University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Zhen Jane Wang, MD

Zhen Jane Wang, MD

Associate Professor of Radiology, UCSF

Cancer Center Program Memberships

Non-aligned

Research Summary

Z. Jane Wang, MD is an associate professor and co-director of the Body Research Interest Group (RIG) in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. She received her undergraduate degree in Electrical Engineering from Brown University, and her medical degree from Northwestern University Medical School. She completed her residency training in Diagnostic Radiology at UCSF in 2007, serving as a Chief Resident from 2006-2007. Dr. Wang subsequently completed a fellowship in Abdominal Imaging at UCSF. She joined the UCSF faculty in 2008.

Dr. Wang’s research interests primarily focus on identification of novel imaging techniques and their development into practical and clinically useful diagnostic tools, with a particular emphasis on renal tumors and diffuse renal disease. One of Dr. Wang’s current research endeavor is to use hyperpolarized 13C MR spectroscopic imaging (MRSI) to assess renal tumor aggressiveness. She has also been studying functional imaging using MR and CT of diffuse renal disease. She is the recipient of several grants, including Department of Defense Peer Reviewed Cancer Research Program Concept Award, Radiological Society of North America (RSNA) Scholar Grant, and RSNA Fellow Grant.

Dr. Wang has been invited to lecture on various topics in Abdominal Imaging at multiple radiology societies, including the Abdominal Radiology Course (Joint Society of Gastrointestinal Radiologists and Society of Uroradiology), American Roentgen Ray Society Meeting, as well as internationally at the Asian-Oceanian Congress of Radiology, and the Brazilian Congress of Radiology.

Expertise:

Abdominal Imaging, Adult

Specialty:

Identification of novel imaging techniques and their development into practical and clinically useful diagnostic tools, with a particular emphasis on renal tumors and diffuse renal disease

Research Interests:

Hyperpolarized C13 for characterization of renal tumors and nephropathy

Imaging of pancreatic cancer

Education and Training:

• Medical School: Northwestern University Medical Center

• Internship: University of California, San Francisco

• Residency: University of California, San Francisco - Radiology and Medical Imaging

• Fellowship: University of California, San Francisco - Radiology and Medical Imaging, Abdominal Imaging

Education

Brown University, Providence, RI, B.S., 1993-1997, Electrical Engineering
Northwestern University Medical School, Chicago, IL, M.D., 1997-2002, Medicine
Dept of Medicine, UCSF Medical Center, San Francisco, CA, 2002-2003, Medicine Internship
Dept of Radiology, UCSF Medical Center, San Francisco, CA, 2003-2007, Radiology Residency
Dept of Radiology, UCSF Medical Center, San Francisco, CA, 2007-2008, Abdominal Imaging Fellowship

Professional Experience

  • 2008 – 2014
    Assistant Professor, Radiology and Biomedical Imaging, UCSF
  • 2014 – present
    Associate Professor, Radiology and Biomedical Imaging, UCSF
  • 2014 – present
    Co-Director, Body Imaging Research Interest Group, Radiology and Biomedical Imaging, UCSF

Honors & Awards

    1996
    Tau Beta Pi National Engineering Honor Society
  • 1999
    Howard Hughes Medical Institute (HHMI) Medical Student Scholar
  • 2000
    Howard Hughes Medical Institute (HHMI) Medical Student Research Award
  • 2001
    Alpha Omega Alpha (AOA) Honor Society
  • 2005
    Radiological Society of North America Roentgen Resident / Fellow Research Award
  • 2005
    Radiological Society of North America Trainee Research Prize
  • 2006
    American Roentgen Ray Society Resident in Radiology President’s Award
  • 2006-7
    Chief Resident, Department of Radiology, UCSF Medical Center
  • 2007
    UCSF Department of Radiology Margulis Society Resident Research Award
  • 2007
    Radiological Society of North America Trainee Research Prize
  • 2008
    Co-recipient: Cum Laude Award, Society of Computed Body Tomography/Magnetic Resonance
  • 2009
    Berdon Award
  • 2011
    Co-recipient: Cum Laude Award for presentation at the 2012 Radiological Society of North America annual meeting
  • 2013
    Second Place Prize in Basic Science Category, Society of Nuclear Medicine and Molecular Imaging Young Professionals
  • 2014
    Inducted as a Fellow of the Society of Abdominal Radiology

