John K. Wiencke, PhD

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Education

University of Minnesota, Minneapolis, MN, B.S., 1976, Biology
University of Minnesota, Minneapolis, MN, M.S., 1978, Environmental Health
University of Minnesota, Minneapolis, MN, Ph.D., 1983, Pathology

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Professional Experience

• 1983-1986
  UCSF, Laboratory of Radiobiology and Environmental Health, Postdoctoral Fellow
• 1986-1989
  UCSF, Epidemiology & Biostatistics, Assistant Research Geneticist
• 1986-1995
  UCSF, Laboratory of Radiobiology and Environmental Health, Research Associate
• 1990-1993
  UCSF, Epidemiology & Biostatistics, Assistant Adjunct Professor
• 1990-present
  UCSF, Epidemiology & Biostatistics, Director, Molecular Epidemiology Laboratory
• 1993-1999
  UCSF, Epidemiology & Biostatistics, Associate Adjunct Professor
• 1995-present
  UCSF, Epidemiology & Biostatistics, Director, Molecular Epidemiology Program
• 1999-2002
  UCSF, Epidemiology & Biostatistics, Adjunct Professor
• 1999-2006
  Harvard School of Public Health, Department of Cancer Cell Biology, Visiting Lecturer
• 2002-2004
  UCSF, Epidemiology & Biostatistics, Professor in Residence
• 2004-present
  UCSF, Dept of Neurological Surgery, Co-Director Division of Epidemiology

