University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Ma Somsouk, MD, MAS

Ma Somsouk, MD, MAS

Assistant Professor, Department of Medicine (Gastroenterology), UCSF

Cancer Center Program Memberships

Cancer Control

Research Summary

1. Precision population health. Quality of care for patient populations can be enhanced by embracing health information technology paired with tailored interventions. Dr. Somsouk's research program is funded by CDC, in partnership with the SF Department of Public Health, to examine how patient panel management can be employed to improve the continuum of colorectal cancer screening as a model condition. Randomized designs test health interventions and health economic approaches quantify the value of efficacious activities.

2. Intestinal mucosal biology. The gastrointestinal tract is a major site of disease pathogenesis. One major focus is HIV, quantifying the HIV reservoir and host control. Another focus is targeted interventions to modulate the microbiota. Approaches employed: organoid models, isolation of epithelial cells, lymphocytes, microbiota, and interventional trials such as fecal transplant.

Education

Pomona College, Claremont, CA, BA, 1993-1997, Chemistry
Harvard Medical School, Boston, MA, MD, 1997-2002, Medicine
Harbor-UCLA Medical Center, Torrance, CA, Residency, 2002-2005, Internal Medicine
University of California, San Francisco, CA, Fellowship, 2005-2008, Gastroenterology
University of California, San Francisco, CA, MAS, 2006-2008, Epidemiology and Biostatistics


Professional Experience

  • 2001-2002
    Research Scholar at Beijing University Health Science Center, China
  • 2002-2003
    Internship in Internal Medicine, Harbor-UCLA Medical Center, Torrance, CA
  • 2003-2005
    Residency in Internal Medicine, Harbor-UCLA Medical Center, Torrance, CA
  • 2005-2008
    Gastroenterology Fellowship, UCSF, San Francisco, CA
  • 2008-present
    Assistant Adjunct Professor of Medicine, UCSF, San Francisco, CA
  • 2009-present
    Director, Gastrointestinal Tissue Core Facility, UCSF, San Francisco, CA

Honors & Awards

  • 1997
    Sigma Xi
  • 1997
    Phi Beta Kappa
  • 1997
    Magna Cum Laude
  • 2000
    China Scholarship Council Research Scholar Fellowship
  • 2000
    Paul Dudley White/Andrew Sellard Fellowship
  • 2003
    Solomon Scholar
  • 2003
    AASLD Resident Scholar Award
  • 2006
    AGA Trainee Scholarship: Methodologies in Healthcare Outcomes in Gastroenterology
  • 2008
    AGA Academic Skills Workshop Scholarship

