University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Annette Molinaro, MA, PhD

Annette Molinaro, MA, PhD

Professor, Dept. of Neurological Surgery, UCSF

Cancer Center Program Memberships

Neurologic Oncology

Research Summary

Dr. Molinaro's research interest and expertise are focused on developing and implementing statistical and machine learning methods in cancer research, spanning basic research, translational, and clinical studies. In her current roles as the Director of Biomedical Statistics and Informatics for the UCSF Department of Neurological Surgery and Biostatistics Core Director for both the Brain SPORE and Program Project, Dr. Molinaro advises study design and modeling, and analyzes data from all UCSF Brain Tumor Center projects in imaging, genetics, genomics, epidemiology and immunology. She is the co-PI of the Brain SPORE Project to develop immune profile markers for risk prediction in glioblastoma patients and the co-PI of the Program Project Project to use machine learning and AI to develop spatial maps of risk from anatomical, physiological, and metabolic images. Dr. Molinaro has over one-hundred and fifty publications in addition to authoring three book chapters and several freely available software packages for the analysis of high-dimensional data. Dr. Molinaro is an elected Board of Directors Member for the Society of Neuro-Oncology as well as an elected member of the International Statistical Institute, an Associate Editor for NeuroOncology Practice and Editor for the 'Series on Biostatistics for the Practicing Clinician" for NeuroOncology Practice.

Education

Florida State University, Tallahassee, FL BS, 05/92, Statistics
University of California, Berkeley, CA, MA, 05/00, Biostatistics
University of California, Berkeley, CA, PhD, 01/04, Biostatistics
National Cancer Institute, Rockville, MD, 06/04-06/05, Cancer Prevention / Biostatistics

Honors & Awards

  • 2004
    Evelyn Fix Prize, University of California, Berkeley
  • 2004
    Chin Long Chiang Biostatistics Student of the Year, University of California, Berkeley
  • 2006
    Elected as a Member of the International Statistical Institute.
  • 2008
    Teacher of the Year Award, Yale University School of Public Health
  • 2009
    Selected as a Yale Center for Clinical Investigation Scholar, Yale University School of Medicine
  • 2013
    Diane D. Ralston Clinical and Basic Neuroscience Teaching Award, UCSF
  • 2017
    Selected for the Teaching Scholars Program, UCSF

