About UCSF Search UCSF UCSF Medical Center

Valerie M. Weaver, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
weaver_valerie

Professor & Director, Center for Bioengineering and Tissue Regeneration & Co-Director Bay Area Center for Physical Sciences and Oncology

weaverv@surgery.ucsf.edu

Phone: (415) 476-3826 (voice)
Box 0456, UCSF
San Francisco, CA 94143-0456

View on UCSF Profiles


Education

University of Waterloo, Canada, B.Sc., 1985, Chemistry/Biochemistry
University of Ottawa, Canada, B.Sc. Honors, 1986, Biochemistry (Summa Cum Laude)
University of Ottawa, Canada, Ph.D., 1992, Biochemistry
Apoptosis Research Group, NRC, Ottawa, Canada, 1992-1994, Postdoctoral Fellow
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 1994-1998, Postdoctoral Fellow


Professional Experience

  • 1999-2006
    Assistant Professor, Pathology, UPenn, Philadelphia, PA
  • 1999-2006
    Member, Institute for Medicine and Engineering, UPenn, Philadelphia, PA
  • 2007-2010
    Adjunct Associate Professor, Department of Bioengineering, UPenn, Philadelphia, PA
  • 2006-2010
    Associate Professor, Departments of Surgery and Anatomy, UCSF, San Francisco, CA
  • 2009-2010
    Associate Professor, Department of Bioengin & Therapeutic Sci., UCSF, San Francisco, CA
  • 2006-Present
    Director, Center for Bioengineering and Tissue Regeneration, Dept of Surgery, UCSF
  • 2009-Present
    Co-Director, Bay Area Center for Physical Sciences and Oncology, UCSF/UCBerkeley
  • 2010-Present
    Professor, Depts of Surgery, Anatomy, and Bioengineering and Therapeutic Sciences, UCSF

Honors & Awards

  • 1986
    University of Ottawa Gold Medal Highest Academic Standing Science
  • 1986
    Society of Chemical Industry Prize
  • 1986
    Alumni & Faculty Plaque Biochemistry
  • 1987
    Mary Eccelstone Research Award Wyeth Canadian Society of Nutrition Sciences
  • 1988
    American Institute of Nutrition Research Award Proctor & Gamble Graduate student award
  • 1996
    Lawrence Berkeley National Laboratory Achievement Award
  • 2000-01
    ACS-New Investigator Pilot Project Award, UPenn Cancer Center Grant
  • 2001-05
    DOD Career Development Award
  • 2002
    International Society of Differentiation Young Investigator Travel Award
  • 2003
    ASCB Co-Chair Mini Symposium ECM & Cancer
  • 2004
    AACR Co-Chair Major Symposium Reversibility of Tumors
  • 2004
    Co-Organizer HOX and Mammary Gland Workshop
  • 2004-10
    DOD Scholar Award
  • 2005
    Chair Engineering Cell Biology Symposium Model Systems for Complex Behaviors
  • 2006
    Co-Chair AACR Educational Session Organotypic Cancer Models
  • 2007
    Co-organizer, Conference on Engineering and Cell Biology
  • 2007
    Co-organizer TUMIC conference
  • 2007
    Chair and speaker AACR Cancer Therapy Symposium on Tumor Microenvironment
  • 2008
    Plenary Speaker Huntsman Cancer Retreat
  • 2009
    Co-Organizer Institute for Regenerative Medicine Retreat
  • 2010
    Speaker at The National Cancer Institute (NCI) and Tumor Microenvironment Network (TMEN) (2010), Speaker at Joint Metastasis Research Society - AACR Conference
  • 2010
    ASCB Co-Chair Mini Symp 50th Anniversary Meeting

