Maurice, Ethel, and Jane Sokolow
Memorial Cancer Endowment Lectureship
Joan S. Brugge, PhD
Chair, Department of Cell Biology, Harvard Medical School
Thursday, December 13, 2012
Medical Grand Rounds, Parnassus, HSW-300, 12:00 noon - 1:00 pm
"Context-Dependent Regulation of Sensitivity to Targeted Therapies For Epithelial Tumors"
Friday, December 14, 2012 3:30 - 4:30 pm >LIVE STREAM WILL BEGIN AT 3:30
Sokolow Lecture, Mission Bay, Genentech Hall, Byers Auditorium
"Control of Cell Migration and Invasion Through Distinct Actin Cytoskeletal Rearrangements"
The Brugge laboratory investigates the cellular processes and pathways involved in normal morphogenesis of epithelial tissues and the initiation and progression of epithelial tumors. Currently, most of their studies involve investigations relating to breast cancer. One of the major approaches that they use to investigate these processes involves culturing breast epithelial cells reconstituted basement membrane gels which allows the cells to organize into 3-dimensional structures that resemble the hollow, spherical glandular units of the breast.
Another major focus is on cellular pathways that regulate the aberrant migration and invasion of tumor cells.
Other studies involve investigations of cellular pathways that control normal differentiation of breast epithelial cells in order to understand the contribution of factors and pathways that regulate these events in tumorigenesis.
>read more about Dr. Joan Brugge and the Brugge Lab
After the deaths of Dr. Sokolow's daughter, Jane, from Burkitt's lymphoma in July 1970, and that of his wife, Ethel, from a breast malignancy the following December, the Ethel and Jane Sokolow Visiting Scientist Program was established at UCSF by their families, classmates, and friends. Upon the death of Maurice Sokolow in 2002, the Fund was renamed as the Maurice, Ethel, and Jane Sokolow Memorial Cancer Endowment Lectureship.
Born in New York, Maurice Sokolow moved to California as a young child with his family, after which he spent seven years in an orphanage following the death of his mother. He attended UCLA and UC-Berkeley with the help of his sister, Josephine Osborne, then worked his way through medical school at UCSF, living at the Laguna Honda Hospital and working there at night. In receiving his medical degree in 1936 he was awarded the Gold Headed Cane, the honor bestowed upon the top graduating medical student.
Maurice Sokolow ("Soke") spent virtually his entire medical career at UCSF, following a residency at New England Medical Center in Boston and a fellowship in cardiology at the Michael Reese Hospital in Chicago. He served in the Navy during World War II, stationed on a hospital ship in Fiji.
During the 1950s, Sokolow was head of the hypertension section at San Francisco General Hospital Medical Center. He earned a reputation as a highly creative researcher and teacher, and became a founding member of the UCSF Cardiovascular Research Institute, merging clinical cardiology with academic and research work. He designed and constructed an ambulatory device to show that blood pressure varied throughout the day. His study also confirmed that blood pressures taken in the clinic setting tended to be higher than ambulatory pressures for the majority of patients. This portable recorder provided a major role in hypertension studies throughout the next decades, including the discovery of "white coat" hypertension, a persistently elevated clinical blood pressure when the patient was being seen by a doctor. Sokolow also developed special expertise in the field of electrocardiography and in treating the complications of rheumatic fever.
Among Sokolow's more than 160 medical publications is the textbook Clinical Cardiology, co-authored with Melvin D. Cheitlin, MD, and Malcolm McIlroy, MD. Now in its 6th edition, the textbook has been translated into seven languages.
Jane Sokolow died in 1970 at the age of 25 of the rare cancer Burkitt's lymphoma, a type of non-Hodgkin's lymphoma. In the U.S., only about 300 new cases of Burkitt's lymphoma are diagnosed each year.
Ethel Schwabacher Sokolow, diagnosed with breast cancer at age 35, was a longtime cancer survivor in an era when few therapeutic options were available, and her resilience continues to serve as an inspiration to her friends and family. An actress, Ethel Sokolow appeared in Woody Allen's "Take the Money and Run" in 1969, the year before she succumbed to metastatic cancer at age 54. Her death followed that of her daughter by five months.
Dr. Maurice Sokolow's own death, 32 years after that of his wife and daughter, was from lymphoma. Surviving members of his family include two daughters, Gail and Anne, and their families. Gail and her husband Marc Goldyne, MD, have two children -- Serena Goldyne Brenner (husband Matthew Brenner, son Eli and daughter, Sophia), and Avi Goldyne (wife Dara). Anne and her husband Peter Levine, MD, have two children, Joshua (wife, Christa) and Sara.