Thea D. Tlsty, PhD

Professor, Department of Pathology and Director of the Center for Translational Research in the Molecular Genetics of Cancer, UCSF; Director for the Program in Cell Cycling and Signaling, UCSF Helen Diller Family Comprehensive Cancer Center

thea.tlsty@ucsf.edu

Phone: (415) 502-6116 (voice)
Box 0506, UCSF
San Francisco, CA 94143-0506

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Education

University of South Florida, Tampa, FL, B.S., 1973, Zoology
Washington University, St. Louis, MO, Ph.D., 1980, Molecular Biology
Washington University, St. Louis, MO, 1976-1980, Predoctoral Fellow
Stanford University, Stanford, CA, 1981-1984, Postdoctoral Fellow
Stanford University, Stanford, CA, 1984-1985, Senior Research Associate

Professional Experience

• 1974-1976
  Ph.D. Candidate, Dept. of Pathology, University of North Carolina, Chapel Hill (transferred)
• 1976-1980
  Pre-doctoral Fellow in Program for Cellular & Molecular Biology, Washington University, St. Louis, Missouri (advisor, Dr. M. Lieberman)
• 1980-1981
  Postdoctoral Fellow in Dept. of Microbiology & Immunology, Washington Univ., St. Louis, MO
• 1981-1985
  Postdoctoral Fellow/Senior Research Associate in Department of Biological Sciences, Stanford University, Stanford, California (advisor, Dr. R.T. Schimke)
• 1985-1994
  Assistant/Associate Professor of Pathology and Member: UNC Lineberger Comprehensive Cancer Center; University of North Carolina at Chapel Hill, North Carolina
• 1994-Present
  Professor of Pathology, Director of the Center for Translational Research in the Molecular Genetics of Cancer, Member: UCSF Comprehensive Cancer Center – Director for the Program in Cell Cycling and Signaling; Program in Biological Sciences (PIBS); Program in Biomedical Sciences (BMS), University of California at San Francisco, CA

Selected Publications

1. A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep. 2013 Apr 25; 3:1449.
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2. Roy S, Gascard P, Dumont N, Zhao J, Pan D, Petrie S, Margeta M, Tlsty TD. Rare somatic cells from human breast tissue exhibit extensive lineage plasticity. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):4598-603.
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3. Dumont N, Liu B, Defilippis RA, Chang H, Rabban JT, Karnezis AN, Tjoe JA, Marx J, Parvin B, Tlsty TD. Breast Fibroblasts Modulate Early Dissemination, Tumorigenesis, and Metastasis through Alteration of Extracellular Matrix Characteristics. Neoplasia. 2013 Mar; 15(3):249-62.
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4. Defilippis RA, Tlsty TD. Hello out there...Is anybody listening? Cancer Discov. 2012 Dec; 2(12):1084-6.
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5. Liao D, Estévez-Salmerón L, Tlsty TD. Conceptualizing a tool to optimize therapy based on dynamic heterogeneity. Phys Biol. 2012 Dec; 9(6):065005.
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6. Liao D, Estévez-Salmerón L, Tlsty TD. Generalized principles of stochasticity can be used to control dynamic heterogeneity. Phys Biol. 2012 Dec; 9(6):065006.
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7. DeFilippis RA, Chang H, Dumont N, Rabban JT, Chen YY, Fontenay GV, Berman HK, Gauthier ML, Zhao J, Hu D, Marx JJ, Tjoe JA, Ziv E, Febbraio M, Kerlikowske K, Parvin B, Tlsty TD. CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues. Cancer Discov. 2012 Sep; 2(9):826-39.
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8. Shah SP, Roth A, Goya R, Oloumi A, Ha G, Zhao Y, Turashvili G, Ding J, Tse K, Haffari G, Bashashati A, Prentice LM, Khattra J, Burleigh A, Yap D, Bernard V, McPherson A, Shumansky K, Crisan A, Giuliany R, Heravi-Moussavi A, Rosner J, Lai D, Birol I, Varhol R, Tam A, Dhalla N, Zeng T, Ma K, Chan SK, Griffith M, Moradian A, Cheng SW, Morin GB, Watson P, Gelmon K, Chia S, Chin SF, Curtis C, Rueda OM, Pharoah PD, Damaraju S, Mackey J, Hoon K, Harkins T, Tadigotla V, Sigaroudinia M, Gascard P, Tlsty T, Costello JF, Meyer IM, Eaves CJ, Wasserman WW, Jones S, Huntsman D, Hirst M, Caldas C, Marra MA, Aparicio S. The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature. 2012 Jun 21; 486(7403):395-9.
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9. Radisky DC, Santisteban M, Berman HK, Gauthier ML, Frost MH, Reynolds CA, Vierkant RA, Pankratz VS, Visscher DW, Tlsty TD, Hartmann LC. p16(INK4a) expression and breast cancer risk in women with atypical hyperplasia. Cancer Prev Res (Phila). 2011 Dec; 4(12):1953-60.
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10. Tlsty TD. Tissue states provide novel insights into attributes that drive metastasis. Cancer Cell. 2011 Sep 13; 20(3):285-6.
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11. Lambert G, Estévez-Salmeron L, Oh S, Liao D, Emerson BM, Tlsty TD, Austin RH. An analogy between the evolution of drug resistance in bacterial communities and malignant tissues. Nat Rev Cancer. 2011 May; 11(5):375-82.
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12. Dvorak HF, Weaver VM, Tlsty TD, Bergers G. Tumor microenvironment and progression. J Surg Oncol. 2011 May 1; 103(6):468-74.
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13. Tlsty TD. A twist of cell fate. Cell Stem Cell. 2011 Feb 4; 8(2):126-7.
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14. Kerlikowske K, Molinaro AM, Gauthier ML, Berman HK, Waldman F, Bennington J, Sanchez H, Jimenez C, Stewart K, Chew K, Ljung BM, Tlsty TD. Biomarker expression and risk of subsequent tumors after initial ductal carcinoma in situ diagnosis. J Natl Cancer Inst. 2010 May 5; 102(9):627-37.
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15. Berman HK, Gauthier ML, Tlsty TD. Premalignant breast neoplasia: a paradigm of interlesional and intralesional molecular heterogeneity and its biological and clinical ramifications. Cancer Prev Res (Phila). 2010 May; 3(5):579-87.
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16. McDermott KM, Liu BY, Tlsty TD, Pazour GJ. Primary cilia regulate branching morphogenesis during mammary gland development. Curr Biol. 2010 Apr 27; 20(8):731-7.
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17. Blackburn EH, Tlsty TD, Lippman SM. Unprecedented opportunities and promise for cancer prevention research. Cancer Prev Res (Phila). 2010 Apr; 3(4):394-402.
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18. Fordyce C, Fessenden T, Pickering C, Jung J, Singla V, Berman H, Tlsty T. DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions. Cancer Prev Res (Phila). 2010 Feb; 3(2):190-201.
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19. Dumont N, Crawford YG, Sigaroudinia M, Nagrani SS, Wilson MB, Buehring GC, Turashvili G, Aparicio S, Gauthier ML, Fordyce CA, McDermott KM, Tlsty TD. Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy. Breast Cancer Res. 2009; 11(6):R87.
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20. Dumont N, Tlsty TD. Reflections on miR-ing effects in metastasis. Cancer Cell. 2009 Jul 7; 16(1):3-4.
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