Valerie M. Weaver, PhD

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Education

University of Waterloo, Canada, B.Sc., 1985, Chemistry/Biochemistry
University of Ottawa, Canada, B.Sc. Honors, 1986, Biochemistry (Summa Cum Laude)
University of Ottawa, Canada, Ph.D., 1992, Biochemistry
Apoptosis Research Group, NRC, Ottawa, Canada, 1992-1994, Postdoctoral Fellow
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 1994-1998, Postdoctoral Fellow

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Professional Experience

• 1998-1999
  Research Scientist, Life Sciences Division, Lawrence Berkeley National Laboratory, CA
• 1999-2006
  Assistant Professor, Pathology, UPenn, Philadelphia, PA
• 1999-2006
  Member, Institute for Medicine and Engineering, UPenn, Philadelphia, PA
• 2006-present
  Associate Professor, Department of Surgery, UCSF, San Francisco, CA
• 2006-present
  Associate Professor, Department of Anatomy, UCSF, San Francisco, CA
• 2006-present
  Adjunct Associate Professor, Department of Bioengineering, UPenn, Philadelphia, PA
• 2006-present
  Director, Center for Bioengineering and Tissue Regeneration, Dept of Surgery, UCSF
• 2008-present
  Associate Professor, Department of Bioengineering and Therapeutics, UCSF

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Honors & Awards

• 1986
  University of Ottawa Gold Medal Highest Academic Standing Science
• 1986
  Society of Chemical Industry Prize
• 1986
  Alumni & Faculty Plaque Biochemistry
• 1987
  Mary Eccelstone Research Award Wyeth Canadian Society of Nutrition Sciences
• 1988
  American Institute of Nutrition Research Award Proctor & Gamble Graduate student award
• 1996
  Lawrence Berkeley National Laboratory Achievement Award
• 2000-01
  ACS-New Investigator Pilot Project Award, UPenn Cancer Center Grant
• 2001-05
  DOD Career Development Award
• 2002
  International Society of Differentiation Young Investigator Travel Award
• 2003
  ASCB Co-Chair Mini Symposium ECM & Cancer
• 2004
  AACR Co-Chair Major Symposium Reversibility of Tumors
• 2004
  Co-Organizer HOX and Mammary Gland Workshop
• 2004-10
  DOD Scholar Award
• 2005
  Chair Engineering Cell Biology Symposium Model Systems for Complex Behaviors
• 2006
  Co-Chair AACR Educational Session Organotypic Cancer Models
• 2007
  Co-organizer, Conference on Engineering and Cell Biology
• 2007
  Co-organizer, TUMIC conference
• 2007
  Chair Symposium on Tumor Microenvironment Symposium speaker, AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications,
• 2008-09
  Co-organizer, 3rd 2009 Engineering Cell Biology Conference

