University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Arturo Alvarez-Buylla, PhD

Arturo Alvarez-Buylla, PhD

Professor, Department of Neurological Surgery, UCSF
Heather and Melanie Muss Endowed Chair, UCSF

Cancer Center Program Memberships

Neurologic Oncology

Education

Physics, 1977-1978, Queens University, Kingston, Canada
UNAM, Mexico City, Licenciado, 1983, Bio-Medicine
Rockefeller University, Ph.D., 1988, Neurobiology
Rockefeller University, Postdoc, 1988-1989, Neurobiology
 


Professional Experience

  • 1983-1988
    Ph.D., Rockefeller University, New York
  • 1988-1989
    Postdoctoral Fellow, Rockefeller University
  • 1989-1992
    Assistant Professor, Rockefeller University
  • 1992-1994
    Assistant Professor/Head of Laboratory, Rockefeller University
  • 1994-2000
    Associate Professor/Head of Laboratory, Rockefeller University
  • 2000-2001
    Professor Neurological Surgery, University of California, San Francisco
  • 2001-present
    Heather and Melanie Muss Endowed Chair, Department of Neurosurgery, UCSF
  • 2000-2008
    Professor, Biomedical Sciences, Anatomy, UCSF

Honors & Awards

  • 1983
    Medal Gavino Barreda -- Universidad Nacional Autonoma de Mexico
  • 1990
    First Award, The origin of new neurons in the adult avian brain
  • 1992
    Sinsheimer Award
  • 1994
    NIH-RO1 HD32116-01
  • 2000
    Jacob Javits Award, 2000/NIH Grant RO1 NS28478
  • 2001
    Brain Tumor Society. Are neural stem cells a source of brain tumors?
  • 2003
    NIH R01 HD032116-09. Origins of new neurons and glia in the postnatal brain
  • 2004
    Goldhirsh Foundation. Brain Tumor Research Grant 7/1/04 - 6/30/08.
  • 2006
    Catedra Santiago Grisolía, Spain. Lecture and Award
  • 2006
    "Académico Correspondiente Extranjero”. Real Academia de Ciencias Exactas, Físicas y Naturales. Spain
  • 2007
    Catedra Ramón y Cajal, Sociedad Española de Neurología, Spain
  • 2011
    Prince of Asturias Award for Technical and Scientific Research, Fundacíon Príncipe de Asturias, Spain. (Shared with Dr. Joseph Altman and Giacomo Rizzolatti)
  • 2012
    NICH; NIH Merit award
  • 2013
    American Academy of Arts and Sciences
  • 2013
    Catedra de Excelencia Banco de Santander, Pompeu Fabra University, Barcelona,
  • 2014
    New York University, Honors Lecture, New York
  • 2014
    Honorary Segerfalk Lecture Award/ Annual Neuroscience Day, Lund University, Sweden,
  • 2016
    Scientific Council of P.K. Anokhin Research Institute of Normal Physiology, Pentennial Medal
  • 2017
    60th annual Faculty Research Lectureship (FRL) in Basic Science

