Research Summary

Dr. Smith is Director of the UCSF Male Reproductive Health practice dedicated to providing outstanding reproductive clinical care, conducting cutting edge research, and improving access to reproductive care. His research program is dedicated to helping men and boys with cancer become fathers after surviving cancer treatment. He and his partners conduct basic science investigations of sperm physiology, sperm stem cells, and semen physiology; translational research focused on fertility restoration by means of testicular and stem cell transplantation; and clinical research into reproductive effects of targeted cancer therapies such as tyrosine kinase inhibitors and MTOR inhibitors., Clinically, Dr. Smith treats men with fertility problems, need for fertility preservation, erectile dysfunction, orchalgia, and hypogonadism in the Center for Reproductive Health. Dr. Smith specializes in the use of minimally invasive vasectomy, microsurgical vasovasostomy, vasoepididymostomy, sperm retrieval techniques, spermatic cord denervation, and varicocelectomy.

Research Funding

  • April 1, 2015 - November 30, 2020 - Molecular identity of human sperm potassium channel and its role in male fertility , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM111802

Education

University of California, Berkeley B.A. 1996 Molecular Biology
UC Berkeley, UCSF Joint Medical Program M.S. 2000 Public Health, Medicine
University of California, San Francisco M.D. 2002 Medicine
University of Utah Urology Residency 2007 Urology
University of California, San Francisco Male Reproductive and Sexual Medicine Fellowship 2009 Urology

