Arthur Weiss, MD, PhD

Professor, Departments of Medicine, Microbiology and Immunology; Investigator, Howard Hughes Medical Institute; Associate Director, The Rosalind Russell Medical Research Center for Arthritis; Director, Medical Scientist Training Program; Co-Director, Institute for Molecular Medicine, UCSF
Ephraim P. Engleman Distinguished Professorship, UCSF

aweiss@medicine.ucsf.edu

Phone: (415) 476-8983 (voice)
Box 0795, UCSF
San Francisco, CA 94143-0795

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Education

University of Chicago, Chicago, IL, Ph.D., 1978, Immunology
University of Chicago, Chicago, IL, M.D., 1979, Medicine

Professional Experience

• 1979-1980
  Postdoctoral Fellow, Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland
• 1980-1982
  Resident, Department of Medicine, University of California, San Francisco (UCSF)
• 1982-1984
  Fellow in Rheumatology/Clinical Immunology, UCSF
• 1982-1985
  Associate, Howard Hughes Medical Institute, UCSF
• 1984-1985
  Instructor, Department of Medicine, Division of Rheumatology/Clinical Immunology, UCSF
• 1985-1989
  Assistant Investigator, Howard Hughes Medical Institute, UCSF
• 1985-1989
  Assistant Professor of Medicine, Microbiology and Immunology, UCSF
• 1987-2011
  Chief, Division of Rheumatology/Clinical Immunology, Department of Medicine, UCSF
• 1989-1993
  Associate Professor or Medicine, Microbiology and Immunology, UCSF
• 1989-1994
  Associate Investigator, Howard Hughes Medical Institute, UCSF
• 1991-present
  Ephraim P. Engleman Distinguished Professor of Rheumatology, UCSF
• 1992-present
  Professor of Medicine, Microbiology and Immunology, UCSF
• 1993-present
  Investigator, Howard Hughes Medical Institute, UCSF
• 1998-2005
  Associate Director, The Rosalind Russell Medical Research Center for Arthritis, UCSF
• 2002-2006
  Director, Medical Scientist Training Program (MSTP), UCSF
• 2007-2010
  Co-Director, Institute for Molecular Medicine, UCSF

Honors & Awards

• 1997
  Lee C. Howley Prize, Arthritis Foundation
• 1998
  Forty-First Faculty Research Lecturer, UCSF
• 2001
  American Association of Immunologist-Huang Foundation Meritorious Career Award
• 2003
  Fellow, American Academy of Arts and Sciences
• 2004
  Member, National Academy of Sciences
• 2004
  Fellow, American Academy of Microbiology
• 2004
  Member, Institute of Medicine
• 2004
  Distinguished Investigator Award, American College of Rheumatology
• 2012
  Lifetime Achievement Award, American Association of Immunology
• 2012
  UCSF Lifetime Achievement in Mentoring Award

Selected Publications

1. Zikherman J, Parameswaran R, Hermiston M, Weiss A. The Structural Wedge Domain of the Receptor-like Tyrosine Phosphatase CD45 Enforces B Cell Tolerance by Regulating Substrate Specificity. J Immunol. 2013 Mar 15; 190(6):2527-35.
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2. Mukherjee S, Zhu J, Zikherman J, Parameswaran R, Kadlecek TA, Wang Q, Au-Yeung B, Ploegh H, Kuriyan J, Das J, Weiss A. Monovalent and Multivalent Ligation of the B Cell Receptor Exhibit Differential Dependence upon Syk and Src Family Kinases. Sci Signal. 2013; 6(256):ra1.
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3. Charles JF, Hsu LY, Niemi EC, Weiss A, Aliprantis AO, Nakamura MC. Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function. J Clin Invest. 2012 Dec 3; 122(12):4592-605.
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4. Zikherman J, Parameswaran R, Weiss A. Endogenous antigen tunes the responsiveness of naive B cells but not T cells. Nature. 2012 Sep 6; 489(7414):160-4.
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5. Wei P, Wong WW, Park JS, Corcoran EE, Peisajovich SG, Onuffer JJ, Weiss A, Lim WA. Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells. Nature. 2012 Aug 16; 488(7411):384-8.
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6. Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus MT. A resource for the conditional ablation of microRNAs in the mouse. Cell Rep. 2012 Apr 19; 1(4):385-91.
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7. Zikherman J, Doan K, Parameswaran R, Raschke W, Weiss A. Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival. Proc Natl Acad Sci U S A. 2012 Jan 3; 109(1):E3-12.
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8. Zikherman J, Weiss A. Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease. J Clin Invest. 2011 Dec; 121(12):4618-21.
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9. Zhu JW, Doan K, Park J, Chau AH, Zhang H, Lowell CA, Weiss A. Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus. Immunity. 2011 Nov 23; 35(5):757-69.
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10. Markegard E, Trager E, Yang CW, Zhang W, Weiss A, Roose JP. Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRa gene expression. PLoS One. 2011; 6(9):e25540.
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11. Schoenborn JR, Tan YX, Zhang C, Shokat KM, Weiss A. Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling. Sci Signal. 2011 Sep 13; 4(190):ra59.
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12. Limnander A, Depeille P, Freedman TS, Liou J, Leitges M, Kurosaki T, Roose JP, Weiss A. STIM1, PKC-d and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. Nat Immunol. 2011 May; 12(5):425-33.
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13. Au-Yeung BB, Levin SE, Zhang C, Hsu LY, Cheng DA, Killeen N, Shokat KM, Weiss A. A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nat Immunol. 2010 Dec; 11(12):1085-92.
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14. Beinke S, Phee H, Clingan JM, Schlessinger J, Matloubian M, Weiss A. Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16234-9.
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15. Phee H, Dzhagalov I, Mollenauer M, Wang Y, Irvine DJ, Robey E, Weiss A. Regulation of thymocyte positive selection and motility by GIT2. Nat Immunol. 2010 Jun; 11(6):503-11.
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16. Wang H, Kadlecek TA, Au-Yeung BB, Goodfellow HE, Hsu LY, Freedman TS, Weiss A. ZAP-70: an essential kinase in T-cell signaling. Cold Spring Harb Perspect Biol. 2010 May; 2(5):a002279.
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17. Zikherman J, Jenne C, Watson S, Doan K, Raschke W, Goodnow CC, Weiss A. CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Immunity. 2010 Mar 26; 32(3):342-54.
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18. Weiss A. The right team at the right time to go for a home run: tyrosine kinase activation by the TCR. Nat Immunol. 2010 Feb; 11(2):101-4.
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19. Hsu LY, Tan YX, Xiao Z, Malissen M, Weiss A. A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity. J Exp Med. 2009 Oct 26; 206(11):2527-41.
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20. Weiss A. TCR signal transduction: opening the black box. J Immunol. 2009 Oct 15; 183(8):4821-7.
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