About UCSF Search UCSF UCSF Medical Center

Arthur Weiss, MD, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
weiss_arthur

Professor, Departments of Medicine, Microbiology and Immunology; Investigator, Howard Hughes Medical Institute; Associate Director, The Rosalind Russell Medical Research Center for Arthritis; Director, Medical Scientist Training Program; Co-Director, Institute for Molecular Medicine, UCSF
Ephraim P. Engleman Distinguished Professorship, UCSF

aweiss@medicine.ucsf.edu

Phone: (415) 476-8983 (voice)
Box 0795, UCSF
San Francisco, CA 94143-0795

View on UCSF Profiles


Education

University of Chicago, Chicago, IL, Ph.D., 1978, Immunology
University of Chicago, Chicago, IL, M.D., 1979, Medicine


Professional Experience

  • 1979-1980
    Postdoctoral Fellow, Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland
  • 1980-1982
    Resident, Department of Medicine, University of California, San Francisco (UCSF)
  • 1982-1984
    Fellow in Rheumatology/Clinical Immunology, UCSF
  • 1982-1985
    Associate, Howard Hughes Medical Institute, UCSF
  • 1984-1985
    Instructor, Department of Medicine, Division of Rheumatology/Clinical Immunology, UCSF
  • 1985-1989
    Assistant Investigator, Howard Hughes Medical Institute, UCSF
  • 1985-1989
    Assistant Professor of Medicine, Microbiology and Immunology, UCSF
  • 1987-2011
    Chief, Division of Rheumatology/Clinical Immunology, Department of Medicine, UCSF
  • 1989-1993
    Associate Professor or Medicine, Microbiology and Immunology, UCSF
  • 1989-1994
    Associate Investigator, Howard Hughes Medical Institute, UCSF
  • 1991-present
    Ephraim P. Engleman Distinguished Professor of Rheumatology, UCSF
  • 1992-present
    Professor of Medicine, Microbiology and Immunology, UCSF
  • 1993-present
    Investigator, Howard Hughes Medical Institute, UCSF
  • 1998-2005
    Associate Director, The Rosalind Russell Medical Research Center for Arthritis, UCSF
  • 2002-2006
    Director, Medical Scientist Training Program (MSTP), UCSF
  • 2007-2010
    Co-Director, Institute for Molecular Medicine, UCSF

Honors & Awards

  • 1997
    Lee C. Howley Prize, Arthritis Foundation
  • 1998
    Forty-First Faculty Research Lecturer, UCSF
  • 2001
    American Association of Immunologist-Huang Foundation Meritorious Career Award
  • 2003
    Fellow, American Academy of Arts and Sciences
  • 2004
    Member, National Academy of Sciences
  • 2004
    Fellow, American Academy of Microbiology
  • 2004
    Member, Institute of Medicine
  • 2004
    Distinguished Investigator Award, American College of Rheumatology
  • 2012
    Lifetime Achievement Award, American Association of Immunology
  • 2012
    UCSF Lifetime Achievement in Mentoring Award

Selected Publications

  1. Zikherman J, Parameswaran R, Hermiston M, Weiss A. The Structural Wedge Domain of the Receptor-like Tyrosine Phosphatase CD45 Enforces B Cell Tolerance by Regulating Substrate Specificity. J Immunol. 2013 Mar 15; 190(6):2527-35.
    View on PubMed
  2. Mukherjee S, Zhu J, Zikherman J, Parameswaran R, Kadlecek TA, Wang Q, Au-Yeung B, Ploegh H, Kuriyan J, Das J, Weiss A. Monovalent and Multivalent Ligation of the B Cell Receptor Exhibit Differential Dependence upon Syk and Src Family Kinases. Sci Signal. 2013; 6(256):ra1.
    View on PubMed
  3. Charles JF, Hsu LY, Niemi EC, Weiss A, Aliprantis AO, Nakamura MC. Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function. J Clin Invest. 2012 Dec 3; 122(12):4592-605.
    View on PubMed
  4. Zikherman J, Parameswaran R, Weiss A. Endogenous antigen tunes the responsiveness of naive B cells but not T cells. Nature. 2012 Sep 6; 489(7414):160-4.
    View on PubMed
  5. Wei P, Wong WW, Park JS, Corcoran EE, Peisajovich SG, Onuffer JJ, Weiss A, Lim WA. Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells. Nature. 2012 Aug 16; 488(7411):384-8.
    View on PubMed
  6. Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus MT. A resource for the conditional ablation of microRNAs in the mouse. Cell Rep. 2012 Apr 19; 1(4):385-91.
    View on PubMed
  7. Zikherman J, Doan K, Parameswaran R, Raschke W, Weiss A. Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival. Proc Natl Acad Sci U S A. 2012 Jan 3; 109(1):E3-12.
    View on PubMed
  8. Zikherman J, Weiss A. Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease. J Clin Invest. 2011 Dec; 121(12):4618-21.
    View on PubMed
  9. Zhu JW, Doan K, Park J, Chau AH, Zhang H, Lowell CA, Weiss A. Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus. Immunity. 2011 Nov 23; 35(5):757-69.
    View on PubMed
  10. Markegard E, Trager E, Yang CW, Zhang W, Weiss A, Roose JP. Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRa gene expression. PLoS One. 2011; 6(9):e25540.
    View on PubMed
  11. Schoenborn JR, Tan YX, Zhang C, Shokat KM, Weiss A. Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling. Sci Signal. 2011 Sep 13; 4(190):ra59.
    View on PubMed
  12. Limnander A, Depeille P, Freedman TS, Liou J, Leitges M, Kurosaki T, Roose JP, Weiss A. STIM1, PKC-d and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. Nat Immunol. 2011 May; 12(5):425-33.
    View on PubMed
  13. Au-Yeung BB, Levin SE, Zhang C, Hsu LY, Cheng DA, Killeen N, Shokat KM, Weiss A. A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nat Immunol. 2010 Dec; 11(12):1085-92.
    View on PubMed
  14. Beinke S, Phee H, Clingan JM, Schlessinger J, Matloubian M, Weiss A. Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16234-9.
    View on PubMed
  15. Phee H, Dzhagalov I, Mollenauer M, Wang Y, Irvine DJ, Robey E, Weiss A. Regulation of thymocyte positive selection and motility by GIT2. Nat Immunol. 2010 Jun; 11(6):503-11.
    View on PubMed
  16. Wang H, Kadlecek TA, Au-Yeung BB, Goodfellow HE, Hsu LY, Freedman TS, Weiss A. ZAP-70: an essential kinase in T-cell signaling. Cold Spring Harb Perspect Biol. 2010 May; 2(5):a002279.
    View on PubMed
  17. Zikherman J, Jenne C, Watson S, Doan K, Raschke W, Goodnow CC, Weiss A. CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Immunity. 2010 Mar 26; 32(3):342-54.
    View on PubMed
  18. Weiss A. The right team at the right time to go for a home run: tyrosine kinase activation by the TCR. Nat Immunol. 2010 Feb; 11(2):101-4.
    View on PubMed
  19. Hsu LY, Tan YX, Xiao Z, Malissen M, Weiss A. A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity. J Exp Med. 2009 Oct 26; 206(11):2527-41.
    View on PubMed
  20. Weiss A. TCR signal transduction: opening the black box. J Immunol. 2009 Oct 15; 183(8):4821-7.
    View on PubMed

View on UCSF Profiles