About UCSF Search UCSF UCSF Medical Center

Keith R. Yamamoto, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
yamamoto_keith

Vice Chancellor for Research; Executive Vice Dean, School of Medicine; Professor, Departments of Cellular/Molecular Pharmacology and Biochemistry/Biophysics, UCSF

yamamoto@cgl.ucsf.edu

Phone: (415) 476-3128 (voice)
Box 2280, UCSF
San Francisco, CA 94143-2280

View on UCSF Profiles


Additional Websites


Education

Iowa State University, Ames, IA, B.Sc., 1968, Biochemistry and Biophysics
Princeton University, Princeton, NJ, Ph.D., 1973, Biochemical Sciences
University of California San Francisco, San Francisco, CA, postdoc, 1973-1975, Molecular Biology


Professional Experience

  • 1976-1979
    Assistant Professor of Biochemistry, Department of Biochemistry and Biophysics, UCSF
  • 1979-1983
    Associate Professor of Biochemistry, Department of Biochemistry and Biophysics, UCSF
  • 1983-2003
    Professor of Biochemistry, Department of Biochemistry and Biophysics, UCSF
  • 1985-1994
    Vice Chairman, Department of Biochemistry and Biophysics, UCSF
  • 1988-2001
    Director, Biochemistry and Molecular Biology Program, Program in Biological Sciences, UCSF
  • 1994-2003
    Chairman, Department of Cellular and Molecular Pharmacology, UCSF
  • 1994-present
    Professor, Department of Cellular and Molecular Pharmacology
  • 2002-2003
    Vice Dean for Research, School of Medicine
  • 2004
    Executive Vice Dean, School of Medicine
  • 2011
    Vice Chancellor for Research, UCSF

Honors & Awards

  • 1977-1982
    NIH Research Career Development Award
  • 1979-1980
    UCSF Distinguished Teaching Award
  • 1982-1986
    Dreyfus Teacher-Scholar Award
  • 1988
    American Academy of Arts and Sciences
  • 1989
    National Academy of Sciences
  • 1990
    Gregory Pincus Medal
  • 1992
    American Academy of Microbiology
  • 1997
    Faculty Research Lecturer, UC San Francisco
  • 1997
    Iowa State University Distinguished Achievement Citation
  • 1998
    Theodore Roosevelt High School Hall of Fame, Des Moines, Iowa
  • 1999
    Vanderbilt Medal of Merit, Vanderbilt University
  • 2001
    Iowa State University D.Sc., honorary
  • 2002
    Elected Fellow, American Association for the Advancement of Science
  • 2003
    Institute of Medicine
  • 2004
    Allan Munck Prize, Dartmouth University
  • 2008
    10 Influential People to Watch in Biomedical Policy, Nature Medicine
  • 2010
    UCSF Postdoctoral Scholars Association Outstanding Faculty Mentorship Award
  • 2012
    The Endocrine Society 2012 Edwin B. Astwood Award
  • 2012
    American Society for Cell Biology 2012 Public Service Award
  • 2013
    John V. Atanasoff Discovery Award

