertility Care. Sex Med. 2016 Sep; 4(3):e190-7.
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  14. Mehta A, Nangia AK, Dupree JM, Smith JF. Limitations and barriers in access to care for male factor infertility. Fertil Steril. 2016 05; 105(5):1128-1137.
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  15. Moline HR, Smith JF. The continuing threat of syphilis in pregnancy. Curr Opin Obstet Gynecol. 2016 Apr; 28(2):101-4.
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  16. Miller MR, Mannowetz N, Iavarone AT, Safavi R, Gracheva EO, Smith JF, Hill RZ, Bautista DM, Kirichok Y, Lishko PV. Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone. Science. 2016 Apr 29; 352(6285):555-9.
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  17. Smith JF, Tran ND. Freezing and thawing testicular cells may not affect growth of cultured testicular cells. Fertil Steril. 2015 Nov; 104(5):1129.
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  18. Singer ST, Killilea D, Suh JH, Wang ZJ, Yuan Q, Ivani K, Evans P, Vichinsky E, Fischer R, Smith JF. Fertility in transfusion-dependent thalassemia men: effects of iron burden on the reproductive axis. Am J Hematol. 2015 Sep; 90(9):E190-2.
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  19. Hussein AA, Tran ND, Smith JF. Fertility preservation for boys and adolescents facing sterilizing medical therapy. Transl Androl Urol. 2014 Dec; 3(4):382-90.
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  20. Yango P, Altman E, Smith JF, Klatsky PC, Tran ND. Optimizing cryopreservation of human spermatogonial stem cells: comparing the effectiveness of testicular tissue and single cell suspension cryopreservation. Fertil Steril. 2014 Nov; 102(5):1491-1498.e1.
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