University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
James F. Smith, MD

James F. Smith, MD

Assistant Professor, Department of Urology, UCSF

Research Summary

Dr. Smith is Director of the UCSF Male Reproductive Health practice dedicated to providing outstanding reproductive clinical care, conducting cutting edge research, and improving access to reproductive care. His research program is dedicated to helping men and boys with cancer become fathers after surviving cancer treatment. He and his partners conduct basic science investigations of sperm physiology, sperm stem cells, and semen physiology; translational research focused on fertility restoration by means of testicular and stem cell transplantation; and clinical research into reproductive effects of targeted cancer therapies such as tyrosine kinase inhibitors and MTOR inhibitors., Clinically, Dr. Smith treats men with fertility problems, need for fertility preservation, erectile dysfunction, orchalgia, and hypogonadism in the Center for Reproductive Health. Dr. Smith specializes in the use of minimally invasive vasectomy, microsurgical vasovasostomy, vasoepididymostomy, sperm retrieval techniques, spermatic cord denervation, and varicocelectomy.

Selected Publications

  1. Ramstein JJ, Tsai KK, Smith JF. Tyrosine Kinase Inhibitors and Male Reproductive Health. Clin Pharmacol Ther. 2017 Aug 09.
    View on PubMed
  2. Swallow JG, Kim JJ, Maloney JM, Chen D, Smith JF, Bishop SR, Tuller HL, Van Vliet KJ. Dynamic chemical expansion of thin-film non-stoichiometric oxides at extreme temperatures. Nat Mater. 2017 Jul; 16(7):749-754.
    View on PubMed
  3. Smith JF. Maternal fetal medicine. Curr Opin Obstet Gynecol. 2017 Apr; 29(2):65.
    View on PubMed
  4. Reynolds NK, Smith ME, Tretter ED, Gause J, Heeney D, Cafaro MJ, Smith JF, Novak SJ, Bourland WA, White MM. Resolving relationships at the animal-fungal divergence: A molecular phylogenetic study of the protist trichomycetes (Ichthyosporea, Eccrinida). Mol Phylogenet Evol. 2017 Apr; 109:447-464.
    View on PubMed
  5. Selvaraj V, Hour S, Gunasekar P, Gray C, Smith JF. Escitalopram-Induced Amenorrhea and False Positive Urine Pregnancy Test. Korean J Fam Med. 2017 Jan; 38(1):40-42.
    View on PubMed
  6. Hussein AA, Yango P, Ezz Y, Smith JF, Tran ND. Fertility preservation options for prepubertal boys facing gonadotoxic therapies. Minerva Ginecol. 2016 Dec; 68(6):668-74.
    View on PubMed
  7. Smith JF, Clark JL, Amaya-Márquez M, Marín-Gómez OH. Resolving incongruence: Species of hybrid origin in Columnea (Gesneriaceae). Mol Phylogenet Evol. 2017 Jan; 106:228-240.
    View on PubMed
  8. Winkelman WD, Katz PP, Smith JF, Rowen TS. The Sexual Impact of Infertility Among Women Seeking Fertility Care. Sex Med. 2016 Sep; 4(3):e190-7.
    View on PubMed
  9. Mehta A, Nangia AK, Dupree JM, Smith JF. Limitations and barriers in access to care for male factor infertility. Fertil Steril. 2016 May; 105(5):1128-1137.
    View on PubMed
  10. Moline HR, Smith JF. The continuing threat of syphilis in pregnancy. Curr Opin Obstet Gynecol. 2016 Apr; 28(2):101-4.
    View on PubMed
  11. Miller MR, Mannowetz N, Iavarone AT, Safavi R, Gracheva EO, Smith JF, Hill RZ, Bautista DM, Kirichok Y, Lishko PV. Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone. Science. 2016 Apr 29; 352(6285):555-9.
    View on PubMed
  12. Smith JF, Tran ND. Freezing and thawing testicular cells may not affect growth of cultured testicular cells. Fertil Steril. 2015 Nov; 104(5):1129.
    View on PubMed
  13. Singer ST, Killilea D, Suh JH, Wang ZJ, Yuan Q, Ivani K, Evans P, Vichinsky E, Fischer R, Smith JF. Fertility in transfusion-dependent thalassemia men: effects of iron burden on the reproductive axis. Am J Hematol. 2015 Sep; 90(9):E190-2.
    View on PubMed
  14. Hussein AA, Tran ND, Smith JF. Fertility preservation for boys and adolescents facing sterilizing medical therapy. Transl Androl Urol. 2014 Dec; 3(4):382-90.
    View on PubMed
  15. Yango P, Altman E, Smith JF, Klatsky PC, Tran ND. Optimizing cryopreservation of human spermatogonial stem cells: comparing the effectiveness of testicular tissue and single cell suspension cryopreservation. Fertil Steril. 2014 Nov; 102(5):1491-1498.e1.
    View on PubMed
  16. Smith JF, Yango P, Altman E, Choudhry S, Poelzl A, Zamah AM, Rosen M, Klatsky PC, Tran ND. Testicular niche required for human spermatogonial stem cell expansion. Stem Cells Transl Med. 2014 Sep; 3(9):1043-54.
    View on PubMed
  17. Altman E, Yango P, Moustafa R, Smith JF, Klatsky PC, Tran ND. Characterization of human spermatogonial stem cell markers in fetal, pediatric, and adult testicular tissues. Reproduction. 2014 Oct; 148(4):417-27.
    View on PubMed
  18. Odisho AY, Nangia AK, Katz PP, Smith JF. Temporal and geospatial trends in male factor infertility with assisted reproductive technology in the United States from 1999-2010. Fertil Steril. 2014 Aug; 102(2):469-75.
    View on PubMed
  19. Roan NR, Liu H, Usmani SM, Neidleman J, Müller JA, Avila-Herrera A, Gawanbacht A, Zirafi O, Chu S, Dong M, Kumar ST, Smith JF, Pollard KS, Fändrich M, Kirchhoff F, Münch J, Witkowska HE, Greene WC. Liquefaction of semen generates and later degrades a conserved semenogelin peptide that enhances HIV infection. J Virol. 2014 Jul; 88(13):7221-34.
    View on PubMed
  20. Mannowetz N, Naidoo NM, Choo SA, Smith JF, Lishko PV. Slo1 is the principal potassium channel of human spermatozoa. Elife. 2013 Oct 08; 2:e01009.
    View on PubMed

Go to UCSF Profiles, powered by CTSI