University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Susanna Rosi, PhD

Susanna Rosi, PhD

Associate Professor, Director of Neurocognitive Research, Brain and Spinal Injury Center, BASIC

Cancer Center Program Memberships

Affiliate Member

Research Summary

My laboratory is located in the Brain and Spinal Injury Center (BASIC) at UCSF, and our research is focused on understanding how innate immune system activation and macrophages polarization affect information processing and cognition from a cellular and network perspective by using different animal models of brain injury. To examine the above effects, my laboratory employs three principle animal models: traumatic brain injury, therapeutic cranial γ-irradiation, and ionizing space radiation. Our ultimate goal is to understand the mechanisms responsible for the cognitive dysfunction observed after brain injury to identify diagnostic tools for treatment and prevention. Our published results demonstrate that neuroinflammation alters the coupling of neuronal activity with the transcription of genes that are implicated in long-term memory and synaptic plasticity (Rosi et al., Journal of Neuroscience, 2005). By modulating different aspects of neuroinflammation we reported that it is possible to restore synaptic plasticity and cognitive functions in different animal models of chronic neuroinflammatory conditions (Rosi et al., Brain 2009; Belarbi et al., Journal of Neuroinflammation, 2012; Twediee et al.; Journal of Neuroinflammation, 2012; Belarbi et al., Journal of Neuroinflammation, 2012; Belarbi et al., Cancer Research, 2013). More recently, we reported that peripheral monocytes infiltrate the brain after traumatic brain injury and drive the inflammatory response to TBI. Most importantly, targeting monocytes infiltration it is possible to modify macrophages polarization and prevent long-term loss of synaptic and cognitive function after injury (Morganti et al., Journal of Neuroscience, 2015).

Education

University of Florence, Italy, B.S., 06/1995, Science
University of Florence, Italy, Ph.D., 06/2000, Biological Sciences
University of Florence, Italy, Postdoctoral, 2000-2001, Pharmacology
University of Arizona, Tucson, Arizona, Postdoctoral Research Associate , 2002-2006, Psychology
 


Professional Experience

  • 2000-2001
    Postdoctoral Fellow, University of Florence, Italy
  • 2002-2006
    Postdoctoral Research Associate, University of Arizona, Tucson, AZ
  • 2006-2011
    Assistant Professor, Departments of Physical Therapy Rehabilitation Science and Neurological Surgery, University of California, San Francisco, San Francisco, CA
  • 2011-present
    Associate Professor (1 year Accelerated), Departments of Physical Therapy Rehabilitation Science and Neurological Surgery, University of California, San Francisco, San Francisco.
  • 2011-present
    Director of Neurocognitive Research, Brain and Spinal Injury Center, University of California, San Francisco, San Francisco, CA

Honors & Awards

  • 1996-2000
    Graduate Fellowship, University of Florence, Italy

  • 2000
    Graduated with Distinction, University of Florence, Italy

  • 2001
    Postdoctoral Fellowship Award, Department of Pharmacology, University of Florence, Italy

  • 2004
    Travel Award, Winter Conference on Brain Research

  • 2006
    Special Award for Research and Career, “Vel l’Etrusco”, Castiglion Fiorentino, Arezzo, Italy

  • 2007
    UCSF, Academic Senate Committee on Research - Individual Investigator Award: seed funding

  • 2007
    UCSF, Research Evaluation and Allocation Committee Award: seed funding

  • 2007
    Tuscany Special Award “Young Talents and Magnificent Excellences”, Arezzo, Italy

