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Valerie M. Weaver, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
weaver_valerie

Professor & Director, Center for Bioengineering and Tissue Regeneration & Co-Director Bay Area Center for Physical Sciences and Oncology

weaverv@surgery.ucsf.edu

Phone: (415) 476-3826 (voice)
Box 0456, UCSF
San Francisco, CA 94143-0456

View on UCSF Profiles


Education

University of Waterloo, Canada, B.Sc., 1985, Chemistry/Biochemistry
University of Ottawa, Canada, B.Sc. Honors, 1986, Biochemistry (Summa Cum Laude)
University of Ottawa, Canada, Ph.D., 1992, Biochemistry
Apoptosis Research Group, NRC, Ottawa, Canada, 1992-1994, Postdoctoral Fellow
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 1994-1998, Postdoctoral Fellow


Professional Experience

  • 1999-2006
    Assistant Professor, Pathology, UPenn, Philadelphia, PA
  • 1999-2006
    Member, Institute for Medicine and Engineering, UPenn, Philadelphia, PA
  • 2007-2010
    Adjunct Associate Professor, Department of Bioengineering, UPenn, Philadelphia, PA
  • 2006-2010
    Associate Professor, Departments of Surgery and Anatomy, UCSF, San Francisco, CA
  • 2009-2010
    Associate Professor, Department of Bioengin & Therapeutic Sci., UCSF, San Francisco, CA
  • 2006-Present
    Director, Center for Bioengineering and Tissue Regeneration, Dept of Surgery, UCSF
  • 2009-Present
    Co-Director, Bay Area Center for Physical Sciences and Oncology, UCSF/UCBerkeley
  • 2010-Present
    Professor, Depts of Surgery, Anatomy, and Bioengineering and Therapeutic Sciences, UCSF

Honors & Awards

  • 1986
    University of Ottawa Gold Medal Highest Academic Standing Science
  • 1986
    Society of Chemical Industry Prize
  • 1986
    Alumni & Faculty Plaque Biochemistry
  • 1987
    Mary Eccelstone Research Award Wyeth Canadian Society of Nutrition Sciences
  • 1988
    American Institute of Nutrition Research Award Proctor & Gamble Graduate student award
  • 1996
    Lawrence Berkeley National Laboratory Achievement Award
  • 2000-01
    ACS-New Investigator Pilot Project Award, UPenn Cancer Center Grant
  • 2001-05
    DOD Career Development Award
  • 2002
    International Society of Differentiation Young Investigator Travel Award
  • 2003
    ASCB Co-Chair Mini Symposium ECM & Cancer
  • 2004
    AACR Co-Chair Major Symposium Reversibility of Tumors
  • 2004
    Co-Organizer HOX and Mammary Gland Workshop
  • 2004-10
    DOD Scholar Award
  • 2005
    Chair Engineering Cell Biology Symposium Model Systems for Complex Behaviors
  • 2006
    Co-Chair AACR Educational Session Organotypic Cancer Models
  • 2007
    Co-organizer, Conference on Engineering and Cell Biology
  • 2007
    Co-organizer TUMIC conference
  • 2007
    Chair and speaker AACR Cancer Therapy Symposium on Tumor Microenvironment
  • 2008
    Plenary Speaker Huntsman Cancer Retreat
  • 2009
    Co-Organizer Institute for Regenerative Medicine Retreat
  • 2010
    Speaker at The National Cancer Institute (NCI) and Tumor Microenvironment Network (TMEN) (2010), Speaker at Joint Metastasis Research Society - AACR Conference
  • 2010
    ASCB Co-Chair Mini Symp 50th Anniversary Meeting

