University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Daniel Lim, MD, PhD

Daniel Lim, MD, PhD

Associate Professor of Neurological Surgery, UCSF

Cancer Center Program Memberships

Neurologic Oncology

Education

  • University of California, Berkeley, B.A., 05/1994, Biochemistry
  • The Rockefeller University, Ph.D., 06/2001, Neurobiology
  • Cornell Medical College, M.D., 06/2002, Medicine
  • University of California, San Francisco, Postdoctoral, 06/2007, Epigenetics/Stem cells
  • University of California, San Francisco, Residency, 06/2008, Neurological Surgery

Professional Experience

  • 2008-2015
    Assistant Professor, UCSF
  • 2008-present
    Staff Neurosurgeon, Veteran’s Affairs Medical Center, San Francisco
  • 2008-present
    Faculty, Biomedical Sciences Graduate School Program (BMS), UCSF
  • 2008-present
    Faculty, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCSF
  • 2008-present
    Director, Restorative Neurosurgery, Dept. of Neurological Surgery, UCSF
  • 2015-present
    Associate Professor, UCSF

Honors & Awards

  • 1990
    National Merit scholarship
  • 1990-1994
    University of California, Regent’s scholarship
  • 2009-2013
    Sontag Foundation Distinguished Researcher Award
  • 2009-2014
    NIH Director’s New Innovator Award
  • 2010
    Kavli Fellow, U.S. National Academy of Sciences

