University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Annette Molinaro, MA, PhD

Annette Molinaro, MA, PhD

Associate Professor, Department of Neurological Surgery and Division of Epidemiology and Biostatistics, UCSF

Cancer Center Program Memberships

Neurologic Oncology

Research Summary

My research interests are primarily focused on statistical methods and implementation in piecewise constant estimation for prediction, survival analysis, classification, and cancer epidemiology, as in the estimation of absolute risk in subsample case-control studies. I have over ninety publications in addition to authoring two book chapters and several freely available software packages for the analysis of high-dimensional data. I am an elected member of the International Statistical Institute and an Associate Editor for NeuroOncology Practice. I am the PI of an NCI-funded R01 to develop statistical methods for risk prediction in cancer. Until 2009, I was the PI of an NCI-funded career award (K22 CA123146) for developing statistical methods for predicting survival outcomes based on genomic data, as well as the PI of a Yale Skin SPORE Career Development Award. I was also PI for a Scholar’s Award granted by the Yale Center for Clinical Investigation’s Clinical and Translational Science Award, as well as the Co-Director of the Bioinformatics/Biostatistics CORE for the Yale Skin SPORE. I also served as the statistical consultant for the UCSF SPORE in Breast Cancer for over ten years. In my current roles as the Director of Biostatistics for the UCSF Brain SPORE and P01, I advise study design and modeling, as well as analyze data from all seven projects including imaging, genetics, genomics, and immunology.

Education

Florida State University, Tallahassee, FL BS, 05/92, Statistics
University of California, Berkeley, CA, MA, 05/00, Biostatistics
University of California, Berkeley, CA, PhD, 01/04, Biostatistics
National Cancer Institute, Rockville, MD, 06/04-06/05, Cancer Prevention / Biostatistics


Professional Experience

  • 1998 - 2004
    Research Assistant, Comprehensive Cancer Center, UCSF, CA.
  • 1999 - 1999
    Instructor, Statistics and Biostatistics Departments, University of California, Berkeley, CA.
  • 1999 - 2005
    Biostatistician, Department of Medicine, UCSF.
  • 2000
    Instructor, Health Careers Opportunity Program, Stanford University, Palo Alto, CA.
  • 2004 - 2005
    Cancer Prevention Fellow, National Cancer Institute, NIH, Rockville, MD.
  • 2005 - 2011
    Assistant Professor, Division of Biostatistics, Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT.
  • 2011 - 2012
    Associate Visiting Professor, Division of Biostatistics, Yale University
  • 2011 - present
    Associate Professor, Department of Neurological Surgery and Division of Epidemiology and Biostatistics, UCSF

Honors & Awards

  • 2004
    Evelyn Fix Prize, UC Berkeley.
  • 2004
    Chin Long Chiang Biostatistics Student of the Year, UC Berkeley.
  • 2006
    Elected member of the International Statistical Institute
  • 2008
    Excellence in Teaching Award, Yale School of Public Health
  • 2009
    Selected as a Yale Center for Clinical Investigation Scholar