Selected Publications

  1. Savoie MB, Paciorek A, Van Loon K, Anwar M, Atreya CE, Johnson PC, Kenfield SA, Laffan A, Levin AO, Smith JF, Stanfield D, Venook A, Zhang L, Van Blarigan EL, Rowen T. Sexual function remains persistently low in women after treatment for colorectal cancer and anal squamous cell carcinoma. J Sex Med. 2023 03 31; 20(4):439-446.  View on PubMed
  2. Adeleye AJ, Stark BA, Jalalian L, Mok-Lin E, Smith JF. Evidence of Spermatogenesis in the Presence of Hypothalamic Suppression and Low Testosterone in an Adolescent Transgender Female: A Case Report. Transgend Health. 2023 Feb; 8(1):104-107.  View on PubMed
  3. Hakam N, Lui J, Shaw NM, Nabavizadeh B, Smith JF, Eisenberg ML, Breyer BN. Hematospermia is rarely associated with urologic malignancy: Analysis of United States claims data. Andrology. 2022 07; 10(5):919-925.  View on PubMed
  4. Baker KC, Steiner AZ, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, Krawetz SA, Usadi R, Baker VL, Coward RM, Sun F, Wild R, Masson P, Smith JF, Santoro N, Zhang H. Poor reproducibility of percentage of normally shaped sperm using the World Health Organization Fifth Edition strict grading criteria. F S Rep. 2022 Jun; 3(2):110-115.  View on PubMed
  5. Ho JR, Aghajanova L, Mok-Lin E, Hoffman JR, Smith JF, Herndon CN. Public attitudes in the United States toward insurance coverage for in vitro fertilization and the provision of infertility services to lower income patients. F S Rep. 2022 May; 3(2 Suppl):122-129.  View on PubMed
  6. Asanad K, Matthew Coward R, Mehta A, Smith JF, Vij SC, Nusbaum DJ, Rodman JCS, Samplaski MK. Factors Influencing the Decision for Fresh vs Cryopreserved Microdissection Testicular Sperm Extraction for Non-Obstructive Azoospermia. Urology. 2021 11; 157:131-137.  View on PubMed
  7. Chen AB, Jarvi KA, Lajkosz K, Smith JF, Lo KC, Grober ED, Lau S, Bieniek JM, Brannigan RE, Chow VDW, Domes T, Dupree JM, Goldstein M, Hedges JC, Hotaling JM, Ko EY, Kolettis PN, Nangia AK, Sandlow JI, Shin D, Spitz A, Trussell JC, Zeitlin SI, Zini AS, Fisher MA, Walsh TJ, Hsieh TM, Fuchs EF, Samplaski MK. One size does not fit all: variations by ethnicity in demographic characteristics of men seeking fertility treatment across North America. Fertil Steril. 2021 11; 116(5):1287-1294.  View on PubMed
  8. Banks N, Sun F, Krawetz SA, Coward RM, Masson P, Smith JF, Trussell JC, Santoro N, Zhang H, Steiner AZ. Male vitamin D status and male factor infertility. Fertil Steril. 2021 10; 116(4):973-979.  View on PubMed
  9. Rios JS, Coward RM, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, Krawetz SA, Usadi R, Baker VL, Sun F, Wild R, Smith JF, Santoro N, Zhang H, Steiner AZ. Sperm deoxyribonucleic acid fragmentation: predictors, fertility outcomes, and assays among infertile males. F S Rep. 2021 Sep; 2(3):282-288.  View on PubMed
  10. Yang H, Lindsey JP, Gillis-Buck EM, Srirangapatanam S, Rosen JE, Hussein AA, Smith JF. Ex vivo human testes as a practical model to simulate ultrasound-guided testicular cell transplantation for human fertility restoration. F S Sci. 2021 05; 2(2):135-140.  View on PubMed
  11. Dupree JM, Coward RM, Hsieh TC, Tanrikut C, Shin P, Mehta A, Hotaling JM, Pastuszak AW, Williams D, Alukal J, Lipshultz LI, Schlegel P, Walsh TJ, Eisenberg ML, Shin D, Honig S, Nagler HM, Samplaski M, Nangia AK, Sandlow J, Smith JF, Society for the Study of Male Reproduction (SSMR) and Society for Male Reproduction and Urology (SMR. The Impact of Physician Productivity Models on Access to Subspecialty Care: A White Paper From the Society for the Study of Male Reproduction and the Society for Male Reproduction and Urology. Urology. 2021 07; 153:28-34.  View on PubMed
  12. Samplaski MK, Falk O, Honig S, Shin D, Matthews W, Smith JF. Development and validation of a novel mail-in semen analysis system and the correlation between one hour and delayed semen analysis testing. Fertil Steril. 2021 04; 115(4):922-929.  View on PubMed