Selected Publications

  1. Telwatte S, Lee S, Somsouk M, Hatano H, Baker C, Kaiser P, Kim P, Chen TH, Milush J, Hunt PW, Deeks SG, Wong JK, Yukl SA. Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency. PLoS Pathog. 2018 Nov; 14(11):e1007357.
    View on PubMed
  2. Issaka RB, Avila P, Whitaker E, Bent S, Somsouk M. Population health interventions to improve colorectal cancer screening by fecal immunochemical tests: A systematic review. Prev Med. 2018 Oct 24; 118:113-121.
    View on PubMed
  3. Ellis L, Abrahão R, McKinley M, Yang J, Somsouk M, Marchand LL, Cheng I, Gomez SL, Shariff-Marco S. Colorectal Cancer Incidence Trends by Age, Stage, and Racial/Ethnic Group in California, 1990-2014. Cancer Epidemiol Biomarkers Prev. 2018 Aug 16.
    View on PubMed
  4. Lidofsky A, Holmes JA, Feeney ER, Kruger AJ, Salloum S, Zheng H, Seguin IS, Altinbas A, Masia R, Corey KE, Gustafson JL, Schaefer EA, Hunt PW, Deeks S, Somsouk M, Chew KW, Chung RT, Alatrakchi N. Macrophage Activation Marker Soluble CD163 is a Dynamic Marker of Liver Fibrogenesis in HIV/HCV Coinfection. J Infect Dis. 2018 Jun 04.
    View on PubMed
  5. Alsayid M, Singh MH, Issaka R, Laleau V, Day L, Lee J, Allison J, Somsouk M. Yield of Colonoscopy After a Positive Result From a Fecal Immunochemical Test OC-Light. Clin Gastroenterol Hepatol. 2018 Apr 13.
    View on PubMed
  6. Chitre AS, Kattah MG, Rosli YY, Pao M, Deswal M, Deeks SG, Hunt PW, Abdel-Mohsen M, Montaner LJ, Kim CC, Ma A, Somsouk M, McCune JM. A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function. PLoS Pathog. 2018 Mar; 14(3):e1006806.
    View on PubMed
  7. Hogan LE, Vasquez J, Hobbs KS, Hanhauser E, Aguilar-Rodriguez B, Hussien R, Thanh C, Gibson EA, Carvidi AB, Smith LCB, Khan S, Trapecar M, Sanjabi S, Somsouk M, Stoddart CA, Kuritzkes DR, Deeks SG, Henrich TJ. Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+ T cells expressing CD30. PLoS Pathog. 2018 Feb; 14(2):e1006856.
    View on PubMed
  8. Wen JW, Kohn MA, Wong R, Somsouk M, Khalili M, Maher J, Tana MM. Hospitalizations for Autoimmune Hepatitis Disproportionately Affect Black and Latino Americans. Am J Gastroenterol. 2018 Feb; 113(2):243-253.
    View on PubMed
  9. Kiniry BE, Hunt PW, Hecht FM, Somsouk M, Deeks SG, Shacklett BL. Differential Expression of CD8+ T Cell Cytotoxic Effector Molecules in Blood and Gastrointestinal Mucosa in HIV-1 Infection. J Immunol. 2018 Mar 01; 200(5):1876-1888.
    View on PubMed
  10. Issaka RB, Singh MH, Rachocki C, Day LW, Horton C, Somsouk M. Missed Opportunities in Colorectal Cancer Prevention in Patients With Inadequate Bowel Preparations. Clin Gastroenterol Hepatol. 2018 Jan 09.
    View on PubMed
  11. Ivey SL, Mukherjea A, Patel A, Kapoor N, Rau S, Kazi E, Bhatia J, Somsouk M, Tseng W. Colorectal Cancer Screening Among South Asians: Focus Group Findings on Attitudes, Knowledge, Barriers and Facilitators. J Health Care Poor Underserved. 2018; 29(4):1416-1437.
    View on PubMed
  12. Hiatt RA, Sibley A, Fejerman L, Glantz S, Nguyen T, Pasick R, Palmer N, Perkins A, Potter MB, Somsouk M, Vargas RA, van 't Veer LJ, Ashworth A. The San Francisco Cancer Initiative: A Community Effort To Reduce The Population Burden Of Cancer. Health Aff (Millwood). 2018 Jan; 37(1):54-61.
    View on PubMed
  13. Lin D, Soetikno RM, McQuaid K, Pham C, Doan G, Mou S, Shergill AK, Somsouk M, Rouse RV, Kaltenbach T. Risk factors for postpolypectomy bleeding in patients receiving anticoagulation or antiplatelet medications. Gastrointest Endosc. 2018 Apr; 87(4):1106-1113.
    View on PubMed
  14. Kiniry BE, Li S, Ganesh A, Hunt PW, Somsouk M, Skinner PJ, Deeks SG, Shacklett BL. Detection of HIV-1-specific gastrointestinal tissue resident CD8+ T-cells in chronic infection. Mucosal Immunol. 2017 Nov 15.
    View on PubMed
  15. Trapecar M, Khan S, Roan NR, Chen TH, Telwatte S, Deswal M, Pao M, Somsouk M, Deeks SG, Hunt PW, Yukl S, Sanjabi S. An Optimized and Validated Method for Isolation and Characterization of Lymphocytes from HIV+ Human Gut Biopsies. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S31-S39.
    View on PubMed
  16. Asmuth DM, Hinkle JE, LaMarca A, Fichtenbaum CJ, Somsouk M, Utay NS, Shaw AL, Petschow BW, Detzel CJ, Weaver EM. Evaluation of oral serum-derived bovine immunoglobulins in HIV-infected patients with chronic idiopathic diarrhea. HIV Clin Trials. 2017 Nov-Dec; 18(5-6):205-213.
    View on PubMed
  17. Cockerham LR, Yukl SA, Harvill K, Somsouk M, Joshi SK, Sinclair E, Liegler T, Hoh R, Lyons S, Hunt PW, Rupert A, Sereti I, Morcock DR, Rhodes A, Emson C, Hellerstein MK, Estes JD, Lewin S, Deeks SG, Hatano H. A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Individuals. Pathog Immun. 2017; 2(3):310-334.
    View on PubMed
  18. Seang S, Somasunderam A, Nigalye M, Somsouk M, Schacker TW, Sanchez JL, Hunt PW, Utay NS, Lake JE. Circulating LOXL2 Levels Reflect Severity of Intestinal Fibrosis and GALT CD4+ T Lymphocyte Depletion in Treated HIV Infection. Pathog Immun. 2017; 2(2):239-252.
    View on PubMed
  19. Vujkovic-Cvijin I, Rutishauser RL, Pao M, Hunt PW, Lynch SV, McCune JM, Somsouk M. Limited engraftment of donor microbiome via one-time fecal microbial transplantation in treated HIV-infected individuals. Gut Microbes. 2017 Sep 03; 8(5):440-450.
    View on PubMed
  20. Khoury G, Fromentin R, Solomon A, Hartogensis W, Killian M, Hoh R, Somsouk M, Hunt PW, Girling V, Sinclair E, Bacchetti P, Anderson JL, Hecht FM, Deeks SG, Cameron PU, Chomont N, Lewin SR. Human Immunodeficiency Virus Persistence and T-Cell Activation in Blood, Rectal, and Lymph Node Tissue in Human Immunodeficiency Virus-Infected Individuals Receiving Suppressive Antiretroviral Therapy. J Infect Dis. 2017 03 15; 215(6):911-919.
    View on PubMed

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