Annette Molinaro, MA, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Annette Molinaro, MA, PhD

Associate Professor, Department of Neurological Surgery and Division of Epidemiology and Biostatistics, UCSF

Annette.Molinaro@ucsf.edu

Phone: (415) 353-2136
Box 0112 , UCSF
San Francisco, CA 94143-0112

UCSF Profiles

Cancer Center Membership

Program Member » Neurologic Oncology

Research Summary

My research interests are primarily focused on statistical methods and implementation in piecewise constant estimation for prediction, survival analysis, classification, and cancer epidemiology, as in the estimation of absolute risk in subsample case-control studies. I have over ninety publications in addition to authoring two book chapters and several freely available software packages for the analysis of high-dimensional data. I am an elected member of the International Statistical Institute and an Associate Editor for NeuroOncology Practice. I am the PI of an NCI-funded R01 to develop statistical methods for risk prediction in cancer. Until 2009, I was the PI of an NCI-funded career award (K22 CA123146) for developing statistical methods for predicting survival outcomes based on genomic data, as well as the PI of a Yale Skin SPORE Career Development Award. I was also PI for a Scholar’s Award granted by the Yale Center for Clinical Investigation’s Clinical and Translational Science Award, as well as the Co-Director of the Bioinformatics/Biostatistics CORE for the Yale Skin SPORE. I also served as the statistical consultant for the UCSF SPORE in Breast Cancer for over ten years. In my current roles as the Director of Biostatistics for the UCSF Brain SPORE and P01, I advise study design and modeling, as well as analyze data from all seven projects including imaging, genetics, genomics, and immunology.

Education

Florida State University, Tallahassee, FL BS, 05/92, Statistics
University of California, Berkeley, CA, MA, 05/00, Biostatistics
University of California, Berkeley, CA, PhD, 01/04, Biostatistics
National Cancer Institute, Rockville, MD, 06/04-06/05, Cancer Prevention / Biostatistics


Professional Experience

  • 1998 - 2004
    Research Assistant, Comprehensive Cancer Center, UCSF, CA.
  • 1999 - 1999
    Instructor, Statistics and Biostatistics Departments, University of California, Berkeley, CA.
  • 1999 - 2005
    Biostatistician, Department of Medicine, UCSF.
  • 2000
    Instructor, Health Careers Opportunity Program, Stanford University, Palo Alto, CA.
  • 2004 - 2005
    Cancer Prevention Fellow, National Cancer Institute, NIH, Rockville, MD.
  • 2005 - 2011
    Assistant Professor, Division of Biostatistics, Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT.
  • 2011 - 2012
    Associate Visiting Professor, Division of Biostatistics, Yale University
  • 2011 - present
    Associate Professor, Department of Neurological Surgery and Division of Epidemiology and Biostatistics, UCSF

Honors & Awards

  • 2004
    Evelyn Fix Prize, UC Berkeley.
  • 2004
    Chin Long Chiang Biostatistics Student of the Year, UC Berkeley.
  • 2006
    Elected member of the International Statistical Institute
  • 2008
    Excellence in Teaching Award, Yale School of Public Health
  • 2009
    Selected as a Yale Center for Clinical Investigation Scholar