Selected Publications

  1. Breshears JD, Chang J, Molinaro AM, Sneed PK, McDermott MW, Tward A, Theodosopoulos PV. Temporal Dynamics of Pseudoprogression After Gamma Knife Radiosurgery for Vestibular Schwannomas-A Retrospective Volumetric Study. Neurosurgery. 2018 Mar 05.
    View on PubMed
  2. Flanigan PM, Jahangiri A, Weinstein D, Dayani F, Chandra A, Kanungo I, Choi S, Sankaran S, Molinaro AM, McDermott MW, Berger MS, Aghi MK. Postoperative Delirium in Glioblastoma Patients: Risk Factors and Prognostic Implications. Neurosurgery. 2018 Feb 16.
    View on PubMed
  3. Flanigan PM, Jahangiri A, Kuang R, Truong A, Choi S, Chou A, Molinaro AM, McDermott MW, Berger MS, Aghi MK. Developing an Algorithm for Optimizing Care of Elderly Patients With Glioblastoma. Neurosurgery. 2018 Jan 01; 82(1):64-75.
    View on PubMed
  4. Flanigan PM, Jahangiri A, Kuang R, Truong A, Choi S, Chou A, Rick JW, Chang SM, Molinaro AM, McDermott MW, Berger MS, Aghi MK. Improved Survival with Decreased Wait Time to Surgery in Glioblastoma Patients Presenting with Seizure. Neurosurgery. 2017 Nov 01; 81(5):824-833.
    View on PubMed
  5. Byron SA, Tran NL, Halperin RF, Phillips JJ, Kuhn JG, de Groot JF, Colman H, Ligon KL, Wen PY, Cloughesy TF, Mellinghoff IK, Butowski NA, Taylor JW, Clarke JL, Chang SM, Berger MS, Molinaro AM, Maggiora GM, Peng S, Nasser S, Liang WS, Trent JM, Berens ME, Carpten JD, Craig DW, Prados MD. Prospective Feasibility Trial for Genomics-Informed Treatment in Recurrent and Progressive Glioblastoma. Clin Cancer Res. 2018 Jan 15; 24(2):295-305.
    View on PubMed
  6. Jacobs DI, Liu Y, Gabrusiewicz K, Tsavachidis S, Armstrong GN, Zhou R, Wei J, Ivan C, Calin G, Molinaro AM, Rice T, Bracci PM, Hansen HM, Wiencke JK, Wrensch MR, Heimberger AB, Bondy ML. Germline polymorphisms in myeloid-associated genes are not associated with survival in glioma patients. J Neurooncol. 2018 Jan; 136(1):33-39.
    View on PubMed
  7. Autry A, Phillips JJ, Maleschlijski S, Roy R, Molinaro AM, Chang SM, Cha S, Lupo JM, Nelson SJ. Characterization of Metabolic, Diffusion, and Perfusion Properties in GBM: Contrast-Enhancing versus Non-Enhancing Tumor. Transl Oncol. 2017 Dec; 10(6):895-903.
    View on PubMed
  8. Mazor T, Chesnelong C, Pankov A, Jalbert LE, Hong C, Hayes J, Smirnov IV, Marshall R, Souza CF, Shen Y, Viswanath P, Noushmehr H, Ronen SM, Jones SJM, Marra MA, Cairncross JG, Perry A, Nelson SJ, Chang SM, Bollen AW, Molinaro AM, Bengtsson H, Olshen AB, Weiss S, Phillips JJ, Luchman HA, Costello JF. Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1. Proc Natl Acad Sci U S A. 2017 Oct 03; 114(40):10743-10748.
    View on PubMed
  9. Wahl M, Chang SM, Phillips JJ, Molinaro AM, Costello JF, Mazor T, Alexandrescu S, Lupo JM, Nelson SJ, Berger M, Prados M, Taylor JW, Butowski N, Clarke JL, Haas-Kogan D. Probing the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in gliomas: A phase 2 study of everolimus for recurrent adult low-grade gliomas. Cancer. 2017 Dec 01; 123(23):4631-4639.
    View on PubMed
  10. Anwar M, Molinaro AM, Morin O, Chang SM, Haas-Kogan DA, Nelson SJ, Lupo JM. Identifying Voxels at Risk for Progression in Glioblastoma Based on Dosimetry, Physiologic and Metabolic MRI. Radiat Res. 2017 09; 188(3):303-313.
