Arthur Weiss, MD, PhD

University of Chicago, Chicago, IL, Ph.D., 1978, Immunology
University of Chicago, Chicago, IL, M.D., 1979, Medicine

• 1979-1980
  Postdoctoral Fellow, Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland
• 1980-1982
  Resident, Department of Medicine, University of California San Francisco
• 1982-1984
  Fellow in Rheumatology/Clinical Immunology, University of California San Francisco
• 1982-1985
  Associate, Howard Hughes Medical Institute, San Francisco
• 1984-1985
  Instructor, Department of Medicine, Division of Rheumatology/Clinical Immunology, University of California San Francisco
• 1985-1989
  Assistant Investigator, Howard Hughes Medical Institute, San Francisco
• 1985-1989
  Assistant Professor of Medicine, Microbiology and Immunology, University of California San Francisco
• 1987-present
  Chief, Division of Rheumatology/Clinical Immunology, Department of Medicine, University of California San Francisco
• 1989-1993
  Associate Investigator, Howard Hughes Medical Institute, San Francisco
• 1991-present
  Ephraim P. Engleman Distinguished Professor of Rheumatology, University of California San Francisco
• 1992-present
  Professor of Medicine, Microbiology and Immunology, University of California San Francisco
• 1993-present
  Investigator, Howard Hughes Medical Institute, University of California San Francisco
• 1998-present
  Associate Director, The Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco
• 2002-present
  Director, Medical Scientist Training Program (MSTP) University of California, San Francisco

• 1990
  Young Investigator, Western Society for Clinical Investigation
• 1990
  Henry Kunkel Young Investigator Award, American College of Rheumatology
• 1993
  Junior Investigator Award, American Association of Immunologists
• 1997
  Lee C. Howley Prize, Arthritis Foundation
• 1998
  Forty-first Faculty Research Lecturer, University of California San Francisco
• 2001
  American Association of Immunologist-Huang Foundation Meritorious Career Award
• 2003
  Fellow, American Academy of Arts and Sciences
• 2004
  Fellow, American Academy of Microbiology
• 2004
  American College of Rheumatology Distinguished Investigator Award
• 2004
  Distinguished Investigator Award, American College of Rheumatology
• 2004
  Walter Bauer Visiting Professor in Rheumatology, Massachusetts General Hospital
• 2004
  Bridget Ogilvie Lecture, University of Dundee, Scotland
• 2004
  Sue Kim Hansen Lecture, Boston University School of Medicine
• 2005
  Dan H. Campbell Memorial Lecture, Midwinter Conference of Immunologists, Asilomar, CA
• 2005
  Visiting Professor, Harvard Medical School Rheumatology Division
• 2005
  Beirne B. Carter Lecture in Immunology, University of Virginia

• Lin, J, Weiss, A: The tyrosine phosphatase CD148 is excluded from the immunologic synapse and downregulates prolonged T cell signaling. J Cell Biol 2003; 162:673-682.
• Tomlinson, MG, Kane, LP, Su, J, Kadlecek, TA, Mollenauer, MN, Weiss, A: Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec. Mol. Cell. Biol 2004; 24:2455-2466.
• Andres, PG, Howland ,KC, Nirula A, Kane, LP, Barron, L, Dresnek D, Sadra, A, Imboden, J, Weiss A, Abass, AK: Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation. Nature Immunol 2004; 5:435-4492.
• Crotzer, VL, Mabardy,AS, Weiss, A, Brodsky FM: T cell receptor engagement leads to phosphorylation of Clathrin heavy chain during receptor internalization. J Exp Med 2004; 199:981-991.
• Kane LP, Mollenauer MN, Weiss, A: A proline-rich motif in the C Terminus of Akt contributes to its localization in the immunological synapse. J Immunol 2004; 172:5441-5449.
• Tomlinson MG, Kane LP, Su J, Kadlecek TA, Mollenauer MN, Weiss, A: Expression and function of Tec, Itk, and Btk in lymphocytes; Evidence for a unique role for Tec. Mol Cell Biol 2004; 24:2455-2466.
• Lin J, Zhu JW, Baker JE, Weiss, A: Regulated expression of the receptor-like tyrosine phosphatase CD148 on hematopoietic cells. J Immunol 2004; 173:2324-2330.
• Rassenti LZ, Huynh L, Toy TL, Chen L, Gribben JG, Keating MJ, Rai KR, Finn IW, Byrd JC, Kay NE, Greaves A, Weiss A, Kipps TJ. ZAP-70 compared with immunoglobulin heavy-chain mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N. Eng. J. Med 2004; 351:893-901.
• Tomlinson MG, Heath VL, Turck CW, Watson SP, Weiss A: SHIP family of inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase. J. Biol. Chem 2004; 279:55089-55096.
• Chen, L, Apgar, J, Huynh, L, Dicker, F, Giago-McGahan, T, Rassenti, L, Weiss,A, Kipps, TJ: ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia. Blood, 2005,105:2036-41.
• Phee, H, Abraham, RT, Weiss, A: Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1. Nat Immunol. 2005, 6:608-17.
• Roose, JP, Mollenauer, M, Gupta, VA, Stone, J, Weiss, A: A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol Cell Biol. 2005, 11:4426-41.
• Brdicka, T, Kadlecek, TA, Roose, JP, Pastuszak, AW, Weiss, A: Intramolecular regulatory switch in ZAP- 70: analogy with receptor tyrosine kinases. Mol Cell Biol, 2005, 12:4924-33.
• Myers, MD, Dragone, LL, Weiss, A: Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation. J Cell Biol, 2005, 170:285-94.
• Hermiston, ML, Tan, AL, Gupta, VA, Majeti, R, Weiss, A: The juxtamembrane wedge negatively regulates CD45 function in B cells. Immunity, 2005, 6:635-47.
• Myers, MD, Sosinowski, T, Dragone, LL, White, C, Band, H, Gu, H, Weiss, A.: Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex. Nat Immunol. 2006, 1:57-66.
• Dragone, LL, Myers, MD, White, C, Sosinowski, T, Weiss, A: Src-like adaptor protein regulates B cell development and function. J Immunol. 2006, 176:335-45.
• Hesslein, D.G.T., Takaki, R., Hermiston, M.L., Weiss, A, Lanier, L.: Dysregulation of signaling pathways in CD-45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production. Proc Natl Acad Sci USA. 103:7012-7017, 2006.
• Nirula, A, Ho, M, Phee, H, Roose, J, Weiss, A: Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4. J. Exp. Med. 203:435-442, 2006.