Keith R. Yamamoto, PhD

Keith R. Yamamoto, PhD

Vice Chancellor for Research; Executive Vice Dean, School of Medicine; Professor, Departments of Cellular/Molecular Pharmacology and Biochemistry/Biophysics, UCSF

Phone: (415) 476-3128 (voice)
Box 2280, UCSF
San Francisco, CA 94143-2280

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Additional Websites


Iowa State University, Ames, IA, B.Sc., 1968, Biochemistry and Biophysics
Princeton University, Princeton, NJ, Ph.D., 1973, Biochemical Sciences
University of California San Francisco, San Francisco, CA, postdoc, 1973-1975, Molecular Biology

Professional Experience

  • 1976-1979
    Assistant Professor of Biochemistry, Department of Biochemistry and Biophysics, UCSF
  • 1979-1983
    Associate Professor of Biochemistry, Department of Biochemistry and Biophysics, UCSF
  • 1983-2003
    Professor of Biochemistry, Department of Biochemistry and Biophysics, UCSF
  • 1985-1994
    Vice Chairman, Department of Biochemistry and Biophysics, UCSF
  • 1988-2001
    Director, Biochemistry and Molecular Biology Program, Program in Biological Sciences, UCSF
  • 1994-2003
    Chairman, Department of Cellular and Molecular Pharmacology, UCSF
  • 1994-present
    Professor, Department of Cellular and Molecular Pharmacology
  • 2002-2003
    Vice Dean for Research, School of Medicine
  • 2004
    Executive Vice Dean, School of Medicine
  • 2011
    Vice Chancellor for Research, UCSF

Honors & Awards

  • 1977-1982
    NIH Research Career Development Award
  • 1979-1980
    UCSF Distinguished Teaching Award
  • 1982-1986
    Dreyfus Teacher-Scholar Award
  • 1988
    American Academy of Arts and Sciences
  • 1989
    National Academy of Sciences
  • 1990
    Gregory Pincus Medal
  • 1992
    American Academy of Microbiology
  • 1997
    Faculty Research Lecturer, UC San Francisco
  • 1997
    Iowa State University Distinguished Achievement Citation
  • 1998
    Theodore Roosevelt High School Hall of Fame, Des Moines, Iowa
  • 1999
    Vanderbilt Medal of Merit, Vanderbilt University
  • 2001
    Iowa State University D.Sc., honorary
  • 2002
    Elected Fellow, American Association for the Advancement of Science
  • 2003
    Institute of Medicine
  • 2004
    Allan Munck Prize, Dartmouth University
  • 2008
    10 Influential People to Watch in Biomedical Policy, Nature Medicine
  • 2010
    UCSF Postdoctoral Scholars Association Outstanding Faculty Mentorship Award
  • 2012
    The Endocrine Society 2012 Edwin B. Astwood Award
  • 2012
    American Society for Cell Biology 2012 Public Service Award
  • 2013
    John V. Atanasoff Discovery Award