Selected Publications

  1. Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. 2018 Mar 15; 555(7696):377-381.
    View on PubMed
  2. Priya R, Paredes MF, Karayannis T, Yusuf N, Liu X, Jaglin X, Graef I, Alvarez-Buylla A, Fishell G. Activity Regulates Cell Death within Cortical Interneurons through a Calcineurin-Dependent Mechanism. Cell Rep. 2018 Feb 13; 22(7):1695-1709.
    View on PubMed
  3. Li J, Wang C, Zhang Z, Wen Y, An L, Liang Q, Xu Z, Wei S, Li W, Guo T, Liu G, Tao G, You Y, Du H, Fu Z, He M, Chen B, Campbell K, Alvarez-Buylla A, Rubenstein JL, Yang Z. Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development. Cereb Cortex. 2017 Aug 01; 1-17.
    View on PubMed
  4. Cebrián-Silla A, Alfaro-Cervelló C, Herranz-Pérez V, Kaneko N, Park DH, Sawamoto K, Alvarez-Buylla A, Lim DA, García-Verdugo JM. Unique Organization of the Nuclear Envelope in the Post-natal Quiescent Neural Stem Cells. Stem Cell Reports. 2017 Jul 11; 9(1):203-216.
    View on PubMed
  5. Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW. Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier. Cell Rep. 2017 Jun 13; 19(11):2257-2271.
    View on PubMed
  6. Larimer P, Spatazza J, Stryker MP, Alvarez-Buylla A, Hasenstaub AR. Development and long-term integration of MGE-lineage cortical interneurons in the heterochronic environment. J Neurophysiol. 2017 Jul 01; 118(1):131-139.
    View on PubMed
  7. Spatazza J, Mancia Leon WR, Alvarez-Buylla A. Transplantation of GABAergic interneurons for cell-based therapy. Prog Brain Res. 2017; 231:57-85.
    View on PubMed
  8. Mirzadeh Z, Kusne Y, Duran-Moreno M, Cabrales E, Gil-Perotin S, Ortiz C, Chen B, Garcia-Verdugo JM, Sanai N, Alvarez-Buylla A. Bi- and uniciliated ependymal cells define continuous floor-plate-derived tanycytic territories. Nat Commun. 2017 Jan 09; 8:13759.
    View on PubMed
  9. Paredes MF, James D, Gil-Perotin S, Kim H, Cotter JA, Ng C, Sandoval K, Rowitch DH, Xu D, McQuillen PS, Garcia-Verdugo JM, Huang EJ, Alvarez-Buylla A. Extensive migration of young neurons into the infant human frontal lobe. Science. 2016 Oct 07; 354(6308).
    View on PubMed
  10. Larimer P, Spatazza J, Espinosa JS, Tang Y, Kaneko M, Hasenstaub AR, Stryker MP, Alvarez-Buylla A. Caudal Ganglionic Eminence Precursor Transplants Disperse and Integrate as Lineage-Specific Interneurons but Do Not Induce Cortical Plasticity. Cell Rep. 2016 08 02; 16(5):1391-1404.
    View on PubMed
  11. Ohata S, Alvarez-Buylla A. Planar Organization of Multiciliated Ependymal (E1) Cells in the Brain Ventricular Epithelium. Trends Neurosci. 2016 08; 39(8):543-551.
    View on PubMed
  12. Lindquist RA, Guinto CD, Rodas-Rodriguez JL, Fuentealba LC, Tate MC, Rowitch DH, Alvarez-Buylla A. Identification of proliferative progenitors associated with prominent postnatal growth of the pons. Nat Commun. 2016 May 18; 7:11628.
    View on PubMed
  13. Lim DA, Alvarez-Buylla A. The Adult Ventricular-Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis. Cold Spring Harb Perspect Biol. 2016 May 02; 8(5).
    View on PubMed
  14. Paredes MF, Sorrells SF, Garcia-Verdugo JM, Alvarez-Buylla A. Brain size and limits to adult neurogenesis. J Comp Neurol. 2016 Feb 15; 524(3):646-64.
    View on PubMed
  15. Tong CK, Fuentealba LC, Shah JK, Lindquist RA, Ihrie RA, Guinto CD, Rodas-Rodriguez JL, Alvarez-Buylla A. A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain. Stem Cell Reports. 2015 Oct 13; 5(4):461-70.
    View on PubMed
  16. Harwell CC, Fuentealba LC, Gonzalez-Cerrillo A, Parker PR, Gertz CC, Mazzola E, Garcia MT, Alvarez-Buylla A, Cepko CL, Kriegstein AR. Wide Dispersion and Diversity of Clonally Related Inhibitory Interneurons. Neuron. 2015 Sep 02; 87(5):999-1007.
    View on PubMed
  17. Fuentealba LC, Rompani SB, Parraguez JI, Obernier K, Romero R, Cepko CL, Alvarez-Buylla A. Embryonic Origin of Postnatal Neural Stem Cells. Cell. 2015 Jun 18; 161(7):1644-55.
    View on PubMed
  18. Vogt D, Wu PR, Sorrells SF, Arnold C, Alvarez-Buylla A, Rubenstein JL. Viral-mediated Labeling and Transplantation of Medial Ganglionic Eminence (MGE) Cells for In Vivo Studies. J Vis Exp. 2015 Apr 23; (98).
    View on PubMed
  19. Fu Y, Kaneko M, Tang Y, Alvarez-Buylla A, Stryker MP. A cortical disinhibitory circuit for enhancing adult plasticity. Elife. 2015 Jan 27; 4:e05558.
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  20. Tang Y, Stryker MP, Alvarez-Buylla A, Espinosa JS. Cortical plasticity induced by transplantation of embryonic somatostatin or parvalbumin interneurons. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18339-44.
    View on PubMed

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