University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Daniel Lim, MD, PhD

Daniel Lim, MD, PhD

Associate Professor of Neurological Surgery, UCSF

Cancer Center Program Memberships

Neurologic Oncology

Education

  • University of California, Berkeley, B.A., 05/1994, Biochemistry
  • The Rockefeller University, Ph.D., 06/2001, Neurobiology
  • Cornell Medical College, M.D., 06/2002, Medicine
  • University of California, San Francisco, Postdoctoral, 06/2007, Epigenetics/Stem cells
  • University of California, San Francisco, Residency, 06/2008, Neurological Surgery

Professional Experience

  • 2008-2015
    Assistant Professor, UCSF
  • 2008-present
    Staff Neurosurgeon, Veteran’s Affairs Medical Center, San Francisco
  • 2008-present
    Faculty, Biomedical Sciences Graduate School Program (BMS), UCSF
  • 2008-present
    Faculty, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCSF
  • 2008-present
    Director, Restorative Neurosurgery, Dept. of Neurological Surgery, UCSF
  • 2015-present
    Associate Professor, UCSF

Honors & Awards

  • 1990
    National Merit scholarship
  • 1990-1994
    University of California, Regent’s scholarship
  • 2009-2013
    Sontag Foundation Distinguished Researcher Award
  • 2009-2014
    NIH Director’s New Innovator Award
  • 2010
    Kavli Fellow, U.S. National Academy of Sciences

Selected Publications

  1. Cebrián-Silla A, Alfaro-Cervelló C, Herranz-Pérez V, Kaneko N, Park DH, Sawamoto K, Alvarez-Buylla A, Lim DA, García-Verdugo JM. Unique Organization of the Nuclear Envelope in the Post-natal Quiescent Neural Stem Cells. Stem Cell Reports. 2017 Jul 11; 9(1):203-216.
    View on PubMed
  2. Rolston JD, Lim DA. In Reply: Thalamotomy-Like Effects from Partial Removal of a Ventral Intermediate Nucleus Deep Brain Stimulator Lead in a Patient With Essential Tremor. Neurosurgery. 2017 May 01; 80(5):E256.
    View on PubMed
  3. Liu SJ, Horlbeck MA, Cho SW, Birk HS, Malatesta M, He D, Attenello FJ, Villalta JE, Cho MY, Chen Y, Mandegar MA, Olvera MP, Gilbert LA, Conklin BR, Chang HY, Weissman JS, Lim DA. CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells. Science. 2017 01 06; 355(6320).
    View on PubMed
  4. Müller S, Liu SJ, Di Lullo E, Malatesta M, Pollen AA, Nowakowski TJ, Kohanbash G, Aghi M, Kriegstein AR, Lim DA, Diaz A. Single-cell sequencing maps gene expression to mutational phylogenies in PDGF- and EGF-driven gliomas. Mol Syst Biol. 2016 Nov 25; 12(11):889.
    View on PubMed
  5. Cohen-Pfeffer JL, Gururangan S, Lester T, Lim DA, Shaywitz AJ, Westphal M, Slavc I. Intracerebroventricular Delivery as a Safe, Long-Term Route of Drug Administration. Pediatr Neurol. 2017 Feb; 67:23-35.
    View on PubMed
  6. Delgado RN, Lu C, Lim DA. Maintenance of neural stem cell regional identity in culture. Neurogenesis (Austin). 2016; 3(1):e1187321.
    View on PubMed
  7. Lim DA, Alvarez-Buylla A. The Adult Ventricular-Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis. Cold Spring Harb Perspect Biol. 2016 May 02; 8(5).
    View on PubMed
  8. Diaz A, Liu SJ, Sandoval C, Pollen A, Nowakowski TJ, Lim DA, Kriegstein A. SCell: integrated analysis of single-cell RNA-seq data. Bioinformatics. 2016 Jul 15; 32(14):2219-20.
    View on PubMed
  9. Liu SJ, Nowakowski TJ, Pollen AA, Lui JH, Horlbeck MA, Attenello FJ, He D, Weissman JS, Kriegstein AR, Diaz AA, Lim DA. Single-cell analysis of long non-coding RNAs in the developing human neocortex. Genome Biol. 2016 Apr 14; 17:67.
    View on PubMed
  10. Rowland NC, Kalia SK, Kalia LV, Larson PS, Lim DA, Bankiewicz KS. Merging DBS with viral vector or stem cell implantation: "hybrid" stereotactic surgery as an evolution in the surgical treatment of Parkinson's disease. Mol Ther Methods Clin Dev. 2016; 3:15051.
    View on PubMed
  11. Ramos AD, Attenello FJ, Lim DA. Uncovering the roles of long noncoding RNAs in neural development and glioma progression. Neurosci Lett. 2016 Jun 20; 625:70-9.
    View on PubMed
  12. Rolston JD, Ramos AD, Heath S, Englot DJ, Lim DA. Thalamotomy-Like Effects From Partial Removal of a Ventral Intermediate Nucleus Deep Brain Stimulator Lead in a Patient With Essential Tremor: Case Report. Neurosurgery. 2015 Nov; 77(5):E831-6; discussion E836-7.
    View on PubMed
  13. Pollen AA, Nowakowski TJ, Chen J, Retallack H, Sandoval-Espinosa C, Nicholas CR, Shuga J, Liu SJ, Oldham MC, Diaz A, Lim DA, Leyrat AA, West JA, Kriegstein AR. Molecular identity of human outer radial glia during cortical development. Cell. 2015 Sep 24; 163(1):55-67.
    View on PubMed
  14. Delgado RN, Lim DA. Embryonic Nkx2.1-expressing neural precursor cells contribute to the regional heterogeneity of adult V-SVZ neural stem cells. Dev Biol. 2015 Nov 15; 407(2):265-74.
    View on PubMed
  15. Lim DA. Transcriptional and epigenetic insights from stem cells and developing tissues. Development. 2015 Aug 01; 142(15):2549-53.
    View on PubMed
  16. Ramos AD, Andersen RE, Liu SJ, Nowakowski TJ, Hong SJ, Gertz C, Salinas RD, Zarabi H, Kriegstein AR, Lim DA. The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells. Cell Stem Cell. 2015 Apr 02; 16(4):439-447.
    View on PubMed
  17. Rowland NC, Starr PA, Larson PS, Ostrem JL, Marks WJ, Lim DA. Combining cell transplants or gene therapy with deep brain stimulation for Parkinson's disease. Mov Disord. 2015 Feb; 30(2):190-5.
    View on PubMed
  18. Potts MB, Siu JJ, Price JD, Salinas RD, Cho MJ, Ramos AD, Hahn J, Margeta M, Oldham MC, Lim DA. Analysis of Mll1 deficiency identifies neurogenic transcriptional modules and Brn4 as a factor for direct astrocyte-to-neuron reprogramming. Neurosurgery. 2014 Oct; 75(4):472-82; discussion 482.
    View on PubMed
  19. Lim DA, Alvarez-Buylla A. Adult neural stem cells stake their ground. Trends Neurosci. 2014 Oct; 37(10):563-71.
    View on PubMed
  20. Price JD, Park KY, Chen J, Salinas RD, Cho MJ, Kriegstein AR, Lim DA. The Ink4a/Arf locus is a barrier to direct neuronal transdifferentiation. J Neurosci. 2014 Sep 10; 34(37):12560-7.
    View on PubMed

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