Selected Publications

  1. Ratnappan R, Amrit FR, Chen SW, Gill H, Holden K, Ward J, Yamamoto KR, Olsen CP, Ghazi A. Germline Signals Deploy NHR-49 to Modulate Fatty-Acid ß-Oxidation and Desaturation in Somatic Tissues of C. elegans. PLoS Genet. 2014 Dec; 10(12):e1004829.
    View on PubMed
  2. Schiller BJ, Chodankar R, Watson LC, Stallcup MR, Yamamoto KR. Glucocorticoid receptor binds half sites as a monomer and regulates specific target genes. Genome Biol. 2014; 15(7):418.
    View on PubMed
  3. Ward JD, Yamamoto KR, Asahina M. SUMO as a nuclear hormone receptor effector: New insights into combinatorial transcriptional regulation. Worm. 2014; 3:e29317.
    View on PubMed
  4. Ward JD, Mullaney B, Schiller BJ, He le D, Petnic SE, Couillault C, Pujol N, Bernal TU, Van Gilst MR, Ashrafi K, Ewbank JJ, Yamamoto KR. Defects in the C. elegans acyl-CoA Synthase, acs-3, and Nuclear Hormone Receptor, nhr-25, Cause Sensitivity to Distinct, but Overlapping Stresses. PLoS One. 2014; 9(3):e92552.
    View on PubMed
  5. Chodankar R, Wu DY, Schiller BJ, Yamamoto KR, Stallcup MR. Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor genome occupancy in a gene-selective manner. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):4007-12.
    View on PubMed
  6. Ward JD, Bojanala N, Bernal T, Ashrafi K, Asahina M, Yamamoto KR. Sumoylated NHR-25/NR5A Regulates Cell Fate duringC. elegans Vulval Development. PLoS Genet. 2013 Dec; 9(12):e1003992.
    View on PubMed
  7. Thomas-Chollier M, Watson LC, Cooper SB, Pufall MA, Liu JS, Borzym K, Vingron M, Yamamoto KR, Meijsing SH. A naturally occurring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):17826-31.
    View on PubMed
  8. Watson LC, Kuchenbecker KM, Schiller BJ, Gross JD, Pufall MA, Yamamoto KR. The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals. Nat Struct Mol Biol. 2013 Jul; 20(7):876-83.
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  9. Chen SH, Masuno K, Cooper SB, Yamamoto KR. Incoherent feed-forward regulatory logic underpinning glucocorticoid receptor action. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):1964-9.
    View on PubMed
  10. Hood LE, Omenn GS, Moritz RL, Aebersold R, Yamamoto KR, Amos M, Hunter-Cevera J, Locascio L. New and improved proteomics technologies for understanding complex biological systems: addressing a grand challenge in the life sciences. Proteomics. 2012 Sep; 12(18):2773-83.
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  11. Norman TC, Bountra C, Edwards AM, Yamamoto KR, Friend SH. Leveraging crowdsourcing to facilitate the discovery of new medicines. Sci Transl Med. 2011 Jun 22; 3(88):88mr1.
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  12. Engel KB, Yamamoto KR. The glucocorticoid receptor and the coregulator Brm selectively modulate each other's occupancy and activity in a gene-specific manner. Mol Cell Biol. 2011 Aug; 31(16):3267-76.
    View on PubMed
  13. Holdorf MM, Cooper SB, Yamamoto KR, Miranda JJ. Occupancy of chromatin organizers in the Epstein-Barr virus genome. Virology. 2011 Jun 20; 415(1):1-5.
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  14. Ou CY, LaBonte MJ, Manegold PC, So AY, Ianculescu I, Gerke DS, Yamamoto KR, Ladner RD, Kahn M, Kim JH, Stallcup MR. A coactivator role of CARM1 in the dysregulation of ß-catenin activity in colorectal cancer cell growth and gene expression. Mol Cancer Res. 2011 May; 9(5):660-70.
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  15. Cvoro A, Yuan C, Paruthiyil S, Miller OH, Yamamoto KR, Leitman DC. Cross talk between glucocorticoid and estrogen receptors occurs at a subset of proinflammatory genes. J Immunol. 2011 Apr 1; 186(7):4354-60.
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  16. Costa MJ, So AY, Kaasik K, Krueger KC, Pillsbury ML, Fu YH, Ptacek LJ, Yamamoto KR, Feldman BJ. Circadian rhythm gene period 3 is an inhibitor of the adipocyte cell fate. J Biol Chem. 2011 Mar 18; 286(11):9063-70.
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  17. Huff JT, Plocik AM, Guthrie C, Yamamoto KR. Reciprocal intronic and exonic histone modification regions in humans. Nat Struct Mol Biol. 2010 Dec; 17(12):1495-9.
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  18. DeKelver RC, Choi VM, Moehle EA, Paschon DE, Hockemeyer D, Meijsing SH, Sancak Y, Cui X, Steine EJ, Miller JC, Tam P, Bartsevich VV, Meng X, Rupniewski I, Gopalan SM, Sun HC, Pitz KJ, Rock JM, Zhang L, Davis GD, Rebar EJ, Cheeseman IM, Yamamoto KR, Sabatini DM, Jaenisch R, Gregory PD, Urnov FD. Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res. 2010 Aug; 20(8):1133-42.
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  19. Arda HE, Taubert S, MacNeil LT, Conine CC, Tsuda B, Van Gilst M, Sequerra R, Doucette-Stamm L, Yamamoto KR, Walhout AJ. Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network. Mol Syst Biol. 2010 May 11; 6:367.
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  20. Taubert S, Ward JD, Yamamoto KR. Nuclear hormone receptors in nematodes: evolution and function. Mol Cell Endocrinol. 2011 Mar 1; 334(1-2):49-55.
    View on PubMed

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