Arie Perry, MD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Arie Perry, MD

Professor of Pathology and Neurological Surgery; Director of Neuropathology; Director of Neuropathology Fellowship Training Program; Vice Chair of Pathology

Arie.Perry@ucsf.edu

Phone: (415) 476-5236
Box 0102, UCSF
San Francisco, CA 94143-0102

UCSF Profiles

Cancer Center Membership

Associate Member » Neurologic Oncology

Research Summary

My clinical interests focus most heavily on surgical neuropathology, especially in terms of its application towards neuro-oncology. As a diagnostic neuropathologist with a focus on CNS tumors, I am primarily involved in translational research with the primary goal of developing new diagnostic and prognostic markers, which can be utilized in the clinical management of brain tumor patients. In order to achieve this goal, my lab has applied immunohistochemical, molecular cytogenetic, and genomic screening techniques primarily towards the study of gliomas, meningiomas, and primitive pediatric malignancies. I have been particularly interested in improved classification and grading schemes as well as the identification of molecular genetic markers associated with tumorigenesis, malignant progression, and/or biologic behavior. I collaborate with a number of clinical and scientific researchers both within and outside UCSF and it is our hope that the markers we identify will improve patient management and lead to the development of novel therapeutic approaches. I also maintain a private consultation service for difficult surgical neuropathology cases obtained from the U.S. and abroad, particularly brain tumors.

Education

The University of Texas at Austin, TX, B.S., 1986, Zoology
UT Southwestern Medical Center, Dallas, TX, M.D., 1990, M.D.
UT Southwestern Medical Center, Dallas, TX, Postdoctoral, 1994, Anatomic and Clinical Pathology Residency
Mayo Clinic, Rochester, MN, Postdoctoral, 1998, Surgical Pathology, Neuropathology, and Research Fellowships


Professional Experience

  • 1997-1998
    Mayo Clinic School of Medicine Instructor Pathology
  • 1998-2003
    Washington U. School of Medicine Assistant Professor Pathology
  • 2003-2008
    Washington U. School of Medicine Associate Professor Pathology
  • 2008-2010
    Washington U. School of Medicine Professor Pathology
  • 2009-2010
    Washington U. School of Medicine Professor Neurosurgery
  • 2010-present
    University of California, San Francisco Professor Pathology
  • 2010-present
    University of California, San Francisco Professor Neurosurgery

Honors & Awards

  • 1993
    First Place Resident Award (poster): Texas Society of Pathologists meeting
  • 1994
    First Place Resident Award (podium): Texas Society of Pathologists meeting
  • 1994
    Matthew T. Moore Award, International Congress of Neuropathology meeting
  • 1995
    Mary Tom Award, Canadian Association of Neuropathologists meeting
  • 1995-1997
    Fellowship Research Award, American Brain Tumor Association
  • 1999
    Distinguished Service Teaching Award, WUSM (Medical School Class of 2001)
  • 2002
    Lucien J. Rubenstein Award, American Association of Neuropathologists meeting
  • 2002
    Distinguished Service Teaching Award, WUSM (Medical School Class of 2004)
  • 2004
    Distinguished Service Teaching Award, WUSM (Medical School Class of 2006)
  • 2005
    Professor of the Year Award, WUSM (Medical School Class of 2007)
  • 2006-now
    America’s Top Doctors and America's Top Doctors for Cancer (Castle Connolly)
  • 2007
    Distinguished Service Teaching Award, WUSM (Medical School Class of 2009)
  • 2008
    Professor of the Year Award, WUSM (Medical School Class of 2010)
  • 2009-now
    Best Doctors in America, U.S. News and World Reports
  • 2009
    Distinguished Service Teaching Award, WUSM (Medical School Class of 2011)
  • 2013
    Nominated for MS1 Essential Core Teaching Award, UCSF (MS Class of 2016)

