Professor and Chair, Biochemistry & Biophysics, UCSF; Investigator, Howard Hughes Medical Institute
| CONTACT | |
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pwalter@biochem.ucsf.edu Box 2200, UCSF; San Francisco, CA 94143-2200 |
additional websites: |
| EDUCATION | |
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Freie Universitat Berlin, Germany, Vordiplom, 1976, Chemistry
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| PROFESSIONAL EXPERIENCE | |
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1976-1977 |
Direct Exchange Fellow, Vanderbilt University, in the laboratory of Dr. T.M. Harris |
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1977-1981 |
Graduate Fellow, The Rockefeller University, in the laboratory of Dr. G. Blobel |
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1981-1982 |
Postdoctoral Fellow, The Rockefeller University, in the laboratory of Dr. G. Blobel |
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1982-1983 |
Assistant Professor, Laboratory of Cell Biology, The Rockefeller University |
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1983-1986 |
Assistant Professor, Department of Biochemistry & Biophysics, University of California, San Francisco |
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1986-1991 |
Associate Professor, Department of Biochemistry & Biophysics, UCSF |
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1991- |
Professor, Department of Biochemistry & Biophysics, UCSF |
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1997- |
Investigator, Howard Hughes Medical Institute |
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2001- |
Chair, Department of Biochemistry & Biophysics Department, UCSF |
| HONORS & AWARDS | |
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1983 |
Searle Scholar Award |
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1988 |
Eli Lilly Award for Fundamental Research in Biological Chemistry |
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1988 |
Passano Award |
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1989 |
Alfred P. Sloan Award |
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1993 |
NIH MERIT Award |
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1996 |
Harvey Lecturer, Rockefeller University, New York |
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1998 |
American Academy of Microbiology (elected Fellow) |
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1998 |
Feodor-Lynen-Lecture, Mosbach Kolloquium, Germany |
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2001 |
American Academy of Arts & Sciences (elected Fellow) |
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2004 |
National Academy of Sciences (elected Member) |
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2004 |
European Molecular Biology Organization (elected Associate Member) |
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2004 |
Virchow Lecture, Universität Würzburg |
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2005 |
Wiley Prize in Biomedical Sciences (with Dr. Kazutoshi Mori) |
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2005 |
George E. Palade Distinguished Lecture, Wayne State University School of Medicine |
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2006 |
47th Stadtler Lecture, University of Texas |
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2006 |
Leopoldina Academy of Scientists (elected member) |
| SELECTED PUBLICATIONS | |
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(from a total of 129) |
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Cox, J.S. & Walter, P. (1996) A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell 87: 391-404. |
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Sidrauski, C., Cox, J.S. & Walter, P. (1996) tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Cell 87: 405-413. |
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Freymann, D.M., Keenan, R.J., Stroud, R.M.,& Walter, P. (1997) Structure of the conserved GTPase domain of the signal recognition particle. Nature 385: 361-364. |
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Cox, J., Chapman, R., & Walter, P. (1997) The unfolded protein response coordinates the production of ER protein and ER membrane. Molecular Biology of the Cell 8:1805-1814. |
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Keenan, R., Freymann, D., Walter, P. & Stroud, R. (1998) Crystal structure of the signal sequence binding subunit of the signal recognition particle. Cell 94: 181-191. |
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Freymann, D.M., Keenan, R.J., Stroud, R.M., & Walter, P. (1999) Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP. Nature Structural Biology 6: 793-801. |
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Gonzalez, T., Sidrauski, C., Drfler, S., & Walter, P. (1999) Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathway. EMBO J. 18: 3119-3132. |
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Niwa, M., Sidrauski, C., & Walter, P. (1999) A Role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response. Cell 99: 691-702. |
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Travers, K.J., Patil, C.K., Wodicka, L., Lockhart, D.J., Weissman, J., & Walter, P. (2000) Functional and genomic analyses reveal essential coordination between the UPR and ER-associated degradation. Cell 101: 249-258. |
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Peluso, P., Herschlag, D., Nock, S., Freymann, D., Johnson, A.E., & Walter, P. (2000) Role of 4.5 S RNA in assembly of the bacterial signal recognition particle with its receptor. Science 288: 1640-1643. |
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Heiman, M.G. & Walter, P. (2000) Prm1p, a pheromone-regulated multispanning membrane protein, facilitates plasma membrane fusion during yeast mating. J. Cell Biology 151: 719-730. |
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Rüegsegger, U., Leber, J.H., & Walter, P. (2001) Block of HAC1 mRNA translation by long-range base pairing is released by cytoplasmic splicing upon induction of the unfolded protein response. Cell 107: 103-114. |
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Peluso, P., Shan, S., Nick, S., Herschlag, D., & Walter, P. (2001) Role of SRP RNA in the GTPase cycles of Ffh and FtsY. Biochemistry 40: 15224-15233. |
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Helenius, J., Ng, D.T.W., Marolda, C.L., Walter, P., Valvano, M.A., & Aebl, M. (2002) Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein. Nature 415: 447-450. |
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Shan, S. & Walter, P. (2003) Induced nucleotide specificity in a GTPase. Proc Natl Acad Sci 100: 4480-85. |
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Papa, F., Zhang, C. Shokat, K. & Walter, P. (2003) Bypassing a kinase activity with an ATP-competitive drug. Science 302: 1533-1537. |
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Egea, P., Shan, S., Napetschnig, J., Savage, D., Walter, P., & Stroud, R. (2004) Substrate twinning activates the signal recognition particle and its receptor. Nature 427: 215-221. |
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Leber,J., Bernales,S., & Walter,P. (2004) IRE1-independent gain control of UPR, PLoS Biol 2 (8): e235. |
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Patil, C., Li, H., & Walter, P. (2004) A role for Gcn4p and novel upstream activating sequences in the unfolded protein response, Public Library of Science, Biology 2 (8): e246. |
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Shan, S., Stroud, R., & Walter, P. (2004) Mechanism of association and reciprocal activation of two GTPases. Public Library of Science, Biology 2 (11): e320. |
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Chu, F., Shan, S. Moustakas, D., Alber, F., Egea, P., Stroud, R., Walter, P. & Burlingame, A. (2004) Unraveling the interface of SRP and its receptor using chemical cross-linking and mass spectrometry. Proc Natl Acad Sciences 101: 16454-16459. |
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Niwa, M., Patil, C., DeRisi, J., & Walter, P. (2004) Genome-scale approaches for discovering novel non-conventional splicing substrates of the Ire1 nuclease. Genome Biol. 6 (1): R3.1-10. |
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Shan, S. & Walter, P. (2005) Molecular crosstalk between the nucleotide specificity determinant of the SRP GTPase and the SRP receptor. Bichemistry 44: 6214-6222. |
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Credle, J., Finer-Moore, J., Papa, F., Stroud, R., & Walter, P. (2005) On the mechanism of sensing unfolded protein in the Endoplasmic Reticulum. Proc Natl Acad Sciences 102: 18773-84. |
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Walther, T., Brickner, J. Aguilar, P., Bernales, S., Pantoja, C., & Walter, P. (2006) Eisosomes define static sites of endocytosis. Nature 439 (23): 998-1003. |
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Bernales, S., McDonald KL, & Walter, P. Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biology 4 (12): e423. |
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2/20/07 |
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