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James A. Wells, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
wells_james

Professor, Department of Pharmaceutical Sciences, UCSF
Harry Wm. and Diana V. Hind Distinguished Professorship in Pharmaceutical Sciences, UCSF

jim.wells@ucsf.edu

Phone: (415) 514-4498 (voice)
Box 2330, UCSF
San Francisco, CA 94158-2330

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Additional Websites


Education

University of California, Berkeley, CA, B.A., 1973, Biochemistry
Washington State University, Ph.D., 1979, Biochemistry
Washington State University, Postdoc, 1979-1980, Chemistry
Stanford University Medical School, Postdoc, 1980-1982, Biochemistry


Professional Experience

  • 1982-1986
    Scientist, Genentech, Inc., Dept. of Protein Engineering
  • 1986-1989
    Senior Scientist, Genentech, Inc., Dept. of Protein Engineering
  • 1989-1998
    Staff Scientist, Genentech, Inc., Dept. of Protein Engineering
  • 1988-2005
    Adjunct Asst, Assoc, and Full Professor, University of California, San Francisco, Dept. of Pharmaceutical Chemistry
  • 1998-2005
    President and CSO, Sunesis Pharmaceuticals
  • 2005-present
    Harry Wm. and Diana V. Hind Distinguished Professorship in Pharmaceutical Sciences, University of California, San Francisco
  • 2005-present
    Director, Small Molecule Discovery Center, University of California, San Francisco

Honors & Awards

  • 1979-1981
    Damon M. Runyon - Walter Winchell Postdoctoral Fellowship
  • 1990
    Pfizer Award (given by the American Chemical Society for achievements in enzyme chemistry)
  • 1998
    Recipient of the Christian B. Anfinsin Award presented by the Protein Society
  • 1998
    Recipient of the Vincent du Vignead Award given by the American Peptide Society
  • 1999
    Elected Member to the National Academy of Sciences
  • 2003
    Recipient of the Hans Neurath Award given by the Protein Society
  • 2006
    Perlman Lecture Award of the ACS biotechnology Division

Selected Publications

  1. Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28; 503(7477):548-51.
    View on PubMed
  2. Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA. Correction: Global cellular response to chemotherapy-induced apoptosis. Elife. 2013; 2(0).
    View on PubMed
  3. Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA. Global cellular response to chemotherapy-induced apoptosis. Elife. 2013; 2:e01236.
    View on PubMed
  4. Koerber JT, Thomsen ND, Hannigan BT, Degrado WF, Wells JA. Nature-inspired design of motif-specific antibody scaffolds. Nat Biotechnol. 2013 Oct; 31(10):916-21.
    View on PubMed
  5. Carter PJ, Hazuda D, Wells JA. Next generation therapeutics. Curr Opin Chem Biol. 2013 Jun; 17(3):317-9.
    View on PubMed
  6. Yang CF, Chiang MC, Gray DC, Prabhakaran M, Alvarado M, Juntti SA, Unger EK, Wells JA, Shah NM. Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males. Cell. 2013 May 9; 153(4):896-909.
    View on PubMed
  7. Thomsen ND, Koerber JT, Wells JA. Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):8477-82.
    View on PubMed
  8. Wang N, Majmudar CY, Pomerantz WC, Gagnon JK, Sadowsky JD, Meagher JL, Johnson TK, Stuckey JA, Brooks CL, Wells JA, Mapp AK. Ordering a dynamic protein via a small-molecule stabilizer. J Am Chem Soc. 2013 Mar 6; 135(9):3363-6.
    View on PubMed
  9. Datta D, McClendon CL, Jacobson MP, Wells JA. Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3. J Biol Chem. 2013 Apr 5; 288(14):9971-81.
    View on PubMed
  10. Crawford ED, Seaman JE, Agard N, Hsu GW, Julien O, Mahrus S, Nguyen H, Shimbo K, Yoshihara HA, Zhuang M, Chalkley RJ, Wells JA. The DegraBase: a database of proteolysis in healthy and apoptotic human cells. Mol Cell Proteomics. 2013 Mar; 12(3):813-24.
    View on PubMed
  11. Zhuang M, Guan S, Wang H, Burlingame AL, Wells JA. Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator. Mol Cell. 2013 Jan 24; 49(2):273-82.
    View on PubMed
  12. Crawford ED, Seaman JE, Barber AE, David DC, Babbitt PC, Burlingame AL, Wells JA. Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. Cell Death Differ. 2012 Dec; 19(12):2040-8.
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  13. Zorn JA, Wolan DW, Agard NJ, Wells JA. Fibrils colocalize caspase-3 with procaspase-3 to foster maturation. J Biol Chem. 2012 Sep 28; 287(40):33781-95.
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  14. Shimbo K, Hsu GW, Nguyen H, Mahrus S, Trinidad JC, Burlingame AL, Wells JA. Quantitative profiling of caspase-cleaved substrates reveals different drug-induced and cell-type patterns in apoptosis. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12432-7.
    View on PubMed
  15. Agard NJ, Mahrus S, Trinidad JC, Lynn A, Burlingame AL, Wells JA. Global kinetic analysis of proteolysis via quantitative targeted proteomics. Proc Natl Acad Sci U S A. 2012 Feb 7; 109(6):1913-8.
    View on PubMed
  16. Gao J, Wells JA. Identification of specific tethered inhibitors for caspase-5. Chem Biol Drug Des. 2012 Feb; 79(2):209-15.
    View on PubMed
  17. Zorn JA, Wille H, Wolan DW, Wells JA. Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation. J Am Chem Soc. 2011 Dec 14; 133(49):19630-3.
    View on PubMed
  18. Tang Y, Wells JA, Arkin MR. Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. J Biol Chem. 2011 Sep 30; 286(39):34147-54.
    View on PubMed
  19. Sadowsky JD, Burlingame MA, Wolan DW, McClendon CL, Jacobson MP, Wells JA. Turning a protein kinase on or off from a single allosteric site via disulfide trapping. Proc Natl Acad Sci U S A. 2011 Apr 12; 108(15):6056-61.
    View on PubMed
  20. Crawford ED, Wells JA. Caspase substrates and cellular remodeling. Annu Rev Biochem. 2011; 80:1055-87.
    View on PubMed

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