University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Zhen Jane Wang, MD

Zhen Jane Wang, MD

Associate Professor of Radiology, UCSF

Cancer Center Program Memberships

Non-aligned

Research Summary

Z. Jane Wang, MD is an associate professor and co-director of the Body Research Interest Group (RIG) in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. She received her undergraduate degree in Electrical Engineering from Brown University, and her medical degree from Northwestern University Medical School. She completed her residency training in Diagnostic Radiology at UCSF in 2007, serving as a Chief Resident from 2006-2007. Dr. Wang subsequently completed a fellowship in Abdominal Imaging at UCSF. She joined the UCSF faculty in 2008.

Dr. Wang’s research interests primarily focus on identification of novel imaging techniques and their development into practical and clinically useful diagnostic tools. Her research program includes hyperpolarized 13C MR spectroscopic imaging (MRSI) to assess renal tumor aggressiveness and diffuse renal disease (nephropathy), as well as quantitative imaging in pancreatic cancer.

Dr. Wang has been invited to lecture on various topics in Abdominal Imaging at multiple radiology societies, including the Society of Abdominal Radiology, American Roentgen Ray Society, Radiological Society of North America, as well as internationally at the Asian-Oceanian Congress of Radiology, International Education Conference Program in Mexico, and the Brazilian Congress of Radiology.

Clinical Expertise:

Computed Tomography, Magnetic Resonance Imaging, Abdominal Imaging, Oncological Imaging, Adult

Research Interests:

-Hyperpolarized C13 for characterization of renal tumors and nephropathy

-Imaging of pancreatic cancer

Education and Training:

• Medical School: Northwestern University Medical Center

• Internship: University of California, San Francisco

• Residency: University of California, San Francisco - Radiology and Medical Imaging

• Fellowship: University of California, San Francisco - Radiology and Medical Imaging, Abdominal Imaging

Education

Brown University, Providence, RI, B.S., 1993-1997, Electrical Engineering
Northwestern University Medical School, Chicago, IL, M.D., 1997-2002, Medicine
Dept of Medicine, UCSF Medical Center, San Francisco, CA, 2002-2003, Medicine Internship
Dept of Radiology, UCSF Medical Center, San Francisco, CA, 2003-2007, Radiology Residency
Dept of Radiology, UCSF Medical Center, San Francisco, CA, 2007-2008, Abdominal Imaging Fellowship

Professional Experience

  • 2008 – 2014
    Assistant Professor, Radiology and Biomedical Imaging, UCSF
  • 2014 – present
    Associate Professor, Radiology and Biomedical Imaging, UCSF
  • 2014 – present
    Co-Director, Body Imaging Research Interest Group, Radiology and Biomedical Imaging, UCSF

Honors & Awards

    1996
    Tau Beta Pi National Engineering Honor Society
  • 1999
    Howard Hughes Medical Institute (HHMI) Medical Student Scholar
  • 2000
    Howard Hughes Medical Institute (HHMI) Medical Student Research Award
  • 2001
    Alpha Omega Alpha (AOA) Honor Society
  • 2005
    Radiological Society of North America Roentgen Resident / Fellow Research Award
  • 2005
    Radiological Society of North America Trainee Research Prize
  • 2006
    American Roentgen Ray Society Resident in Radiology President’s Award
  • 2006-7
    Chief Resident, Department of Radiology, UCSF Medical Center
  • 2007
    UCSF Department of Radiology Margulis Society Resident Research Award
  • 2007
    Radiological Society of North America Trainee Research Prize
  • 2008
    Co-recipient: Cum Laude Award, Society of Computed Body Tomography/Magnetic Resonance
  • 2009
    Berdon Award
  • 2011
    Co-recipient: Cum Laude Award for presentation at the 2012 Radiological Society of North America annual meeting
  • 2013
    Second Place Prize in Basic Science Category, Society of Nuclear Medicine and Molecular Imaging Young Professionals
  • 2014
    Inducted as a Fellow of the Society of Abdominal Radiology

