wittej@humgen.ucsf.edu
(415) 514-8114 (voice)
(415) 476-6014 (fax)

Box 0560, UCSF, San Francisco, CA 94143-0560

additional websites:

Witte Lab Website

University of California, Santa Barbara, CA, BS, 1986, Mathematical Sciences
University of California, Berkeley, CA, MS, 1988, Industrial Engineering and Operations Research
University of California, Los Angeles, CA, PhD, 1994, Epidemiology

(out of 90 papers)

Witte JS, Greenland S, Haile RW, Bird CL. Hierarchical regression analysis applied to a study of multiple dietary exposures and breast cancer. Epidemiology 5:612-621, 1994.

Witte JS, Greenland S. Simulation study of hierarchical regression. Stat Med 15:1161-1170, 1996.

Witte JS, Longnecker MP, Bird CL, Lee ER, Frankl HD, Haile RW. Relation of vegetable, fruit, and grain consumption to colorectal adenomatous polyps [w/commentary]. Am J Epidemiol 144:1015-1025, 1996.

Witte JS, Elston RC, Schork NJ. Re: Genetic dissection of complex traits. Nat Genet 12:355-356, 1996.

Witte JS, Ursin G, Siemiatycki J, Thompson WD, Paganini-Hill A, Haile RW. Diet and premenopausal bilateral breast cancer: a case-control study. Breast Cancer Res Treat 42:243-251, 1997.

Witte JS, Greenland S. A nested approach to evaluating dose-response and trend. Ann Epidemiol 7:188-193, 1997.

Witte JS. Genetic analysis with hierarchical modeling. Genet Epidemiol 14:1137-1142, 1997.

Witte JS, Greenland S, Kim LL. Software for hierarchical modeling of epidemiologic data. Epidemiology 9:563-566,1998

Witte JS, Carlin JB, Hopper JL. Likelihood-based approach to estimating twin concordance for dichotomous traits. Genet Epidemiol 16:290-304, 1999.

Witte JS, Gauderman WJ, Thomas DC. Asymptotic bias and efficiency in case-control studies of candidate genes and gene-environment interactions: basic family designs. Am J Epidemiol 149:693-705, 1999.

Paris PL, Kupelian PA, Hall JM, Williams TL, Levin H, Klein EA, Casey G, Witte JS. Association between a CYP3A4 genetic variant and clinical presentation in African-American prostate cancer patients. Cancer Epidemiol Biomarkers Prev 8:901-906, 1999.

Witte JS, Elston RC, Cardon LR. On the relative sample size required for multiple comparisons. Stat Med 19:369-72, 2000

Witte JS, Goddard KAB, Conti DV, Elston RC, Lin J, Suarez BK, Broman KW, Burmester JK, Weber JL, Catalona WJ. Genomewide scan for prostate cancer-aggressiveness loci. Am J Hum Genet 67:92-99, 2000.

Witte JS, Greenland SÉ Arab L. Multilevel modeling in epidemiology with GLIMMIX. Epidemiology 11:684-688, 2000.

Goddard KA, Witte JS, Suarez BK, Catalona WJ, Olson JM. Model-free linkage analysis with covariates confirms linkage of prostate cancer chromosomes 1 and 4. Am J Hum Genet 68:1197-1206, 2001.

Thomas DC, Witte JS. Population stratification: a problem for case-control studies of candidate gene associations? Cancer Epidemiol, Biomarkers Prev 11:505-512, 2002.

Casey GC, Neville PJ, Plummer SJ, Krumroy LM, Wand Z, Catalona WJ, Carpten J, Trent J, Silverman R, Witte JS. RNASEL R462Q variant is implicated in up to 13% of prostate cancer cases. Nat Genet 32:581-583, 2002.

Conti DV, Witte JS. Hierarchical modeling of linkage disequilibrium: genetic structure and spatial relations. Am J Hum Genet 72:351-363, 2003.

Plummer SJ, Conti DV, Paris PL, Curran AP, Casey G, Witte JS. CYP3A4 and CYP3A5 genotypes, haplotypes and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 12:928-932, 2003.

Witte JS, Suarez BK, Thiel B, Lin J, Yu A, Banerjee TK, Burmester JK, Casey G, Catalona WJ. Genome-wide scan of brothers: replication and fine mapping of prostate cancer susceptibility and aggressiveness loci. The Prostate 2003;57: 298-308.

Thompson D, Goldgar D, Stram D, Witte JS. Design issues in using haplotype tagging SNPs for association studies. Human Heredity 2003;56:48-55.

Li L, Yu H, Schumacher F, Casey G, Witte JS. Relation of serum insulin-like growth factor-I (IGF-I) and IGF binding protein-3 to risk of prostate cancer. Cancer Causes and Control 2003;14: 721-726.

