The HDFCCC Biostatistics Core is a shared resource providing statistical expertise and collaboration to Cancer Center investigators on all phases of basic science, translational, clinical, epidemiological, and prevention research.
The mission of the Core is to ensure rigorous and efficient planning, conduct, and reporting of research using best practices in biostatistics, and to advance research methodologies via education and innovation.
We support development and review of protocols, grant applications, and other collaborations by providing statistical expertise in the following areas:
Providing statistical expertise on overall study design considerations including formulation of research questions and hypotheses, selection of appropriate sampling scheme and endpoints, sample size and power computation, statistical analysis planning, and randomization. Expertise on adaptive trial design is also provided.
Providing statistical expertise regarding randomization, questionnaire design, variable definition, database structure, interim analysis, resolution of statistical questions as they arise during ongoing studies, and data safety monitoring (through participation in the Data Monitoring Committee).
Data Analysis and Study Results Reporting
Conducting or supervising data analyses, and assisting with interpretation and reporting study results.
Offering formal courses through the Department of Epidemiology and Biostatistics and informal lectures via individual presentations. Topics covered in the informal lectures include:
- Statistical issues in the design/conduct of clinical trials
- Sample size determination
- Interim analyses
- Multiple hypothesis testing
- The role of regression adjustment in analysis of data from clinical trials
Priorities and Utilization Limits
- Funded peer-reviewed studies, peer-reviewed grant applications, investigator-initiated protocols based on discoveries at UCSF
- Investigator-initiated PRC-approved clinical trials, abstracts/manuscripts intended for grant development
- Non-peer-reviewed grants and clinical studies
- Non-funded projects intended for abstracts and manuscripts, non-investigator initiated industry sponsored trials
We also give a high priority to teaching affiliated medical fellows, residents, and post-docs intent on pursuing research careers. Projects are addressed by the priority order on a time-available basis.
Supported by the Cancer Center grant, the Core collaborates on the development of protocols by Cancer Center members and on trainee’s career development work without requiring additional funding. Development of grant applications that include salary support for Core members are also supported without requiring additional funding. In all other cases, efforts will be made to find alternative funds and/or statistical support, for example, those provided by CTSI.