Peter Walter, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
walter_peter

Professor and Chair, Department of Biochemistry/Biophysics, UCSF; Investigator, Howard Hughes Medical Institute

pwalter@biochem.ucsf.edu

Phone: (415) 476-5017 (voice)
Box 2200, UCSF
San Francisco, CA 94143-2200

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Additional Websites


Education

Freie Universitat Berlin, Germany, Vordiplom, 1976, Chemistry
Vanderbilt University, Nashville, TN, M.Sc., 1977, Organic Chemistry
The Rockefeller University, New York, Ph.D., 1981, Cell Biology


Professional Experience

  • 1976-1977
    Direct Exchange Fellow, Vanderbilt University, in the laboratory of Dr. T.M. Harris
  • 1977-1981
    Graduate Fellow, The Rockefeller University, in the laboratory of Dr. G. Blobel
  • 1981-1982
    Postdoctoral Fellow, The Rockefeller University, in the laboratory of Dr. G. Blobel
  • 1982-1983
    Assistant Professor, Laboratory of Cell Biology, The Rockefeller University
  • 1983-1986
    Assistant Professor, Department of Biochemistry & Biophysics, University of California, San Francisco
  • 1986-1991
    Associate Professor, Department of Biochemistry & Biophysics, UCSF
  • 1991-present
    Professor, Department of Biochemistry & Biophysics, UCSF
  • 1997-present
    Investigator, Howard Hughes Medical Institute
  • 2001-present
    Chair, Department of Biochemistry & Biophysics Department, UCSF

Honors & Awards

  • 1983
    Searle Scholar Award
  • 1988
    Eli Lilly Award for Fundamental Research in Biological Chemistry
  • 1988
    Passano Award
  • 1989
    Alfred P. Sloan Award
  • 1993
    NIH MERIT Award
  • 1996
    Harvey Lecturer, Rockefeller University, New York
  • 1998
    American Academy of Microbiology (elected Fellow)
  • 1998
    Feodor-Lynen-Lecture, Mosbach Kolloquium, Germany
  • 2001
    American Academy of Arts & Sciences (elected Fellow)
  • 2004
    National Academy of Sciences (elected Member)
  • 2004
    European Molecular Biology Organization (elected Associate Member)
  • 2004
    Virchow Lecture, Universität Würzburg
  • 2005
    Wiley Prize in Biomedical Sciences (with Dr. Kazutoshi Mori)
  • 2005
    George E. Palade Distinguished Lecture, Wayne State University School of Medicine
  • 2006
    47th Stadtler Lecture, University of Texas
  • 2006
    Leopoldina Academy of Scientists (elected member)

Selected Publications

  1. Noriega TR, Chen J, Walter P, Puglisi JD. Real-time observation of signal recognition particle binding to actively translating ribosomes. Elife. 2014; 3.
    View on PubMed
  2. Pincus D, Aranda-Díaz A, Zuleta IA, Walter P, El-Samad H. Delayed Ras/PKA signaling augments the unfolded protein response. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14800-5.
    View on PubMed
  3. Schuck S, Gallagher CM, Walter P. ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery. J Cell Sci. 2014 Sep 15; 127(Pt 18):4078-88.
    View on PubMed
  4. Lu M, Lawrence DA, Marsters S, Acosta-Alvear D, Kimmig P, Mendez AS, Paton AW, Paton JC, Walter P, Ashkenazi A. Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis. Science. 2014 Jul 4; 345(6192):98-101.
    View on PubMed
  5. Di Prisco GV, Huang W, Buffington SA, Hsu CC, Bonnen PE, Placzek AN, Sidrauski C, Krnjevic K, Kaufman RJ, Walter P, Costa-Mattioli M. Translational control of mGluR-dependent long-term depression and object-place learning by eIF2a. Nat Neurosci. 2014 Aug; 17(8):1073-82.
    View on PubMed
  6. Okreglak V, Walter P. The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteins. Proc Natl Acad Sci U S A. 2014 Jun 3; 111(22):8019-24.
    View on PubMed
  7. Noriega TR, Tsai A, Elvekrog MM, Petrov A, Neher SB, Chen J, Bradshaw N, Puglisi JD, Walter P. Signal Recognition Particle-ribosome Binding Is Sensitive to Nascent Chain Length. J Biol Chem. 2014 Jul 11; 289(28):19294-305.
    View on PubMed
  8. Chang YC, Khanal Lamichhane A, Garraffo HM, Walter PJ, Leerkes M, Kwon-Chung KJ. Molecular Mechanisms of Hypoxic Responses via Unique Roles of Ras1, Cdc24 and Ptp3 in a Human Fungal Pathogen Cryptococcus neoformans. PLoS Genet. 2014 Apr; 10(4):e1004292.
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  9. Lim B, Miyazaki R, Neher S, Siegele DA, Ito K, Walter P, Akiyama Y, Yura T, Gross CA. Heat Shock Transcription Factor s(32) Co-opts the Signal Recognition Particle to Regulate Protein Homeostasis in E. coli. PLoS Biol. 2013 Dec; 11(12):e1001735.
    View on PubMed
  10. Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin MR, Renslo AR, Sonenberg N, Walter P. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2013; 2:e00498.
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  11. Cho JA, Lee AH, Platzer B, Cross BC, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI. The unfolded protein response element IRE1a senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe. 2013 May 15; 13(5):558-69.
    View on PubMed
  12. Murley A, Lackner LL, Osman C, West M, Voeltz GK, Walter P, Nunnari J. ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast. Elife. 2013; 2:e00422.
    View on PubMed
  13. Walter P. Two structure papers, a call from Frankfurt airport, and how to escape from reviewer delays: an interview with Peter Walter by Miranda Robertson. BMC Biol. 2013; 11:34.
    View on PubMed
  14. Gardner BM, Pincus D, Gotthardt K, Gallagher CM, Walter P. Endoplasmic reticulum stress sensing in the unfolded protein response. Cold Spring Harb Perspect Biol. 2013 Mar; 5(3):a013169.
    View on PubMed
  15. Kimmig P, Diaz M, Zheng J, Williams CC, Lang A, Aragón T, Li H, Walter P. The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis. Elife. 2012; 1:e00048.
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  16. Fordyce PM, Pincus D, Kimmig P, Nelson CS, El-Samad H, Walter P, DeRisi JL. Basic leucine zipper transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses. Proc Natl Acad Sci U S A. 2012 Nov 6; 109(45):E3084-93.
    View on PubMed
  17. Pincus D, Walter P. A first line of defense against ER stress. J Cell Biol. 2012 Aug 6; 198(3):277-9.
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  18. Moreira KE, Schuck S, Schrul B, Fröhlich F, Moseley JB, Walther TC, Walter P. Seg1 controls eisosome assembly and shape. J Cell Biol. 2012 Aug 6; 198(3):405-20.
    View on PubMed
  19. Korennykh A, Walter P. Structural basis of the unfolded protein response. Annu Rev Cell Dev Biol. 2012; 28:251-77.
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  20. Walter P, Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science. 2011 Nov 25; 334(6059):1081-6.
    View on PubMed

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