    View on PubMed
  11. Jalbert LE, Elkhaled A, Phillips JJ, Neill E, Williams A, Crane JC, Olson MP, Molinaro AM, Berger MS, Kurhanewicz J, Ronen SM, Chang SM, Nelson SJ. Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma. Sci Rep. 2017 Mar 22; 7:44792.
    View on PubMed
  12. Pekmezci M, Rice T, Molinaro AM, Walsh KM, Decker PA, Hansen H, Sicotte H, Kollmeyer TM, McCoy LS, Sarkar G, Perry A, Giannini C, Tihan T, Berger MS, Wiemels JL, Bracci PM, Eckel-Passow JE, Lachance DH, Clarke J, Taylor JW, Luks T, Wiencke JK, Jenkins RB, Wrensch MR. Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT. Acta Neuropathol. 2017 Jun; 133(6):1001-1016.
    View on PubMed
  13. Nelson SJ, Kadambi AK, Park I, Li Y, Crane J, Olson M, Molinaro A, Roy R, Butowski N, Cha S, Chang S. Association of early changes in 1H MRSI parameters with survival for patients with newly diagnosed glioblastoma receiving a multimodality treatment regimen. Neuro Oncol. 2017 03 01; 19(3):430-439.
    View on PubMed
  14. Clarke JL, Molinaro AM, Cabrera JR, DeSilva AA, Rabbitt JE, Prey J, Drummond DC, Kim J, Noble C, Fitzgerald JB, Chang SM, Butowski NA, Taylor JW, Park JW, Prados MD. A phase 1 trial of intravenous liposomal irinotecan in patients with recurrent high-grade glioma. Cancer Chemother Pharmacol. 2017 Mar; 79(3):603-610.
    View on PubMed
  15. Wiencke JK, Koestler DC, Salas LA, Wiemels JL, Roy RP, Hansen HM, Rice T, McCoy LS, Bracci PM, Molinaro AM, Kelsey KT, Wrensch MR, Christensen BC. Immunomethylomic approach to explore the blood neutrophil lymphocyte ratio (NLR) in glioma survival. Clin Epigenetics. 2017; 9:10.
    View on PubMed
  16. Wahl M, Phillips JJ, Molinaro AM, Lin Y, Perry A, Haas-Kogan DA, Costello JF, Dayal M, Butowski N, Clarke JL, Prados M, Nelson S, Berger MS, Chang SM. Chemotherapy for adult low-grade gliomas: clinical outcomes by molecular subtype in a phase II study of adjuvant temozolomide. Neuro Oncol. 2017 02 01; 19(2):242-251.
    View on PubMed
  17. Kuang R, Jahangiri A, Mascharak S, Nguyen A, Chandra A, Flanigan PM, Yagnik G, Wagner JR, De Lay M, Carrera D, Castro BA, Hayes J, Sidorov M, Garcia JL, Eriksson P, Ronen S, Phillips J, Molinaro A, Koliwad S, Aghi MK. GLUT3 upregulation promotes metabolic reprogramming associated with antiangiogenic therapy resistance. JCI Insight. 2017 Jan 26; 2(2):e88815.
    View on PubMed
  18. Neill E, Luks T, Dayal M, Phillips JJ, Perry A, Jalbert LE, Cha S, Molinaro A, Chang SM, Nelson SJ. Quantitative multi-modal MR imaging as a non-invasive prognostic tool for patients with recurrent low-grade glioma. J Neurooncol. 2017 03; 132(1):171-179.
    View on PubMed
  19. Imber BS, Kanungo I, Braunstein S, Barani IJ, Fogh SE, Nakamura JL, Berger MS, Chang EF, Molinaro AM, Cabrera JR, McDermott MW, Sneed PK, Aghi MK. Indications and Efficacy of Gamma Knife Stereotactic Radiosurgery for Recurrent Glioblastoma: 2 Decades of Institutional Experience. Neurosurgery. 2017 01 01; 80(1):129-139.
    View on PubMed
  20. Zhang Y, Cartmel B, Choy CC, Molinaro AM, Leffell DJ, Bale AE, Mayne ST, Ferrucci LM. Body mass index, height and early-onset basal cell carcinoma in a case-control study. Cancer Epidemiol. 2017 Feb; 46:66-72.
    View on PubMed

Go to UCSF Profiles, powered by CTSI