University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Annette Molinaro, MA, PhD

Annette Molinaro, MA, PhD

Associate Professor, Department of Neurological Surgery and Division of Epidemiology and Biostatistics, UCSF

Cancer Center Program Memberships

Neurologic Oncology

Research Summary

My research interests are primarily focused on statistical methods and implementation in piecewise constant estimation for prediction, survival analysis, classification, and cancer epidemiology, as in the estimation of absolute risk in subsample case-control studies. I have over ninety publications in addition to authoring two book chapters and several freely available software packages for the analysis of high-dimensional data. I am an elected member of the International Statistical Institute and an Associate Editor for NeuroOncology Practice. I am the PI of an NCI-funded R01 to develop statistical methods for risk prediction in cancer. Until 2009, I was the PI of an NCI-funded career award (K22 CA123146) for developing statistical methods for predicting survival outcomes based on genomic data, as well as the PI of a Yale Skin SPORE Career Development Award. I was also PI for a Scholar’s Award granted by the Yale Center for Clinical Investigation’s Clinical and Translational Science Award, as well as the Co-Director of the Bioinformatics/Biostatistics CORE for the Yale Skin SPORE. I also served as the statistical consultant for the UCSF SPORE in Breast Cancer for over ten years. In my current roles as the Director of Biostatistics for the UCSF Brain SPORE and P01, I advise study design and modeling, as well as analyze data from all seven projects including imaging, genetics, genomics, and immunology.

Education

Florida State University, Tallahassee, FL BS, 05/92, Statistics
University of California, Berkeley, CA, MA, 05/00, Biostatistics
University of California, Berkeley, CA, PhD, 01/04, Biostatistics
National Cancer Institute, Rockville, MD, 06/04-06/05, Cancer Prevention / Biostatistics


Professional Experience

  • 1998 - 2004
    Research Assistant, Comprehensive Cancer Center, UCSF, CA.
  • 1999 - 1999
    Instructor, Statistics and Biostatistics Departments, University of California, Berkeley, CA.
  • 1999 - 2005
    Biostatistician, Department of Medicine, UCSF.
  • 2000
    Instructor, Health Careers Opportunity Program, Stanford University, Palo Alto, CA.
  • 2004 - 2005
    Cancer Prevention Fellow, National Cancer Institute, NIH, Rockville, MD.
  • 2005 - 2011
    Assistant Professor, Division of Biostatistics, Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT.
  • 2011 - 2012
    Associate Visiting Professor, Division of Biostatistics, Yale University
  • 2011 - present
    Associate Professor, Department of Neurological Surgery and Division of Epidemiology and Biostatistics, UCSF

Honors & Awards

  • 2004
    Evelyn Fix Prize, UC Berkeley.
  • 2004
    Chin Long Chiang Biostatistics Student of the Year, UC Berkeley.
  • 2006
    Elected member of the International Statistical Institute
  • 2008
    Excellence in Teaching Award, Yale School of Public Health
  • 2009
    Selected as a Yale Center for Clinical Investigation Scholar