Selected Publications

  1. Bainer R, Weaver V. Cell biology. Strength under tension. Science. 2013 Aug 30; 341(6149):965-6.
    View on PubMed
  2. Pickup MW, Laklai H, Acerbi I, Owens P, Gorska AE, Chytil A, Aakre M, Weaver VM, Moses HL. Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-ß-deficient mouse mammary carcinomas. Cancer Res. 2013 Sep 1; 73(17):5336-46.
    View on PubMed
  3. Maller O, Hansen KC, Lyons TR, Acerbi I, Weaver VM, Prekeris R, Tan AC, Schedin P. Collagen architecture in pregnancy-induced protection from breast cancer. J Cell Sci. 2013 Sep 15; 126(Pt 18):4108-10.
    View on PubMed
  4. Maller O, DuFort CC, Weaver VM. YAP forces fibroblasts to feel the tension. Nat Cell Biol. 2013 Jun; 15(6):570-2.
    View on PubMed
  5. Tang Y, Rowe RG, Botvinick EL, Kurup A, Putnam AJ, Seiki M, Weaver VM, Keller ET, Goldstein S, Dai J, Begun D, Saunders T, Weiss SJ. MT1-MMP-dependent control of skeletal stem cell commitment via a ß1-integrin/YAP/TAZ signaling axis. Dev Cell. 2013 May 28; 25(4):402-16.
    View on PubMed
  6. A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep. 2013; 3:1449.
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  7. Li CR, Su JJ, Wang WY, Lee MT, Wang TY, Jiang KY, Li CF, Hsu JM, Chen CK, Chen M, Jiang SS, Weaver VM, Tsai KK. Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer. Am J Pathol. 2013 Feb; 182(2):363-74.
    View on PubMed
  8. Paszek MJ, DuFort CC, Rubashkin MG, Davidson MW, Thorn KS, Liphardt JT, Weaver VM. Scanning angle interference microscopy reveals cell dynamics at the nanoscale. Nat Methods. 2012 Aug; 9(8):825-7.
    View on PubMed
  9. Cassereau L, DuFort CC, Weaver VM. Morphogenesis: Laying down the tracks. Nat Mater. 2012 Jun; 11(6):490-2.
    View on PubMed
  10. Lu P, Weaver VM, Werb Z. The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol. 2012 Feb 20; 196(4):395-406.
    View on PubMed
  11. Lakins JN, Chin AR, Weaver VM. Exploring the link between human embryonic stem cell organization and fate using tension-calibrated extracellular matrix functionalized polyacrylamide gels. Methods Mol Biol. 2012; 916:317-50.
    View on PubMed
  12. Lu P, Takai K, Weaver VM, Werb Z. Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol. 2011 Dec; 3(12).
    View on PubMed
  13. Lopez JI, Kang I, You WK, McDonald DM, Weaver VM. In situ force mapping of mammary gland transformation. Integr Biol (Camb). 2011 Sep; 3(9):910-21.
    View on PubMed
  14. Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, Munro J, Schröder E, Zhou J, Brunton VG, Barker N, Clevers H, Sansom OJ, Anderson KI, Weaver VM, Olson MF. Actomyosin-mediated cellular tension drives increased tissue stiffness and ß-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell. 2011 Jun 14; 19(6):776-91.
    View on PubMed
  15. Weaver V. Valerie Weaver: overcoming cancer's stiff resistance. Interview by Caitlin Sedwick. J Cell Biol. 2011 May 30; 193(5):802-3.
    View on PubMed
  16. DuFort CC, Paszek MJ, Weaver VM. Balancing forces: architectural control of mechanotransduction. Nat Rev Mol Cell Biol. 2011 May; 12(5):308-19.
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  17. Dvorak HF, Weaver VM, Tlsty TD, Bergers G. Tumor microenvironment and progression. J Surg Oncol. 2011 May 1; 103(6):468-74.
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  18. Miroshnikova YA, Jorgens DM, Spirio L, Auer M, Sarang-Sieminski AL, Weaver VM. Engineering strategies to recapitulate epithelial morphogenesis within synthetic three-dimensional extracellular matrix with tunable mechanical properties. Phys Biol. 2011 Apr; 8(2):026013.
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  19. Frantz C, Stewart KM, Weaver VM. The extracellular matrix at a glance. J Cell Sci. 2010 Dec 15; 123(Pt 24):4195-200.
    View on PubMed
  20. Brown XQ, Bartolak-Suki E, Williams C, Walker ML, Weaver VM, Wong JY. Effect of substrate stiffness and PDGF on the behavior of vascular smooth muscle cells: implications for atherosclerosis. J Cell Physiol. 2010 Oct; 225(1):115-22.
    View on PubMed

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