Rong Wang, PhD

Rong Wang, PhD

Associate Professor in Residence, Department of Surgery, UCSF; and Director, Laboratory for Accelerated Vascular Research
Mildred V. Strouss Endowed Chair in Vascular Surgery, UCSF

Phone: (415) 476-6855 (voice)
Box 0507, UCSF
San Francisco, CA 94143-0507


Sichuan University, Chendu, China, B.Sc., 1980-84, Biology
Graduate School of Chinese Science and Technology University, Institute of Genetics, Academia Sinica, Beijing, China, M.Sc. candidate, 1984-88, Genetics
University of North Carolina at Chapel Hill, Ph.D., 1988-93, Biology (Angiogenesis)
University of California, San Francisco, Postdoctoral Fellow, 1994-2001, Cancer Biology

Professional Experience

  • 1988-1993
    Graduate Research Assistant, Dr. Victoria L. Bautch, Department of Biology, University of North Carolina at Chapel Hill
  • 1994-2001
    Postdoctoral Fellow, J. Michael Bishop, G.W. Hooper Laboratory, UCSF
  • 2001-2007
    Assistant Professor, Surgery and Anatomy, UCSF
  • 2001-present
    Director, Laboratory for Accelerated Vascular Research, UCSF
  • 2006-present
    Mildred V. Strouss Endowed Chair in Vascular Surgery
  • 2007-2008
    Associate Professor, Anatomy, UCSF
  • 2007-present
    Associate Professor, Surgery, UCSF

Honors & Awards

  • 1994-97
    Leukemia Society of America, Postdoctoral Fellowship
  • 1997-99
    American Heart Association, Postdoctoral Fellowship
  • 2003-2005
    Pfizer Atorvastatin Research Award

Selected Publications

  • Dubois, NA, LC Kolpack, R Wang, RG Azizkhan and VL Bautch. Isolation and characterization of an established endothelial cell line from transgenic mouse hemangiomas. Exp Cell Res, 1991 196(2): 302-13.
  • Wang, R and VL Bautch. The polyomavirus early region gene in transgenic mice causes vascular and bone tumors. J Virol, 1991 65(10): 5174-83.
  • Wang, R, R Clark and VL Bautch. Embryonic stem cell-derived cystic embryoid bodies form vascular channels: an in vitro model of blood vessel development. Development, 1992 114(2): 303-16.
  • Wang, R, GP Siegal, DL Scott and VL Bautch. Developmental analysis of bone tumors in polyomavirus transgenic mice. Lab Invest, 1994 70(1): 86-94.
  • Wang, R, R Kobayashi and JM Bishop. Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor. Proc Natl Acad Sci U S A, 1996 93(16): 8425-30.
  • Wang, R, LD Ferrell, S Faouzi, JJ Maher and JM Bishop. Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice. J Cell Biol, 2001 153(5): 1023-34.
  • Chang, DS, H Su, GL Tang, LS Brevetti, R Sarkar, R Wang, YW Kan and LM Messina. Adeno-associated viral vector- mediated gene transfer of VEGF normalizes skeletal muscle oxygen tension and induces arteriogenesis in ischemic rat hindlimb. Mol Ther, 2003 7(1): 44-51.
  • Tang, G, DN Charo, R Wang, IF Charo and L Messina. CCR2-/- knockout mice revascularize normally in response to severe hindlimb ischemia. J Vasc Surg, 2004 40(4): 786-95.
  • Tang, GL, DS Chang, R Sarkar, R Wang and LM Messina. The effect of gradual or acute arterial occlusion on skeletal muscle blood flow, arteriogenesis, and inflammation in rat hindlimb ischemia. J Vasc Surg, 2005 41(2): 312-20.
  • Yan, J, GL Tang, R Wang and LM Messina. Optimization of Adenovirus-mediated endothelial nitric oxide synthase delivery in rat hindlimb ischemia. Gene Therapy, 2005 12(22):1640-50.
  • Carpenter, B, Y Lin, S Stoll, RL Raffai, R McCuskey and R Wang. VEGF is crucial for the hepatic vascular development required for lipoprotein uptake. Development, 2005 132(14): 3293-303.
  • Carlson, TR, Y Yan, X Wu, MT Lam, GL Tang, LJ Beverly, LM Messina, AJ Capobianco, Z Werb and R Wang. Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice. Proc Natl Acad Sci U S A, 2005 102(28): 9884-9.
  • Proctor, JM, K Zang, D Wang, R Wang and LF Reichardt. Vascular Development of the Brain Requires beta8 Integrin Expression in the Neuroepithelium. J Neurosci, 2005 25(43): 9940-8.
  • Braren, R, H Hu, YH Kim, H Beggs, LF Reichardt and R Wang. Endothelial FAK is essential for vascular network stability by regulating lamellipodial formation and cell survival. J Cell Biol, 2006 176(1): 151-162.
  • Tward, AD, KD Jones, S Yant, ST Cheung, ST Fan, X Chen, MA Kay, R Wang, JM Bishop. Distinct pathways of genomic progression to benign and malignant tumors of the liver. Proc Natl Acad Sci U S A, 2007 104(37):14771- 14776.
  • Carlson, TR, H Hu, R Braren, YH Kim, and RA Wang. Cell-autonomous requirement for β1 integrin in endothelial cell adhesion, migration, and survival during angiogenesis in mice. Development, 2008 135(12):2193-202 (PMC2582018).
  • He, C, H Hu, R Braren, S-Y Fong, A Trumpp, TR Carlson, and RA Wang. c-myc in the hematopoetic lineage is crucial for its angiogenic function in the mouse embryo. Development, 2008 135(14):2467-77 (PMC2597486).
  • Dubois, NC, C Adolphe, A Ehninger, RA Wang, EJ Robertson, and A Trumpp. Placental rescue reveals a sole requirement for C-Myc in embryonic erythroblast survival and hematopoietic stem cell function. Development, 2008 135(14):2455-65.
  • Murphy, PA, MTY Lam, X Wu, TN Kim, SM Vartanian, AW Bollen, TR Carlson, and RA Wang. Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice. Proc Natl Acad Sci U S A, 2008 105(31):10901-10906 (PMC2504798).
  • Kim, YH, H Hu, S Guevara-Gallardo, MTY Lam, S-Y Fong, and RA Wang. Artery and vein size is balanced by Notch and ephrinB2/EphB4 during angiogenesis. Development, 2008 135(22):3755-3764 (PMC2596923).
  • Murphy, PA, G Lu, S Shiah, AW Bollen, and RA Wang. Endothelial Notch signaling is upregulated in human brainarteriovenous malformations and a mouse model of the disease. Lab Invest, 2009 89(9):971-82.
  • Herbert, SP, J Huisken, TN Kim, ME Feldman, BT Houseman, RA Wang, KM Shokat, and DYR Stainier. Arterial/Venous Segregation by Selective Cell Sprouting: An Alternative Mode of Blood Vessel Formation. Science, 2009 326(5950):294-8.
  • Miniati, D, EB Jelin, J Ng, J Wu, TR Carlson, X Wu, MR Looney, RA Wang. Constitutively active endothelial Notch4causes lung arteriovenous shunts in mice. Am J Physiol Lung Cell Mol Physiol, 2010 298(2):L169-77 (PMC2822562).
  • Clever, JL, Y Sakai, RA Wang, and DB Schneider. Inefficient skeletal muscle repair in inhibitor of differentiation (Id)knockout mice suggests a crucial role for BMP signaling during adult muscle regeneration. Am J Physiol Cell Physiol, 2010, 298(5):C1087-99 (PMC2867391).