Selected Publications

  1. Yeh R, Dercle L, Garg I, Wang ZJ, Hough DM, Goenka AH. The Role of 18F-FDG PET/CT and PET/MRI in Pancreatic Ductal Adenocarcinoma. Abdom Radiol (NY). 2018 Feb; 43(2):415-434.
    View on PubMed
  2. von Morze C, Ohliger MA, Marco-Rius I, Wilson DM, Flavell RR, Pearce D, Vigneron DB, Kurhanewicz J, Wang ZJ. Direct assessment of renal mitochondrial redox state using hyperpolarized 13 C-acetoacetate. Magn Reson Med. 2018 Apr; 79(4):1862-1869.
    View on PubMed
  3. Lall C, Bura V, Lee TK, Bhosale P, Faria SC, Choi JI, Wang ZJ. Diffusion-weighted imaging in hemorrhagic abdominal and pelvic lesions: restricted diffusion can mimic malignancy. Abdom Radiol (NY). 2017 Nov 06.
    View on PubMed
  4. Tzou DT, Isaacson D, Usawachintachit M, Wang ZJ, Taguchi K, Hills NK, Hsi RS, Sherer BA, Reliford-Titus S, Duty B, Harper JD, Sorensen M, Sur RL, Stoller ML, Chi T. Variation in Radiologic and Urologic Computed Tomography Interpretation of Urinary Tract Stone Burden: Results From the Registry for Stones of the Kidney and Ureter. Urology. 2018 Jan; 111:59-64.
    View on PubMed
  5. Leapman MS, Wang ZJ, Behr SC, Kurhanewicz J, Zagoria RJ, Carroll PR, Westphalen AC. Impact of the integration of proton magnetic resonance imaging spectroscopy to PI-RADS 2 for prediction of high grade and high stage prostate cancer. Radiol Bras. 2017 Sep-Oct; 50(5):299-307.
    View on PubMed
  6. Baligand C, Qin H, True-Yasaki A, Gordon JW, von Morze C, Santos JD, Wilson DM, Raffai R, Cowley PM, Baker AJ, Kurhanewicz J, Lovett DH, Wang ZJ. Hyperpolarized 13 C magnetic resonance evaluation of renal ischemia reperfusion injury in a murine model. NMR Biomed. 2017 Oct; 30(10).
    View on PubMed
  7. Wilson DM, Di Gialleonardo V, Wang ZJ, Carroll V, Von Morze C, Taylor A, Sai V, VanCriekinge M, Bok R, Ohliger MA, Keshari KR. Hyperpolarized 13C Spectroscopic Evaluation of Oxidative Stress in a Rodent Model of Steatohepatitis. Sci Rep. 2017 Apr 20; 7:46014.
    View on PubMed
  8. Ceron CS, Baligand C, Joshi S, Wanga S, Cowley PM, Walker JP, Song SH, Mahimkar R, Baker AJ, Raffai RL, Wang ZJ, Lovett DH. An intracellular matrix metalloproteinase-2 isoform induces tubular regulated necrosis: implications for acute kidney injury. Am J Physiol Renal Physiol. 2017 Jun 01; 312(6):F1166-F1183.
    View on PubMed
  9. Cai L, Yeh BM, Westphalen AC, Roberts J, Wang ZJ. 3D T2-weighted and Gd-EOB-DTPA-enhanced 3D T1-weighted MR cholangiography for evaluation of biliary anatomy in living liver donors. Abdom Radiol (NY). 2017 Mar; 42(3):842-850.
    View on PubMed
  10. Dotson B, Lambert JW, Wang ZJ, Sun Y, Ohliger MA, Winklhofer S, Yeh BM. Benefit of iodine density images to reduce out-of-field image artifacts at rapid kVp switching dual-energy CT. Abdom Radiol (NY). 2017 Mar; 42(3):735-741.
    View on PubMed
  11. Winklhofer S, Lambert JW, Sun Y, Wang ZJ, Sun DS, Yeh BM. Pelvic Beam-Hardening Artifacts in Dual-Energy CT Image Reconstructions: Occurrence and Impact on Image Quality. AJR Am J Roentgenol. 2017 Jan; 208(1):114-123.
    View on PubMed
  12. Kim SY, Wu EH, Park SH, Wang ZJ, Hope TA, Yee J, Zhao LQ, Chang WC, Yeh BM. Comparison of hepatocellular carcinoma conspicuity on hepatobiliary phase images with gadoxetate disodium vs. delayed phase images with extracellular cellular contrast agent. Abdom Radiol (NY). 2016 Aug; 41(8):1522-31.
    View on PubMed
  13. Winklhofer S, Lambert JW, Wang ZJ, Sun Y, Gould RG, Zagoria RJ, Yeh BM. Reduction of peristalsis-related gastrointestinal streak artifacts with dual-energy CT: a patient and phantom study. Abdom Radiol (NY). 2016 Aug; 41(8):1456-65.
    View on PubMed
  14. Kim SS, Nakakura EK, Wang ZJ, Kim GE, Corvera CU, Harris HW, Kirkwood KS, Hirose R, Tempero MA, Ko AH. Preoperative FOLFIRINOX for borderline resectable pancreatic cancer: Is radiation necessary in the modern era of chemotherapy? J Surg Oncol. 2016 Oct; 114(5):587-596.
    View on PubMed
  15. Koelsch BL, Sriram R, Keshari KR, Leon Swisher C, Van Criekinge M, Sukumar S, Vigneron DB, Wang ZJ, Larson PEZ, Kurhanewicz J. Separation of extra- and intracellular metabolites using hyperpolarized (13)C diffusion weighted MR. J Magn Reson. 2016 09; 270:115-123.
    View on PubMed
  16. Chang WC, Sun Y, Wu EH, Kim SY, Wang ZJ, Huang GS, Yeh BM. CT Findings for Detecting the Presence of Gangrenous Ischemia in Cholecystitis. AJR Am J Roentgenol. 2016 Aug; 207(2):302-9.
    View on PubMed
  17. Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB. Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry. Tomography. 2016 Jun; 2(2):125-135.
    View on PubMed
  18. Cai L, Yeh BM, Westphalen AC, Roberts JP, Wang ZJ. Adult living donor liver imaging. Diagn Interv Radiol. 2016 May-Jun; 22(3):207-14.
    View on PubMed
  19. Vikram R, Beland MD, Blaufox MD, Moreno CC, Gore JL, Harvin HJ, Heilbrun ME, Liauw SL, Nguyen PL, Nikolaidis P, Preminger GM, Purysko AS, Raman SS, Taffel MT, Wang ZJ, Weinfeld RM, Remer EM, Lockhart ME. ACR Appropriateness Criteria Renal Cell Carcinoma Staging. J Am Coll Radiol. 2016 May; 13(5):518-25.
    View on PubMed
  20. Sriram R, Van Criekinge M, DeLos Santos J, Keshari KR, Wilson DM, Peehl D, Kurhanewicz J, Wang ZJ. Non-invasive differentiation of benign renal tumors from clear cell renal cell carcinomas using clinically translatable hyperpolarized 13C pyruvate magnetic resonance. Tomography. 2016 Mar; 2(1):35-42.
    View on PubMed

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