University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Iwei Yeh , MD, PhD

Iwei Yeh , MD, PhD

Assistant Professor, Dermatology and Pathology, UCSF

Cancer Center Program Memberships

Cancer Immunology | Cancer Genetics

Education

Harvard College, AB, 06/97, Summa Cum Laude, Biochemical Sciences
Stanford University, MD, 06/06
Stanford University, PhD, 06/06, Biomedical Informatics
Santa Clara Valley Medical Center, Intern, 06/07, Transitional Internship
University of Washington, Resident, 06/10, Dermatology
University of California, San Francisco, Fellow, 06/11, Dermatopathology


Professional Experience

  • 2011-2011
    Assistant Member, Pathology, Memorial Sloan Kettering Cancer Center
  • 2011-present
    Assistant Professor, Dermatology and Pathology, University of California, San Francisco

Honors & Awards

  • 1993
    National Merit Scholar
  • 1994
    Valedictorian, California High School; San Ramon, CA
  • 1996
    Goldwater Scholarship for Scientific Excellence
  • 1997
    Phi Beta Kappa, Harvard College Chapter, Cambridge, MA
  • 1998
    Medical Scientist Training Program, Predoctoral Fellowship, National Institutes of Health
  • 2003
    Graduate Fellowship, National Library of Medicine
  • 2006
    Doctoral Commencement Speaker, Stanford Medical School

