Arthur Weiss, MD, PhD

Arthur Weiss, MD, PhD

Professor, Departments of Medicine, Microbiology and Immunology; Investigator, Howard Hughes Medical Institute, UCSF
Ephraim P. Engleman Distinguished Professorship, UCSF

Phone: (415) 476-8983 (voice)
Box 0795, UCSF
San Francisco, CA 94143-0795

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University of Chicago, Chicago, IL, Ph.D., 1978, Immunology
University of Chicago, Chicago, IL, M.D., 1979, Medicine

Professional Experience

  • 1979-1980
    Postdoctoral Fellow, Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland
  • 1980-1982
    Resident, Department of Medicine, University of California, San Francisco (UCSF)
  • 1982-1984
    Fellow in Rheumatology/Clinical Immunology, UCSF
  • 1982-1985
    Associate, Howard Hughes Medical Institute, UCSF
  • 1984-1985
    Instructor, Department of Medicine, Division of Rheumatology/Clinical Immunology, UCSF
  • 1985-1989
    Assistant Investigator, Howard Hughes Medical Institute, UCSF
  • 1985-1989
    Assistant Professor of Medicine, Microbiology and Immunology, UCSF
  • 1987-2011
    Chief, Division of Rheumatology/Clinical Immunology, Department of Medicine, UCSF
  • 1989-1993
    Associate Professor or Medicine, Microbiology and Immunology, UCSF
  • 1989-1994
    Associate Investigator, Howard Hughes Medical Institute, UCSF
  • 1991-present
    Ephraim P. Engleman Distinguished Professor of Rheumatology, UCSF
  • 1992-present
    Professor of Medicine, Microbiology and Immunology, UCSF
  • 1993-present
    Investigator, Howard Hughes Medical Institute, UCSF
  • 1998-2005
    Associate Director, The Rosalind Russell Medical Research Center for Arthritis, UCSF
  • 2002-2006
    Director, Medical Scientist Training Program (MSTP), UCSF
  • 2007-2010
    Co-Director, Institute for Molecular Medicine, UCSF

Honors & Awards

  • 1997
    Lee C. Howley Prize, Arthritis Foundation
  • 1998
    Forty-First Faculty Research Lecturer, UCSF
  • 2001
    American Association of Immunologist-Huang Foundation Meritorious Career Award
  • 2003
    Fellow, American Academy of Arts and Sciences
  • 2004
    Member, National Academy of Sciences
  • 2004
    Fellow, American Academy of Microbiology
  • 2004
    Member, Institute of Medicine
  • 2004
    Distinguished Investigator Award, American College of Rheumatology
  • 2012
    Lifetime Achievement Award, American Association of Immunology
  • 2012
    UCSF Lifetime Achievement in Mentoring Award

Selected Publications

  1. Au-Yeung BB, Melichar HJ, Ross JO, Cheng DA, Zikherman J, Shokat KM, Robey EA, Weiss A. Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. Nat Immunol. 2014 Jul; 15(7):687-94.
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  2. Wang H, Flach H, Onizawa M, Wei L, McManus MT, Weiss A. Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210. Nat Immunol. 2014 Apr; 15(4):393-401.
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  3. Limnander A, Zikherman J, Lau T, Leitges M, Weiss A, Roose JP. Protein kinase cd promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance. Mol Cell Biol. 2014 Apr; 34(8):1474-85.
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  4. Tan YX, Manz BN, Freedman TS, Zhang C, Shokat KM, Weiss A. Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling. Nat Immunol. 2014 Feb; 15(2):186-94.
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  5. Weiss A. Tony Pawson: Modular protein domains and the links to intracellular signaling. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):17604-5.
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  6. Tan YX, Zikherman J, Weiss A. Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45. Cold Spring Harb Symp Quant Biol. 2013; 78:131-9.
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  7. Gardner JM, Metzger TC, McMahon EJ, Au-Yeung BB, Krawisz AK, Lu W, Price JD, Johannes KP, Satpathy AT, Murphy KM, Tarbell KV, Weiss A, Anderson MS. Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4? T cells. Immunity. 2013 Sep 19; 39(3):560-72.
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  8. Xie M, Hong C, Zhang B, Lowdon RF, Xing X, Li D, Zhou X, Lee HJ, Maire CL, Ligon KL, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O'Geen H, Farnham PJ, Madden PA, Mungall AJ, Tam A, Kamoh B, Cho S, Moore R, Hirst M, Marra MA, Costello JF, Wang T. DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape. Nat Genet. 2013 Jul; 45(7):836-41.
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  9. Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A. The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. J Clin Invest. 2013 May 1; 123(5):2037-48.
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  10. Yan Q, Barros T, Visperas PR, Deindl S, Kadlecek TA, Weiss A, Kuriyan J. Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker. Mol Cell Biol. 2013 Jun; 33(11):2188-201.
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  11. Zikherman J, Parameswaran R, Hermiston M, Weiss A. The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity. J Immunol. 2013 Mar 15; 190(6):2527-35.
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  12. Mukherjee S, Zhu J, Zikherman J, Parameswaran R, Kadlecek TA, Wang Q, Au-Yeung B, Ploegh H, Kuriyan J, Das J, Weiss A. Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases. Sci Signal. 2013 Jan 1; 6(256):ra1.
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  13. Charles JF, Hsu LY, Niemi EC, Weiss A, Aliprantis AO, Nakamura MC. Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function. J Clin Invest. 2012 Dec 3; 122(12):4592-605.
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  14. Zikherman J, Parameswaran R, Weiss A. Endogenous antigen tunes the responsiveness of naive B cells but not T cells. Nature. 2012 Sep 6; 489(7414):160-4.
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  15. Wei P, Wong WW, Park JS, Corcoran EE, Peisajovich SG, Onuffer JJ, Weiss A, Lim WA. Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells. Nature. 2012 Aug 16; 488(7411):384-8.
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  16. Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus MT. A resource for the conditional ablation of microRNAs in the mouse. Cell Rep. 2012 Apr 19; 1(4):385-91.
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  17. Abel SM, Roose JP, Groves JT, Weiss A, Chakraborty AK. The membrane environment can promote or suppress bistability in cell signaling networks. J Phys Chem B. 2012 Mar 22; 116(11):3630-40.
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  18. Baldari CT, Acuto O, Batista F, Koretzky G, Weiss A. Lymphocyte signaling: a Tuscan affair. Nat Immunol. 2012 Jan; 13(1):3-6.
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  19. Zikherman J, Doan K, Parameswaran R, Raschke W, Weiss A. Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival. Proc Natl Acad Sci U S A. 2012 Jan 3; 109(1):E3-12.
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  20. Zikherman J, Weiss A. Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease. J Clin Invest. 2011 Dec; 121(12):4618-21.
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