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Selected Publications

• Wiencke JK, Thurston SW, Kelsey KT, Varkonyi A, Wain JC, Mark EJ, Christiani DC. Early age at smoking initiation and tobacco carcinogen DNA damage in the lung. J Natl Cancer Inst 91: 614-619, 1999.
• Wiencke JK, Zheng Z, Lafuente A, Lafuente MJ, Grudzen C, Wrensch MR, Miike R, Ballesta A, Trias M. Aberrant methylation of p16INK4a in anatomic and gender specific subtypes of sporadic colorectal cancer. Cancer Epidemiol Biomarkers Prev 8: 501-506, 1999.
• Nelson HH, Christiani DC, Mark EJ, Wiencke JK, Wain JC, Kelsey KT. Implications and prognostic value of K-ras mutation for early-stage lung cancer in women. J Natl Cancer Inst 91: 2032-2038, 1999.
• Thurston SW,Wand MP,WienckeJK.Negative binomial additive models.Biometrics 56:139 144, 2000..
• Zheng S, Chen P, McMillan A, LaFuente A, Lafuente MJ, Ballesta A, Trias M, Wiencke JK. Correlations of partial and extensive methylation at the p14ARF locus with reduced mRNA expression in colorectal cancer cell lines and clinicopathological features in primary tumors. Carcinogenesis: 21: 2057-2064, 2000.
• Wiencke JK, Weinberg A, Kelsey KT, Wrensch M. Genetic resistance factor for HIV-1 and immune response to Varicella Zoster. Lancet, 357:360-361, 2001.
• Caggana M, Kilgallen J, Conroy JM, Wiencke JK, Kelsey KT, Miike R, Chen P, Wrensch MR. Associations between ERCC2 polymorphisms and gliomas.Cancer Epid Biomarkers Prev 10:355-360,2001.
• Zheng S, Ma X, Buffler PA, Smith MT, Wiencke JK. Whole genome amplification increases the efficiency and validity of buccal cell genotyping in pediatric populations. Cancer Epidemiol Biomarkers Prev, 10:697-700, 2001.
• Wiemels JL, Wiencke JK, Sison JD, Miike R, McMillan A, Wrensch M. History of allergies among adults with glioma and controls. Int J Cancer, 98:609-615, 2002.
• Ma X, Buffler PA, Selvin S, Matthay KK, Wiencke JK, Wiemels JL, Reynolds P. Daycare attendance and risk of childhood acute lymphoblastic leukemia. Br. J Cancer, 86(9):1419-1424, 2002.
• Wiencke JK and Kelsey KT. Teen smoking, field cancerization and a 'critical period' hypothesis for lung cancer susceptibility. Environmental Health Perspectives, 110(5): 555-558, 2002.
• Wiencke JK. DNA adducts in tobacco carcinogenesis. Oncogene, 21:7376-7391, 2002
• Cabral CN, Napoles-Springer AM, Miike R, McMillan A, Sison J, Wrensch MR, Perez-Stable E, Wiencke JK. Population and community based recruitment of African American and Latinos: The San Francisco Bay Area Lung Cancer Study. In press Am J Epidemiol, 158(3):272-279, 2003.
• Wiencke JK. Impact of race/ethnicity on molecular pathways in human cancer. Nature Reviews Cancer, 4(1) 79-84, 2004.
• Zheng S, Ma X, Zhang L, Gunn L, Smith MT, Wiemels JL, Leung K, Buffler PA, Wiencke JK. Hypermethylation of the 5' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia. Cancer Res. 2004 Mar 15;64(6):2000-6.
• Wiemels JL, Wiencke JK, Patoka J, Moghadassi M, Chew T, McMillan A, Miike R, Barker G, Wrensch M. Reduced immunoglobin E and allergy among adults with glioma compared to controls. Cancer Res. 2004 Nov 15; 64(22):8468-73
• Marsit CJ, Hasegawa M, Hirao T, Kim DH, Aldape K, Hinds PW, Wiencke JK, Nelson HH, Kelsey KT. Loss of heterozygosity of chromosome 3p21 is associated with mutant TP53 and better patient survival in non-small-cell lung cancer. Cancer Research, 2004 Dec 1; 64(23):8702-8707.
• Wrensch MR, Miike R, Sison JD, Kelsey KT, Liu M, McMillan A, Quesenberry C, Wiencke JK. CYP1A1 variants and smoking-related lung cancer in San Francisco Bay Area Latinos and African Americans. Int J Cancer. 2005 Jan 1;113(1):141-7.
• Wiemels JL, Zhang Y, Chang J, Zheng S, Metayer C, Zhang L, Smith MT, Ma X, Selvin S, Buffler PA, Wiencke JK. RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia. Leukemia, 19(3)415-419, 2005.
• Wrensch M, Weinberg A, Wiencke JK, Miike R, Sison J, Wiemels J, Barger G, Delorenze G, Aldape K, Kelsey K. History of chickenpox and shingles and prevalence of antibodies to Varicella-Zoster virus and three other herpesviruses among adults with glioma and controls. Am J Epidemiol. 2005;161(10):929-38.
• Tang JJ, Shao W, Dorak TM, Yufeng Li Y, Miike R, Lobashevsky E, Wiencke JK, Wrensch M , Kaslow RA, Cobbs CS. Positive and negative associations of human leukocyte antigen (HLA) variants with the onset and prognosis of adult glioblastoma multiforme (GBM). Cancer Epidemiol Biomarkers Prev, 14(8) 2040-2044,. 2005.
• Wiencke JK, Aldape K, McMillan A, Wiemels J, Moghadassi MM, Miike R, Kelsey KT, Patoka J, Long J, Wrensch M. Molecular features of adult glioma associated with patient race/ethnicity, age and a polymorphism in O6-methylguanine-DNA-methyltransferase. Cancer Epidemiol Biomarkers Prev. 14(7):1774-1783, 2005.
• Miller KL, Kelsey KT, Wiencke JK, Moghadassi M, Miike R, Liu M, Wrensch M. The C3435T polymorphism of MDR1 and susceptibility to adult glioma. Neuroepidemiology, 25:85-90, 2005.
• Marsit CJ, Zheng S, Aldape K, Hinds PW, Nelson HH, Wiencke JK, Kelsey KT. PTEN expression in non-small cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration. Hum Path, 36:768-776, 2005.
• Ma X, Buffler PA, Wiemels JL, Selvin S, Metayer C, Loh M, Does MB, Wiencke JK. Ethnic difference in daycare attendance, early infections, and risk of childhood acute lymphoblastic leukemia. Cancer Epidemiol Biomarkers Prev 2005;14 1928-1934.
• Wrensch M, Kelsey KT, Liu M, Miike R, Moghadassi M, Sison JD, Aldape K, McMIllan A, Wiemels J, Wiencke JK. ERCC1 and ERCC2 polymorphisms and adult glioma. Neuro-Oncology 7(4):795-507, 2005.
• Kraunz KS, Nelson HH, Lemos M, Godleski JJ, Wiencke JK, Kelsey KT. Homozygous deletion of p16INK4a and tobacco carcinogen exposure in nonsmall cell lung cancer. Int J Cancer: 118(6): 1364-1369, 2006.
• Wrensch M, Wiencke JK, Wiemels J, Miike R, Patoka J, Moghadassi M, McMillan A, Kelsey KT, Aldape K, Lamborn K, Parsa A, Sison J, Prados M. Serum IgE, tumor EGFR expression and inherited polymorphisms associated with glioma survival. Cancer Research 66(8): 4531-4541, 2006.