Selected Publications

  1. Mueller S, Taitt JM, Villanueva-Meyer JE, Bonner ER, Nejo T, Lulla RR, Goldman S, Banerjee A, Chi SN, Whipple NS, Crawford JR, Gauvain K, Nazemi KJ, Watchmaker PB, Almeida ND, Okada K, Salazar AM, Gilbert RD, Nazarian J, Molinaro AM, Butterfield LH, Prados MD, Okada H. Mass cytometry detects H3.3K27M-specific vaccine responses in diffuse midline glioma. J Clin Invest. 2020 Oct 26.
    View on PubMed
  2. Cluceru J, Nelson SJ, Wen Q, Phillips JJ, Shai A, Molinaro AM, Alcaide-Leon P, Olson MP, Nair D, LaFontaine M, Chunduru P, Villanueva-Meyer JE, Cha S, Chang SM, Berger MS, Lupo JM. Recurrent tumor and treatment-induced effects have different MR signatures in contrast enhancing and non-enhancing lesions of high-grade gliomas. Neuro Oncol. 2020 Oct 14; 22(10):1516-1526.
    View on PubMed
  3. Mummaneni PV, Burke JF, Chan AK, Sosa JA, Lobo EP, Mummaneni VP, Antrum S, Berven SH, Conte MS, Doernberg SB, Goldberg AN, Hess CP, Hetts SW, Josephson SA, Kohi MP, Ma CB, Mahadevan VS, Molinaro AM, Murr AH, Narayana S, Roberts JP, Stoller ML, Theodosopoulos PV, Vail TP, Wienholz S, Gropper MA, Green A, Berger MS. Consensus-based perioperative protocols during the COVID-19 pandemic. J Neurosurg Spine. 2020 Oct 02; 1-9.
    View on PubMed
  4. Morrison MA, Mueller S, Felton E, Jakary A, Stoller S, Avadiappan S, Yuan J, Molinaro AM, Braunstein S, Banerjee A, Hess CP, Lupo JM. Rate of radiation-induced microbleed formation on 7T MRI relates to cognitive impairment in young patients treated with radiation therapy for a brain tumor. Radiother Oncol. 2020 Sep 20.
    View on PubMed
  5. Nicolaides T, Nazemi KJ, Crawford J, Kilburn L, Minturn J, Gajjar A, Gauvain K, Leary S, Dhall G, Aboian M, Robinson G, Long-Boyle J, Wang H, Molinaro AM, Mueller S, Prados M. Phase I study of vemurafenib in children with recurrent or progressive BRAFV600E mutant brain tumors: Pacific Pediatric Neuro-Oncology Consortium study (PNOC-002). Oncotarget. 2020 May 26; 11(21):1942-1952.
    View on PubMed
  6. Eckel-Passow JE, Drucker KL, Kollmeyer TM, Kosel ML, Decker PA, Molinaro AM, Rice T, Praska CE, Clark L, Caron A, Abyzov A, Batzler A, Song JS, Pekmezci M, Hansen HM, McCoy LS, Bracci PM, Wiemels J, Wiencke JK, Francis S, Burns TC, Giannini C, Lachance DH, Wrensch M, Jenkins RB. Adult Diffuse Glioma GWAS by Molecular Subtype Identifies Variants in D2HGDH and FAM20C. Neuro Oncol. 2020 May 09.
    View on PubMed
  7. Morshed RA, Reihl SJ, Molinaro AM, Kakaizada S, Young JS, Schulte JD, Butowski N, Taylor J, Bush NA, Aghi MK, Berger MS, Chang S, Clarke J, Hervey-Jumper SL. The influence of race and socioeconomic status on therapeutic clinical trial screening and enrollment. J Neurooncol. 2020 May; 148(1):131-139.
    View on PubMed
  8. Safaee MM, Tenorio A, Osorio JA, Choy W, Amara D, Lai L, Molinaro AM, Zhang Y, Hu SS, Tay B, Burch S, Berven SH, Deviren V, Dhall SS, Chou D, Mummaneni PV, Eichler CM, Ames CP, Clark AJ. The impact of obesity on perioperative complications in patients undergoing anterior lumbar interbody fusion. J Neurosurg Spine. 2020 Apr 24; 1-10.
    View on PubMed
  9. Molinaro AM, Hervey-Jumper S, Morshed RA, Young J, Han SJ, Chunduru P, Zhang Y, Phillips JJ, Shai A, Lafontaine M, Crane J, Chandra A, Flanigan P, Jahangiri A, Cioffi G, Ostrom Q, Anderson JE, Badve C, Barnholtz-Sloan J, Sloan AE, Erickson BJ, Decker PA, Kosel ML, LaChance D, Eckel-Passow J, Jenkins R, Villanueva-Meyer J, Rice T, Wrensch M, Wiencke JK, Oberheim Bush NA, Taylor J, Butowski N, Prados M, Clarke J, Chang S, Chang E, Aghi M, Theodosopoulos P, McDermott M, Berger MS. Association of Maximal Extent of Resection of Contrast-Enhanced and Non-Contrast-Enhanced Tumor With Survival Within Molecular Subgroups of Patients With Newly Diagnosed Glioblastoma. JAMA Oncol. 2020 Apr 01; 6(4):495-503.
