University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Arturo Alvarez-Buylla, PhD

Arturo Alvarez-Buylla, PhD

Professor, Department of Neurological Surgery, UCSF
Heather and Melanie Muss Endowed Chair, UCSF

Cancer Center Program Memberships

Neurologic Oncology

Education

Physics, 1977-1978, Queens University, Kingston, Canada
UNAM, Mexico City, Licenciado, 1983, Bio-Medicine
Rockefeller University, Ph.D., 1988, Neurobiology
Rockefeller University, Postdoc, 1988-1989, Neurobiology
 


Professional Experience

  • 1983-1988
    Ph.D., Rockefeller University, New York
  • 1988-1989
    Postdoctoral Fellow, Rockefeller University
  • 1989-1992
    Assistant Professor, Rockefeller University
  • 1992-1994
    Assistant Professor/Head of Laboratory, Rockefeller University
  • 1994-2000
    Associate Professor/Head of Laboratory, Rockefeller University
  • 2000-2001
    Professor Neurological Surgery, University of California, San Francisco
  • 2001-present
    Heather and Melanie Muss Endowed Chair, Department of Neurosurgery, UCSF
  • 2000-2008
    Professor, Biomedical Sciences, Anatomy, UCSF

Honors & Awards

  • 1983
    Medal Gavino Barreda -- Universidad Nacional Autonoma de Mexico
  • 1990
    First Award, The origin of new neurons in the adult avian brain
  • 1992
    Sinsheimer Award
  • 1994
    NIH-RO1 HD32116-01
  • 2000
    Jacob Javits Award, 2000/NIH Grant RO1 NS28478
  • 2001
    Brain Tumor Society. Are neural stem cells a source of brain tumors?
  • 2003
    NIH R01 HD032116-09. Origins of new neurons and glia in the postnatal brain
  • 2004
    Goldhirsh Foundation. Brain Tumor Research Grant 7/1/04 - 6/30/08.
  • 2006
    Catedra Santiago Grisolía, Spain. Lecture and Award
  • 2006
    "Académico Correspondiente Extranjero”. Real Academia de Ciencias Exactas, Físicas y Naturales. Spain
  • 2007
    Catedra Ramón y Cajal, Sociedad Española de Neurología, Spain
  • 2011
    Prince of Asturias Award for Technical and Scientific Research, Fundacíon Príncipe de Asturias, Spain. (Shared with Dr. Joseph Altman and Giacomo Rizzolatti)
  • 2012
    NICH; NIH Merit award
  • 2013
    American Academy of Arts and Sciences
  • 2013
    Catedra de Excelencia Banco de Santander, Pompeu Fabra University, Barcelona,
  • 2014
    New York University, Honors Lecture, New York
  • 2014
    Honorary Segerfalk Lecture Award/ Annual Neuroscience Day, Lund University, Sweden,
  • 2016
    Scientific Council of P.K. Anokhin Research Institute of Normal Physiology, Pentennial Medal
  • 2017
    60th annual Faculty Research Lectureship (FRL) in Basic Science

