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Christian Vaisse, MD, PhD


Associate Professor, Department of Medicine (Diabetes Center), UCSF


Phone: (415) 514-0530 (voice)
Box 0540, UCSF
San Francisco, CA 94143-0540

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University of Paris XI, MD, 1983-88, Medicine
University of Paris XI, PhD, 1988-91, Molecular Endocrinology

Professional Experience

  • 1991-1995
    Resident in Internal Medicine/ Endocrinology and Metabolism, Paris, France.
  • 1995-1997
    Post-Doctoral Fellow, Rockefeller University, New-York
  • 1997
    Resident in Internal Medicine/ Endocrinology and Metabolism, Paris, France.
  • 1997-1999
    Senior Scientist (INSERM Tenure) Pasteur institute and Attending Physician Department of Internal medicine and Nutrition at Hospital Hotel-Dieu, Paris
  • 1999-present
    Assistant Professor in Residence, Department of Medicine and Diabetes Research Center, University of California San Francisco

Honors & Awards

  • 1995
    ALFEDIAM/NOVO-NORDISK-Post-doctoral research award
  • 1996
    Philippe Foundation Post-Doctoral Research Award
  • 1998
    INSERM-CR1 tenure
  • 1999-00
    Served as an expert on genetics of childhood obesity on an Advisory Committee to the French government entitled "Overweight and Obesity in Children and Adolescents, Diagnosis, Prevention and Treatment"
  • 2000
    American Diabetes Association-Career Development Award
  • 2000
    North American Association for the Study of Obesity-Pilot Study Award
  • 2002
    Greenberg Young Investigator Award in Cardiovascular Genetics

