University of California San Francisco
Helen Diller Family Comprehensive Cancer Center

New Model of Breast Cancer's Causes Developed by UCSF-led Team

'Paradigm II' Interactively Illustrates the Complex, Dynamic Relationships Between Causes

By Elizabeth Fernandez | UCSF.edu | July 8, 2020

New Model of Breast Cancer's Causes Developed by UCSF-led Team

The interactive website Paradigm II is available online at https://www.ucop.edu/causes/, the website of the California Breast Cancer Research Program.

A new model of the causes of breast cancer, created by a team led by researchers at UC San Francisco, Genentech and Stanford University, is designed to capture the complex interrelationships between dozens of primary and secondary breast cancer causes and stimulate further research.

Breast cancer is the most common cancer in women, with an estimated 268,600 new cases and 41,760 deaths in the United States in 2019.

“Even though breast cancer can be treated successfully if caught early, we’re looking for the best ways to prevent it in the first place,” said lead author Robert A. Hiatt, MD, PhD, UCSF professor of epidemiology and biostatistics and associate director for population science at the UCSF Helen Diller Family Comprehensive Cancer Center.

“This model weighs what we currently know about the relationships and potential interactions between factors that individual women can control—such as drinking alcohol, hormone replacement therapy and overweight and obesity—and areas of public health policy that affect how people are influenced by social factors,” Hiatt said. “It illustrates the dynamic and sometimes unexpected ways in which the many different causes of breast cancer interact with and influence one another.”

The model, published on July 8, 2020 in Cancer Epidemiology, Biomarkers and Prevention, a journal of the American Association for Cancer Research, includes biological variables such as age, breast density and genetics as well as physical risk factors such as exposure to carcinogenic chemicals, radiation and second-hand smoke.

Robert Hiatt

Robert Hiatt, MD, PhD. Photo by Steve Babuljack

Overall, the model, called Paradigm II, illustrates 96 potential interactions between biological, behavioral, social and physical domains of breast cancer causation.

A dynamic interactive version of Paradigm II is available online at https://www.ucop.edu/causes/, the website of the California Breast Cancer Research Program, which sponsored the study.

Read more at UCSF.edu