(415) 353-9600 (appts)
(415) 502-7062 (fax)

Box 0128, UCSF; San Francisco, CA 94143-0128

additional websites:

UCSF Physician Referral Directory
Smith-McCune Lab Website

McGill University, B.Sc., 1975, Biochem (Honors)
University of Cambridge, Diploma, 1976, Hist. & Phil. of Sci.
Rockefeller University, Ph.D., 1982
Stanford University, M.D., 1986

Strickland S, Smith K and Marotti KR. Hormonal induction of differentiation in teratocarcinoma cells: Generation of parietal endoderm cells by retinoic acid and dibutyryl cyclic AMP. Cell 21:347-355, 1980.

Smith K and Strickland S. Structural components and characteristics of Reichert's membrane, an extra-embryonic basement membrane. J Biol Chem 256:4654-4661, 1981

Smith K and Strickland S. Plasminogen activator production by parietal endoderm cells: Stimulation by a protein from pituitary. Dev Biol 90:227-237, 1982.

Smith K, Parham P and Ma NSF. Two distinct forms of 2-microglobulin in different races of owl monkey (Aotus Trivergatus). Immunogen 20:459-464, 1984.

Bell J, Rassenth L, Smoot S, Smith K, Newby C, Hohlfeld R, Toyka K, McDevitt H and Steinman L. HLA-DQ beta-chain polymorphism linked to myasthenia gravis. Lancet May 10:1058-1060, 1986.

Smith-McCune K, Horbach N and Dattel B. Incidence and clinical correlates of human papillomavirus disease in a pediatric population referred for evaluation of sexual abuse. Adol Pediat Gynecol 6:20-24, 1993.

Smith-McCune K and Weidner N. Demonstration and Characterization of the Angiogenic Properties of Cervical Dysplasia. Cancer Res 54:800-804, 1994.

Smith-McCune K, Zhu Y-H, Hanahan D, and Arbeit J. Cross-species Comparison of Angiogenesis during the Premalignant Stages of Squamous Carcinogenesis in the Human Cervix and K14-HPV16 Transgenic Mice. Cancer Research 57:1294-1300, 1997.

Smith-McCune K. Angiogenesis in squamous cell carcinoma in situ and microinvasive carcinoma of the uterine cervix [letter]. Obstet Gynecol 89:482, 1997.

Suh-Burgmann E, Darragh T, Smith-McCune K. Atypical squamous cells of undetermined significance: Management patterns at an academic medical center. Am J Obstet Gynecol 178:991-995, 1998.

Smith-McCune K, Zhu Y H and Darragh T. Angiogenesis in histologically benign squamous mucosa is a sensitive marker for nearby cervical intraepithelial neoplasia. Angiogenesis 2:135-42, 1998.

Smith-McCune K, Kallman D, Robbins CA, Shivakumar S, Yuschenkoff L, and Bishop JM. Intraanuclear localization of human papillomavirus 16 E7 during transformation and preferential binding of E7 to the Rb family member p130. PNAS 96: 6999-7004, 1999.

A McGaraghan and K. Smith-McCune Follow-up of unsatisfactory Pap test results. JAMA 283:1290-1, 2000.

Litle VR, Leavenworth JD, Darragh TM, Kosinski LA, Moore DH, Smith-McCune K, Warren RS, Palefsky JM, Welton LM. Angiogenesis, proliferation and apoptosis in anal high-grade squamous intrapeithelial lesions (HSIL). Dis Colon Rectum 3:346-52, 2000 ;

Kobayashi A, Miaskowski C, Wallhagen M and Smith-McCune K. Recent developments in understanding the immune response to HPV infection and to cervical neoplasia. Oncol Nurs Forum 27(4):643-51, 2000.

Bernard-Pearl L and Smith-McCune K. Controversies in the management of ASCUS and AGCUS, two very different beasts. Current Prob in Obstet, Gynecol and Fertil 2000;Jan/Feb, p 6-23.

Smith-McCune, K, Mancuso V, Contant T, and R. Jackson Management of abnormal Pap smears by Board-certified gynecologists: Discrepancies with recommendations of the Bethesda system. Am J Obstet Gynecol 185:551-556, 2001.