Selected Publications

  1. Winklhofer S, Lambert JW, Wang ZJ, Sun Y, Gould RG, Zagoria RJ, Yeh BM. Reduction of peristalsis-related gastrointestinal streak artifacts with dual-energy CT: a patient and phantom study. Abdom Radiol (NY). 2016 Aug; 41(8):1456-65.
    View on PubMed
  2. Kim SY, Wu EH, Park SH, Wang ZJ, Hope TA, Yee J, Zhao LQ, Chang WC, Yeh BM. Comparison of hepatocellular carcinoma conspicuity on hepatobiliary phase images with gadoxetate disodium vs. delayed phase images with extracellular cellular contrast agent. Abdom Radiol (NY). 2016 Aug; 41(8):1522-31.
    View on PubMed
  3. Cai L, Yeh BM, Westphalen AC, Roberts JP, Wang ZJ. Adult living donor liver imaging. Diagn Interv Radiol. 2016 May-Jun; 22(3):207-14.
    View on PubMed
  4. Vikram R, Beland MD, Blaufox MD, Moreno CC, Gore JL, Harvin HJ, Heilbrun ME, Liauw SL, Nguyen PL, Nikolaidis P, Preminger GM, Purysko AS, Raman SS, Taffel MT, Wang ZJ, Weinfeld RM, Remer EM, Lockhart ME. ACR Appropriateness Criteria Renal Cell Carcinoma Staging. J Am Coll Radiol. 2016 May; 13(5):518-25.
    View on PubMed
  5. Sriram R, Van Criekinge M, DeLos Santos J, Keshari KR, Wilson DM, Peehl D, Kurhanewicz J, Wang ZJ. Non-invasive differentiation of benign renal tumors from clear cell renal cell carcinomas using clinically translatable hyperpolarized 13C pyruvate magnetic resonance. Tomography. 2016 Mar; 2(1):35-42.
    View on PubMed
  6. Tong GE, Kumar S, Chong KC, Shah N, Wong MJ, Zimmet JM, Wang ZJ, Yee J, Fu Y, Yeh BM. Risk of contrast-induced nephropathy for patients receiving intravenous vs. intra-arterial iodixanol administration. Abdom Radiol (NY). 2016 Jan; 41(1):91-9.
    View on PubMed
  7. Dhatt HS, Behr SC, Miracle A, Wang ZJ, Yeh BM. Radiological Evaluation of Bowel Ischemia. Radiol Clin North Am. 2015 Nov; 53(6):1241-54.
    View on PubMed
  8. Flavell RR, von Morze C, Blecha JE, Korenchan DE, Van Criekinge M, Sriram R, Gordon JW, Chen HY, Subramaniam S, Bok RA, Wang ZJ, Vigneron DB, Larson PE, Kurhanewicz J, Wilson DM. Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI. Chem Commun (Camb). 2015 Sep 25; 51(74):14119-22.
    View on PubMed
  9. Sriram R, Van Criekinge M, Hansen A, Wang ZJ, Vigneron DB, Wilson DM, Keshari KR, Kurhanewicz J. Real-time measurement of hyperpolarized lactate production and efflux as a biomarker of tumor aggressiveness in an MR compatible 3D cell culture bioreactor. NMR Biomed. 2015 Sep; 28(9):1141-9.
    View on PubMed
  10. Keshari KR, Wilson DM, Van Criekinge M, Sriram R, Koelsch BL, Wang ZJ, VanBrocklin HF, Peehl DM, O'Brien T, Sampath D, Carano RA, Kurhanewicz J. Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor. Prostate. 2015 Oct; 75(14):1601-9.
    View on PubMed
  11. Chapman JS, Asthana S, Cade L, Chang MT, Wang Z, Zaloudek CJ, Ueda S, Collisson EA, Taylor BS. Clinical Sequencing Contributes to a BRCA-Associated Cancer Rediagnosis That Guides an Effective Therapeutic Course. J Natl Compr Canc Netw. 2015 Jul; 13(7):835-45.
    View on PubMed
  12. Zill OA, Greene C, Sebisanovic D, Siew LM, Leng J, Vu M, Hendifar AE, Wang Z, Atreya CE, Kelley RK, Van Loon K, Ko AH, Tempero MA, Bivona TG, Munster PN, Talasaz A, Collisson EA. Cell-Free DNA Next-Generation Sequencing in Pancreatobiliary Carcinomas. Cancer Discov. 2015 Oct; 5(10):1040-8.
    View on PubMed
  13. Leon Swisher C, Koelsch B, Sukumar S, Sriram R, Santos RD, Wang ZJ, Kurhanewicz J, Vigneron D, Larson P. Dynamic UltraFast 2D EXchange SpectroscopY (UF-EXSY) of hyperpolarized substrates. J Magn Reson. 2015 Aug; 257:102-9.
    View on PubMed
  14. Zhang W, Kong X, Wang ZJ, Luo S, Huang W, Zhang LJ. Dynamic Contrast-Enhanced Magnetic Resonance Imaging with Gd-EOB-DTPA for the Evaluation of Liver Fibrosis Induced by Carbon Tetrachloride in Rats. PLoS One. 2015; 10(6):e0129621.
    View on PubMed
  15. Wu EH, Wojciechowski D, Chandran S, Yeh BM, Park M, Westphalen A, Wang ZJ. Prevalence of abdominal aortic calcifications in older living renal donors and its effect on graft function and histology. Transpl Int. 2015 Oct; 28(10):1172-8.
    View on PubMed
  16. Sebro R, Aslam R, Muglia VF, Wang ZJ, Westphalen AC. Low yield of chemical shift MRI for characterization of adrenal lesions with high attenuation density on unenhanced CT. Abdom Imaging. 2015 Feb; 40(2):318-26.
    View on PubMed
  17. Flavell RR, Westphalen AC, Liang C, Sotto CC, Noworolski SM, Vigneron DB, Wang ZJ, Kurhanewicz J. Abnormal findings on multiparametric prostate magnetic resonance imaging predict subsequent biopsy upgrade in patients with low risk prostate cancer managed with active surveillance. Abdom Imaging. 2014 Oct; 39(5):1027-35.
    View on PubMed
  18. Keshari KR, Wilson DM, Sai V, Bok R, Jen KY, Larson P, Van Criekinge M, Kurhanewicz J, Wang ZJ. Noninvasive in vivo imaging of diabetes-induced renal oxidative stress and response to therapy using hyperpolarized 13C dehydroascorbate magnetic resonance. Diabetes. 2015 Feb; 64(2):344-52.
    View on PubMed
  19. Zhao J, Wang ZJ, Liu M, Zhu J, Zhang X, Zhang T, Li S, Li Y. Assessment of renal fibrosis in chronic kidney disease using diffusion-weighted MRI. Clin Radiol. 2014 Nov; 69(11):1117-22.
    View on PubMed
  20. Valenzuela DM, Behr SC, Coakley FV, Wang ZJ, Webb EM, Yeh BM. Computed tomography of iatrogenic complications of upper gastrointestinal endoscopy, stenting, and intubation. Radiol Clin North Am. 2014 Sep; 52(5):1055-70.
    View on PubMed

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