Selected Publications

  1. Cuevas-Ocampo AK, Bollen AW, Goode B, Pajtler KW, Chavez L, Sharma T, Dai SC, McDermott M, Perry A, Korshunov A, Solomon DA. Genetic confirmation that ependymoma can arise as part of multiple endocrine neoplasia type 1 (MEN1) syndrome. Acta Neuropathol. 2017 Feb 25.
    View on PubMed
  2. Louis DN, Aldape K, Brat DJ, Capper D, Ellison DW, Hawkins C, Paulus W, Perry A, Reifenberger G, Figarella-Branger D, Wesseling P, Batchelor TT, Cairncross JG, Pfister SM, Rutkowski S, Weller M, Wick W, von Deimling A. Announcing cIMPACT-NOW: the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy. Acta Neuropathol. 2017 Jan; 133(1):1-3.
    View on PubMed
  3. Winkler EA, Birk H, Safaee M, Yue JK, Burke JF, Viner JA, Pekmezci M, Perry A, Aghi MK, Berger MS, McDermott MW. Erratum to: Surgical resection of fourth ventricular ependymomas: case series and technical nuances. J Neurooncol. 2016 Dec 30.
    View on PubMed
  4. Louis DN, Aldape K, Brat DJ, Capper D, Ellison DW, Hawkins C, Paulus W, Perry A, Reifenberger G, Figarella-Branger D, Wesseling P, Batchelor TT, Gregory Cairncross J, Pfister SM, Rutkowski S, Weller M, Wick W, von Deimling A. cIMPACT-NOW (the consortium to inform molecular and practical approaches to CNS tumor taxonomy): a new initiative in advancing nervous system tumor classification. Brain Pathol. 2016 Dec 20.
    View on PubMed
  5. Hirbe AC, Kaushal M, Sharma MK, Dahiya S, Pekmezci M, Perry A, Gutmann DH. Clinical genomic profiling identifies TYK2 mutation and overexpression in patients with neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors. Cancer. 2016 Nov 22.
    View on PubMed
  6. Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AG, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen AW, Phillips JJ, Korn WM, Yeh I, Bastian BC, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon DA. Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro Oncol. 2016 Nov 14.
    View on PubMed
  7. Winkler EA, Birk H, Safaee M, Yue JK, Burke JF, Viner JA, Pekmezci M, Perry A, Aghi MK, Berger MS, McDermott MW. Surgical resection of fourth ventricular ependymomas: case series and technical nuances. J Neurooncol. 2016 Nov; 130(2):341-349.
    View on PubMed
  8. Ohba S, Mukherjee J, Johannessen TC, Mancini A, Chow TT, Wood M, Jones L, Mazor T, Marshall RE, Viswanath P, Walsh KM, Perry A, Bell RJ, Phillips JJ, Costello JF, Ronen SM, Pieper RO. Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process. Cancer Res. 2016 Nov 15; 76(22):6680-6689.
    View on PubMed
  9. Johanns TM, Miller CA, Dorward IG, Tsien C, Chang E, Perry A, Uppaluri R, Ferguson C, Schmidt RE, Dahiya S, Ansstas G, Mardis ER, Dunn GP. Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline POLE Deficiency Treated with Checkpoint Blockade Immunotherapy. Cancer Discov. 2016 Nov; 6(11):1230-1236.
    View on PubMed
  10. Han SJ, Reis G, Kohanbash G, Shrivastav S, Magill ST, Molinaro AM, McDermott MW, Theodosopoulos PV, Aghi MK, Berger MS, Butowski NA, Barani I, Phillips JJ, Perry A, Okada H. Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma. J Neurooncol. 2016 Dec; 130(3):543-552.
    View on PubMed
  11. Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Jin LW, Bastian BC, Bollen AW, Perry A, Nicolaides T, Solomon DA, Shieh JT. Activating NRF1-BRAF and ATG7-RAF1 fusions in anaplastic pleomorphic xanthoastrocytoma without BRAF p.V600E mutation. Acta Neuropathol. 2016 Sep 13.
    View on PubMed
  12. Olar A, Lapadat R, Davidson CJ, Stein TD, Dahiya S, Perry A, Gheorghe G. Central nervous system involvement by myeloid sarcoma: a report of 12 cases and review of the literature. Clin Neuropathol. 2016 Sep-Oct; 35(5):314-25.