  13. Woodruff TK, Ataman-Millhouse L, Acharya KS, Almeida-Santos T, Anazodo A, Anderson RA, Appiah L, Bader J, Becktell K, Brannigan RE, Breech L, Bourlon MT, Bumbuliene Ž, Burns K, Campo-Engelstein L, Campos JR, Centola GM, Chehin MB, Chen D, De Vos M, Duncan FE, El-Damen A, Fair D, Famuyiwa Y, Fechner PY, Fontoura P, Frias O, Gerkowicz SA, Ginsberg J, Gracia CR, Goldman K, Gomez-Lobo V, Hazelrigg B, Hsieh MH, Hoyos LR, Hoyos-Martinez A, Jach R, Jassem J, Javed M, Jayasinghe Y, Jeelani R, Jeruss JS, Kaul-Mahajan N, Keim-Malpass J, Ketterl TG, Khrouf M, Kimelman D, Kusuhara A, Kutteh WH, Laronda MM, Lee JR, Lehmann V, Letourneau JM, McGinnis LK, McMahon E, Meacham LR, Mijangos MFV, Moravek M, Nahata L, Ogweno GM, Orwig KE, Pavone ME, Peccatori FA, Pesce RI, Pulaski H, Quinn G, Quintana R, Quintana T, de Carvalho BR, Ramsey-Goldman R, Reinecke J, Reis FM, Rios J, Rhoton-Vlasak AS, Rodriguez-Wallberg KA, Roeca C, Rotz SJ, Rowell E, Salama M, Saraf AJ, Scarella A, Schafer-Kalkhoff T, Schmidt D, Senapati S, Shah D, Shikanov A, Shnorhavorian M, Skiles JL, Smith JF, Smith K, Sobral F, Stimpert K, Su HI, Sugimoto K, Suzuki N, Thakur M, Victorson D, Viale L, Vitek W, Wallace WH, Wartella EA, Westphal LM, Whiteside S, Wilcox LH, Wyns C, Xiao S, Xu J, Zelinski M. A View from the past into our collective future: the oncofertility consortium vision statement. J Assist Reprod Genet. 2021 Jan; 38(1):3-15.  View on PubMed
  14. Hoffman JR, Delaney MA, Valdes CT, Herrera D, Washington SL, Aghajanova L, Smith JF, Herndon CN. Disparities in fertility knowledge among women from low and high resource settings presenting for fertility care in two United States metropolitan centers. Fertil Res Pract. 2020; 6:15.  View on PubMed
  15. Steiner AZ, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, Krawetz SA, Usadi R, Baker VL, Coward RM, Huang H, Wild R, Masson P, Smith JF, Santoro N, Eisenberg E, Zhang H, Reproductive Medicine Network. The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial. Fertil Steril. 2020 03; 113(3):552-560.e3.  View on PubMed
  16. Samplaski MK, Smith JF, Lo KC, Hotaling JM, Lau S, Grober ED, Trussell JC, Walsh TJ, Kolettis PN, Chow VDW, Zini AS, Spitz A, Fischer MA, Domes T, Zeitlin SI, Fuchs EF, Hedges JC, Sandlow JI, Brannigan RE, Dupree JM, Goldstein M, Ko EY, Hsieh TM, Bieniek JM, Shin D, Nangia AK, Jarvi KA. Reproductive endocrinologists are the gatekeepers for male infertility care in North America: results of a North American survey on the referral patterns and characteristics of men presenting to male infertility specialists for infertility investigations. Fertil Steril. 2019 10; 112(4):657-662.  View on PubMed
  17. Coward RM, Stetter C, Kunselman A, Trussell JC, Lindgren MC, Alvero RR, Casson P, Christman GM, Coutifaris C, Diamond MP, Hansen KR, Krawetz SA, Legro RS, Robinson RD, Smith JF, Steiner AZ, Wild RA, Zhang H, Santoro N, Reproductive Medicine Network. Fertility Related Quality of Life, Gonadal Function and Erectile Dysfunction in Male Partners of Couples with Unexplained Infertility. J Urol. 2019 08; 202(2):379-384.  View on PubMed
  18. Smith BM, Duncan FE, Ataman L, Smith K, Quinn GP, Chang RJ, Finlayson C, Orwig K, Valli-Pulaski H, Moravek MB, Zelinski MB, Irene Su H, Vitek W, Smith JF, Jeruss JS, Gracia C, Coutifaris C, Shah D, Nahata L, Gomez-Lobo V, Appiah LC, Brannigan RE, Gillis V, Gradishar W, Javed A, Rhoton-Vlasak AS, Kondapalli LA, Neuber E, Ginsberg JP, Muller CH, Hirshfeld-Cytron J, Kutteh WH, Lindheim SR, Cherven B, Meacham LR, Rao P, Torno L, Sender LS, Vadaparampil ST, Skiles JL, Schafer-Kalkhoff T, Frias OJ, Byrne J, Westphal LM, Schust DJ, Klosky JL, McCracken KA, Ting A, Khan Z, Granberg C, Lockart B, Scoccia B, Laronda MM, Mersereau JE, Marsh C, Pavone ME, Woodruff TK. The National Physicians Cooperative: transforming fertility management in the cancer setting and beyond. Future Oncol. 2018 Dec; 14(29):3059-3072.  View on PubMed
  19. Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, MacKenzie TC, Patel T, Price RW, Smith JF, Woodruff PG, Erle DJ. Large Differences in Small RNA Composition Between Human Biofluids. Cell Rep. 2018 10 30; 25(5):1346-1358.  View on PubMed
  20. Adeleye AJ, Reid G, Kao CN, Mok-Lin E, Smith JF. Semen Parameters Among Transgender Women With a History of Hormonal Treatment. Urology. 2019 02; 124:136-141.  View on PubMed

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