Xing C, Schumacher FR, Conti DV, Nock NL, Li L, Witte JS. Comparison of missing data approaches in linkage analysis. BioMed Central Genetics 2003;4:S44.

Rybicki BA, Conti DV, Moreira A, Casey G, Witte JS. DNA repair gene XRCC1 and XPD polymorphisms and risk of prostate cancer. Cancer Epidemiology, Biomarkers & Prevention 2004;13:23-29.

Loukola A, Chadha M, Penn DG, Rank D, Thiel B, Cicek M, Conti DV, Thompson D, Love B, Jonsson J, Brinne A, Chen W, Ji Y, Loder RT, Yang Q, Jiang Y, Dains K, Hanzel DK, Paris PL, Casey G, Witte JS. Comprehensive evaluation of the association between prostate cancer and genotypes / haplotypes in CYP17, CYP3A4, SRD5A2, and the Androgen Receptor. European Journal of Human Genetics 2004;12:321-332.

Li L, Cicek M, Casey G, Witte JS. No association between genetic polymorphisms in IGF-I and IGFBP-3 and prostate cancer. Cancer Epidemiology, Biomarkers & Prevention 2004;13: 497-498.

Cicek M, Conti DV, Paris PL, Neville PJ, Casey G, Witte JS. SRD5A2, the Androgen Receptor, and CYP17 gene polymorphisms and prostate cancer risk and aggressiveness. Prostate 2004;59:69-76.

Singer JB, Hill AE, Burrage LC, Olszens KR, Song J, Justice M, O'Brien WE, Conti DV, Witte JS, Lander ES, Nadeau JH. Genetic dissection of complex traits with chromosome substitution strains of mice. Science 2004;304:445-448.

Hung RJ, Brennan P, Malaveille C, Porru S, Donato F, Boffetta P, Witte JS. Using hierarchical modeling in genetic association studies with multiple markers: application to a case-control study of bladder cancer. Cancer Epidemiology, Biomarkers & Prevention 2004;13:1013-1021.

Cicek M, Nock NL, Li L, Conti DV, Casey G Witte JS. Relation of Methylenetetrahydrofolate reductase C677T and A1298C genotypes and haplotypes to prostate cancer risk and aggressiveness. Cancer Epidemiology, Biomarkers & Prevention 2004;13:1331-1336.

Thompson D, Witte JS, Slattery M, Goldgar D. Increased power for case-control studies of single nucleotide polymorphisms through incorporation of family history and genetic constraints. Genetic Epidemiology 2004;27:215-224.

Li L, Cicek M, Casey G, Witte JS. No association between a tetranucleotide repeat polymorphism of CYP19 and prostate cancer. Cancer Epidemiology, Biomarkers & Prevention 2004;13:2280-2281.

Cicek M, Liu X, Casey G, Witte JS. Role of androgen metabolism genes CYP1B1, PSA/KLK3, and CYP11-B in prostate cancer risk and aggressiveness. Cancer Epidemiology, Biomarkers & Prevention 2005;14:2173-2177.

Jorgenson E, Liu X, Witte JS. Case-Control Analyses: Geneopardy! Genetic Epidemiology 2005,29:S86-91.

Liu X, Rybicki B, Casey G, Witte JS. Relation between body size and prostate cancer in a sibling-based case-control study. Journal of Urology 2005;174:2169-2173.

Li L, Cicek MS, Casey G, Witte JS. No Association between Genetic Polymorphisms in Insulin (INS) and Insulin Receptor Substrate-1 (IRS1) and Prostate Cancer. Cancer Epidemiology, Biomarkers & Prevention 2005;14:2462-2463.

Liu X, Jorgenson E, Witte JS. Evaluation of hierarchical modeling for association studies. BioMed Central Genetics 2005;6 Suppl 1:S104.

Tung JY, Rosen MP, Nelson LM, Turek PJ, Witte JS, Cramer DW, Reijo Pera RA. Variants in Deleted in AZoospermia-Like (DAZL) are correlated with reproductive parameters in men and women. Human Genetics 2006;118:730-740.

Casey G, Neville PJ, Cicek MS, Plummer SJ, Krumroy LM, Curran AP, Martin MR, Liu X, Catalona WJ, Witte JS. Association between Podocalyxin variants and prostate cancer risk and tumor aggressiveness. Human Molecular Genetics 2006;15:735-741.

Nock NL, Liu X, Cicek MS, Li L, Macarie F, Rybicki BA, Plummer SJ, MacLennan GT, Casey G, Witte JS. Polymorphisms in PAH metabolism and conjugation genes, interactions with smoking and prostate cancer risk. Cancer Epidemiology, Biomarkers & Prevention 2006, 15:756-61.

Jorgenson E, Witte JS. Coverage and power in genomewide association studies. American Journal of Human Genetics 2006;78:884-888.

12/8/06