Keith R. Yamamoto, PhD

Executive Vice Dean, School of Medicine; Professor, Departments of Cellular/Molecular Pharmacology and Biochemistry/Biophysics, UCSF

yamamoto@cgl.ucsf.edu

Phone: (415) 476-3128 (voice)
Box 2280, UCSF
San Francisco, CA 94143-2280

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Additional Websites

• Lab Website

Education

Iowa State University, Ames, IA, B.Sc., 1968, Biochemistry and Biophysics
Princeton University, Princeton, NJ, Ph.D., 1973, Biochemical Sciences
University of California San Francisco, San Francisco, CA, postdoc, 1973-1975, Molecular Biology

Professional Experience

• 1976-1979
  Assistant Professor of Biochemistry, Department of Biochemistry and Biophysics, UCSF
• 1979-1983
  Associate Professor of Biochemistry, Department of Biochemistry and Biophysics, UCSF
• 1983-2003
  Professor of Biochemistry, Department of Biochemistry and Biophysics, UCSF
• 1985-1994
  Vice Chairman, Department of Biochemistry and Biophysics, UCSF
• 1988-2001
  Director, Biochemistry and Molecular Biology Program, Program in Biological Sciences, UCSF
• 1994-2003
  Chairman, Department of Cellular and Molecular Pharmacology, UCSF
• 1994-present
  Professor, Department of Cellular and Molecular Pharmacology
• 2002-2003
  Vice Dean for Research, School of Medicine
• 2002-present
  Executive Vice Dean, School of Medicine

Honors & Awards

• 1977-1982
  NIH Research Career Development Award
• 1979-1980
  UCSF Distinguished Teaching Award
• 1982-1986
  Dreyfus Teacher-Scholar Award
• 1988
  American Academy of Arts and Sciences
• 1989
  National Academy of Sciences
• 1990
  Gregory Pincus Medal
• 1992
  American Academy of Microbiology
• 1997
  Faculty Research Lecturer, UC San Francisco
• 1997
  Iowa State University Distinguished Achievement Citation
• 1998
  Theodore Roosevelt High School Hall of Fame, Des Moines, Iowa
• 1999
  Vanderbilt Medal of Merit, Vanderbilt University
• 2001
  Iowa State University D.Sc., honorary
• 2002
  Elected Fellow, American Association for the Advancement of Science
• 2003
  Institute of Medicine

Selected Publications

1. O'Brien T, Yamamoto K, Hawgood S. Commentary: team science. Acad Med. 2013 Feb; 88(2):156-7.
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2. Chen SH, Masuno K, Cooper SB, Yamamoto KR. Incoherent feed-forward regulatory logic underpinning glucocorticoid receptor action. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):1964-9.
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3. Engel KB, Yamamoto KR. The glucocorticoid receptor and the coregulator Brm selectively modulate each other's occupancy and activity in a gene-specific manner. Mol Cell Biol. 2011 Aug; 31(16):3267-76.
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4. Holdorf MM, Cooper SB, Yamamoto KR, Miranda JJ. Occupancy of chromatin organizers in the Epstein-Barr virus genome. Virology. 2011 Jun 20; 415(1):1-5.
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5. Ou CY, LaBonte MJ, Manegold PC, So AY, Ianculescu I, Gerke DS, Yamamoto KR, Ladner RD, Kahn M, Kim JH, Stallcup MR. A coactivator role of CARM1 in the dysregulation of ß-catenin activity in colorectal cancer cell growth and gene expression. Mol Cancer Res. 2011 May; 9(5):660-70.
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6. Cvoro A, Yuan C, Paruthiyil S, Miller OH, Yamamoto KR, Leitman DC. Cross talk between glucocorticoid and estrogen receptors occurs at a subset of proinflammatory genes. J Immunol. 2011 Apr 1; 186(7):4354-60.
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7. Costa MJ, So AY, Kaasik K, Krueger KC, Pillsbury ML, Fu YH, Ptacek LJ, Yamamoto KR, Feldman BJ. Circadian rhythm gene period 3 is an inhibitor of the adipocyte cell fate. J Biol Chem. 2011 Mar 18; 286(11):9063-70.
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8. Huff JT, Plocik AM, Guthrie C, Yamamoto KR. Reciprocal intronic and exonic histone modification regions in humans. Nat Struct Mol Biol. 2010 Dec; 17(12):1495-9.
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9. DeKelver RC, Choi VM, Moehle EA, Paschon DE, Hockemeyer D, Meijsing SH, Sancak Y, Cui X, Steine EJ, Miller JC, Tam P, Bartsevich VV, Meng X, Rupniewski I, Gopalan SM, Sun HC, Pitz KJ, Rock JM, Zhang L, Davis GD, Rebar EJ, Cheeseman IM, Yamamoto KR, Sabatini DM, Jaenisch R, Gregory PD, Urnov FD. Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res. 2010 Aug; 20(8):1133-42.
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10. Arda HE, Taubert S, MacNeil LT, Conine CC, Tsuda B, Van Gilst M, Sequerra R, Doucette-Stamm L, Yamamoto KR, Walhout AJ. Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network. Mol Syst Biol. 2010 May 11; 6:367.
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11. Taubert S, Ward JD, Yamamoto KR. Nuclear hormone receptors in nematodes: evolution and function. Mol Cell Endocrinol. 2011 Mar 1; 334(1-2):49-55.
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12. Beck IM, Vanden Berghe W, Vermeulen L, Yamamoto KR, Haegeman G, De Bosscher K. Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases. Endocr Rev. 2009 Dec; 30(7):830-82.
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13. So AY, Bernal TU, Pillsbury ML, Yamamoto KR, Feldman BJ. Glucocorticoid regulation of the circadian clock modulates glucose homeostasis. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17582-7.
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14. Meijsing SH, Pufall MA, So AY, Bates DL, Chen L, Yamamoto KR. DNA binding site sequence directs glucocorticoid receptor structure and activity. Science. 2009 Apr 17; 324(5925):407-10.
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15. Jones JO, Bolton EC, Huang Y, Feau C, Guy RK, Yamamoto KR, Hann B, Diamond MI. Non-competitive androgen receptor inhibition in vitro and in vivo. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7233-8.
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16. Pantoja C, Huff JT, Yamamoto KR. Glucocorticoid signaling defines a novel commitment state during adipogenesis in vitro. Mol Biol Cell. 2008 Oct; 19(10):4032-41.
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17. So AY, Cooper SB, Feldman BJ, Manuchehri M, Yamamoto KR. Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5745-9.
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18. Taubert S, Hansen M, Van Gilst MR, Cooper SB, Yamamoto KR. The Mediator subunit MDT-15 confers metabolic adaptation to ingested material. PLoS Genet. 2008 Feb; 4(2):e1000021.
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19. Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, Erle DJ, Yamamoto KR, Fahy JV. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci U S A. 2007 Oct 2; 104(40):15858-63.
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20. Bolton EC, So AY, Chaivorapol C, Haqq CM, Li H, Yamamoto KR. Cell- and gene-specific regulation of primary target genes by the androgen receptor. Genes Dev. 2007 Aug 15; 21(16):2005-17.
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