University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Annette Molinaro, MA, PhD

Annette Molinaro, MA, PhD

Associate Professor, Department of Neurological Surgery and Division of Epidemiology and Biostatistics, UCSF

Cancer Center Program Memberships

Neurologic Oncology

Research Summary

My research interests are primarily focused on statistical methods and implementation in piecewise constant estimation for prediction, survival analysis, classification, and cancer epidemiology, as in the estimation of absolute risk in subsample case-control studies. I have over ninety publications in addition to authoring two book chapters and several freely available software packages for the analysis of high-dimensional data. I am an elected member of the International Statistical Institute and an Associate Editor for NeuroOncology Practice. I am the PI of an NCI-funded R01 to develop statistical methods for risk prediction in cancer. Until 2009, I was the PI of an NCI-funded career award (K22 CA123146) for developing statistical methods for predicting survival outcomes based on genomic data, as well as the PI of a Yale Skin SPORE Career Development Award. I was also PI for a Scholar’s Award granted by the Yale Center for Clinical Investigation’s Clinical and Translational Science Award, as well as the Co-Director of the Bioinformatics/Biostatistics CORE for the Yale Skin SPORE. I also served as the statistical consultant for the UCSF SPORE in Breast Cancer for over ten years. In my current roles as the Director of Biostatistics for the UCSF Brain SPORE and P01, I advise study design and modeling, as well as analyze data from all seven projects including imaging, genetics, genomics, and immunology.

Education

Florida State University, Tallahassee, FL BS, 05/92, Statistics
University of California, Berkeley, CA, MA, 05/00, Biostatistics
University of California, Berkeley, CA, PhD, 01/04, Biostatistics
National Cancer Institute, Rockville, MD, 06/04-06/05, Cancer Prevention / Biostatistics


Professional Experience

  • 1998 - 2004
    Research Assistant, Comprehensive Cancer Center, UCSF, CA.
  • 1999 - 1999
    Instructor, Statistics and Biostatistics Departments, University of California, Berkeley, CA.
  • 1999 - 2005
    Biostatistician, Department of Medicine, UCSF.
  • 2000
    Instructor, Health Careers Opportunity Program, Stanford University, Palo Alto, CA.
  • 2004 - 2005
    Cancer Prevention Fellow, National Cancer Institute, NIH, Rockville, MD.
  • 2005 - 2011
    Assistant Professor, Division of Biostatistics, Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT.
  • 2011 - 2012
    Associate Visiting Professor, Division of Biostatistics, Yale University
  • 2011 - present
    Associate Professor, Department of Neurological Surgery and Division of Epidemiology and Biostatistics, UCSF

Honors & Awards

  • 2004
    Evelyn Fix Prize, UC Berkeley.
  • 2004
    Chin Long Chiang Biostatistics Student of the Year, UC Berkeley.
  • 2006
    Elected member of the International Statistical Institute
  • 2008
    Excellence in Teaching Award, Yale School of Public Health
  • 2009
    Selected as a Yale Center for Clinical Investigation Scholar