Selected Publications

  1. Slavc I, Cohen-Pfeffer JL, Gururangan S, Krauser J, Lim DA, Maldaun M, Schwering C, Shaywitz AJ, Westphal M. Best practices for the use of intracerebroventricular drug delivery devices. Mol Genet Metab. 2018 May 16.
    View on PubMed
  2. Cho SW, Xu J, Sun R, Mumbach MR, Carter AC, Chen YG, Yost KE, Kim J, He J, Nevins SA, Chin SF, Caldas C, Liu SJ, Horlbeck MA, Lim DA, Weissman JS, Curtis C, Chang HY. Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element. Cell. 2018 Apr 25.
    View on PubMed
  3. Müller S, Kohanbash G, Liu SJ, Alvarado B, Carrera D, Bhaduri A, Watchmaker PB, Yagnik G, Di Lullo E, Malatesta M, Amankulor NM, Kriegstein AR, Lim DA, Aghi M, Okada H, Diaz A. Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment. Genome Biol. 2017 Dec 20; 18(1):234.
    View on PubMed
  4. Nowakowski TJ, Bhaduri A, Pollen AA, Alvarado B, Mostajo-Radji MA, Di Lullo E, Haeussler M, Sandoval-Espinosa C, Liu SJ, Velmeshev D, Ounadjela JR, Shuga J, Wang X, Lim DA, West JA, Leyrat AA, Kent WJ, Kriegstein AR. Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex. Science. 2017 12 08; 358(6368):1318-1323.
    View on PubMed
  5. Delgado RN, Lim DA. Maintenance of Positional Identity of Neural Progenitors in the Embryonic and Postnatal Telencephalon. Front Mol Neurosci. 2017; 10:373.
    View on PubMed
  6. Andersen RE, Lim DA. Forging our understanding of lncRNAs in the brain. Cell Tissue Res. 2018 01; 371(1):55-71.
    View on PubMed
  7. Cebrián-Silla A, Alfaro-Cervelló C, Herranz-Pérez V, Kaneko N, Park DH, Sawamoto K, Alvarez-Buylla A, Lim DA, García-Verdugo JM. Unique Organization of the Nuclear Envelope in the Post-natal Quiescent Neural Stem Cells. Stem Cell Reports. 2017 Jul 11; 9(1):203-216.
    View on PubMed
  8. Gittleman H, Lim D, Kattan MW, Chakravarti A, Gilbert MR, Lassman AB, Lo SS, Machtay M, Sloan AE, Sulman EP, Tian D, Vogelbaum MA, Wang TJC, Penas-Prado M, Youssef E, Blumenthal DT, Zhang P, Mehta MP, Barnholtz-Sloan JS. An independently validated nomogram for individualized estimation of survival among patients with newly diagnosed glioblastoma: NRG Oncology RTOG 0525 and 0825. Neuro Oncol. 2017 05 01; 19(5):669-677.
    View on PubMed
  9. Rolston JD, Lim DA. In Reply: Thalamotomy-Like Effects from Partial Removal of a Ventral Intermediate Nucleus Deep Brain Stimulator Lead in a Patient With Essential Tremor. Neurosurgery. 2017 May 01; 80(5):E256.
    View on PubMed
  10. Liu SJ, Horlbeck MA, Cho SW, Birk HS, Malatesta M, He D, Attenello FJ, Villalta JE, Cho MY, Chen Y, Mandegar MA, Olvera MP, Gilbert LA, Conklin BR, Chang HY, Weissman JS, Lim DA. CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells. Science. 2017 01 06; 355(6320).
    View on PubMed
  11. Müller S, Liu SJ, Di Lullo E, Malatesta M, Pollen AA, Nowakowski TJ, Kohanbash G, Aghi M, Kriegstein AR, Lim DA, Diaz A. Single-cell sequencing maps gene expression to mutational phylogenies in PDGF- and EGF-driven gliomas. Mol Syst Biol. 2016 Nov 25; 12(11):889.
    View on PubMed
  12. Cohen-Pfeffer JL, Gururangan S, Lester T, Lim DA, Shaywitz AJ, Westphal M, Slavc I. Intracerebroventricular Delivery as a Safe, Long-Term Route of Drug Administration. Pediatr Neurol. 2017 Feb; 67:23-35.
    View on PubMed
  13. Delgado RN, Lu C, Lim DA. Maintenance of neural stem cell regional identity in culture. Neurogenesis (Austin). 2016; 3(1):e1187321.
    View on PubMed
  14. Lim DA, Alvarez-Buylla A. The Adult Ventricular-Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis. Cold Spring Harb Perspect Biol. 2016 May 02; 8(5).
    View on PubMed
  15. Diaz A, Liu SJ, Sandoval C, Pollen A, Nowakowski TJ, Lim DA, Kriegstein A. SCell: integrated analysis of single-cell RNA-seq data. Bioinformatics. 2016 07 15; 32(14):2219-20.
    View on PubMed
  16. Liu SJ, Nowakowski TJ, Pollen AA, Lui JH, Horlbeck MA, Attenello FJ, He D, Weissman JS, Kriegstein AR, Diaz AA, Lim DA. Single-cell analysis of long non-coding RNAs in the developing human neocortex. Genome Biol. 2016 Apr 14; 17:67.
    View on PubMed
  17. Rowland NC, Kalia SK, Kalia LV, Larson PS, Lim DA, Bankiewicz KS. Merging DBS with viral vector or stem cell implantation: "hybrid" stereotactic surgery as an evolution in the surgical treatment of Parkinson's disease. Mol Ther Methods Clin Dev. 2016; 3:15051.
    View on PubMed
  18. Ramos AD, Attenello FJ, Lim DA. Uncovering the roles of long noncoding RNAs in neural development and glioma progression. Neurosci Lett. 2016 06 20; 625:70-9.
    View on PubMed
  19. Rolston JD, Ramos AD, Heath S, Englot DJ, Lim DA. Thalamotomy-Like Effects From Partial Removal of a Ventral Intermediate Nucleus Deep Brain Stimulator Lead in a Patient With Essential Tremor: Case Report. Neurosurgery. 2015 Nov; 77(5):E831-6; discussion E836-7.
    View on PubMed
  20. Delgado RN, Lim DA. Embryonic Nkx2.1-expressing neural precursor cells contribute to the regional heterogeneity of adult V-SVZ neural stem cells. Dev Biol. 2015 Nov 15; 407(2):265-74.
    View on PubMed

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