Executive Vice Dean, School of Medicine; Professor, Cellular/Molecular Pharmacology and Biochemistry/Biophysics, UCSF
Member, Biomedical Sciences Graduate Program (BMS) and Herbert Boyer Program in Biological Sciences (PIBS)
| CONTACT | |
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yamamoto@cgl.ucsf.edu Box 2280, UCSF; San Francisco, CA 94143-2280 |
additional websites: |
| EDUCATION | |
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Iowa State University, Ames, IA, B.Sc., 1968, Biochemistry and Biophysics |
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| PROFESSIONAL EXPERIENCE | |
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1976-1979 |
Assistant Professor of Biochemistry, Department of Biochemistry and Biophysics, UCSF |
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1979-1983 |
Associate Professor of Biochemistry, Department of Biochemistry and Biophysics, UCSF |
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1983-2003 |
Professor of Biochemistry, Department of Biochemistry and Biophysics, UCSF |
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1985-1994 |
Vice Chairman, Department of Biochemistry and Biophysics, UCSF |
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1988-2001 |
Director, Biochemistry and Molecular Biology Program, Program in Biological Sciences, UCSF |
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1994-2003 |
Chairman, Department of Cellular and Molecular Pharmacology, UCSF |
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1994-present |
Professor, Department of Cellular and Molecular Pharmacology |
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2002-2003 |
Vice Dean for Research, School of Medicine |
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2002-present |
Executive Vice Dean, School of Medicine |
| HONORS & AWARDS | |
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1977-1982 |
NIH Research Career Development Award |
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1979-1980 |
UCSF Distinguished Teaching Award |
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1982-1986 |
Dreyfus Teacher-Scholar Award |
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1988 |
American Academy of Arts and Sciences |
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1989 |
National Academy of Sciences |
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1990 |
Gregory Pincus Medal |
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1992 |
American Academy of Microbiology |
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1997 |
Faculty Research Lecturer, UC San Francisco |
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1997 |
Iowa State University Distinguished Achievement Citation |
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1998 |
Theodore Roosevelt High School Hall of Fame, Des Moines, Iowa |
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1999 |
Vanderbilt Medal of Merit, Vanderbilt University |
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2001 |
Iowa State University D.Sc., honorary |
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2002 |
Elected Fellow, American Association for the Advancement of Science |
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2003 |
Institute of Medicine |
| SELECTED PUBLICATIONS | |
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(112 Total) | |
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Nissen, R.M., Yamamoto, K.R. (2000) The glucocorticoid receptor inhibits NFκB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxyl-terminal domain. Genes Dev. 14, 2314-2329. | |
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van Tilborg, M.A.A., Lefstin, J.A., Kruiskamp, M., Teuben, J-M., Boelens, R., Yamamoto, K.R., Kaptein, R. (2000) Mutations in the glucocorticoid receptor DNA-binding domain mimic an allosteric effect of DNA. J. Mol Biol. 301, 947-958. | |
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Freeman, B.C. and Yamamoto, K.R. (2001) Continuous recycling: A mechanism for modulatory signal transduction. Trends Biochem. Sci. 26, 285-290. | |
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Rogatsky I., Zarember K.A., Yamamoto K.R. (2001) Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones. EMBO J. 20, 6071-6083. | |
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Freeman, B.C., Yamamoto, K.R. (2002) Disassembly of transcriptional regulatory complexes by molecular chaperones. Science 296, 2232-2235. | |
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Rogatsky, I., Luecke, H.F., Leitman, D.C., Yamamoto, K.R. (2002) Alternate surfaces of transcriptional co-regulator GRIP1 function in different glucocorticoid receptor activation and repression contexts. Proc. Natl. Acad. Sci. USA 99, 16701-16706. | |
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Rogatsky, I., Wang, J-C., Derynck, M.K., Nonaka, D., Khodabakhsh, D.B., Haqq, C.M., Darimont, B.D., Garabedian, M.J., and Yamamoto, K.R. (2003) Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA 100, 13845-13850. | |
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Kian Tee, M., Rogatsky, I., Tzagarakis-Foster, C., Cvoro, A., An, J., Christy, R.J., Yamamoto, K.R. and Leitman, D.C. (2004) Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors α and β Mol. Biol. Cell 15, 1262-1272. | |
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Freedman, N.D. and Yamamoto, K.R. (2004) Importin 7 and Importin α/Importin β Are Nuclear Import Receptors for the Glucocorticoid Receptor. Mol. Biol. Cell 15, 2276-2286. | |
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Wang, J-C., Walker, A., Blackwell, T.K., and Yamamoto, K.R. (2004) The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis. J. Biol. Chem. 279, 29270 - 29277. | |
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Shostak, Y., Van Gilst, M.R., Antebi, A., and Yamamoto, K.R. (2004). Identification of C. elegans DAF-12 binding sites, response elements and target genes. Genes Dev. 18, 2529-2544. | |
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Wang, J.-C., Derynck, M.K., Nonaka, D.F., Khodabakhsh,D.B., Haqq, C., Yamamoto, K.R. (2004) Chromatin Immunoprecipitation (ChIP) Scanning Identifies Primary Glucocorticoid Receptor Target Genes. Proc. Natl. Acad. Sci. USA 101, 15603-15608. | |
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Van Gilst, M.R., Hadjivassiliou, H., Jolly, A., and Yamamoto, K.R. (2005) Nuclear Hormone Receptor NHR-49 Controls Fat Consumption and Fatty Acid Composition in C. elegans. PLoS Biol. 3, e53. | |
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Shostak, Y. and Yamamoto, K.R. (2005) Overlapping but Separable Determinants of DNA Binding and Nuclear Localization Map to the C-terminal End of the C. elegans DAF-12 DNA Binding Domain. J. Biol. Chem. 280, 6554-6560. | |
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Luecke, H.F. and Yamamoto, K.R. (2005). The Glucocorticoid Receptor blocks P-TEFb recruitment by NF κB to effect promoter specific transcriptional repression. Genes Dev. 19, 1116 - 1127. | |
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Van Gilst, M.R., Hadjivassiliou, and Yamamoto, K.R. (2005) A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Proc. Natl. Acad. Sci. USA 102, 13496-13501. | |
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Wang, J-C., Shah, N., Pantoja, C., Meijsing, S.H., Ho, J.D., Scanlan, T.S., Yamamoto, K.R. (2006) Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity. Genes Dev. 20, 689-699. | |
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Taubert, S., Van Gilst, M.R., Hansen, M., Yamamoto, K.R. (2006) A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Genes Dev. 20, 1137-1149. | |
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12/11/06 |
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