Bruce Wang, MD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Bruce Wang, MD

Assistant Professor in Residence, Div. of Gastroenterology, UCSF

bruce.wang@ucsf.edu

Box 0538, UCSF
San Francisco, CA 94143-0538

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Cancer Center Membership

Member » Cancer Genetics

Research Summary

My lab studies how the different cell types in the liver, in particular the hepatocyte, are generated during development, patterned and maintained during adulthood, and regenerate after injury. Our long-term goals are to improve the understanding of liver disease pathophysiology and develop novel methods of treatment for liver diseases, including cell replacement therapy. Currently, we have two major research focuses: 1) understanding the biology of adult hepatocyte stem cells and 2) developing a liver cell atlas. We take innovative and integrated approaches to address these two areas using the tools of stem cell biology, developmental biology, genomics and tissue engineering.

Education

Stanford University, B.A.S., 06/2000, Philosophy, Biological Sciences
University of California San Francisco, MD, 06/2007, Medicine


Professional Experience

  • 2004-2006
    Research Fellow, Hepatology, Howard Hughes Medical Institute/UCSF
  • 2007-2008
    Intern, Internal Medicine, UCSF
  • 2009-2009
    Resident, Internal Medicine, UCSF
  • 2009-2014
    Clinical Fellow, Gastroenterology, UCSF
  • 2011-2014
    Postdoctoral Fellow, Developmental Biology, Stanford University
  • 2014-2016
    Adjunct Assistant Professor, Gastroenterology, UCSF
  • 2017-present
    Assistant Professor in Residence, Gastroenterology, UCSF

Honors & Awards

  • 2004-2005
    Howard Hughes Medical Institute Research Training Fellowship for Medical Students
  • 2005-2006
    Howard Hughes Medical Institute Research Training Fellowship for Medical Students Continued Research Support
  • 2005-2007
    Howard Hughes Medical Institute Research Training Fellowship for Medical Students Continued Medical Education Support
  • 2006
    Dean’s Prize in Research, University of California San Francisco
  • 2007-2014
    Molecular Medicine Fellow, University of California San Francisco
  • 2009-2010
    Clinical Fellow Award, UCSF Gastroenterology Division
  • 2016-2021
    Career Award for Medical Scientists, Burroughs Wellcome Fund

Selected Publications

  1. Gou EW, Balwani M, Bissell DM, Bloomer JR, Bonkovsky HL, Desnick RJ, Naik H, Phillips JD, Singal AK, Wang B, Keel S, Anderson KE. Pitfalls in Erythrocyte Protoporphyrin Measurement for Diagnosis and Monitoring of Protoporphyrias. Clin Chem. 2015 Dec; 61(12):1453-6.
    View on PubMed
  2. Wang B, Zhao L, Fish M, Logan CY, Nusse R. Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver. Nature. 2015 Aug 13; 524(7564):180-5.
    View on PubMed
  3. Bissell DM, Wang B. Acute Hepatic Porphyria. J Clin Transl Hepatol. 2015 Mar; 3(1):17-26.
    View on PubMed
  4. Cascino MD, McNabb B, Gardner DG, Woeber KA, Fox AN, Wang B, Fix OK. Acute liver failure with thyrotoxicosis treated with liver transplantation. Endocr Pract. 2013 May-Jun; 19(3):e57-60.
    View on PubMed
  5. Malato Y, Naqvi S, Schürmann N, Ng R, Wang B, Zape J, Kay MA, Grimm D, Willenbring H. Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. J Clin Invest. 2011 Dec; 121(12):4850-60.
    View on PubMed
  6. Wang B, Dolinski BM, Kikuchi N, Leone DR, Peters MG, Weinreb PH, Violette SM, Bissell DM. Role of alphavbeta6 integrin in acute biliary fibrosis. Hepatology. 2007 Nov; 46(5):1404-12.
    View on PubMed
  7. Wang B, Dhaliwal G, Sleisenger MH. Six decades of progress and change in hospital medicine, 1947-2007. Pharos Alpha Omega Alpha Honor Med Soc. 2007; 70(1):10-5.
    View on PubMed
  8. Jakubowski A, Ambrose C, Parr M, Lincecum JM, Wang MZ, Zheng TS, Browning B, Michaelson JS, Baetscher M, Baestcher M, Wang B, Bissell DM, Burkly LC. TWEAK induces liver progenitor cell proliferation. J Clin Invest. 2005 Sep; 115(9):2330-40.
    View on PubMed
  9. Winter CG, Wang B, Ballew A, Royou A, Karess R, Axelrod JD, Luo L. Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell. 2001 Apr 6; 105(1):81-91.
    View on PubMed

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