Luika Timmerman, PhD


Assistant Research Molecular Biologist and Independent Investigator, UCSF Helen Diller Family Comprehensive Center

Phone: (415) 385-5735
UCSF Box 0875
San Francisco, CA 94143-0875

Cancer Center Membership

Associate Member ยป Breast Oncology


Stanford University, Stanford California, MS, 1987, Biology
Stanford University, Stanford California, PhD, 1999, Immunology
University of California at San Francisco, Postdoctoral Research, 2000-2003, Cancer Biology


Professional Experience

  • 1988-1990
    Research Technician, with Prof. Hugh McDevitt, Stanford University
  • 1990-1999
    Graduate Research/Teaching Assistant with Prof. Gerald Crabtree, Stanford University
  • 2000-2002
    Carol Frank Buck Plummer Fellowship, UCSF/Diller Family Comprehensive Cancer Center.
  • 2000-2003
    Postdoctoral Research Fellow, UCSF/Diller Family Comprehensive Cancer Center, with Dr. Frank McCormick
  • 2004-present
    Assistant Research Molecular Biologist and Independent Investigator, UCSF/Diller Family Comprehensive Center

Selected Publications

  • Timmerman LA; Holton T; Yuneva M; Louie RJ; Padró M; Daemen A; Hu M; Chan DA; Ethier SP ; van 't Veer LJ ; Polyak K ; McCormick F ; Gray JW. Glutamine sensitivity analysis identifies the xCT antiporter as a common triple negative breast tumor therapeutic target. Cancer Cell, in press.
  • Kuemmerle NB; Rysman E; Lombardo PS; Flanagan AJ; Lipe BC; Wells WA; Pettus JR; Froehlich HM; Memoli VA; Morganelli PM; Swinnen JV; Timmerman LA; Chaychi L; Fricano CJ; Eisenberg BL; Coleman WB; Kinlaw WB. Lipoprotein lipase links dietary fat to solid tumor cell proliferation. Molecular Cancer Therapeutics (2011), 10; 427. PMID: 21282354
  • Additional Publications
  • Fronek Z; Timmerman LA; McDevitt HO. A rare HLA DQB allele sequenced from patients with systemic lupus erythematosus. Hum Immunol. (1991), 30(2), 77-84. PMID: 2022497
  • Northrop JP; Ho SN; Chen L; Thomas DJ; Timmerman LA; Nolan GP; Admon A; Crabtree GR. NF-AT components define a family of transcription factors targeted in T-cell activation. Nature (1994), Jun 9, 369(6480), 497-502. PMID: 8202141
  • Ho SN; Thomas DJ; Timmerman LA; Li X; Francke U; Crabtree GR. NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity. J Biol Chem. (1995), 270(34),19898-907. PMID: 7650004
  • Li X; Ho SN; Luna J; Giacalone J; Thomas DJ; Timmerman LA; Crabtree GR; Francke U. Cloning and chromosomal location of the human and murine genes for the T-cell transcription factors NFATc and NFATp. Cytogenet Cell Genet. (1995), 68(3-4): 185-91. PMID: 7842733
  • Timmerman LA; Clipstone NA; Ho SN; Northrop JP; Crabtree GR. Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression. Nature (1996), 383(6603), 837-40. PMID: 8893011
  • Weiss DL; Hural J; Tara D; Timmerman LA; Henkel G; Brown MA. Nuclear factor of activated T cells is associated with a mast cell interleukin 4 transcription complex. Mol Cell Biol. (1996), 16(1), 228-35. PMID: 8524300
  • Timmerman LA; Healy JI; Ho SN; Chen L; Goodnow CC; Crabtree GR. Redundant expression but selective utilization of nuclear factor of activated T cells family members. J Immunol. (1997), 159(6), 2735-40. PMID: 9300694
  • Healy JI; Dolmetsch RE; Timmerman LA; Cyster JG; Thomas ML; Crabtree GR; Lewis RS; Goodnow CC. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Immunity (1997), 6(4), 419-28. PMID: 9133421
  • Kinoshita S; Su L; Amano M; Timmerman LA; Kaneshima H; Nolan GP. The T cell activation factor NFATc positively regulates HIV-1 replication and gene expression in T cells. Immunity (1997), 6(3), 235-44. PMID: 9075924
  • de la Pompa JL; Timmerman LA; Takimoto H; Yoshida H; Elia AJ; Samper E; Potter J; Wakeham A; Marengere L; Langille BL; Crabtree GR; Mak TW. Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature (1998), 392(6672),182-6. PMID: 9515963
  • Maldonado, J.L.; Timmerman L; Fridlyand, J.; Bastian, B.C. Mechanisms of cell-cycle arrest in Spitz nevi with constitutive activation of the MAP-kinase pathway. Am J Pathol (2004), 164(5), 1783-7. PMID: 15111324
  • Timmerman, LA; Grego-Bessa, J.; Raya, A.; Bertran, E.; Perez-Pomares, J.M.; Diez, J.; Aranda, S.; Palomo, S.; McCormick, F.M.; Izpisua-Belmonte, J.C.; de la Pompa, J.L. Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev (2004), 18(1). 99-115. PMID: 14701881
  • Oda K; Okada J; Timmerman L; Rodriguez-Viciana P; Stokoe D; Shoji K; Taketani Y; Kuramoto H; Knight ZA; Shokat KM; McCormick F. PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation. Cancer Res. (2008), 68(19), 8127-36. PMID: 18829572