University of California San Francisco
Helen Diller Family Comprehensive Cancer Center

Symposium on Role of Statistics in Cancer Immunotherapy

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Thursday, April 30, 2020  |  8:30 am - 12:00 pm
Friday, May 1, 2020  |  8:30 am - 12:15 pm

VIRTUAL SYMPOSIUM

Overview | Agenda | RegistrationContact


Overview

This online symposium will focus on two major aspects: (1) novel clinical trial design and advanced quantitative models during the development of cancer immunotherapy, and (2) computational algorithms and data integration techniques that are under active development to solve the challenges raised in cutting edge high throughput sequencing being applied to cancer immunology and immuno-oncology research and clinical applications.


Agenda

DAY 1: THURSDAY, APRIL 30, 2020

8:25 am

Introductions

Li Zhang, PhD
Chair, Symposium Planning Committee
UCSF Helen Diller Family Comprehensive Cancer Center

8:30 am

Welcome

Eric Small, MD, FASCO
Deputy Director and Chief Scientific Officer
Program Leader, Prostate Cancer Program
UCSF Helen Diller Family Comprehensive Cancer Center

Overview of Cancer Immunology and Immunotherapy 

8:45 am

KEYNOTE: Mechanisms of Response and Resistance to Cancer Immunotherapy

Lawrence Fong, MD
Efim Guzik Distinguished Professor in Cancer Biology
Leader, Cancer Immunotherapy Program
UCSF Helen Diller Family Comprehensive Cancer Center

Session 1: Clinical Study Design and Novel Quantitative Methodology (Chair: Ron Yu, PhD, Gilead)

9:35 am

KEYNOTE: Novel Bayesian Adaptive Trial Designs to Accelerate Development of Immunotherapy

Ying Yuan, PhD, FRSC
Deputy Chair of Department of Biostatistics
University of Texas MD Anderson Cancer Center

10:20 am

A practical design approach to Phase III trials in immuno-oncology

Keaven Anderson, PhD
Scientific AVP
Biostatistics Merck & Co, Inc.

10:50 am

Design, monitoring and analysis of randomized clinical trials based on the restricted mean survival time

Bo Huang, PhD
Statistics Group Lead, Pfizer

11:20 am

Q&A with Session 1 speakers

Ying Yuan, PhD, FRSC
Keaven Anderson, PhD
Bo Huang, PhD

11:30 am

Sponsor Presentation: Immune Repertoire Sequencing for Immuno-Oncology Biomarker Discovery

Timothy Looney, PhD
Associate Director, Bioinformatics Clinical-Next Generation Sequencing
Thermo Fisher Scientific

12:00 pm

Adjourn Day 1

DAY 2: FRIDAY, MAY 1, 2020

Session 2: Cutting-edge Technologies and Advancements in Computational Approaches (Chair: Li Zhang, PhD, UCSF)

8:30 am

KEYNOTE: Biomarkers and regulators of tumor immunotherapy response

Shirley Liu, PhD
Co-director, Center for Functional Cancer Epigenetics
Dana-Farber Cancer Institute

9:15 am

Understanding immune responses to cancer from single-cell data

Matthew H. Spitzer, PhD
Werbe Assistant Professor
Depts. of Otolaryngology—Head and Neck Surgery & Microbiology and Immunology, UCSF

9:45 am

Leveraging Multi-Omics Data To Better Understand Cancer

Marina Sirota, PhD
Associate Professor
Bakar Computational Health Sciences Institute, UCSF

10:15 am

Q&A with Session 2 speakers

Shirley Liu, PhD
Matthew H. Spitzer, PhD
Marina Sirota, PhD

Session 3: Enhanced Personalized Immunotherapy (Chair: Ray Lin, PhD, Genentech)

10:30 am

Estimating and Interpreting Treatment Effect in Oncology Immune Therapies

Susan Halabi, PhD
Chief, Division of Biostatistics, Dept. of Biostatistics & Bioinformatics
School of Medicine, Duke University

11:00 am 

Dose Selection for Cancer Immunotherapy

Yaning Wang, PhD
Director
Division of Pharmacometrics, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration

11:30 am

Multiplexed Single Cell Genomics

Jimmie Ye, PhD
Associate Professor of Medicine, UCSF

12:00 pm

Q&A with Session 3 speakers

Susan Halabi, PhD
Yaning Wang, PhD
Jimmie Ye, PhD

12:10 pm

Closing remarks

Li Zhang, PhD

12:15 pm

Adjourn Day 2


Registration

**Registration is now closed**

Registrants: please check your email for login/participation details. If you did not receive the Zoom link and instructions, contact Erin Hayes (erin.hayes@ucsf.edu) directly for assistance.


Contact

For general event questions, please contact:
Geraldine Pacheco, geraldine.pacheco@ucsf.edu

For questions related to session topics and sponsorship, please contact:
Li Zhang, PhD, li.zhang@ucsf.edu

Planning Committee

  • Li Zhang, PhD (Chair), Associate Professor, Department of Medicine and Department of Epidemiology and Biostatistics, UCSF
  • Jing Huang, PhD, SVP of Bioinformatics & Data Science, Veracyte, Inc.
  • Ray Lin, PhD, Principal Statistical Scientist, Department of Biostatistics, Genentech/Roche
  • Timothy Looney, PhD, Associate Director, Bioinformatics at Thermo Fisher Scientific
  • Ron Yu, PhD, Senior Director, Biostatistics at Gilead Sciences
  • Tao He, PhD, Assistant Professor of Statistics, Department of Mathematics, San Francisco State University

Scientific Advisors

  • Mi-OK Kim, PhD, Director, Biostatistics Core, UCSF Helen Diller Family Comprehensive Cancer Center; Professor in Residence, Dept. of Epidemiology & Biostatistics, UCSF
  • Lawrence Fong, MD, PhD, Efim Guzik Distinguished Professor in Cancer Biology; Leader, Cancer Immunotherapy Program, UCSF Helen Diller Family Comprehensive Cancer Center 

Event Sponsors

**This retreat is supported by the Biostatistics Shared Resource and the Cancer Immunology Program of the UCSF Helen Diller Family Comprehensive Cancer Center; Thermo Fisher Scientific; San Francisco Bay Area Chapter of the American Statistical Association; and DahShu**