University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Susanna Rosi, PhD

Susanna Rosi, PhD

Associate Professor, Director of Neurocognitive Research, Brain and Spinal Injury Center, BASIC

Cancer Center Program Memberships

Affiliate Member

Research Summary

My laboratory is located in the Brain and Spinal Injury Center (BASIC) at UCSF, and our research is focused on understanding how innate immune system activation and macrophages polarization affect information processing and cognition from a cellular and network perspective by using different animal models of brain injury. To examine the above effects, my laboratory employs three principle animal models: traumatic brain injury, therapeutic cranial γ-irradiation, and ionizing space radiation. Our ultimate goal is to understand the mechanisms responsible for the cognitive dysfunction observed after brain injury to identify diagnostic tools for treatment and prevention. Our published results demonstrate that neuroinflammation alters the coupling of neuronal activity with the transcription of genes that are implicated in long-term memory and synaptic plasticity (Rosi et al., Journal of Neuroscience, 2005). By modulating different aspects of neuroinflammation we reported that it is possible to restore synaptic plasticity and cognitive functions in different animal models of chronic neuroinflammatory conditions (Rosi et al., Brain 2009; Belarbi et al., Journal of Neuroinflammation, 2012; Twediee et al.; Journal of Neuroinflammation, 2012; Belarbi et al., Journal of Neuroinflammation, 2012; Belarbi et al., Cancer Research, 2013). More recently, we reported that peripheral monocytes infiltrate the brain after traumatic brain injury and drive the inflammatory response to TBI. Most importantly, targeting monocytes infiltration it is possible to modify macrophages polarization and prevent long-term loss of synaptic and cognitive function after injury (Morganti et al., Journal of Neuroscience, 2015).

Education

University of Florence, Italy, B.S., 06/1995, Science
University of Florence, Italy, Ph.D., 06/2000, Biological Sciences
University of Florence, Italy, Postdoctoral, 2000-2001, Pharmacology
University of Arizona, Tucson, Arizona, Postdoctoral Research Associate , 2002-2006, Psychology
 


Professional Experience

  • 2000-2001
    Postdoctoral Fellow, University of Florence, Italy
  • 2002-2006
    Postdoctoral Research Associate, University of Arizona, Tucson, AZ
  • 2006-2011
    Assistant Professor, Departments of Physical Therapy Rehabilitation Science and Neurological Surgery, University of California, San Francisco, San Francisco, CA
  • 2011-present
    Associate Professor (1 year Accelerated), Departments of Physical Therapy Rehabilitation Science and Neurological Surgery, University of California, San Francisco, San Francisco.
  • 2011-present
    Director of Neurocognitive Research, Brain and Spinal Injury Center, University of California, San Francisco, San Francisco, CA

Honors & Awards

  • 1996-2000
    Graduate Fellowship, University of Florence, Italy

  • 2000
    Graduated with Distinction, University of Florence, Italy

  • 2001
    Postdoctoral Fellowship Award, Department of Pharmacology, University of Florence, Italy

  • 2004
    Travel Award, Winter Conference on Brain Research

  • 2006
    Special Award for Research and Career, “Vel l’Etrusco”, Castiglion Fiorentino, Arezzo, Italy

  • 2007
    UCSF, Academic Senate Committee on Research - Individual Investigator Award: seed funding

  • 2007
    UCSF, Research Evaluation and Allocation Committee Award: seed funding

  • 2007
    Tuscany Special Award “Young Talents and Magnificent Excellences”, Arezzo, Italy

  • 2008
    New Investigator Research Grant, Alzheimer’s Association

  • 2012
    UCSF, Department of Radiology and Biomedical Imaging, Seed Grant

Selected Publications

  1. Krukowski K, Rosi S. The dark side of antiviral T cell responses. Nat Neurosci. 2019 Aug; 22(8):1199-1200.
    View on PubMed
  2. Krukowski K, Chou A, Feng X, Tiret B, Paladini MS, Riparip LK, Chaumeil MM, Lemere C, Rosi S. Traumatic Brain Injury in Aged Mice Induces Chronic Microglia Activation, Synapse Loss, and Complement-Dependent Memory Deficits. Int J Mol Sci. 2018 Nov 26; 19(12).
    View on PubMed
  3. Cekanaviciute E, Rosi S, Costes SV. Central Nervous System Responses to Simulated Galactic Cosmic Rays. Int J Mol Sci. 2018 Nov 20; 19(11).
    View on PubMed
  4. Feng X, Liu S, Chen D, Rosi S, Gupta N. Rescue of cognitive function following fractionated brain irradiation in a novel preclinical glioma model. Elife. 2018 11 13; 7.
    View on PubMed
  5. Rosi S. The final frontier: Transient microglia reduction after cosmic radiation exposure mitigates cognitive impairments and modulates phagocytic activity. Brain Circ. 2018 Jul-Sep; 4(3):109-113.
    View on PubMed
  6. Vonder Haar C, Ferland JN, Kaur S, Riparip LK, Rosi S, Winstanley CA. Cocaine self-administration is increased after frontal traumatic brain injury and associated with neuroinflammation. Eur J Neurosci. 2018 Aug 17.
    View on PubMed
  7. Krukowski K, Grue K, Frias ES, Pietrykowski J, Jones T, Nelson G, Rosi S. Female mice are protected from space radiation-induced maladaptive responses. Brain Behav Immun. 2018 Nov; 74:106-120.
    View on PubMed
  8. Krukowski K, Feng X, Paladini MS, Chou A, Sacramento K, Grue K, