Research Summary

I am an advanced heart failure and heart transplant cardiologist who has expertise in the management of patients with heart failure and pulmonary hypertension, heart transplant, and mechanical circulatory support devices. I am co-Director of the UCSF Comprehensive Amyloidosis Program, and the clinical cardiology lead for the UCSF HHT Center of Excellence. In addition to my expertise in heart failure and cardiomyopathies, I developed a specific focus in cardio-oncology (management of cardiovascular issues in cancer patients).

My research interests focus on cardiac amyloidosis and in understanding risk predictors and outcomes of cancer patients with heart disease.

Education

2020 - Diversity, Equity, and Inclusion Champion Training, University of California
Fellowship, 2018 - Advanced Heart Failure/Transplant, University of California
Fellowship, 2017 - Cardiovascular disease, University of California
Residency, 2014 - Internal Medicine, Duke University Medical Center
MD, PhD, 2011 - Medicine, Neurobiology, University of Pittsburgh

Honors & Awards

  • ACC Clinical Excellence in Cardiology Fellowship Award, UCSF, 2016
  • Califf Medicine Resident Research Award, Duke, 2014
  • International Society for Zinc Biology Best Poster Award, 2009
  • International Society for Zinc Biology Best Student Oral Presentation, 2008
  • Summa Cum Laude with Honors, University of Pittsburgh, 2004

Selected Publications

  1. Durstenfeld MS, Peluso MJ, Kaveti P, Hill C, Li D, Sander E, Swaminathan S, Arechiga VM, Lu S, Goldberg SA, Hoh R, Chenna A, Yee BC, Winslow JW, Petropoulos CJ, Kelly JD, Glidden DV, Henrich TJ, Martin JN, Lee YJ, Aras MA, Long CS, Grandis DJ, Deeks SG, Hsue PY. Reduced Exercise Capacity, Chronotropic Incompetence, and Early Systemic Inflammation in Cardiopulmonary Phenotype Long Coronavirus Disease 2019. J Infect Dis. 2023 Aug 31; 228(5):542-554.  View on PubMed
  2. Javid J. Moslehi, Mandar A. Aras, Vivian G. Oehler, James E. Thompson, James K. McCloskey, Michael C. Heinrich, Irene S. DeGutis, Susan Meredith Fish, Michael J. Mauro. Longitudinal, prospective cardiovascular and metabolic risk in treatment-naive patients with chronic myeloid leukemia in chronic phase (CML-CP) starting tyrosine kinase inhibitor (TKI) therapy in a real-world setting. Journal of Clinical Oncology. 2023 Jun 1; 41(16_suppl):7053-7053.  View on PubMed
  3. Durstenfeld MS, Peluso MJ, Spinelli MA, Li D, Hoh R, Gandhi M, Henrich TJ, Aras MA, Long CS, Deeks SG, Hsue PY. Association of SARS-CoV-2 Infection and Cardiopulmonary Long COVID with Exercise Capacity and Chronotropic Incompetence among People with HIV. medRxiv. 2023 May 02.  View on PubMed
  4. Durstenfeld MS, Peluso MJ, Kaveti P, Hill C, Li D, Sander E, Swaminathan S, Arechiga VM, Lu S, Goldberg SA, Hoh R, Chenna A, Yee BC, Winslow JW, Petropoulos CJ, Kelly JD, Glidden DV, Henrich TJ, Martin JN, Lee YJ, Aras MA, Long CS, Grandis DJ, Deeks SG, Hsue PY. Reduced exercise capacity, chronotropic incompetence, and early systemic inflammation in cardiopulmonary phenotype Long COVID. medRxiv. 2023 Mar 21.  View on PubMed
  5. Albert K. Feeny, Joshua Barrios, Sean Abreau, Jeffrey E. Olgin, Mandar Aras, Geoffrey H. Tison. ASSOCIATION BETWEEN ECG-BASED DEEP LEARNING PREDICTION OF PULMONARY HYPERTENSION AND TRANSTHORACIC ECHOCARDIOGRAM ESTIMATION OF PULMONARY ARTERY SYSTOLIC PRESSURE. Journal of the American College of Cardiology. 2023 Mar 1; 81(8):440.  View on PubMed
  6. Kennedy VE, Natsuhara K, Maringanti SA, Shah ND, Arora S, Wolf J, Martin TG, Aras MA, Chung A, Wong SW. Daratumumab Plus Bortezomib and Dexamethasone in Newly Diagnosed Systemic Light Chain Amyloidosis. Curr Probl Cancer. 2023 06; 47(3):100953.  View on PubMed
  7. Aras MA, Abreau S, Mills H, Radhakrishnan L, Klein L, Mantri N, Rubin B, Barrios J, Chehoud C, Kogan E, Gitton X, Nnewihe A, Quinn D, Bridges C, Butte AJ, Olgin JE, Tison GH. Electrocardiogram Detection of Pulmonary Hypertension Using Deep Learning. J Card Fail. 2023 Jul; 29(7):1017-1028.  View on PubMed
  8. Lai M, Aras MA, Park M. Post-transplant ejection fraction and renal failure in cardiac transplant recipients: An analysis of the OPTN database. Clin Transplant. 2023 02; 37(2):e14881.  View on PubMed
  9. Benza RL, Franco V, Aras MA, Spikes L, Grinnan D, Satler C. Safety and efficacy of RT234 vardenafil inhalation powder on exercise parameters in pulmonary arterial hypertension: phase II, dose-escalation study design. Respir Res. 2022 Dec 17; 23(1):355.  View on PubMed
  10. Matthew S Durstenfeld, Michael J Peluso, Punita Kaveti, Christopher Hill, Danny Li, Erica Sander, Shreya Swaminathan, Victor M Arechiga, Kaiwen Sun, Yifei Ma, victor zepeda, Scott Lu, Sarah A Goldberg, Rebecca Hoh, Ahmed Chenna, Brandon C Yee, JOhn W Winslow, christos J petropoulos, Sithu Win, JOHN D KELLY, David V Glidden, Timothy J Henrich, Jeffrey N Martin, Yoo Jin Lee, Mandar A Aras, Carlin S Long, Donald J Grandis, Steven G Deeks, Priscilla Y Hsue. Abstract 10570: Inflammation During Early Post-Acute Covid-19 is Associated With Reduced Exercise Capacity and Long Covid Symptoms After 1 Year. Circulation. 2022 Nov 8; 146(Suppl_1):a10570-a10570.  View on PubMed
