Joanna Phillips, MD, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Joanna Phillips, MD, PhD

Assistant Professor, Neurological Surgery and Pathology; Co-Director UCSF Brain Tumor SPORE Biorepository

joanna.phillips@ucsf.edu

Phone: (415) 514-4929
Box 0520 , UCSF
San Francisco, CA 94143-0520

UCSF Profiles

Cancer Center Membership

Program Member » Neurologic Oncology

Research Summary

I am an Assistant Professor in the UCSF Departments of Neurological Surgery and Pathology, Director of the UCSF Brain Tumor Research Center Tissue Biorepository and Histology Core, Co-Director of the UCSF Neuropathology BTRC Biomarkers Laboratory, Co-Director of the UCSF Brain Tumor SPORE Biorepository, and Director of the Biospecimen and Biostatistics Core for a UCSF brain tumor-focused Program Project (P01). I received my MD and PhD in Neuroscience from the University of Pennsylvania School of Medicine in 2002, and I have over ten years of experience working in cancer and neuropathology. My research interests focus on studying how factors in the brain tumor microenvironment, including the extracellular matrix and immune cells, influence tumor development and invasion. I am the PI of an NINDS-funded R01 and an NCI-funded U01, and have published over 70 publications related to the development and therapy of brain tumors.

Education

Cornell University, Ithaca, NY, BS, 05/1994, Biology/Biochemistry
University of Pennsylvania, Philadelphia, PA, PhD, 05/2001, Neuroscience
University of Pennsylvania, Philadelphia, PA, MD, 05/2002, Medicine
University of Washington, Seattle, WA, Residency, 2002-2004, Anatomic Pathology
University of California SF, San Francisco, CA, Fellow, 2004-2006, Neuropathology


Professional Experience

  • 2002–2004
    Resident, Department of Anatomic Pathology, University of Washington
  • 2004–2006
    Clinical Fellow, Department of Pathology, University of California San Francisco
  • 2006-2008
    Postdoctoral Fellow, Mentor: Zena Werb, Ph.D., Department of Anatomy, University of California San Francisco
  • 2008–2010
    Clinical Instructor, Department of Pathology, University of California San Francisco
  • 2009-Present
    UCSF Brain Tumor Research Center Tissue Bank, Neuropathologist
  • 2010-Present
    Assistant Professor Neurological Surgery and Pathology, University of California, San Francisco
  • 2010-Present
    Co-Director UCSF Brain Tumor SPORE Biorepository
  • 2012-Present
    UCSF Helen Diller Family Comprehensive Cancer Center, Member
  • 2012-Present
    Society for Glycobiology

Honors & Awards

  • 1993-94
    Cornell University, Hughes Scholars Program
  • 1994
    Cornell University, graduated with honors and distinction in Biology
  • 1999
    American Society for Virology travel award
  • 2001
    Stuart Mudd Award in Microbiology, University of Pennsylvania School of Medicine
  • 2005
    Moore Award for best paper on clinico-pathologic correlation, annual meeting of American Association of Neuropathologists
  • 2006
    Nominated UCSF School of Medicine Essential Teaching Award
  • 2006
    Young Pathologist Fellowship, American Society for Investigative Pathology, Experimental Biology annual meeting
  • 2006-08
    American Brain Tumor Association: Susan Resnick Fisher/American Brain Tumor Association Fellowship
  • 2008
    Rubinstein Award, best paper on neuro-oncology, annual meeting of American Association of Neuropathologists
  • 2010
    Aspen Cancer Conference Fellow
  • 2012
    Second place, Moore Award, Best paper on clinic-pathological correlation, annual meeting of American Association of Neuropathologists
  • 2013
    Nominated UCSF School of Medicine Essential Core Teaching Award