Selected Publications

  1. Venugopalan G, Camarillo DB, Webster KD, Reber CD, Sethian JA, Weaver VM, Fletcher DA, El-Samad H, Rycroft CH. Multicellular architecture of malignant breast epithelia influences mechanics. PLoS One. 2014; 9(8):e101955.
    View on PubMed
  2. Paszek MJ, DuFort CC, Rossier O, Bainer R, Mouw JK, Godula K, Hudak JE, Lakins JN, Wijekoon AC, Cassereau L, Rubashkin MG, Magbanua MJ, Thorn KS, Davidson MW, Rugo HS, Park JW, Hammer DA, Giannone G, Bertozzi CR, Weaver VM. The cancer glycocalyx mechanically primes integrin-mediated growth and survival. Nature. 2014 Jul 17; 511(7509):319-25.
    View on PubMed
  3. Ozdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell. 2014 Jun 16; 25(6):719-34.
    View on PubMed
  4. Michor F, Weaver VM. Understanding tissue context influences on intratumour heterogeneity. Nat Cell Biol. 2014 Apr 1; 16(4):301-2.
    View on PubMed
  5. Rubashkin MG, Ou G, Weaver VM. Deconstructing signaling in three dimensions. Biochemistry. 2014 Apr 8; 53(13):2078-90.
    View on PubMed
  6. Mouw JK, Yui Y, Damiano L, Bainer RO, Lakins JN, Acerbi I, Ou G, Wijekoon AC, Levental KR, Gilbert PM, Hwang ES, Chen YY, Weaver VM. Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression. Nat Med. 2014 Apr; 20(4):360-7.
    View on PubMed
  7. Shi Q, Ghosh RP, Engelke H, Rycroft CH, Cassereau L, Sethian JA, Weaver VM, Liphardt JT. Rapid disorganization of mechanically interacting systems of mammary acini. Proc Natl Acad Sci U S A. 2014 Jan 14; 111(2):658-63.
    View on PubMed
  8. Bainer R, Weaver V. Cell biology. Strength under tension. Science. 2013 Aug 30; 341(6149):965-6.
    View on PubMed
  9. Pickup MW, Laklai H, Acerbi I, Owens P, Gorska AE, Chytil A, Aakre M, Weaver VM, Moses HL. Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-ß-deficient mouse mammary carcinomas. Cancer Res. 2013 Sep 1; 73(17):5336-46.
    View on PubMed
  10. Maller O, Hansen KC, Lyons TR, Acerbi I, Weaver VM, Prekeris R, Tan AC, Schedin P. Collagen architecture in pregnancy-induced protection from breast cancer. J Cell Sci. 2013 Sep 15; 126(Pt 18):4108-10.
    View on PubMed
  11. Damiano L, Stewart KM, Cohet N, Mouw JK, Lakins JN, Debnath J, Reisman D, Nickerson JA, Imbalzano AN, Weaver VM. Oncogenic targeting of BRM drives malignancy through C/EBPß-dependent induction of a5 integrin. Oncogene. 2014 May 8; 33(19):2441-53.
    View on PubMed
  12. Maller O, DuFort CC, Weaver VM. YAP forces fibroblasts to feel the tension. Nat Cell Biol. 2013 Jun; 15(6):570-2.
    View on PubMed
  13. Tang Y, Rowe RG, Botvinick EL, Kurup A, Putnam AJ, Seiki M, Weaver VM, Keller ET, Goldstein S, Dai J, Begun D, Saunders T, Weiss SJ. MT1-MMP-dependent control of skeletal stem cell commitment via a ß1-integrin/YAP/TAZ signaling axis. Dev Cell. 2013 May 28; 25(4):402-16.
    View on PubMed
  14. A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep. 2013; 3:1449.
    View on PubMed
  15. Li CR, Su JJ, Wang WY, Lee MT, Wang TY, Jiang KY, Li CF, Hsu JM, Chen CK, Chen M, Jiang SS, Weaver VM, Tsai KK. Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer. Am J Pathol. 2013 Feb; 182(2):363-74.
    View on PubMed
  16. Paszek MJ, DuFort CC, Rubashkin MG, Davidson MW, Thorn KS, Liphardt JT, Weaver VM. Scanning angle interference microscopy reveals cell dynamics at the nanoscale. Nat Methods. 2012 Aug; 9(8):825-7.
    View on PubMed
  17. Cassereau L, DuFort CC, Weaver VM. Morphogenesis: Laying down the tracks. Nat Mater. 2012 Jun; 11(6):490-2.
    View on PubMed
  18. Lu P, Weaver VM, Werb Z. The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol. 2012 Feb 20; 196(4):395-406.
    View on PubMed
  19. Lakins JN, Chin AR, Weaver VM. Exploring the link between human embryonic stem cell organization and fate using tension-calibrated extracellular matrix functionalized polyacrylamide gels. Methods Mol Biol. 2012; 916:317-50.
    View on PubMed
  20. Lu P, Takai K, Weaver VM, Werb Z. Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol. 2011 Dec; 3(12).
    View on PubMed

Go to UCSF Profiles, powered by CTSI