  • 2008
    New Investigator Research Grant, Alzheimer’s Association

  • 2012
    UCSF, Department of Radiology and Biomedical Imaging, Seed Grant

Selected Publications

  1. Impey S, Jopson T, Pelz C, Tafessu A, Fareh F, Zuloaga D, Marzulla T, Riparip LK, Stewart B, Rosi S, Turker MS, Raber J. Bi-directional and shared epigenomic signatures following proton and 56Fe irradiation. Sci Rep. 2017 Aug 31; 7(1):10227.
    View on PubMed
  2. Chou A, Krukowski K, Jopson T, Zhu PJ, Costa-Mattioli M, Walter P, Rosi S. Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury. Proc Natl Acad Sci U S A. 2017 Aug 01; 114(31):E6420-E6426.
    View on PubMed
  3. Vonder Haar C, Martens KM, Riparip LK, Rosi S, Wellington CL, Winstanley CA. Frontal Traumatic Brain Injury Increases Impulsive Decision Making in Rats: A Potential Role for the Inflammatory Cytokine Interleukin-12. J Neurotrauma. 2017 Oct 01; 34(19):2790-2800.
    View on PubMed
  4. Klein RS, Voskuhl R, Segal BM, Dittel BN, Lane TE, Bethea JR, Carson MJ, Colton C, Rosi S, Anderson A, Piccio L, Goverman JM, Benveniste EN, Brown MA, Tiwari-Woodruff SK, Harris TH, Cross AH. Speaking out about gender imbalance in invited speakers improves diversity. Nat Immunol. 2017 Apr 18; 18(5):475-478.
    View on PubMed
  5. Feng X, Rosi S. Targeting colony stimulating factor 1 receptor to prevent cognitive deficits induced by fractionated whole-brain irradiation. Neural Regen Res. 2017 Mar; 12(3):399-400.
    View on PubMed
  6. Impey S, Jopson T, Pelz C, Tafessu A, Fareh F, Zuloaga D, Marzulla T, Riparip LK, Stewart B, Rosi S, Turker MS, Raber J. Short- and long-term effects of 56Fe irradiation on cognition and hippocampal DNA methylation and gene expression. BMC Genomics. 2016 Oct 24; 17(1):825.
    View on PubMed
  7. Feng X, Jopson TD, Paladini MS, Liu S, West BL, Gupta N, Rosi S. Colony-stimulating factor 1 receptor blockade prevents fractionated whole-brain irradiation-induced memory deficits. J Neuroinflammation. 2016 Aug 30; 13(1):215.
    View on PubMed
  8. Vonder Haar C, Lam FC, Adams WK, Riparip LK, Kaur S, Muthukrishna M, Rosi S, Winstanley CA. Frontal Traumatic Brain Injury in Rats Causes Long-Lasting Impairments in Impulse Control That Are Differentially Sensitive to Pharmacotherapeutics and Associated with Chronic Neuroinflammation. ACS Chem Neurosci. 2016 Nov 16; 7(11):1531-1542.
    View on PubMed
  9. Lee S, Mattingly A, Lin A, Sacramento J, Mannent L, Castel MN, Canolle B, Delbary-Gossart S, Ferzaz B, Morganti JM, Rosi S, Ferguson AR, Manley GT, Bresnahan JC, Beattie MS. A novel antagonist of p75NTR reduces peripheral expansion and CNS trafficking of pro-inflammatory monocytes and spares function after traumatic brain injury. J Neuroinflammation. 2016 Apr 22; 13(1):88.
    View on PubMed
  10. Morganti JM, Riparip LK, Chou A, Liu S, Gupta N, Rosi S. Age exacerbates the CCR2/5-mediated neuroinflammatory response to traumatic brain injury. J Neuroinflammation. 2016 Apr 18; 13(1):80.
    View on PubMed
  11. Chou A, Morganti JM, Rosi S. Frontal Lobe Contusion in Mice Chronically Impairs Prefrontal-Dependent Behavior. PLoS One. 2016; 11(3):e0151418.
    View on PubMed
  12. Morganti JM, Riparip LK, Rosi S. Call Off the Dog(ma): M1/M2 Polarization Is Concurrent following Traumatic Brain Injury. PLoS One. 2016; 11(1):e0148001.
    View on PubMed
  13. Raber J, Allen AR, Sharma S, Allen B, Rosi S, Olsen RH, Davis MJ, Eiwaz M, Fike JR, Nelson GA. Effects of Proton and Combined Proton and (56)Fe Radiation on the Hippocampus. Radiat Res. 2016 Jan; 185(1):20-30.
    View on PubMed
  14. Morganti JM, Jopson TD, Liu S, Riparip LK, Guandique CK, Gupta N, Ferguson AR, Rosi S. CCR2 antagonism alters brain macrophage polarization and ameliorates cognitive dysfunction induced by traumatic brain injury. J Neurosci. 2015 Jan 14; 35(2):748-60.
    View on PubMed
  15. Parihar VK, Allen BD, Tran KK, Chmielewski NN, Craver BM, Martirosian V, Morganti JM, Rosi S, Vlkolinsky R, Acharya MM, Nelson GA, Allen AR, Limoli CL. Targeted overexpression of mitochondrial catalase prevents radiation-induced cognitive dysfunction. Antioxid Redox Signal. 2015 Jan 01; 22(1):78-91.
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  16. Allen AR, Eilertson K, Sharma S, Baure J, Allen B, Leu D, Rosi S, Raber J, Huang TT, Fike JR. Delayed administration of alpha-difluoromethylornithine prevents hippocampus-dependent cognitive impairment after single and combined injury in mice. Radiat Res. 2014 Nov; 182(5):489-98.
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  17. Acharya MM, Rosi S, Jopson T, Limoli CL. Human neural stem cell transplantation provides long-term restoration of neuronal plasticity in the irradiated hippocampus. Cell Transplant. 2015; 24(4):691-702.
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  18. Morganti JM, Jopson TD, Liu S, Gupta N, Rosi S. Cranial irradiation alters the brain's microenvironment and permits CCR2+ macrophage infiltration. PLoS One. 2014; 9(4):e93650.
    View on PubMed
  19. Raber J, Rudobeck E, Campbell-Beachler M, Allen AR, Allen B, Rosi S, Nelson GA, Ramachandran S, Turner J, Fike JR, Vlkolinsky R. (28)Silicon radiation-induced enhancement of synaptic plasticity in the hippocampus of naïve and cognitively tested mice. Radiat Res. 2014 Apr; 181(4):362-8.
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  20. Allen AR, Eilertson K, Chakraborti A, Sharma S, Baure J, Habdank-Kolaczkowski J, Allen B, Rosi S, Raber J, Fike JR. Radiation exposure prior to traumatic brain injury induces responses that differ as a function of animal age. Int J Radiat Biol. 2014 Mar; 90(3):214-23.
    View on PubMed

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