University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Valerie M. Weaver, PhD

Valerie M. Weaver, PhD

Professor & Director, Center for Bioengineering and Tissue Regeneration & Co-Director Bay Area Center for Physical Sciences and Oncology

Cancer Center Program Memberships

Breast Oncology | Cancer Immunology

Education

University of Waterloo, Canada, B.Sc., 1985, Chemistry/Biochemistry
University of Ottawa, Canada, B.Sc. Honors, 1986, Biochemistry (Summa Cum Laude)
University of Ottawa, Canada, Ph.D., 1992, Biochemistry
Apoptosis Research Group, NRC, Ottawa, Canada, 1992-1994, Postdoctoral Fellow
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 1994-1998, Postdoctoral Fellow


Professional Experience

  • 1999-2006
    Assistant Professor, Pathology, UPenn, Philadelphia, PA
  • 1999-2006
    Member, Institute for Medicine and Engineering, UPenn, Philadelphia, PA
  • 2007-2010
    Adjunct Associate Professor, Department of Bioengineering, UPenn, Philadelphia, PA
  • 2006-2010
    Associate Professor, Departments of Surgery and Anatomy, UCSF, San Francisco, CA
  • 2009-2010
    Associate Professor, Department of Bioengin & Therapeutic Sci., UCSF, San Francisco, CA
  • 2006-Present
    Director, Center for Bioengineering and Tissue Regeneration, Dept of Surgery, UCSF
  • 2009-Present
    Co-Director, Bay Area Center for Physical Sciences and Oncology, UCSF/UCBerkeley
  • 2010-Present
    Professor, Depts of Surgery, Anatomy, and Bioengineering and Therapeutic Sciences, UCSF

Honors & Awards

  • 1986
    University of Ottawa Gold Medal Highest Academic Standing Science
  • 1986
    Society of Chemical Industry Prize
  • 1986
    Alumni & Faculty Plaque Biochemistry
  • 1987
    Mary Eccelstone Research Award Wyeth Canadian Society of Nutrition Sciences
  • 1988
    American Institute of Nutrition Research Award Proctor & Gamble Graduate student award
  • 1996
    Lawrence Berkeley National Laboratory Achievement Award
  • 2000-01
    ACS-New Investigator Pilot Project Award, UPenn Cancer Center Grant
  • 2001-05
    DOD Career Development Award
  • 2002
    International Society of Differentiation Young Investigator Travel Award
  • 2003
    ASCB Co-Chair Mini Symposium ECM & Cancer
  • 2004
    AACR Co-Chair Major Symposium Reversibility of Tumors
  • 2004
    Co-Organizer HOX and Mammary Gland Workshop
  • 2004-10
    DOD Scholar Award
  • 2005
    Chair Engineering Cell Biology Symposium Model Systems for Complex Behaviors
  • 2006
    Co-Chair AACR Educational Session Organotypic Cancer Models
  • 2007
    Co-organizer, Conference on Engineering and Cell Biology
  • 2007
    Co-organizer TUMIC conference
  • 2007
    Chair and speaker AACR Cancer Therapy Symposium on Tumor Microenvironment
  • 2008
    Plenary Speaker Huntsman Cancer Retreat
  • 2009
    Co-Organizer Institute for Regenerative Medicine Retreat
  • 2010
    Speaker at The National Cancer Institute (NCI) and Tumor Microenvironment Network (TMEN) (2010), Speaker at Joint Metastasis Research Society - AACR Conference
  • 2010
    ASCB Co-Chair Mini Symp 50th Anniversary Meeting

