Ma Somsouk, MD, MAS

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Ma Somsouk, MD, MAS

Assistant Professor, Department of Medicine (Gastroenterology), UCSF

somsoukma@medsfgh.ucsf.edu

Phone: (415) 206-6480
Box 0862, UCSF
San Francisco, CA 94143-0862

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Cancer Center Membership

Associate Member » Cancer, Immunity, and Microenvironment» Cancer Control

Research Summary

1. Gastrointestinal tract as a site of HIV pathogenesis and persistence. Dr. Somsouk's research program examines the impact of HIV in the gut, answering questions related to viral persistence, immune activation, epithelial barrier dysfunction, and microbial dysbiosis and their relationship with systemic inflammation, aging, and cancer using observational studies and interventional trials. Stool, gut mucosal samples, and blood are routinely collected from subjects.

2. Prevention of colorectal cancer. Dr. Somsouk's research program is supported by the CDC, in collaboration with the SF Department of Public Health, to examine how a centralized patient panel management system could improve uptake of colorectal cancer screening and improve other health behaviors and conditions in the safety-net. In addition to interventional cohort studies, retrospective and administrative methods and mathematical simulation models are employed to identify barriers and best practices for colorectal cancer screening / surveillance.

Education

Pomona College, Claremont, CA, BA, 1993-1997, Chemistry
Harvard Medical School, Boston, MA, MD, 1997-2002, Medicine
Harbor-UCLA Medical Center, Torrance, CA, Residency, 2002-2005, Internal Medicine
University of California, San Francisco, CA, Fellowship, 2005-2008, Gastroenterology
University of California, San Francisco, CA, MAS, 2006-2008, Epidemiology and Biostatistics


Professional Experience

  • 2001-2002
    Research Scholar at Beijing University Health Science Center, China
  • 2002-2003
    Internship in Internal Medicine, Harbor-UCLA Medical Center, Torrance, CA
  • 2003-2005
    Residency in Internal Medicine, Harbor-UCLA Medical Center, Torrance, CA
  • 2005-2008
    Gastroenterology Fellowship, UCSF, San Francisco, CA
  • 2008-present
    Assistant Adjunct Professor of Medicine, UCSF, San Francisco, CA
  • 2009-present
    Director, Gastrointestinal Tissue Core Facility, UCSF, San Francisco, CA

Honors & Awards

  • 1997
    Sigma Xi
  • 1997
    Phi Beta Kappa
  • 1997
    Magna Cum Laude
  • 2000
    China Scholarship Council Research Scholar Fellowship
  • 2000
    Paul Dudley White/Andrew Sellard Fellowship
  • 2003
    Solomon Scholar
  • 2003
    AASLD Resident Scholar Award
  • 2006
    AGA Trainee Scholarship: Methodologies in Healthcare Outcomes in Gastroenterology
  • 2008
    AGA Academic Skills Workshop Scholarship

Selected Publications

  1. Protective association of colonoscopy against proximal and distal colon cancer and patterns in interval cancer. Gastrointest Endosc. 2015 Sep; 82(3):529-537.e1.
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  2. Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool During Effective HIV Therapy. J Infect Dis. 2015 Aug 15; 212(4):596-607.
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  3. Gut epithelial barrier and systemic inflammation during chronic HIV infection. AIDS. 2015 Jan 2; 29(1):43-51.
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  4. The Immunologic Effects of Mesalamine in Treated HIV-Infected Individuals with Incomplete CD4+ T Cell Recovery: A Randomized Crossover Trial. PLoS One. 2014; 9(12):e116306.
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  5. Lymphoid fibrosis occurs in long-term nonprogressors and persists with antiretroviral therapy but may be reversible with curative interventions. J Infect Dis. 2015 Apr 1; 211(7):1068-75.
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  6. The CD8+ Memory Stem T Cell (TSCM) Subset Is Associated with Improved Prognosis in Chronic HIV-1 Infection. J Virol. 2014 Dec 1; 88(23):13836-44.
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  7. HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality. PLoS Pathog. 2014 May; 10(5):e1004078.
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  8. Esophageal varices on computed tomography and subsequent variceal hemorrhage. Abdom Imaging. 2014 Apr; 39(2):251-6.
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  9. Challenges and possible solutions to colorectal cancer screening for the underserved. J Natl Cancer Inst. 2014 Apr; 106(4):dju032.
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  10. Non-physician performance of lower and upper endoscopy: a systematic review and meta-analysis. Endoscopy. 2014 May; 46(5):401-10.
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  11. Adverse events in older patients undergoing ERCP: a systematic review and meta-analysis. Endosc Int Open. 2014 Mar; 2(1):E28-36.
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  12. Discordance between peripheral and colonic markers of inflammation during suppressive ART. J Acquir Immune Defic Syndr. 2014 Feb 1; 65(2):133-41.
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  13. A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cells. AIDS. 2014 Jan 28; 28(3):439-42.
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  14. Commentary: Towards an effective and safe treatment of small intestine bacterial overgrowth - Authors' reply. Aliment Pharmacol Ther. 2013 Dec; 38(11-12):1411.
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  15. The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time. Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51):E4987-96.
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  16. Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers. PLoS Pathog. 2013; 9(10):e1003691.
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  17. Helicobacter pylori: evidence-based review with a focus on immigrant populations. J Gen Intern Med. 2014 Mar; 29(3):520-8.
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  18. Comparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollers. AIDS. 2013 Sep 10; 27(14):2255-60.
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  19. Meta-analysis: antibiotic therapy for small intestinal bacterial overgrowth. Aliment Pharmacol Ther. 2013 Oct; 38(8):925-34.
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  20. Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism. Sci Transl Med. 2013 Jul 10; 5(193):193ra91.
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