Selected Publications

  1. Evans DS, Calton MA, Kim MJ, Kwok PY, Miljkovic I, Harris T, Koster A, Liu Y, Tranah GJ, Ahituv N, Hsueh WC, Vaisse C. Genetic Association Study of Adiposity and Melanocortin-4 Receptor (MC4R) Common Variants: Replication and Functional Characterization of Non-Coding Regions. PLoS One. 2014; 9(5):e96805.
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  2. Heymsfield SB, Avena NM, Baier L, Brantley P, Bray GA, Burnett LC, Butler MG, Driscoll DJ, Egli D, Elmquist J, Forster JL, Goldstone AP, Gourash LM, Greenway FL, Han JC, Kane JG, Leibel RL, Loos RJ, Scheimann AO, Roth CL, Seeley RJ, Sheffield V, Tauber M, Vaisse C, Wang L, Waterland RA, Wevrick R, Yanovski JA, Zinn AR. Hyperphagia: Current concepts and future directions proceedings of the 2nd international conference on hyperphagia. Obesity (Silver Spring). 2014 Feb; 22 Suppl 1:S1-S17.
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  3. Kim MJ, Oksenberg N, Hoffmann TJ, Vaisse C, Ahituv N. Functional characterization of SIM1-associated enhancers. Hum Mol Genet. 2014 Apr 1; 23(7):1700-8.
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  4. Aslan IR, Ranadive SA, Valle I, Kollipara S, Noble JA, Vaisse C. The melanocortin system and insulin resistance in humans: insights from a patient with complete POMC deficiency and type 1 diabetes mellitus. Int J Obes (Lond). 2014 Jan; 38(1):148-51.
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  5. Ersoy BA, Pardo L, Zhang S, Thompson DA, Millhauser G, Govaerts C, Vaisse C. Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR. Nat Chem Biol. 2012 Aug; 8(8):725-30.
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  6. Aslan IR, Campos GM, Calton MA, Evans DS, Merriman RB, Vaisse C. Weight loss after Roux-en-Y gastric bypass in obese patients heterozygous for MC4R mutations. Obes Surg. 2011 Jul; 21(7):930-4.
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  7. Swarbrick MM, Evans DS, Valle MI, Favre H, Wu SH, Njajou OT, Li R, Zmuda JM, Miljkovic I, Harris TB, Kwok PY, Vaisse C, Hsueh WC. Replication and extension of association between common genetic variants in SIM1 and human adiposity. Obesity (Silver Spring). 2011 Dec; 19(12):2394-403.
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  8. Ionova-Martin SS, Wade JM, Tang S, Shahnazari M, Ager JW, Lane NE, Yao W, Alliston T, Vaisse C, Ritchie RO. Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice. Osteoporos Int. 2011 Aug; 22(8):2283-93.
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  9. Aslan IR, Ranadive SA, Ersoy BA, Rogers SJ, Lustig RH, Vaisse C. Bariatric surgery in a patient with complete MC4R deficiency. Int J Obes (Lond). 2011 Mar; 35(3):457-61.
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  10. Ionova-Martin SS, Do SH, Barth HD, Szadkowska M, Porter AE, Ager JW, Ager JW, Alliston T, Vaisse C, Ritchie RO. Reduced size-independent mechanical properties of cortical bone in high-fat diet-induced obesity. Bone. 2010 Jan; 46(1):217-25.
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  11. Bromberg Y, Overton J, Vaisse C, Leibel RL, Rost B. In silico mutagenesis: a case study of the melanocortin 4 receptor. FASEB J. 2009 Sep; 23(9):3059-69.
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  12. Calton MA, Vaisse C. Narrowing down the role of common variants in the genetic predisposition to obesity. Genome Med. 2009; 1(3):31.
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  13. Ranadive SA, Ersoy B, Favre H, Cheung CC, Rosenthal SM, Miller WL, Vaisse C. Identification, characterization and rescue of a novel vasopressin-2 receptor mutation causing nephrogenic diabetes insipidus. Clin Endocrinol (Oxf). 2009 Sep; 71(3):388-93.
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  14. Calton MA, Ersoy BA, Zhang S, Kane JP, Malloy MJ, Pullinger CR, Bromberg Y, Pennacchio LA, Dent R, McPherson R, Ahituv N, Vaisse C. Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study. Hum Mol Genet. 2009 Mar 15; 18(6):1140-7.
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  15. Clément K, Dubern B, Mencarelli M, Czernichow P, Ito S, Wakamatsu K, Barsh GS, Vaisse C, Leger J. Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene. J Clin Endocrinol Metab. 2008 Dec; 93(12):4955-62.
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  16. Ranadive SA, Vaisse C. Lessons from extreme human obesity: monogenic disorders. Endocrinol Metab Clin North Am. 2008 Sep; 37(3):733-51, x.
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  17. Dubern B, Lubrano-Berthelier C, Mencarelli M, Ersoy B, Frelut ML, Bouglé D, Costes B, Simon C, Tounian P, Vaisse C, Clement K. Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain. Pediatr Res. 2008 Feb; 63(2):211-6.
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  18. Louet JF, Smith SB, Gautier JF, Molokhia M, Virally ML, Kevorkian JP, Guillausseau PJ, Vexiau P, Charpentier G, German MS, Vaisse C, Urbanek M, Mauvais-Jarvis F. Gender and neurogenin3 influence the pathogenesis of ketosis-prone diabetes. Diabetes Obes Metab. 2008 Sep; 10(10):912-20.
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  19. Srinivasan S, Santiago P, Lubrano C, Vaisse C, Conklin BR. Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo. PLoS One. 2007; 2(7):e668.
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  20. Ahituv N, Kavaslar N, Schackwitz W, Ustaszewska A, Martin J, Hebert S, Doelle H, Ersoy B, Kryukov G, Schmidt S, Yosef N, Ruppin E, Sharan R, Vaisse C, Sunyaev S, Dent R, Cohen J, McPherson R, Pennacchio LA. Medical sequencing at the extremes of human body mass. Am J Hum Genet. 2007 Apr; 80(4):779-91.
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