Selected Publications

  1. Miroshnikova YA, Mouw JK, Barnes JM, Pickup MW, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight TR, Holland EC, Phillips JJ, Weaver VM. Tissue mechanics promote IDH1-dependent HIF1a-tenascin C feedback to regulate glioblastoma aggression. Nat Cell Biol. 2016 Nov 07.
    View on PubMed
  2. Vatsavayai SC, Yoon SJ, Gardner RC, Gendron TF, Vargas JN, Trujillo A, Pribadi M, Phillips JJ, Gaus SE, Hixson JD, Garcia PA, Rabinovici GD, Coppola G, Geschwind DH, Petrucelli L, Miller BL, Seeley WW. Timing and significance of pathological features in C9orf72 expansion-associated frontotemporal dementia. Brain. 2016 Oct 22.
    View on PubMed
  3. Lindberg OR, McKinney A, Engler JR, Koshkakaryan G, Gong H, Robinson AE, Ewald AJ, Huillard E, James CD, Molinaro AM, Shieh JT, Phillips JJ. GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity. Oncotarget. 2016 Oct 12.
    View on PubMed
  4. Han SJ, Reis G, Kohanbash G, Shrivastav S, Magill ST, Molinaro AM, McDermott MW, Theodosopoulos PV, Aghi MK, Berger MS, Butowski NA, Barani I, Phillips JJ, Perry A, Okada H. Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma. J Neurooncol. 2016 Dec; 130(3):543-552.
    View on PubMed
  5. Lal S, Peng KW, Steele MB, Jenks N, Ma H, Kohanbash G, Phillips JJ, Raffel C. Safety Study: Intraventricular Injection of a Modified Oncolytic Measles Virus into Measles-Immune, hCD46-Transgenic, IFNaRko Mice. Hum Gene Ther Clin Dev. 2016 Sep 7.
    View on PubMed
  6. Mukherjee J, Ohba S, See WL, Phillips JJ, Molinaro AM, Pieper RO. PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells. Int J Cancer. 2016 Jul 1; 139(1):99-111.
    View on PubMed
  7. Jalbert LE, Neill E, Phillips JJ, Lupo JM, Olson MP, Molinaro AM, Berger MS, Chang SM, Nelson SJ. Magnetic resonance analysis of malignant transformation in recurrent glioma. Neuro Oncol. 2016 Aug; 18(8):1169-79.
    View on PubMed
  8. Radoul M, Chaumeil MM, Eriksson P, Wang AS, Phillips JJ, Ronen SM. MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival. Mol Cancer Ther. 2016 May; 15(5):1113-22.
    View on PubMed
  9. Lerner RG, Grossauer S, Kadkhodaei B, Meyers I, Sidorov M, Koeck K, Hashizume R, Ozawa T, Phillips JJ, Berger MS, Nicolaides T, James CD, Petritsch CK. Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells. Cancer Res. 2015 Dec 15; 75(24):5355-66.
    View on PubMed
  10. Solomon DA, Wood MD, Tihan T, Bollen AW, Gupta N, Phillips JJ, Perry A. Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations. Brain Pathol. 2015 Oct 30.
    View on PubMed
  11. Mazor T, Pankov A, Johnson BE, Hong C, Hamilton EG, Bell RJ, Smirnov IV, Reis GF, Phillips JJ, Barnes MJ, Idbaih A, Alentorn A, Kloezeman JJ, Lamfers ML, Bollen AW, Taylor BS, Molinaro AM, Olshen AB, Chang SM, Song JS, Costello JF. DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors. Cancer Cell. 2015 Sep 14; 28(3):307-17.
    View on PubMed
  12. Izquierdo-Garcia JL, Viswanath P, Eriksson P, Cai L, Radoul M, Chaumeil MM, Blough M, Luchman HA, Weiss S, Cairncross JG, Phillips JJ, Pieper RO, Ronen SM. IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism. Cancer Res. 2015 Aug 1; 75(15):2999-3009.
    View on PubMed
  13. Reis GF, Pekmezci M, Hansen HM, Rice T, Marshall RE, Molinaro AM, Phillips JJ, Vogel H, Wiencke JK, Wrensch MR, Walsh KM, Perry A. CDKN2A loss is associated with shortened overall survival in lower-grade (World Health Organization Grades II-III) astrocytomas. J Neuropathol Exp Neurol. 2015 May; 74(5):442-52.
    View on PubMed
  14. Izquierdo-Garcia JL, Viswanath P, Eriksson P, Chaumeil MM, Pieper RO, Phillips JJ, Ronen SM. Metabolic reprogramming in mutant IDH1 glioma cells. PLoS One. 2015; 10(2):e0118781.
    View on PubMed
  15. Lemjabbar-Alaoui H, McKinney A, Yang YW, Tran VM, Phillips JJ. Glycosylation alterations in lung and brain cancer. Adv Cancer Res. 2015; 126:305-44.
    View on PubMed
  16. Wade A, Engler JR, Tran VM, Phillips JJ. Measuring sulfatase expression and invasion in glioblastoma. Methods Mol Biol. 2015; 1229:507-16.
    View on PubMed
  17. Phillips J, Tihan T, Fuller G. Practical molecular pathology and histopathology of embryonal tumors. Surg Pathol Clin. 2015 Mar; 8(1):73-88.
    View on PubMed
  18. Izquierdo-Garcia JL, Cai LM, Chaumeil MM, Eriksson P, Robinson AE, Pieper RO, Phillips JJ, Ronen SM. Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase. PLoS One. 2014; 9(9):e108289.
    View on PubMed
  19. Ivan ME, Safaee M, Oh T, Clark AJ, Sun MZ, Kim J, Bloch O, Jahangiri A, Phillips JJ, Aghi MK, Parsa AT. Epidermal growth factor-like module containing mucin-like hormone receptor 2 expression in gliomas. J Neurooncol. 2015 Jan; 121(1):53-61.
    View on PubMed
  20. Elkhaled A, Jalbert L, Constantin A, Yoshihara HA, Phillips JJ, Molinaro AM, Chang SM, Nelson SJ. Characterization of metabolites in infiltrating gliomas using ex vivo ¹H high-resolution magic angle spinning spectroscopy. NMR Biomed. 2014 May; 27(5):578-93.
    View on PubMed

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