A Kobayashi, Darragh T, Herndier B, Anastos K, Minkoff H, Cohen M, Young M, Levine A, Ahdieh L, Weinberg V, Hyun W, Greenblatt R, Smith-McCune K. Lymphoid Follicles are Generated in High Grade Cervical Dysplasia and have Differing Characteristics Depending on HIV Status. Am J Pathol.160:151-64, 2002.

Lamarcq LH, Deeds J, Ginzinger D, Perry J, Padmanabha S, and Smith-McCune K. Measurement of E7 transcripts by real time quantitative RT-PCR in samples collected for cervical cancer screening. J Mol Diagn. 4:97-102, 2002.

Sawaya G and Smith-McCune K. Testing for human papillomavirus in women with abnormal Pap smear results [letter]. JAMA 288:1350-51, 2002.

Gray JW, Suzuki S, Kuo WL, Polikoff D, Deavers M, Smith-McCune K, Berchuck A, Pinkel D, Albertson D, Mills GB. Specific keynote: genome copy number abnormalities in ovarian cancer. Gynecol Oncol. 2003 88; S16-21; 2003

Lee C, Mancuso V, Contant T, Jackson R, Smith-McCune K. Management of women with low-grade squamous intraepithelial lesions on cytology or biopsy by board-certified gynecologists. Am J Obstet Gynecol188: 693-8, 2003

Chen Y, Miller C, Mosher R, Zhao X, Deeds J, Bryant B, Yang D, Meyer R, Cronin F, Gostout BS, Smith-McCune K and Schlegel R. Identification of cervical cancer markers by cDNA and tissue microarrays, Cancer Res 2003;63:1927-35

Tanyi, J L, Hasegawa Y, Lapushin R, Morris AJ, Wolf JK, Berchuck A, Lu K, Smith DI, Kalli K, Hartmann LC, McCune K, Fishman D, Broaddus R, Cheng KW, Atkinson EN, Yamal JM, Bast RC, Felix EA, Newman RA, Mills GB. Role of Decreased Levels of Lipid Phosphate Phosphatase-1 in Accumulation of Lysophosphatidic Acid in Ovarian Cancer. Clin Cancer Res 2003;9:3534-3545.

Powell CB, Cohen I, DellAra J, Jackson J, Lewkowicz D and Smith-McCune K. Aqueous extract of Herba Scutellaria Barbata, a Chinese herb used for ovarian cancer, induces apoptosis of ovarian cancer cell lines. Gynecol Oncol 2003; 91: 332 Ð 340.

Ancheta E, Perry J, Bernard-Pearl L, Paul T, Darragh T and Smith-McCune K. Participants at the ASCCP 2000 Biennial Meeting Adhere to Published Guidelines in Their Management of Atypical Squamous Cells and Atypical Glandular Cells on Pap Test. Journal of Lower Genital Tract Disease 2003:7;279-84.

Kobayashi A, Greenblatt RM, Anastos K, Minkoff H, Massad SL, Young M, Levine AM, Darragh TM, Weinberg V, and Smith-McCune KK. Functional attributes of mucosal immunity in cervical intraepithelial neoplasia and effects of HIV infection. Cancer Res, 2004:64; 6766-74.

Cheng KW, Lahad JP, Kuo WL, Lapuk A, Yamada K, Auersperg N, Liu J, Smith-McCune K, Lu KH, Fishman D, Gray JW, Mills GB. The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. Nat Med 2004:10;1251-6.

Chen LM, Rubin M and Smith-McCune K. Screening and treatment of HPV-related diseases in gynecologic practice. Sem Colon Rect Surg 2004:14;201-209.

Smith-McCune K. Chapter 13: Pathogenesis of human papillomavirus-related malignancies. In Viral and Immunologic Malignancies. P Volberding and J Palefsky, ed. BC Decker Inc, Hamilton, Ontario 2006.

Smith-McCune K, Tuveson J, Rubin M, Da Costa M, Darragh T, Shiboski S, Van Der Pol B, Moscicki A-B, Palefsky J, Sawaya G. Effect of Replens¨ gel used with a diaphragm on tests for human papillomavirus and other lower genital tract infections. J Low Genit Tract Dis. 2006:10;213-8.

Nanjundan M, Zhang F, Schmandt R, Smith-McCune K, and Mills GB. Identification of a novel splice variant of AML1b in ovarian cancer patients conferring loss of wild-type tumor suppressive functions.mOncogene. 2006 Oct 30; [Epub ahead of print]

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