Keith R. Yamamoto, PhD

Iowa State University, Ames, IA, B.Sc., 1968, Biochemistry and Biophysics
Princeton University, Princeton, NJ, Ph.D., 1973, Biochemical Sciences
University of California San Francisco, San Francisco, CA, postdoc, 1973-1975, Molecular Biology

• 1976-1979
  Assistant Professor of Biochemistry, Department of Biochemistry and Biophysics, UCSF
• 1979-1983
  Associate Professor of Biochemistry, Department of Biochemistry and Biophysics, UCSF
• 1983-2003
  Professor of Biochemistry, Department of Biochemistry and Biophysics, UCSF
• 1985-1994
  Vice Chairman, Department of Biochemistry and Biophysics, UCSF
• 1988-2001
  Director, Biochemistry and Molecular Biology Program, Program in Biological Sciences, UCSF
• 1994-2003
  Chairman, Department of Cellular and Molecular Pharmacology, UCSF
• 1994-present
  Professor, Department of Cellular and Molecular Pharmacology
• 2002-2003
  Vice Dean for Research, School of Medicine
• 2002-present
  Executive Vice Dean, School of Medicine

• 1977-1982
  NIH Research Career Development Award
• 1979-1980
  UCSF Distinguished Teaching Award
• 1982-1986
  Dreyfus Teacher-Scholar Award
• 1988
  American Academy of Arts and Sciences
• 1989
  National Academy of Sciences
• 1990
  Gregory Pincus Medal
• 1992
  American Academy of Microbiology
• 1997
  Faculty Research Lecturer, UC San Francisco
• 1997
  Iowa State University Distinguished Achievement Citation
• 1998
  Theodore Roosevelt High School Hall of Fame, Des Moines, Iowa
• 1999
  Vanderbilt Medal of Merit, Vanderbilt University
• 2001
  Iowa State University D.Sc., honorary
• 2002
  Elected Fellow, American Association for the Advancement of Science
• 2003
  Institute of Medicine

• Nissen, R.M., Yamamoto, K.R. (2000) The glucocorticoid receptor inhibits NFκB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxyl-terminal domain. Genes Dev. 14, 2314-2329.
• van Tilborg, M.A.A., Lefstin, J.A., Kruiskamp, M., Teuben, J-M., Boelens, R., Yamamoto, K.R., Kaptein, R. (2000) Mutations in the glucocorticoid receptor DNA-binding domain mimic an allosteric effect of DNA. J. Mol Biol. 301, 947-958.
• Freeman, B.C. and Yamamoto, K.R. (2001) Continuous recycling: A mechanism for modulatory signal transduction. Trends Biochem. Sci. 26, 285-290.
• Rogatsky I., Zarember K.A., Yamamoto K.R. (2001) Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones. EMBO J. 20, 6071-6083.
• Freeman, B.C., Yamamoto, K.R. (2002) Disassembly of transcriptional regulatory complexes by molecular chaperones. Science 296, 2232-2235.
• Rogatsky, I., Luecke, H.F., Leitman, D.C., Yamamoto, K.R. (2002) Alternate surfaces of transcriptional co-regulator GRIP1 function in different glucocorticoid receptor activation and repression contexts. Proc. Natl. Acad. Sci. USA 99, 16701-16706.
• Rogatsky, I., Wang, J-C., Derynck, M.K., Nonaka, D., Khodabakhsh, D.B., Haqq, C.M., Darimont, B.D., Garabedian, M.J., and Yamamoto, K.R. (2003) Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA 100, 13845-13850.
• Kian Tee, M., Rogatsky, I., Tzagarakis-Foster, C., Cvoro, A., An, J., Christy, R.J., Yamamoto, K.R. and Leitman, D.C. (2004) Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors α and β Mol. Biol. Cell 15, 1262-1272.
• Freedman, N.D. and Yamamoto, K.R. (2004) Importin 7 and Importin α/Importin β Are Nuclear Import Receptors for the Glucocorticoid Receptor. Mol. Biol. Cell 15, 2276-2286.
• Wang, J-C., Walker, A., Blackwell, T.K., and Yamamoto, K.R. (2004) The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis. J. Biol. Chem. 279, 29270 - 29277.
• Shostak, Y., Van Gilst, M.R., Antebi, A., and Yamamoto, K.R. (2004). Identification of C. elegans DAF-12 binding sites, response elements and target genes. Genes Dev. 18, 2529-2544.
• Wang, J.-C., Derynck, M.K., Nonaka, D.F., Khodabakhsh,D.B., Haqq, C., Yamamoto, K.R. (2004) Chromatin Immunoprecipitation (ChIP) Scanning Identifies Primary Glucocorticoid Receptor Target Genes. Proc. Natl. Acad. Sci. USA 101, 15603-15608.
• Van Gilst, M.R., Hadjivassiliou, H., Jolly, A., and Yamamoto, K.R. (2005) Nuclear Hormone Receptor NHR-49 Controls Fat Consumption and Fatty Acid Composition in C. elegans. PLoS Biol. 3, e53.
• Shostak, Y. and Yamamoto, K.R. (2005) Overlapping but Separable Determinants of DNA Binding and Nuclear Localization Map to the C-terminal End of the C. elegans DAF-12 DNA Binding Domain. J. Biol. Chem. 280, 6554-6560.
• Luecke, H.F. and Yamamoto, K.R. (2005). The Glucocorticoid Receptor blocks P-TEFb recruitment by NF κB to effect promoter specific transcriptional repression. Genes Dev. 19, 1116 - 1127.
• Van Gilst, M.R., Hadjivassiliou, and Yamamoto, K.R. (2005) A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Proc. Natl. Acad. Sci. USA 102, 13496-13501.
• Wang, J-C., Shah, N., Pantoja, C., Meijsing, S.H., Ho, J.D., Scanlan, T.S., Yamamoto, K.R. (2006) Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity. Genes Dev. 20, 689-699.
• Taubert, S., Van Gilst, M.R., Hansen, M., Yamamoto, K.R. (2006) A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Genes Dev. 20, 1137-1149.