Selected Publications

  1. Ward JD, Bojanala N, Bernal T, Ashrafi K, Asahina M, Yamamoto KR. Sumoylated NHR-25/NR5A Regulates Cell Fate duringC. elegans Vulval Development. PLoS Genet. 2013 Dec; 9(12):e1003992.
    View on PubMed
  2. Thomas-Chollier M, Watson LC, Cooper SB, Pufall MA, Liu JS, Borzym K, Vingron M, Yamamoto KR, Meijsing SH. A naturally occurring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):17826-31.
    View on PubMed
  3. Watson LC, Kuchenbecker KM, Schiller BJ, Gross JD, Pufall MA, Yamamoto KR. The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals. Nat Struct Mol Biol. 2013 Jul; 20(7):876-83.
    View on PubMed
  4. Chen SH, Masuno K, Cooper SB, Yamamoto KR. Incoherent feed-forward regulatory logic underpinning glucocorticoid receptor action. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):1964-9.
    View on PubMed
  5. Engel KB, Yamamoto KR. The glucocorticoid receptor and the coregulator Brm selectively modulate each other's occupancy and activity in a gene-specific manner. Mol Cell Biol. 2011 Aug; 31(16):3267-76.
    View on PubMed
  6. Holdorf MM, Cooper SB, Yamamoto KR, Miranda JJ. Occupancy of chromatin organizers in the Epstein-Barr virus genome. Virology. 2011 Jun 20; 415(1):1-5.
    View on PubMed
  7. Ou CY, LaBonte MJ, Manegold PC, So AY, Ianculescu I, Gerke DS, Yamamoto KR, Ladner RD, Kahn M, Kim JH, Stallcup MR. A coactivator role of CARM1 in the dysregulation of ß-catenin activity in colorectal cancer cell growth and gene expression. Mol Cancer Res. 2011 May; 9(5):660-70.
    View on PubMed
  8. Cvoro A, Yuan C, Paruthiyil S, Miller OH, Yamamoto KR, Leitman DC. Cross talk between glucocorticoid and estrogen receptors occurs at a subset of proinflammatory genes. J Immunol. 2011 Apr 1; 186(7):4354-60.
    View on PubMed
  9. Costa MJ, So AY, Kaasik K, Krueger KC, Pillsbury ML, Fu YH, Ptacek LJ, Yamamoto KR, Feldman BJ. Circadian rhythm gene period 3 is an inhibitor of the adipocyte cell fate. J Biol Chem. 2011 Mar 18; 286(11):9063-70.
    View on PubMed
  10. Huff JT, Plocik AM, Guthrie C, Yamamoto KR. Reciprocal intronic and exonic histone modification regions in humans. Nat Struct Mol Biol. 2010 Dec; 17(12):1495-9.
    View on PubMed
  11. DeKelver RC, Choi VM, Moehle EA, Paschon DE, Hockemeyer D, Meijsing SH, Sancak Y, Cui X, Steine EJ, Miller JC, Tam P, Bartsevich VV, Meng X, Rupniewski I, Gopalan SM, Sun HC, Pitz KJ, Rock JM, Zhang L, Davis GD, Rebar EJ, Cheeseman IM, Yamamoto KR, Sabatini DM, Jaenisch R, Gregory PD, Urnov FD. Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res. 2010 Aug; 20(8):1133-42.
    View on PubMed
  12. Arda HE, Taubert S, MacNeil LT, Conine CC, Tsuda B, Van Gilst M, Sequerra R, Doucette-Stamm L, Yamamoto KR, Walhout AJ. Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network. Mol Syst Biol. 2010 May 11; 6:367.
    View on PubMed
  13. Taubert S, Ward JD, Yamamoto KR. Nuclear hormone receptors in nematodes: evolution and function. Mol Cell Endocrinol. 2011 Mar 1; 334(1-2):49-55.
    View on PubMed
  14. Beck IM, Vanden Berghe W, Vermeulen L, Yamamoto KR, Haegeman G, De Bosscher K. Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases. Endocr Rev. 2009 Dec; 30(7):830-82.
    View on PubMed
  15. So AY, Bernal TU, Pillsbury ML, Yamamoto KR, Feldman BJ. Glucocorticoid regulation of the circadian clock modulates glucose homeostasis. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17582-7.
    View on PubMed
  16. Meijsing SH, Pufall MA, So AY, Bates DL, Chen L, Yamamoto KR. DNA binding site sequence directs glucocorticoid receptor structure and activity. Science. 2009 Apr 17; 324(5925):407-10.
    View on PubMed
  17. Jones JO, Bolton EC, Huang Y, Feau C, Guy RK, Yamamoto KR, Hann B, Diamond MI. Non-competitive androgen receptor inhibition in vitro and in vivo. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7233-8.
    View on PubMed
  18. Pantoja C, Huff JT, Yamamoto KR. Glucocorticoid signaling defines a novel commitment state during adipogenesis in vitro. Mol Biol Cell. 2008 Oct; 19(10):4032-41.
    View on PubMed
  19. So AY, Cooper SB, Feldman BJ, Manuchehri M, Yamamoto KR. Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5745-9.
    View on PubMed
  20. Taubert S, Hansen M, Van Gilst MR, Cooper SB, Yamamoto KR. The Mediator subunit MDT-15 confers metabolic adaptation to ingested material. PLoS Genet. 2008 Feb; 4(2):e1000021.
    View on PubMed

Go to UCSF Profiles, powered by CTSI