Selected Publications

  1. Chang J, Breshears JD, Molinaro AM, Sneed PK, McDermott MW, Theodosopoulos PV, Tward AD. Impact of pretreatment growth on Tumor control for vestibular schwannomas following gamma knife. Laryngoscope. 2018 Nov 08.
    View on PubMed
  2. Taylor JW, Parikh M, Phillips JJ, James CD, Molinaro AM, Butowski NA, Clarke JL, Oberheim-Bush NA, Chang SM, Berger MS, Prados M. Phase-2 trial of palbociclib in adult patients with recurrent RB1-positive glioblastoma. J Neurooncol. 2018 Aug 27.
    View on PubMed
  3. Luks TL, McKnight TR, Jalbert LE, Williams A, Neill E, Lobo KA, Persson AI, Perry A, Phillips JJ, Molinaro AM, Chang SM, Nelson SJ. Relationship of In Vivo MR Parameters to Histopathological and Molecular Characteristics of Newly Diagnosed, Nonenhancing Lower-Grade Gliomas. Transl Oncol. 2018 Jun 05; 11(4):941-949.
    View on PubMed
  4. Chandra A, Rick JW, Dalle Ore C, Lau D, Nguyen AT, Carrera D, Bonte A, Molinaro AM, Theodosopoulos PV, McDermott MW, Berger MS, Aghi MK. Disparities in health care determine prognosis in newly diagnosed glioblastoma. Neurosurg Focus. 2018 Jun; 44(6):E16.
    View on PubMed
  5. Breshears JD, Chang J, Molinaro AM, Sneed PK, McDermott MW, Tward A, Theodosopoulos PV. Temporal Dynamics of Pseudoprogression After Gamma Knife Radiosurgery for Vestibular Schwannomas-A Retrospective Volumetric Study. Neurosurgery. 2018 Mar 05.
    View on PubMed
  6. Flanigan PM, Jahangiri A, Weinstein D, Dayani F, Chandra A, Kanungo I, Choi S, Sankaran S, Molinaro AM, McDermott MW, Berger MS, Aghi MK. Postoperative Delirium in Glioblastoma Patients: Risk Factors and Prognostic Implications. Neurosurgery. 2018 Feb 16.
    View on PubMed
  7. Flanigan PM, Jahangiri A, Kuang R, Truong A, Choi S, Chou A, Molinaro AM, McDermott MW, Berger MS, Aghi MK. Developing an Algorithm for Optimizing Care of Elderly Patients With Glioblastoma. Neurosurgery. 2018 Jan 01; 82(1):64-75.
    View on PubMed
  8. Flanigan PM, Jahangiri A, Kuang R, Truong A, Choi S, Chou A, Rick JW, Chang SM, Molinaro AM, McDermott MW, Berger MS, Aghi MK. Improved Survival with Decreased Wait Time to Surgery in Glioblastoma Patients Presenting with Seizure. Neurosurgery. 2017 Nov 01; 81(5):824-833.
    View on PubMed
  9. Byron SA, Tran NL, Halperin RF, Phillips JJ, Kuhn JG, de Groot JF, Colman H, Ligon KL, Wen PY, Cloughesy TF, Mellinghoff IK, Butowski NA, Taylor JW, Clarke JL, Chang SM, Berger MS, Molinaro AM, Maggiora GM, Peng S, Nasser S, Liang WS, Trent JM, Berens ME, Carpten JD, Craig DW, Prados MD. Prospective Feasibility Trial for Genomics-Informed Treatment in Recurrent and Progressive Glioblastoma. Clin Cancer Res. 2018 Jan 15; 24(2):295-305.
    View on PubMed
  10. Jacobs DI, Liu Y, Gabrusiewicz K, Tsavachidis S, Armstrong GN, Zhou R, Wei J, Ivan C, Calin G, Molinaro AM, Rice T, Bracci PM, Hansen HM, Wiencke JK, Wrensch MR, Heimberger AB, Bondy ML. Germline polymorphisms in myeloid-associated genes are not associated with survival in glioma patients. J Neurooncol. 2018 Jan; 136(1):33-39.
    View on PubMed
  11. Autry A, Phillips JJ, Maleschlijski S, Roy R, Molinaro AM, Chang SM, Cha S, Lupo JM, Nelson SJ. Characterization of Metabolic, Diffusion, and Perfusion Properties in GBM: Contrast-Enhancing versus Non-Enhancing Tumor. Transl Oncol. 2017 Dec; 10(6):895-903.
    View on PubMed
  12. Mazor T, Chesnelong C, Pankov A, Jalbert LE, Hong C, Hayes J, Smirnov IV, Marshall R, Souza CF, Shen Y, Viswanath P, Noushmehr H, Ronen SM, Jones SJM, Marra MA, Cairncross JG, Perry A, Nelson SJ, Chang SM, Bollen AW, Molinaro AM, Bengtsson H, Olshen AB, Weiss S, Phillips JJ, Luchman HA, Costello JF. Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1. Proc Natl Acad Sci U S A. 2017 Oct 03; 114(40):10743-10748.
    View on PubMed
  13. Wahl M, Chang SM, Phillips JJ, Molinaro AM, Costello JF, Mazor T, Alexandrescu S, Lupo JM, Nelson SJ, Berger M, Prados M, Taylor JW, Butowski N, Clarke JL, Haas-Kogan D. Probing the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in gliomas: A phase 2 study of everolimus for recurrent adult low-grade gliomas. Cancer. 2017 Dec 01; 123(23):4631-4639.
    View on PubMed
  14. Anwar M, Molinaro AM, Morin O, Chang SM, Haas-Kogan DA, Nelson SJ, Lupo JM. Identifying Voxels at Risk for Progression in Glioblastoma Based on Dosimetry, Physiologic and Metabolic MRI. Radiat Res. 2017 09; 188(3):303-313.
    View on PubMed
  15. Jalbert LE, Elkhaled A, Phillips JJ, Neill E, Williams A, Crane JC, Olson MP, Molinaro AM, Berger MS, Kurhanewicz J, Ronen SM, Chang SM, Nelson SJ. Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma. Sci Rep. 2017 Mar 22; 7:44792.
    View on PubMed
  16. Pekmezci M, Rice T, Molinaro AM, Walsh KM, Decker PA, Hansen H, Sicotte H, Kollmeyer TM, McCoy LS, Sarkar G, Perry A, Giannini C, Tihan T, Berger MS, Wiemels JL, Bracci PM, Eckel-Passow JE, Lachance DH, Clarke J, Taylor JW, Luks T, Wiencke JK, Jenkins RB, Wrensch MR. Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT. Acta Neuropathol. 2017 Jun; 133(6):1001-1016.
    View on PubMed
  17. Nelson SJ, Kadambi AK, Park I, Li Y, Crane J, Olson M, Molinaro A, Roy R, Butowski N, Cha S, Chang S. Association of early changes in 1H MRSI parameters with survival for patients with newly diagnosed glioblastoma receiving a multimodality treatment regimen. Neuro Oncol. 2017 03 01; 19(3):430-439.
    View on PubMed
  18. Clarke JL, Molinaro AM, Cabrera JR, DeSilva AA, Rabbitt JE, Prey J, Drummond DC, Kim J, Noble C, Fitzgerald JB, Chang SM, Butowski NA, Taylor JW, Park JW, Prados MD. A phase 1 trial of intravenous liposomal irinotecan in patients with recurrent high-grade glioma. Cancer Chemother Pharmacol. 2017 Mar; 79(3):603-610.
    View on PubMed
  19. Wiencke JK, Koestler DC, Salas LA, Wiemels JL, Roy RP, Hansen HM, Rice T, McCoy LS, Bracci PM, Molinaro AM, Kelsey KT, Wrensch MR, Christensen BC. Immunomethylomic approach to explore the blood neutrophil lymphocyte ratio (NLR) in glioma survival. Clin Epigenetics. 2017; 9:10.
    View on PubMed
  20. Wahl M, Phillips JJ, Molinaro AM, Lin Y, Perry A, Haas-Kogan DA, Costello JF, Dayal M, Butowski N, Clarke JL, Prados M, Nelson S, Berger MS, Chang SM. Chemotherapy for adult low-grade gliomas: clinical outcomes by molecular subtype in a phase II study of adjuvant temozolomide. Neuro Oncol. 2017 02 01; 19(2):242-251.
    View on PubMed

Go to UCSF Profiles, powered by CTSI