Selected Publications

  1. Mazor T, Chesnelong C, Pankov A, Jalbert LE, Hong C, Hayes J, Smirnov IV, Marshall R, Souza CF, Shen Y, Viswanath P, Noushmehr H, Ronen SM, Jones SJM, Marra MA, Cairncross JG, Perry A, Nelson SJ, Chang SM, Bollen AW, Molinaro AM, Bengtsson H, Olshen AB, Weiss S, Phillips JJ, Luchman HA, Costello JF. Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1. Proc Natl Acad Sci U S A. 2017 Sep 15.
    View on PubMed
  2. Anwar M, Molinaro AM, Morin O, Chang SM, Haas-Kogan DA, Nelson SJ, Lupo JM. Identifying Voxels at Risk for Progression in Glioblastoma Based on Dosimetry, Physiologic and Metabolic MRI. Radiat Res. 2017 Sep; 188(3):303-313.
    View on PubMed
  3. Jalbert LE, Elkhaled A, Phillips JJ, Neill E, Williams A, Crane JC, Olson MP, Molinaro AM, Berger MS, Kurhanewicz J, Ronen SM, Chang SM, Nelson SJ. Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma. Sci Rep. 2017 Mar 22; 7:44792.
    View on PubMed
  4. Pekmezci M, Rice T, Molinaro AM, Walsh KM, Decker PA, Hansen H, Sicotte H, Kollmeyer TM, McCoy LS, Sarkar G, Perry A, Giannini C, Tihan T, Berger MS, Wiemels JL, Bracci PM, Eckel-Passow JE, Lachance DH, Clarke J, Taylor JW, Luks T, Wiencke JK, Jenkins RB, Wrensch MR. Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT. Acta Neuropathol. 2017 Jun; 133(6):1001-1016.
    View on PubMed
  5. Nelson SJ, Kadambi AK, Park I, Li Y, Crane J, Olson M, Molinaro A, Roy R, Butowski N, Cha S, Chang S. Association of early changes in 1H MRSI parameters with survival for patients with newly diagnosed glioblastoma receiving a multimodality treatment regimen. Neuro Oncol. 2017 03 01; 19(3):430-439.
    View on PubMed
  6. Clarke JL, Molinaro AM, Cabrera JR, DeSilva AA, Rabbitt JE, Prey J, Drummond DC, Kim J, Noble C, Fitzgerald JB, Chang SM, Butowski NA, Taylor JW, Park JW, Prados MD. A phase 1 trial of intravenous liposomal irinotecan in patients with recurrent high-grade glioma. Cancer Chemother Pharmacol. 2017 Mar; 79(3):603-610.
    View on PubMed
  7. Wahl M, Phillips JJ, Molinaro AM, Lin Y, Perry A, Haas-Kogan DA, Costello JF, Dayal M, Butowski N, Clarke JL, Prados M, Nelson S, Berger MS, Chang SM. Chemotherapy for adult low-grade gliomas: clinical outcomes by molecular subtype in a phase II study of adjuvant temozolomide. Neuro Oncol. 2017 02 01; 19(2):242-251.
    View on PubMed
  8. Kuang R, Jahangiri A, Mascharak S, Nguyen A, Chandra A, Flanigan PM, Yagnik G, Wagner JR, De Lay M, Carrera D, Castro BA, Hayes J, Sidorov M, Garcia JL, Eriksson P, Ronen S, Phillips J, Molinaro A, Koliwad S, Aghi MK. GLUT3 upregulation promotes metabolic reprogramming associated with antiangiogenic therapy resistance. JCI Insight. 2017 Jan 26; 2(2):e88815.
    View on PubMed
  9. Neill E, Luks T, Dayal M, Phillips JJ, Perry A, Jalbert LE, Cha S, Molinaro A, Chang SM, Nelson SJ. Quantitative multi-modal MR imaging as a non-invasive prognostic tool for patients with recurrent low-grade glioma. J Neurooncol. 2017 Mar; 132(1):171-179.
    View on PubMed
  10. Imber BS, Kanungo I, Braunstein S, Barani IJ, Fogh SE, Nakamura JL, Berger MS, Chang EF, Molinaro AM, Cabrera JR, McDermott MW, Sneed PK, Aghi MK. Indications and Efficacy of Gamma Knife Stereotactic Radiosurgery for Recurrent Glioblastoma: 2 Decades of Institutional Experience. Neurosurgery. 2017 Jan 01; 80(1):129-139.
    View on PubMed
  11. Zhang Y, Cartmel B, Choy CC, Molinaro AM, Leffell DJ, Bale AE, Mayne ST, Ferrucci LM. Body mass index, height and early-onset basal cell carcinoma in a case-control study. Cancer Epidemiol. 2017 Feb; 46:66-72.
    View on PubMed
  12. Zygourakis CC, Imber BS, Chen R, Han SJ, Blevins L, Molinaro A, Kahn JG, Aghi MK. Cost-Effectiveness Analysis of Surgical versus Medical Treatment of Prolactinomas. J Neurol Surg B Skull Base. 2017 Apr; 78(2):125-131.
    View on PubMed
  13. Han SJ, Reis G, Kohanbash G, Shrivastav S, Magill ST, Molinaro AM, McDermott MW, Theodosopoulos PV, Aghi MK, Berger MS, Butowski NA, Barani I, Phillips JJ, Perry A, Okada H. Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma. J Neurooncol. 2016 Dec; 130(3):543-552.
    View on PubMed
  14. Roddy E, Sear K, Felton E, Tamrazi B, Gauvain K, Torkildson J, Buono BD, Samuel D, Haas-Kogan DA, Chen J, Goldsby RE, Banerjee A, Lupo JM, Molinaro AM, Fullerton HJ, Mueller S. Presence of cerebral microbleeds is associated with worse executive function in pediatric brain tumor survivors. Neuro Oncol. 2016 Nov; 18(11):1548-1558.
    View on PubMed
  15. Molinaro AM, Sison JD, Ljung BM, Tlsty TD, Kerlikowske K. Risk prediction for local versus regional/metastatic tumors after initial ductal carcinoma in situ diagnosis treated by lumpectomy. Breast Cancer Res Treat. 2016 Jun; 157(2):351-361.
    View on PubMed
  16. Steingrimsson JA, Diao L, Molinaro AM, Strawderman RL. Doubly robust survival trees. Stat Med. 2016 Sep 10; 35(20):3595-612.
    View on PubMed
  17. Moore CL, Daniels B, Singh D, Luty S, Gunabushanam G, Ghita M, Molinaro A, Gross CP. Ureteral Stones: Implementation of a Reduced-Dose CT Protocol in Patients in the Emergency Department with Moderate to High Likelihood of Calculi on the Basis of STONE Score. Radiology. 2016 Sep; 280(3):743-51.
    View on PubMed
  18. Mukherjee J, Ohba S, See WL, Phillips JJ, Molinaro AM, Pieper RO. PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells. Int J Cancer. 2016 Jul 01; 139(1):99-111.
    View on PubMed
  19. Jalbert LE, Neill E, Phillips JJ, Lupo JM, Olson MP, Molinaro AM, Berger MS, Chang SM, Nelson SJ. Magnetic resonance analysis of malignant transformation in recurrent glioma. Neuro Oncol. 2016 Aug; 18(8):1169-79.
    View on PubMed
  20. Chang EF, Breshears JD, Raygor KP, Lau D, Molinaro AM, Berger MS. Stereotactic probability and variability of speech arrest and anomia sites during stimulation mapping of the language dominant hemisphere. J Neurosurg. 2017 Jan; 126(1):114-121.
    View on PubMed

Go to UCSF Profiles, powered by CTSI