    View on PubMed
  10. Mathur R, Zhang Y, Grimmer MR, Hong C, Zhang M, Bollam S, Petrecca K, Clarke J, Berger MS, Phillips JJ, Oberheim-Bush NA, Molinaro AM, Chang SM, Costello JF. MGMT promoter methylation level in newly diagnosed low-grade glioma is a predictor of hypermutation at recurrence. Neuro Oncol. 2020 Mar 13.
    View on PubMed
  11. Breshears JD, Morshed RA, Molinaro AM, McDermott MW, Cheung SW, Theodosopoulos PV. Residual Tumor Volume and Location Predict Progression After Primary Subtotal Resection of Sporadic Vestibular Schwannomas: A Retrospective Volumetric Study. Neurosurgery. 2020 03 01; 86(3):410-416.
    View on PubMed
  12. Yerneni K, Burke JF, Chunduru P, Molinaro AM, Riew KD, Traynelis VC, Tan LA. Safety of Outpatient Anterior Cervical Discectomy and Fusion: A Systematic Review and Meta-Analysis. Neurosurgery. 2020 01 01; 86(1):30-45.
    View on PubMed
  13. Barthel FP, Johnson KC, Varn FS, Moskalik AD, Tanner G, Kocakavuk E, Anderson KJ, Abiola O, Aldape K, Alfaro KD, Alpar D, Amin SB, Ashley DM, Bandopadhayay P, Barnholtz-Sloan JS, Beroukhim R, Bock C, Brastianos PK, Brat DJ, Brodbelt AR, Bruns AF, Bulsara KR, Chakrabarty A, Chakravarti A, Chuang JH, Claus EB, Cochran EJ, Connelly J, Costello JF, Finocchiaro G, Fletcher MN, French PJ, Gan HK, Gilbert MR, Gould PV, Grimmer MR, Iavarone A, Ismail A, Jenkinson MD, Khasraw M, Kim H, Kouwenhoven MCM, LaViolette PS, Li M, Lichter P, Ligon KL, Lowman AK, Malta TM, Mazor T, McDonald KL, Molinaro AM, Nam DH, Nayyar N, Ng HK, Ngan CY, Niclou SP, Niers JM, Noushmehr H, Noorbakhsh J, Ormond DR, Park CK, Poisson LM, Rabadan R, Radlwimmer B, Rao G, Reifenberger G, Sa JK, Schuster M, Shaw BL, Short SC, Smitt PAS, Sloan AE, Smits M, Suzuki H, Tabatabai G, Van Meir EG, Watts C, Weller M, Wesseling P, Westerman BA, Widhalm G, Woehrer A, Yung WKA, Zadeh G, Huse JT, De Groot JF, Stead LF, Verhaak RGW. Longitudinal molecular trajectories of diffuse glioma in adults. Nature. 2019 12; 576(7785):112-120.
    View on PubMed
  14. Molinaro AM, Phillips JJ. EGFR amplification status for clinical trial inclusion: where do we draw the line? Neuro Oncol. 2019 10 09; 21(10):1215-1216.
    View on PubMed
  15. Badiee RK, Chan AK, Rivera J, Molinaro A, Doherty BR, Riew KD, Chou D, Mummaneni PV, Tan LA. Preoperative Narcotic Use, Impaired Ambulation Status, and Increased Intraoperative Blood Loss Are Independent Risk Factors for Complications Following Posterior Cervical Laminectomy and Fusion Surgery. Neurospine. 2019 Sep; 16(3):548-557.
    View on PubMed
  16. Cheung SW, Racine CA, Henderson-Sabes J, Demopoulos C, Molinaro AM, Heath S, Nagarajan SS, Bourne AL, Rietcheck JE, Wang SS, Larson PS. Phase I trial of caudate deep brain stimulation for treatment-resistant tinnitus. J Neurosurg. 2019 Sep 24; 1-10.
    View on PubMed
  17. Lee AT, Burke JF, Chunduru P, Molinaro AM, Knowlton R, Chang EF. A historical cohort of temporal lobe surgery for medically refractory epilepsy: a systematic review and meta-analysis to guide future nonrandomized controlled trial studies. J Neurosurg. 2019 Jun 28; 1-8.
    View on PubMed
  18. Molinaro AM, Taylor JW, Wiencke JK, Wrensch MR. Genetic and molecular epidemiology of adult diffuse glioma. Nat Rev Neurol. 2019 07; 15(7):405-417.
    View on PubMed
  19. McCurdy S, Molinaro A, Pachter L. Factor analysis for survival time prediction with informative censoring and diverse covariates. Stat Med. 2019 09 10; 38(20):3719-3732.
    View on PubMed
  20. Gittleman H, Cioffi G, Chunduru P, Molinaro AM, Berger MS, Sloan AE, Barnholtz-Sloan JS. An independently validated nomogram for isocitrate dehydrogenase-wild-type glioblastoma patient survival. Neurooncol Adv. 2019 May-Dec; 1(1):vdz007.
    View on PubMed

Go to UCSF Profiles, powered by CTSI