Christian Vaisse, MD, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Christian Vaisse, MD, PhD

Associate Professor, Department of Medicine (Diabetes Center), UCSF

vaisse@medicine.ucsf.edu

Phone: (415) 514-0530 (voice)
Box 0540, UCSF
San Francisco, CA 94143-0540

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Cancer Center Membership

Associate Member » Breast Oncology» Cancer Genetics

Education

University of Paris XI, MD, 1983-88, Medicine
University of Paris XI, PhD, 1988-91, Molecular Endocrinology


Professional Experience

  • 1991-1995
    Resident in Internal Medicine/ Endocrinology and Metabolism, Paris, France.
  • 1995-1997
    Post-Doctoral Fellow, Rockefeller University, New-York
  • 1997
    Resident in Internal Medicine/ Endocrinology and Metabolism, Paris, France.
  • 1997-1999
    Senior Scientist (INSERM Tenure) Pasteur institute and Attending Physician Department of Internal medicine and Nutrition at Hospital Hotel-Dieu, Paris
  • 1999-present
    Assistant Professor in Residence, Department of Medicine and Diabetes Research Center, University of California San Francisco

Honors & Awards

  • 1995
    ALFEDIAM/NOVO-NORDISK-Post-doctoral research award
  • 1996
    Philippe Foundation Post-Doctoral Research Award
  • 1998
    INSERM-CR1 tenure
  • 1999-00
    Served as an expert on genetics of childhood obesity on an Advisory Committee to the French government entitled "Overweight and Obesity in Children and Adolescents, Diagnosis, Prevention and Treatment"
  • 2000
    American Diabetes Association-Career Development Award
  • 2000
    North American Association for the Study of Obesity-Pilot Study Award
  • 2002
    Greenberg Young Investigator Award in Cardiovascular Genetics

Selected Publications

  1. The Association of Serum Leptin with Mortality in Older Adults. PLoS One. 2015; 10(10):e0140763.
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  2. Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions. PLoS One. 2014; 9(5):e96805.
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  3. Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia. Obesity (Silver Spring). 2014 Feb; 22 Suppl 1:S1-S17.
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  4. Functional characterization of SIM1-associated enhancers. Hum Mol Genet. 2014 Apr 1; 23(7):1700-8.
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  5. The melanocortin system and insulin resistance in humans: insights from a patient with complete POMC deficiency and type 1 diabetes mellitus. Int J Obes (Lond). 2014 Jan; 38(1):148-51.
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  6. Weight loss after Roux-en-Y gastric bypass in obese patients heterozygous for MC4R mutations. Obes Surg. 2011 Jul; 21(7):930-4.
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  7. Replication and extension of association between common genetic variants in SIM1 and human adiposity. Obesity (Silver Spring). 2011 Dec; 19(12):2394-403.
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  8. Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice. Osteoporos Int. 2011 Aug; 22(8):2283-93.
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  9. Bariatric surgery in a patient with complete MC4R deficiency. Int J Obes (Lond). 2011 Mar; 35(3):457-61.
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  10. Reduced size-independent mechanical properties of cortical bone in high-fat diet-induced obesity. Bone. 2010 Jan; 46(1):217-25.
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  11. In silico mutagenesis: a case study of the melanocortin 4 receptor. FASEB J. 2009 Sep; 23(9):3059-69.
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  12. Narrowing down the role of common variants in the genetic predisposition to obesity. Genome Med. 2009; 1(3):31.
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  13. Identification, characterization and rescue of a novel vasopressin-2 receptor mutation causing nephrogenic diabetes insipidus. Clin Endocrinol (Oxf). 2009 Sep; 71(3):388-93.
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  14. Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study. Hum Mol Genet. 2009 Mar 15; 18(6):1140-7.
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  15. Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene. J Clin Endocrinol Metab. 2008 Dec; 93(12):4955-62.
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  16. Lessons from extreme human obesity: monogenic disorders. Endocrinol Metab Clin North Am. 2008 Sep; 37(3):733-51, x.
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  17. Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain. Pediatr Res. 2008 Feb; 63(2):211-6.
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  18. Gender and neurogenin3 influence the pathogenesis of ketosis-prone diabetes. Diabetes Obes Metab. 2008 Sep; 10(10):912-20.
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  19. Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo. PLoS One. 2007; 2(7):e668.
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  20. Medical sequencing at the extremes of human body mass. Am J Hum Genet. 2007 Apr; 80(4):779-91.
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