University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Robert M. Stroud, PhD

Robert M. Stroud, PhD

Professor, Departments of Biochemistry/Biophysics and Pharmaceutical Chemistry, UCSF

Education

Clare College, U. of Cambridge, U.K., B.A., 1964, Natural Sciences
Clare College, U. of Cambridge, U.K., M.A., 1968, Natural Sciences
Birkbeck College, London University, U.K., Ph.D., 1968, Biological Crystallography


Professional Experience

  • 1973-1975
    Assistant Professor of Chemistry, Cal Tech
  • 1975-1977
    Associate Professor of Chemistry, Cal Tech
  • 1977-1979
    Associate Professor of Biophysics, Department of Biochemistry & Biophysics, UCSF
  • 1977-1979
    Associate Professor, Dept. of Pharmaceutical Chemistry, UCSF
  • 1979-present
    Professor, Department of Biochemistry & Biophysics, UCSF

Honors & Awards

  • 1961-1964
    State Scholar, University of Cambridge, England
  • 1965-1968
    Moulton Trust Fellow, University of London
  • 1972-1977
    National Institutes of Health Career Development Award
  • 1975-1977
    Alfred P. Sloan Foundation Fellow
  • 1984
    DeWitt Stetton Jr. Lecturer of the National Institutes of Health
  • 1988-1989
    President, Biophysical Society of the United States
  • 1988
    Fellow of the Royal Society of Medicine (United Kingdom)
  • 1993-2004
    The Editor, Annual Review of Biophysics and Biomolecular Structure
  • 1997
    Member National Committee for the IUPAB
  • 1998
    Founding Fellow of the Biophysical Society of the United States
  • 2003
    Member of the National Academies of Science (NAS)
  • 2004
    Tenth Annual Lectureship on Applications of Molecular Biology to Biomedical Sciences, Carnegie Mellon University
  • 2005
    The 'Fred Richards' Lecturer at Yale University
  • 2006
    The 'Friedman' Lecturer Rutgers University

Selected Publications

  1. Kintzer AF, Green EM, Dominik PK, Bridges M, Armache JP, Deneka D, Kim SS, Hubbell W, Kossiakoff AA, Cheng Y, Stroud RM. Structural basis for activation of voltage sensor domains in an ion channel TPC1. Proc Natl Acad Sci U S A. 2018 Sep 06.
    View on PubMed
  2. Chen SH, Jang GM, Hüttenhain R, Gordon DE, Du D, Newton BW, Johnson JR, Hiatt J, Hultquist JF, Johnson TL, Liu YL, Burton LA, Ye J, Reichermeier KM, Stroud RM, Marson A, Debnath J, Gross JD, Krogan NJ. CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling. EMBO J. 2018 Aug 30.
    View on PubMed
  3. Kumar H, Finer-Moore JS, Jiang X, Smirnova I, Kasho V, Pardon E, Steyaert J, Kaback HR, Stroud RM. Crystal Structure of a ligand-bound LacY-Nanobody Complex. Proc Natl Acad Sci U S A. 2018 Aug 14.
    View on PubMed
  4. Finer-Moore JS, Lee TT, Stroud RM. A Single Mutation Traps a Half-Sites Reactive Enzyme in Midstream, Explaining Asymmetry in Hydride Transfer. Biochemistry. 2018 May 15; 57(19):2786-2795.
    View on PubMed
  5. Kintzer AF, Stroud RM. On the structure and mechanism of two-pore channels. FEBS J. 2018 Jan; 285(2):233-243.
    View on PubMed
  6. Nöll A, Thomas C, Herbring V, Zollmann T, Barth K, Mehdipour AR, Tomasiak TM, Brüchert S, Joseph B, Abele R, Oliéric V, Wang M, Diederichs K, Hummer G, Stroud RM, Pos KM, Tampé R. Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP. Proc Natl Acad Sci U S A. 2017 01 24; 114(4):E438-E447.
    View on PubMed
  7. Galilee M, Britan-Rosich E, Griner SL, Uysal S, Baumgärtel V, Lamb DC, Kossiakoff AA, Kotler M, Stroud RM, Marx A, Alian A. The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical. Structure. 2016 11 01; 24(11):1936-1946.
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  8. Thurtle-Schmidt BH, Stroud RM. Structure of Bor1 supports an elevator transport mechanism for SLC4 anion exchangers. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):10542-6.
    View on PubMed
  9. Kapoor K, Finer-Moore JS, Pedersen BP, Caboni L, Waight A, Hillig RC, Bringmann P, Heisler I, Müller T, Siebeneicher H, Stroud RM. Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides. Proc Natl Acad Sci U S A. 2016 Apr 26; 113(17):4711-6.
    View on PubMed
  10. Kintzer AF, Stroud RM. Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana. Nature. 2016 Mar 10; 531(7593):258-62.
    View on PubMed
  11. Boswell-Casteel RC, Johnson JM, Stroud RM, Hays FA. Integral Membrane Protein Expression in Saccharomyces cerevisiae. Methods Mol Biol. 2016; 1432:163-86.
    View on PubMed
  12. Chaudhary S, Saha S, Thamminana S, Stroud RM. Small-Scale Screening to Large-Scale Over-Expression of Human Membrane Proteins for Structural Studies. Methods Mol Biol. 2016; 1432:203-21.
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  13. Finer-Moore J, Czudnochowski N, O'Connell JD, Wang AL, Stroud RM. Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. J Mol Biol. 2015 Dec 04; 427(24):3862-76.
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  14. Johri AK, Oelmüller R, Dua M, Yadav V, Kumar M, Tuteja N, Varma A, Bonfante P, Persson BL, Stroud RM. Fungal association and utilization of phosphate by plants: success, limitations, and future prospects. Front Microbiol. 2015; 6:984.
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  15. Kumar H, Finer-Moore JS, Kaback HR, Stroud RM. Structure of LacY with an a-substituted galactoside: Connecting the binding site to the protonation site. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):9004-9.
    View on PubMed
  16. Rosenberg OS, Dovala D, Li X, Connolly L, Bendebury A, Finer-Moore J, Holton J, Cheng Y, Stroud RM, Cox JS. Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion. Cell. 2015 Apr 23; 161(3):501-512.
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  17. Salo-Ahen OM, Tochowicz A, Pozzi C, Cardinale D, Ferrari S, Boum Y, Mangani S, Stroud RM, Saxena P, Myllykallio H, Costi MP, Ponterini G, Wade RC. Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase. J Med Chem. 2015 Apr 23; 58(8):3572-81.
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  18. Tochowicz A, Santucci M, Saxena P, Guaitoli G, Trande M, Finer-Moore J, Stroud RM, Costi MP. Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides. J Med Chem. 2015 Jan 22; 58(2):1012-8.
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  19. Kim J, Wu S, Tomasiak TM, Mergel C, Winter MB, Stiller SB, Robles-Colmanares Y, Stroud RM, Tampé R, Craik CS, Cheng Y. Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter. Nature. 2015 Jan 15; 517(7534):396-400.
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  20. Tomasiak TM, Pedersen BP, Chaudhary S, Rodriguez A, Colmanares YR, Roe-Zurz Z, Thamminana S, Tessema M, Stroud RM. General qPCR and Plate Reader Methods for Rapid Optimization of Membrane Protein Purification and Crystallization Using Thermostability Assays. Curr Protoc Protein Sci. 2014 Aug 01; 77:29.11.1-14.
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