Selected Publications

  1. Hoseini MS, Rakela B, Flores-Ramirez Q, Hasenstaub AR, Alvarez-Buylla A, Stryker MP. Transplanted cells are essential for the induction but not the expression of cortical plasticity. J Neurosci. 2019 Aug 07.
    View on PubMed
  2. Sorrells SF, Paredes MF, Velmeshev D, Herranz-Pérez V, Sandoval K, Mayer S, Chang EF, Insausti R, Kriegstein AR, Rubenstein JL, Manuel Garcia-Verdugo J, Huang EJ, Alvarez-Buylla A. Immature excitatory neurons develop during adolescence in the human amygdala. Nat Commun. 2019 06 21; 10(1):2748.
    View on PubMed
  3. Redmond SA, Figueres-Oñate M, Obernier K, Nascimento MA, Parraguez JI, López-Mascaraque L, Fuentealba LC, Alvarez-Buylla A. Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor. Cell Rep. 2019 Apr 09; 27(2):429-441.e3.
    View on PubMed
  4. Obernier K, Alvarez-Buylla A. Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain. Development. 2019 Feb 18; 146(4).
    View on PubMed
  5. Mayer S, Chen J, Velmeshev D, Mayer A, Eze UC, Bhaduri A, Cunha CE, Jung D, Arjun A, Li E, Alvarado B, Wang S, Lovegren N, Gonzales ML, Szpankowski L, Leyrat A, West JAA, Panagiotakos G, Alvarez-Buylla A, Paredes MF, Nowakowski TJ, Pollen AA, Kriegstein AR. Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex. Neuron. 2019 Apr 03; 102(1):143-158.e7.
    View on PubMed
  6. Priya R, Rakela B, Kaneko M, Spatazza J, Larimer P, Hoseini MS, Hasenstaub AR, Alvarez-Buylla A, Stryker MP. Vesicular GABA Transporter Is Necessary for Transplant-Induced Critical Period Plasticity in Mouse Visual Cortex. J Neurosci. 2019 Apr 03; 39(14):2635-2648.
    View on PubMed
  7. Paredes MF, Sorrells SF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez Martin AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A. Does Adult Neurogenesis Persist in the Human Hippocampus? Cell Stem Cell. 2018 Dec 06; 23(6):780-781.
    View on PubMed
  8. Barnes JM, Kaushik S, Bainer RO, Sa JK, Woods EC, Kai F, Przybyla L, Lee M, Lee HW, Tung JC, Maller O, Barrett AS, Lu KV, Lakins JN, Hansen KC, Obernier K, Alvarez-Buylla A, Bergers G, Phillips JJ, Nam DH, Bertozzi CR, Weaver VM. A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma. Nat Cell Biol. 2018 10; 20(10):1203-1214.
    View on PubMed
  9. Li J, Wang C, Zhang Z, Wen Y, An L, Liang Q, Xu Z, Wei S, Li W, Guo T, Liu G, Tao G, You Y, Du H, Fu Z, He M, Chen B, Campbell K, Alvarez-Buylla A, Rubenstein JL, Yang Z. Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development. Cereb Cortex. 2018 Sep 01; 28(9):3278-3294.
    View on PubMed
  10. Raju CS, Spatazza J, Stanco A, Larimer P, Sorrells SF, Kelley KW, Nicholas CR, Paredes MF, Lui JH, Hasenstaub AR, Kriegstein AR, Alvarez-Buylla A, Rubenstein JL, Oldham MC. Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity. Cereb Cortex. 2018 Jun 01; 28(6):1946-1958.
    View on PubMed
  11. Griveau A, Seano G, Shelton SJ, Kupp R, Jahangiri A, Obernier K, Krishnan S, Lindberg OR, Yuen TJ, Tien AC, Sabo JK, Wang N, Chen I, Kloepper J, Larrouquere L, Ghosh M, Tirosh I, Huillard E, Alvarez-Buylla A, Oldham MC, Persson AI, Weiss WA, Batchelor TT, Stemmer-Rachamimov A, Suvà ML, Phillips JJ, Aghi MK, Mehta S, Jain RK, Rowitch DH. A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment. Cancer Cell. 2018 05 14; 33(5):874-889.e7.
    View on PubMed
  12. Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. 2018 03 15; 555(7696):377-381.
    View on PubMed
  13. Priya R, Paredes MF, Karayannis T, Yusuf N, Liu X, Jaglin X, Graef I, Alvarez-Buylla A, Fishell G. Activity Regulates Cell Death within Cortical Interneurons through a Calcineurin-Dependent Mechanism. Cell Rep. 2018 02 13; 22(7):1695-1709.
    View on PubMed
  14. Obernier K, Cebrian-Silla A, Thomson M, Parraguez JI, Anderson R, Guinto C, Rodas Rodriguez J, Garcia-Verdugo JM, Alvarez-Buylla A. Adult Neurogenesis Is Sustained by Symmetric Self-Renewal and Differentiation. Cell Stem Cell. 2018 02 01; 22(2):221-234.e8.
    View on PubMed
  15. Cebrián-Silla A, Alfaro-Cervelló C, Herranz-Pérez V, Kaneko N, Park DH, Sawamoto K, Alvarez-Buylla A, Lim DA, García-Verdugo JM. Unique Organization of the Nuclear Envelope in the Post-natal Quiescent Neural Stem Cells. Stem Cell Reports. 2017 07 11; 9(1):203-216.
    View on PubMed
  16. Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW. Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier. Cell Rep. 2017 06 13; 19(11):2257-2271.
    View on PubMed
  17. Larimer P, Spatazza J, Stryker MP, Alvarez-Buylla A, Hasenstaub AR. Development and long-term integration of MGE-lineage cortical interneurons in the heterochronic environment. J Neurophysiol. 2017 Jul 01; 118(1):131-139.
    View on PubMed
  18. Spatazza J, Mancia Leon WR, Alvarez-Buylla A. Transplantation of GABAergic interneurons for cell-based therapy. Prog Brain Res. 2017; 231:57-85.
    View on PubMed
  19. Mirzadeh Z, Kusne Y, Duran-Moreno M, Cabrales E, Gil-Perotin S, Ortiz C, Chen B, Garcia-Verdugo JM, Sanai N, Alvarez-Buylla A. Bi- and uniciliated ependymal cells define continuous floor-plate-derived tanycytic territories. Nat Commun. 2017 01 09; 8:13759.
    View on PubMed
  20. Paredes MF, James D, Gil-Perotin S, Kim H, Cotter JA, Ng C, Sandoval K, Rowitch DH, Xu D, McQuillen PS, Garcia-Verdugo JM, Huang EJ, Alvarez-Buylla A. Extensive migration of young neurons into the infant human frontal lobe. Science. 2016 Oct 07; 354(6308).
    View on PubMed

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