Selected Publications

  1. Lindberg OR, McKinney A, Engler JR, Koshkakaryan G, Gong H, Robinson AE, Ewald AJ, Huillard E, James CD, Molinaro AM, Shieh JT, Phillips JJ. GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity. Oncotarget. 2016 Oct 12.
    View on PubMed
  2. Han SJ, Reis G, Kohanbash G, Shrivastav S, Magill ST, Molinaro AM, McDermott MW, Theodosopoulos PV, Aghi MK, Berger MS, Butowski NA, Barani I, Phillips JJ, Perry A, Okada H. Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma. J Neurooncol. 2016 Dec; 130(3):543-552.
    View on PubMed
  3. Roddy E, Sear K, Felton E, Tamrazi B, Gauvain K, Torkildson J, Buono BD, Samuel D, Haas-Kogan DA, Chen J, Goldsby RE, Banerjee A, Lupo JM, Molinaro AM, Fullerton HJ, Mueller S. Presence of cerebral microbleeds is associated with worse executive function in pediatric brain tumor survivors. Neuro Oncol. 2016 Nov; 18(11):1548-1558.
    View on PubMed
  4. Imber BS, Kanungo I, Braunstein S, Barani IJ, Fogh SE, Nakamura JL, Berger MS, Chang EF, Molinaro AM, Cabrera JR, McDermott MW, Sneed PK, Aghi MK. Indications and Efficacy of Gamma Knife Stereotactic Radiosurgery for Recurrent Glioblastoma: 2 Decades of Institutional Experience. Neurosurgery. 2016 Jul 13.
    View on PubMed
  5. Molinaro AM, Sison JD, Ljung BM, Tlsty TD, Kerlikowske K. Risk prediction for local versus regional/metastatic tumors after initial ductal carcinoma in situ diagnosis treated by lumpectomy. Breast Cancer Res Treat. 2016 Jun; 157(2):351-61.
    View on PubMed
  6. Steingrimsson JA, Diao L, Molinaro AM, Strawderman RL. Doubly robust survival trees. Stat Med. 2016 Sep 10; 35(20):3595-612.
    View on PubMed
  7. Moore CL, Daniels B, Singh D, Luty S, Gunabushanam G, Ghita M, Molinaro A, Gross CP. Ureteral Stones: Implementation of a Reduced-Dose CT Protocol in Patients in the Emergency Department with Moderate to High Likelihood of Calculi on the Basis of STONE Score. Radiology. 2016 Sep; 280(3):743-51.
    View on PubMed
  8. Mukherjee J, Ohba S, See WL, Phillips JJ, Molinaro AM, Pieper RO. PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells. Int J Cancer. 2016 Jul 1; 139(1):99-111.
    View on PubMed
  9. Jalbert LE, Neill E, Phillips JJ, Lupo JM, Olson MP, Molinaro AM, Berger MS, Chang SM, Nelson SJ. Magnetic resonance analysis of malignant transformation in recurrent glioma. Neuro Oncol. 2016 Aug; 18(8):1169-79.
    View on PubMed
  10. Daniels B, Gross CP, Molinaro A, Singh D, Luty S, Jessey R, Moore CL. STONE PLUS: Evaluation of Emergency Department Patients With Suspected Renal Colic, Using a Clinical Prediction Tool Combined With Point-of-Care Limited Ultrasonography. Ann Emerg Med. 2016 Apr; 67(4):439-48.
    View on PubMed
  11. Walsh KM, Codd V, Rice T, Nelson CP, Smirnov IV, McCoy LS, Hansen HM, Elhauge E, Ojha J, Francis SS, Madsen NR, Bracci PM, Pico AR, Molinaro AM, Tihan T, Berger MS, Chang SM, Prados MD, Jenkins RB, Wiemels JL. Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk. Oncotarget. 2015 Dec 15; 6(40):42468-77.
    View on PubMed
  12. Molinaro AM, Wrensch MR, Jenkins RB, Eckel-Passow JE. Statistical considerations on prognostic models for glioma. Neuro Oncol. 2016 May; 18(5):609-23.
    View on PubMed
  13. Wen Q, Jalilian L, Lupo JM, Li Y, Roy R, Molinaro AM, Chang SM, Prados M, Butowski N, Clarke J, Nelson SJ. Association of Diffusion and Anatomic Imaging Parameters with Survival for Patients with Newly Diagnosed Glioblastoma Participating in Two Different Clinical Trials. Transl Oncol. 2015 Dec; 8(6):446-55.
    View on PubMed
  14. Lau D, Hervey-Jumper SL, Chang S, Molinaro AM, McDermott MW, Phillips JJ, Berger MS. A prospective Phase II clinical trial of 5-aminolevulinic acid to assess the correlation of intraoperative fluorescence intensity and degree of histologic cellularity during resection of high-grade gliomas. J Neurosurg. 2016 May; 124(5):1300-9.
    View on PubMed
  15. Clark AJ, Safaee M, Chou D, Weinstein PR, Molinaro AM, Clark JP, Mummaneni PV. Comparative Sensitivity of Intraoperative Motor Evoked Potential Monitoring in Predicting Postoperative Neurologic Deficits: Nondegenerative versus Degenerative Myelopathy. Global Spine J. 2016 Aug; 6(5):452-8.
    View on PubMed
  16. Mazor T, Pankov A, Johnson BE, Hong C, Hamilton EG, Bell RJ, Smirnov IV, Reis GF, Phillips JJ, Barnes MJ, Idbaih A, Alentorn A, Kloezeman JJ, Lamfers ML, Bollen AW, Taylor BS, Molinaro AM, Olshen AB, Chang SM, Song JS, Costello JF. DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors. Cancer Cell. 2015 Sep 14; 28(3):307-17.
    View on PubMed
  17. Hervey-Jumper SL, Li J, Osorio JA, Lau D, Molinaro AM, Benet A, Berger MS. Surgical assessment of the insula. Part 2: validation of the Berger-Sanai zone classification system for predicting extent of glioma resection. J Neurosurg. 2016 Feb; 124(2):482-8.
    View on PubMed
  18. Racine CA, Li J, Molinaro AM, Butowski N, Berger MS. Neurocognitive Function in Newly Diagnosed Low-grade Glioma Patients Undergoing Surgical Resection With Awake Mapping Techniques. Neurosurgery. 2015 Sep; 77(3):371-9; discussion 379.
    View on PubMed
  19. Rice T, Lachance DH, Molinaro AM, Eckel-Passow JE, Walsh KM, Barnholtz-Sloan J, Ostrom QT, Francis SS, Wiemels J, Jenkins RB, Wiencke JK, Wrensch MR. Understanding inherited genetic risk of adult glioma - a review. Neurooncol Pract. 2016 Mar; 3(1):10-16.
    View on PubMed
  20. Han SJ, Englot DJ, Birk H, Molinaro AM, Chang SM, Clarke JL, Prados MD, Taylor JW, Berger MS, Butowski NA. Impact of Timing of Concurrent Chemoradiation for Newly Diagnosed Glioblastoma: A Critical Review of Current Evidence. Neurosurgery. 2015 Aug; 62 Suppl 1:160-5.
    View on PubMed

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