    View on PubMed
  13. Gospodarev V, Câmara J, Chakravarthy V, Perry A, Wood M, Dietz R, Wang J, De Los Reyes K, Raghavan R. Treatment of IgG4-related pachymeningitis in a patient with steroid intolerance: The role of early use of rituximab. J Neuroimmunol. 2016 Oct 15; 299:62-65.
    View on PubMed
  14. Perry A. WHO's arrived in 2016! An updated weather forecast for integrated brain tumor diagnosis. Brain Tumor Pathol. 2016 Jul; 33(3):157-60.
    View on PubMed
  15. Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016 Jun; 131(6):803-20.
    View on PubMed
  16. Ferris SP, Goode B, Joseph NM, Kline CN, Samuel D, Gupta N, Bollen A, Perry A, Mueller S, Solomon DA. IDH1 mutation can be present in diffuse astrocytomas and giant cell glioblastomas of young children under 10 years of age. Acta Neuropathol. 2016 Jul; 132(1):153-5.
    View on PubMed
  17. Hasselblatt M, Thomas C, Hovestadt V, Schrimpf D, Johann P, Bens S, Oyen F, Peetz-Dienhart S, Crede Y, Wefers A, Vogel H, Riemenschneider MJ, Antonelli M, Giangaspero F, Bernardo MC, Giannini C, Ud Din N, Perry A, Keyvani K, van Landeghem F, Sumerauer D, Hauser P, Capper D, Korshunov A, Jones DT, Pfister SM, Schneppenheim R, Siebert R, Frühwald MC, Kool M. Poorly differentiated chordoma with SMARCB1/INI1 loss: a distinct molecular entity with dismal prognosis. Acta Neuropathol. 2016 Jul; 132(1):149-51.
    View on PubMed
  18. Schwetye KE, Joseph NM, Al-Kateb H, Rich KM, Schmidt RE, Perry A, Gutmann DH, Dahiya S. Gliosarcomas lack BRAF(V600E) mutation, but a subset exhibit ß-catenin nuclear localization. Neuropathology. 2016 Oct; 36(5):448-455.
    View on PubMed
  19. Sturm D, Orr BA, Toprak UH, Hovestadt V, Jones DT, Capper D, Sill M, Buchhalter I, Northcott PA, Leis I, Ryzhova M, Koelsche C, Pfaff E, Allen SJ, Balasubramanian G, Worst BC, Pajtler KW, Brabetz S, Johann PD, Sahm F, Reimand J, Mackay A, Carvalho DM, Remke M, Phillips JJ, Perry A, Cowdrey C, Drissi R, Fouladi M, Giangaspero F, Lastowska M, Grajkowska W, Scheurlen W, Pietsch T, Hagel C, Gojo J, Lötsch D, Berger W, Slavc I, Haberler C, Jouvet A, Holm S, Hofer S, Prinz M, Keohane C, Fried I, Mawrin C, Scheie D, Mobley BC, Schniederjan MJ, Santi M, Buccoliero AM, Dahiya S, Kramm CM, von Bueren AO, von Hoff K, Rutkowski S, Herold-Mende C, Frühwald MC, Milde T, Hasselblatt M, Wesseling P, Rößler J, Schüller U, Ebinger M, Schittenhelm J, Frank S, Grobholz R, Vajtai I, Hans V, Schneppenheim R, Zitterbart K, Collins VP, Aronica E, Varlet P, Puget S, Dufour C, Grill J, Figarella-Branger D, Wolter M, Schuhmann MU, Shalaby T, Grotzer M, van Meter T, Monoranu CM, Felsberg J, Reifenberger G, Snuderl M, Forrester LA, Koster J, Versteeg R, Volckmann R, van Sluis P, Wolf S, Mikkelsen T, Gajjar A, Aldape K, Moore AS, Taylor MD, Jones C, Jabado N, Karajannis MA, Eils R, Schlesner M, Lichter P, von Deimling A, Pfister SM, Ellison DW, Korshunov A, Kool M. New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs. Cell. 2016 Feb 25; 164(5):1060-72.
    View on PubMed
  20. Röhrich M, Koelsche C, Schrimpf D, Capper D, Sahm F, Kratz A, Reuss J, Hovestadt V, Jones DT, Bewerunge-Hudler M, Becker A, Weis J, Mawrin C, Mittelbronn M, Perry A, Mautner VF, Mechtersheimer G, Hartmann C, Okuducu AF, Arp M, Seiz-Rosenhagen M, Hänggi D, Heim S, Paulus W, Schittenhelm J, Ahmadi R, Herold-Mende C, Unterberg A, Pfister SM, von Deimling A, Reuss DE. Methylation-based classification of benign and malignant peripheral nerve sheath tumors. Acta Neuropathol. 2016 Jun; 131(6):877-87.
    View on PubMed

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