Selected Publications

  1. Miroshnikova YA, Rozenberg GI, Cassereau L, Pickup M, Mouw JK, Ou G, Templeman KL, Elloumi-Hannachi I, Gooch KJ, Sarang-Sieminski AL, García AJ, Weaver VM. a5ß1-integrinpromotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site. Mol Biol Cell. 2017 Sep 06.
    View on PubMed
  2. Pickup MW, Owens P, Gorska AE, Chytil A, Ye F, Shi C, Weaver VM, Kalluri R, Moses HL, Novitskiy SV. Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells. Cancer Immunol Res. 2017 Sep; 5(9):718-729.
    View on PubMed
  3. Salvador F, Martin A, López-Menéndez C, Moreno-Bueno G, Santos V, Vazquez-Naharro A, Santamaría PG, Morales S, Dubus P, Muinelo-Romay L, López López R, Tung JC, Weaver VM, Portillo F, Cano A. Lysyl oxidase-like protein LOXL2 promotes lung metastasis of breast cancer. Cancer Res. 2017 Jul 18.
    View on PubMed
  4. Weaver VM. Cell and tissue mechanics: the new cell biology frontier. Mol Biol Cell. 2017 Jul 07; 28(14):1815-1818.
    View on PubMed
  5. Cai E, Marchuk K, Beemiller P, Beppler C, Rubashkin MG, Weaver VM, Gérard A, Liu TL, Chen BC, Betzig E, Bartumeus F, Krummel MF. Visualizing dynamic microvillar search and stabilization during ligand detection by T cells. Science. 2017 May 12; 356(6338).
    View on PubMed
  6. Oudin MJ, Weaver VM. Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis. Cold Spring Harb Symp Quant Biol. 2016; 81:189-205.
    View on PubMed
  7. Khuc E, Bainer R, Wolf M, Clay SM, Weisenberger DJ, Kemmer J, Weaver VM, Hwang DG, Chan MF. Comprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy. PLoS One. 2017; 12(4):e0175112.
    View on PubMed
  8. Mekhdjian AH, Kai F, Rubashkin MG, Prahl LS, Przybyla LM, McGregor AL, Bell ES, Barnes JM, DuFort CC, Ou G, Chang AC, Cassereau L, Tan SJ, Pickup MW, Lakins JN, Ye X, Davidson MW, Lammerding J, Odde DJ, Dunn AR, Weaver VM. Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. Mol Biol Cell. 2017 Jun 01; 28(11):1467-1488.
    View on PubMed
  9. Barnes JM, Przybyla L, Weaver VM. Tissue mechanics regulate brain development, homeostasis and disease. J Cell Sci. 2017 Jan 01; 130(1):71-82.
    View on PubMed
  10. Chang TT, Thakar D, Weaver VM. Force-dependent breaching of the basement membrane. Matrix Biol. 2017 Jan; 57-58:178-189.
    View on PubMed
  11. Takai K, Le A, Weaver VM, Werb Z. Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer. Oncotarget. 2016 Dec 13; 7(50):82889-82901.
    View on PubMed
  12. Kaushik S, Pickup MW, Weaver VM. From transformation to metastasis: deconstructing the extracellular matrix in breast cancer. Cancer Metastasis Rev. 2016 Dec; 35(4):655-667.
    View on PubMed
  13. Miroshnikova YA, Mouw JK, Barnes JM, Pickup MW, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight TR, Holland EC, Phillips JJ, Weaver VM. Tissue mechanics promote IDH1-dependent HIF1a-tenascin C feedback to regulate glioblastoma aggression. Nat Cell Biol. 2016 Dec; 18(12):1336-1345.
    View on PubMed
  14. Gilbert PM, Weaver VM. Cellular adaptation to biomechanical stress across length scales in tissue homeostasis and disease. Semin Cell Dev Biol. 2017 Jul; 67:141-152.
    View on PubMed
  15. Przybyla L, Lakins JN, Weaver VM. Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation. Cell Stem Cell. 2016 Oct 06; 19(4):462-475.
    View on PubMed
  16. Ou G, Thakar D, Tung JC, Miroshnikova YA, Dufort CC, Gutierrez E, Groisman A, Weaver VM. Visualizing mechanical modulation of nanoscale organization of cell-matrix adhesions. Integr Biol (Camb). 2016 Jul 11; 8(7):795-804.
    View on PubMed
  17. Przybyla L, Muncie JM, Weaver VM. Mechanical Control of Epithelial-to-Mesenchymal Transitions in Development and Cancer. Annu Rev Cell Dev Biol. 2016 Oct 06; 32:527-554.
    View on PubMed
  18. Bhagawati M, Rubashkin MG, Lee JP, Ananthanarayanan B, Weaver VM, Kumar S. Site-Specific Modulation of Charge Controls the Structure and Stimulus Responsiveness of Intrinsically Disordered Peptide Brushes. Langmuir. 2016 Jun 14; 32(23):5990-6.
    View on PubMed
  19. Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2016 May; 22(5):497-505.
    View on PubMed
  20. Kai F, Laklai H, Weaver VM. Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease. Trends Cell Biol. 2016 Jul; 26(7):486-497.
    View on PubMed

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