Selected Publications

  1. Krings G, Joseph NM, Bean GR, Solomon D, Onodera C, Talevich E, Yeh I, Grenert JP, Hosfield E, Crawford ED, Jordan RC, van Zante A, Zaloudek C, Shin SJ, Chen YY. Genomic profiling of breast secretory carcinomas reveals distinct genetics from other breast cancers and similarity to mammary analog secretory carcinomas. Mod Pathol. 2017 May 26.
    View on PubMed
  2. Joseph NM, Chen YY, Nasr A, Yeh I, Talevich E, Onodera C, Bastian BC, Rabban JT, Garg K, Zaloudek C, Solomon DA. Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X. Mod Pathol. 2016 Nov 04.
    View on PubMed
  3. Yeh I, Tee MK, Botton T, Shain AH, Sparatta AJ, Gagnon A, Vemula SS, Garrido MC, Nakamaru K, Isoyama T, McCalmont TH, LeBoit PE, Bastian BC. NTRK3 kinase fusions in Spitz tumours. J Pathol. 2016 Nov; 240(3):282-290.
    View on PubMed
  4. Yeh I. Recent advances in molecular genetics of melanoma progression: implications for diagnosis and treatment. F1000Res. 2016; 5.
    View on PubMed
  5. Liu SY, Joseph NM, Ravindranathan A, Stohr BA, Greenland NY, Vohra P, Hosfield E, Yeh I, Talevich E, Onodera C, Van Ziffle JA, Grenert JP, Bastian BC, Chen YY, Krings G. Genomic profiling of malignant phyllodes tumors reveals aberrations in FGFR1 and PI-3 kinase/RAS signaling pathways and provides insights into intratumoral heterogeneity. Mod Pathol. 2016 Jun 3.
    View on PubMed
  6. Kline CN, Joseph NM, Grenert JP, van Ziffle J, Yeh I, Bastian BC, Mueller S, Solomon DA. Inactivating MUTYH germline mutations in pediatric patients with high-grade midline gliomas. Neuro Oncol. 2016 May; 18(5):752-3.
    View on PubMed
  7. Shain AH, Yeh I, Kovalyshyn I, Sriharan A, Talevich E, Gagnon A, Dummer R, North J, Pincus L, Ruben B, Rickaby W, D'Arrigo C, Robson A, Bastian BC. The Genetic Evolution of Melanoma from Precursor Lesions. N Engl J Med. 2015 Nov 12; 373(20):1926-36.
    View on PubMed
  8. Shain AH, Garrido M, Botton T, Talevich E, Yeh I, Sanborn JZ, Chung J, Wang NJ, Kakavand H, Mann GJ, Thompson JF, Wiesner T, Roy R, Olshen AB, Gagnon A, Gray JW, Huh N, Hur JS, Busam KJ, Scolyer RA, Cho RJ, Murali R, Bastian BC. Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway. Nat Genet. 2015 Oct; 47(10):1194-9.
    View on PubMed
  9. Menzies AM, Yeh I, Botton T, Bastian BC, Scolyer RA, Long GV. Clinical activity of the MEK inhibitor trametinib in metastatic melanoma containing BRAF kinase fusion. Pigment Cell Melanoma Res. 2015 Sep; 28(5):607-10.
    View on PubMed
  10. Yeh I, Botton T, Talevich E, Shain AH, Sparatta AJ, de la Fouchardiere A, Mully TW, North JP, Garrido MC, Gagnon A, Vemula SS, McCalmont TH, LeBoit PE, Bastian BC. Activating MET kinase rearrangements in melanoma and Spitz tumours. Nat Commun. 2015; 6:7174.
    View on PubMed
  11. Yeh I, de la Fouchardiere A, Pissaloux D, Mully TW, Garrido MC, Vemula SS, Busam KJ, LeBoit PE, McCalmont TH, Bastian BC. Clinical, histopathologic, and genomic features of Spitz tumors with ALK fusions. Am J Surg Pathol. 2015 May; 39(5):581-91.
    View on PubMed
  12. Botton T, Yeh I, Bastian BC. Melanoma BRAF fusions--letter. Clin Cancer Res. 2014 Dec 15; 20(24):6631.
    View on PubMed
  13. Yeh I, Mully TW, Wiesner T, Vemula SS, Mirza SA, Sparatta AJ, McCalmont TH, Bastian BC, LeBoit PE. Ambiguous melanocytic tumors with loss of 3p21. Am J Surg Pathol. 2014 Aug; 38(8):1088-95.
    View on PubMed
  14. Yang SH, McCalmont TH, Ahn GG, Yeh I. Supraorbital cutaneous fetal rhabdomyoma of intermediate type: a case report. Am J Dermatopathol. 2014 May; 36(5):e93-6.
    View on PubMed
  15. Naujokas A, Charli-Joseph Y, Ruben BS, Yeh I, LeBoit PE, McCalmont TH, Pincus LB. SOX-10 expression in cutaneous myoepitheliomas and mixed tumors. J Cutan Pathol. 2014 Apr; 41(4):353-63.
    View on PubMed
  16. Wiesner T, He J, Yelensky R, Esteve-Puig R, Botton T, Yeh I, Lipson D, Otto G, Brennan K, Murali R, Garrido M, Miller VA, Ross JS, Berger MF, Sparatta A, Palmedo G, Cerroni L, Busam KJ, Kutzner H, Cronin MT, Stephens PJ, Bastian BC. Kinase fusions are frequent in Spitz tumours and spitzoid melanomas. Nat Commun. 2014; 5:3116.
    View on PubMed
  17. Botton T, Yeh I, Nelson T, Vemula SS, Sparatta A, Garrido MC, Allegra M, Rocchi S, Bahadoran P, McCalmont TH, LeBoit PE, Burton EA, Bollag G, Ballotti R, Bastian BC. Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy. Pigment Cell Melanoma Res. 2013 Nov; 26(6):845-51.
    View on PubMed
  18. Moore C, Cevikbas F, Pasolli HA, Chen Y, Kong W, Kempkes C, Parekh P, Lee SH, Kontchou NA, Yeh I, Ye I, Jokerst NM, Fuchs E, Steinhoff M, Liedtke WB. UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling. Proc Natl Acad Sci U S A. 2013 Aug 20; 110(34):E3225-34.
    View on PubMed
  19. Yeh I, von Deimling A, Bastian BC. Clonal BRAF mutations in melanocytic nevi and initiating role of BRAF in melanocytic neoplasia. J Natl Cancer Inst. 2013 Jun 19; 105(12):917-9.
    View on PubMed
  20. North JP, Yeh I, McCalmont TH, LeBoit PE. Melanoma ex blue nevus: two cases resembling large plaque-type blue nevus with subcutaneous cellular nodules. J Cutan Pathol. 2012 Dec; 39(12):1094-9.
    View on PubMed

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