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Selected Publications

• Chrenek, M, Wong, P, and Weaver, VM. Tumor-stromal interactions - Integrins and cell adhesions as modulators of mammary cell survival and transformation.Breast Cancer Res. 3:224-229, 2001.
• Unger, M, and Weaver, VM. The tissue microenvironment as an epigenetic tumor suppressor. Meth Mol Biol 223:315-347, 2002.
• Weaver, VM, Membrane associated MMP regulators: novel cell adhesion tumor suppressor proteins? Dev. Cell 2:6-7, 2002.
• Weaver, VM, Lelievre, S, Lakins, JN, Chrenek, M, Jones, J, Giancotti, F, Werb, Z, and Bissell, M.J. beta4-integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell 2:205-216, 2002.
• Bissell, MJ, Rizki, A., Weaver, VM, Petersen, OW. Use of Premalignant Breast Epithelial Cell Lines in Discovery of Factors Functionally Significant in Breast Cancer Progression. JIB-2003.
• Russell, A, Fincher, EF, Millman, L, Smith, R, Vela, V, Weaver, VM and Marinkovich, PM, alpha6/beta4-integrin coordinates EGF-induced chemotaxis in keratinocytes. J. Cell Sci. 116:3543-3556, 2003.
• Zahir, N, and Weaver, VM. Death in the third dimension: apoptosis regulation and tissue architecture. Curr Opin Gene Dev. 14:71-80, 2004.
• Paszek, M, and Weaver VM. The tension mounts: mechanics meets morphogenesis and malignancy. J Mammary Gland Biol Neoplasia. 9:325-42, 2004.
• Weaver, VM, and Gilbert, P, Watch thy neighbor: tumorigenesis is a communal affair. J. Cell Sci. 117:1287-90, 2004.
• Cowden-Dahl, KD, Weaver, VM and Simon, MC. HIF regulates alphavbeta3 integrin cell surface expression. Mol Biol Cell. 16:1901-12, 2005.
• Paszek, MJ*, Zahir, N*, Lakins, JN, Johnson, K, Rozenberg, GI, Gefen, A, Reinhart-King, C, Dembo, M, Margulies, S, Boettiger, D, Hammer, DA and Weaver,VM. Tensional homeostasis and the malignant phenotype. *These authors contributed equally to this work. Cancer Cell. 8:241-54, 2005. 12. Yan, Y, Weaver, VM and Blair, IA. Analysis of Protein Expression During Oxidative Stress in Breast Epithelial Cells Using a Stable Isotope Labeled Proteome Internal Standard. J. Proteome Research 4:7-14, 2005.
• Yang, C, Liu, Y, Leskow, FC, Weaver, VM and Kazanietz, MG. RAC-Gap-dependent inhibition of breast cancer cell proliferation by the diacylglycerol/phorbol ester receptor b2-chimaerin. J Biol Chem. 280:24363-70, 2005.
• Yeung, T, Georges, PC, Flanagan, L, Marg, B, Ortiz, M, Ming, W, Funaki, M, Weaver, VM, Janmey, PA. Effect of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. Cell Motil Cytoskeleton. 60:24-34, 2005.
• Boudreau, N., and Weaver, VM Forcing the third dimension. Cell. 125:429-31, 2006.
• Underwood, JM, Imbalzano, KM, Weaver, VM., Fischer, AH, Imbalzano, AN, and Nickerson, JA. The ultrastructure of MCF-10A acini. J Cell Physiology, 208:141-148, 2006.
• Friedland. JC, Lakins, JN, Kazanietz, M.G., Chernoff, J., Boettiger, D. and Weaver, V.M. alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NFkappaB-dependent apoptosis resistance in 3D mammary acini. J Cell Sci. 120: 3700-12, 2007.
• Hebner, C, Weaver, VM, and Debnath, J, Modeling Morphogensis and Oncogenesis in Three dimensional Breast Epithelial Cultures. Annu. Rev. Pathol. 3: 313-319, 2007.
• Johnson, K, Leight, J, Weaver, VM. Demystifying the Effects of a Three-Dimensional Microenvironment in Tissue Morphogenesis. Methods Cell Biology. 83:547-583, 2007.
• Kang, I, and Weaver VM. Tensional Homeostasis. Encylopedia of Cancer. In press. 2007. 21. Kass, L, Erler, JT, Dembo, M, Weaver, VM, Mammary epithelial cell: Influence of extracellular matrix composition and organization during development and tumorigenesis. Int J Biochem Cell Biol. 39:1987-1994, 2007.
• Weaver, V.M., Tsai, K., Methods for predicting and treating drug-, immunotherapy- and/or radiation-resistant tumors. SF2008-034, 2007.
• Weaver, VM and Werb, Z, G'rab'bing the Microenvironment for Invasion. Dev Cell, 13:462-463, 2007.
• Fournier, AK, Campbell, LE, Castagnino, P, Liu, WF, Chung, BM, Weaver, VM, Chen, CS and Assoian, RK, Rac-dependent cyclin D1 gene expression regulated by cadherin and integrin-mediated cell adhesion. J Cell Sci. 121:226-233, 2008.
• Rizki, A, Weaver, VM, Lee, SY, Rozenberg, GI, Chin, K, Myers, CA, Bascom, JL, Mott, JD, Semiks, JR, Grate, LR, Mian, IS, Borowsky, AD, Jensen, RA, Idowu, MO, Chen, F, Chen, DJ, Petersen, OW, Gray, JW, Bissell, MJ. A human breast cell model of preinvasive to invasive transition. Cancer Res. 68:1378-1387, 2008.
• Yee, KL, Weaver, VM, and Hammer, D, Integrin-mediated Signaling through the MAP-kinase Pathway. IET Systems Biology. 2:8-15, 2008.
• Mouw, J, Desai, S, and Weaver VM, Forcing transformation: biophysical regulation of mammary epithelial cell trans-formation, In the Pathomechanics of Tissue Injury and Disease, and the Mechanophysiology of Healing, In Press, 2008
• Erler, J, and Weaver VM Tissue Context and Tumor Metastasis, In a special issue of Clinical and Experimental Metastasis, In Press, 2008.
• Gilbert, P., Unger, M., Lakins, J.N., Gbegnon, M.K., Nuth, M., Clemmer, V., Colligon, T., Naylor, T., Licht, J., Boudreau, N., Weber, B., and Weaver, V.M. Global expression profiling reveals a novel role for HoxA9 in breast cancer and BRCA1 regulation. Under Review, Dev Cell.
• Tsai K.K.C. Chatterjee, C., Werner, M.E., Jonathan N. Lakins, Nuth, M., Tobias, J, Mian, S. and Weaver V.M. The Third Dimension Drives N-CoR2-dependent Death Resistance. Under Review Nature Medicine.