  11. Durstenfeld MS, Sun K, Tahir P, Peluso MJ, Deeks SG, Aras MA, Grandis DJ, Long CS, Beatty A, Hsue PY. Use of Cardiopulmonary Exercise Testing to Evaluate Long COVID-19 Symptoms in Adults: A Systematic Review and Meta-analysis. JAMA Netw Open. 2022 10 03; 5(10):e2236057.  View on PubMed
  12. Nowatzke J, Guedeney P, Palaskas N, Lehmann L, Ederhy S, Zhu H, Cautela J, Francis S, Courand PY, Deswal A, Ewer SM, Aras M, Arangalage D, Ghafourian K, Fenioux C, Finke D, Peretto G, Zaha V, Itzhaki Ben Zadok O, Tajiri K, Akhter N, Levenson J, Baldassarre L, Power J, Huang S, Collet JP, Moslehi J, Salem JE, International ICI-myocarditis registry contributors. Coronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: Report from an international registry. Eur J Cancer. 2022 12; 177:197-205.  View on PubMed
  13. Durstenfeld MS, Sun K, Tahir PM, Peluso MJ, Deeks SG, Aras MA, Grandis DJ, Long CS, Beatty A, Hsue PY. Cardiopulmonary exercise testing to evaluate post-acute sequelae of COVID-19 ("Long COVID"): a systematic review and meta-analysis. medRxiv. 2022 Jun 16.  View on PubMed
  14. Power JR, Alexandre J, Choudhary A, Ozbay B, Hayek SS, Asnani A, Tamura Y, Aras M, Cautela J, Thuny F, Gilstrap L, Arangalage D, Ewer S, Huang S, Deswal A, Palaskas NL, Finke D, Lehmann LH, Ederhy S, Moslehi J, Salem JE, International ICI-Myocarditis Registry. Association of early electrical changes with cardiovascular outcomes in immune checkpoint inhibitor myocarditis. Arch Cardiovasc Dis. 2022 May; 115(5):315-330.  View on PubMed
  15. Andrew Hughes, John Power, Olusola A. Orimoloye, Joseph F. Nowatzke, Yuichi Tamura, Mandar Aras, Aarti Asnani, Pierre-Yves Courand, Roberta Florido, Salim Hayek, Vlad Gabriel Zaha, Anita Deswal, Javid Moslehi, Nicolas L. Palaskas. CLINICAL SIGNIFICANCE OF PERICARDIAL EFFUSION IN PATIENTS HOSPITALIZED WITH IMMUNE CHECKPOINT INHIBITOR ASSOCIATED MYOCARDITIS. Journal of the American College of Cardiology. 2022 Mar 1; 79(9):1916.  View on PubMed
  16. Ahmad Masri, Mandar Aras, Rodney H. Falk, Martha Grogan, Daniel Jacoby, Daniel P. Judge, Sanjiv Jayendra Shah, Ronald Witteles, Alan X. Ji, Paul W. Wong, Xiaofan Cao, Rebecca Vanlandingham, Leonid Katz, Uma Sinha, Jonathan C. Fox, Mathew S. Maurer. LONG-TERM SAFETY AND TOLERABILITY OF ACORAMIDIS (AG10) IN SYMPTOMATIC TRANSTHYRETIN AMYLOID CARDIOMYOPATHY: UPDATED ANALYSIS FROM AN ONGOING PHASE 2 OPEN-LABEL EXTENSION STUDY. Journal of the American College of Cardiology. 2022 Mar 1; 79(9):227.  View on PubMed
  17. Banerjee R, Lo M, Klein L, Aras M, Logan AC. Anthracyclines in a patient with acute leukemia and severe cardiomyopathy requiring mechanical support: A case report. J Oncol Pharm Pract. 2022 Apr; 28(3):729-732.  View on PubMed
  18. Lehmann LH, Cautela J, Palaskas N, Baik AH, Meijers WC, Allenbach Y, Alexandre J, Rassaf T, Müller OJ, Aras M, Asnani AH, Deswal A, Laufer-Perl M, Thuny F, Kerneis M, Hayek SS, Ederhy S, Salem JE, Moslehi JJ. Clinical Strategy for the Diagnosis and Treatment of Immune Checkpoint Inhibitor-Associated Myocarditis: A Narrative Review. JAMA Cardiol. 2021 11 01; 6(11):1329-1337.  View on PubMed
  19. Power JR, Alexandre J, Choudhary A, Ozbay B, Hayek S, Asnani A, Tamura Y, Aras M, Cautela J, Thuny F, Gilstrap L, Arangalage D, Ewer S, Huang S, Deswal A, Palaskas NL, Finke D, Lehman L, Ederhy S, Moslehi J, Salem JE, International ICI-Myocarditis Registry†. Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Myocarditis. Circulation. 2021 11 02; 144(18):1521-1523.  View on PubMed
  20. Olusola Orimoloye, John R. Power, Joseph Nowatzke, Andrew M. Hughes, Lorenz Lehmann, Jennifer Cautela, Mandar Aras, Alison Weppler, Anna Narezkina, Giovanni Peretto, Michal Pela, Shanthini M. Crusz, Aarti Asnani, Joe-Elie Salem, Anita Deswal, Nicolas Palaskas, Javid Moslehi. ECHOCARDIOGRAPHIC FEATURES OF IMMUNE CHECKPOINT INHIBITOR ASSOCIATED MYOCARDITIS AND THEIR ASSOCIATION WITH ADVERSE OUTCOMES. Journal of the American College of Cardiology. 2021 May 1; 77(18):3336.  View on PubMed

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