John K. Wiencke, PhD

John K. Wiencke, PhD

Professor, Department of Neurological Surgery, and Co-Director, Division of Epidemiology, UCSF
Robert Magnin Newman Endowed Chair in Neuro-oncology, UCSF

Phone: (415) 476-3059 (voice)
Box 0560, UCSF
San Francisco, CA 94143-0560

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Cancer Center Membership

Program Member ยป Cancer Genetics


University of Minnesota, Minneapolis, MN, B.S., 1976, Biology
University of Minnesota, Minneapolis, MN, M.S., 1978, Environmental Health
University of Minnesota, Minneapolis, MN, Ph.D., 1983, Pathology

Professional Experience

  • 1983-1986
    UCSF, Laboratory of Radiobiology and Environmental Health, Postdoctoral Fellow
  • 1986-1989
    UCSF, Epidemiology & Biostatistics, Assistant Research Geneticist
  • 1986-1995
    UCSF, Laboratory of Radiobiology and Environmental Health, Research Associate
  • 1990-1993
    UCSF, Epidemiology & Biostatistics, Assistant Adjunct Professor
  • 1990-present
    UCSF, Epidemiology & Biostatistics, Director, Molecular Epidemiology Laboratory
  • 1993-1999
    UCSF, Epidemiology & Biostatistics, Associate Adjunct Professor
  • 1995-present
    UCSF, Epidemiology & Biostatistics, Director, Molecular Epidemiology Program
  • 1999-2002
    UCSF, Epidemiology & Biostatistics, Adjunct Professor
  • 1999-2006
    Harvard School of Public Health, Department of Cancer Cell Biology, Visiting Lecturer
  • 2002-2004
    UCSF, Epidemiology & Biostatistics, Professor in Residence
  • 2004-present
    UCSF, Dept of Neurological Surgery, Co-Director Division of Epidemiology

Selected Publications

  1. Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk. Oncotarget. 2015 Dec 4.
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  2. Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA. PLoS One. 2015; 10(11):e0143343.
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  3. A Heritable Missense Polymorphism in CDKN2A Confers Strong Risk of Childhood Acute Lymphoblastic Leukemia and Is Preferentially Selected during Clonal Evolution. Cancer Res. 2015 Nov 2.
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  4. Understanding the Role of the Immune System in the Development of Cancer: New Opportunities for Population-Based Research. Cancer Epidemiol Biomarkers Prev. 2015 Dec; 24(12):1811-9.
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  5. Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors. N Engl J Med. 2015 Jun 25; 372(26):2499-508.
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  6. DNA Methylation in Whole Blood: Uses and Challenges. Curr Environ Health Rep. 2015 Jun; 2(2):145-54.
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  7. Telomere maintenance and the etiology of adult glioma. Neuro Oncol. 2015 May 25.
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  8. Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer. Science. 2015 May 29; 348(6238):1036-9.
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  9. CDKN2A Loss Is Associated With Shortened Overall Survival in Lower-Grade (World Health Organization Grades II-III) Astrocytomas. J Neuropathol Exp Neurol. 2015 May; 74(5):442-52.
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  10. CHRNA5 Risk Variant Predicts Delayed Smoking Cessation and Earlier Lung Cancer Diagnosis-A Meta-Analysis. J Natl Cancer Inst. 2015 May; 107(5).
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  11. Cell-composition effects in the analysis of DNA methylation array data: a mathematical perspective. BMC Bioinformatics. 2015; 16(1):95.
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  12. Characterization of large structural genetic mosaicism in human autosomes. Am J Hum Genet. 2015 Mar 5; 96(3):487-97.
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  13. Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures. Nucleic Acids Res. 2015 Mar 11; 43(5):2590-602.
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  14. Serum macrophage-derived chemokine/CCL22 levels are associated with glioma risk, CD4 T cell lymphopenia and survival time. Int J Cancer. 2015 Aug 15; 137(4):826-36.
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  15. A steroid metabolizing gene variant in a polyfactorial model improves risk prediction in a high incidence breast cancer population. BBA Clin. 2014 Dec; 2:94-102.
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  16. A comparison of DNA methylation specific droplet digital PCR (ddPCR) and real time qPCR with flow cytometry in characterizing human T cells in peripheral blood. Epigenetics. 2014 Oct 3; 9(10):1360-5.
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  17. Genome-wide scan of 29,141 African Americans finds no evidence of directional selection since admixture. Am J Hum Genet. 2014 Oct 2; 95(4):437-44.
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  18. Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33. Hum Mol Genet. 2014 Dec 15; 23(24):6616-33.
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  19. Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nat Genet. 2014 Jul; 46(7):731-5.
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  20. Leukocyte-adjusted epigenome-wide association studies of blood from solid tumor patients. Epigenetics. 2014 Jun; 9(6):884-95.
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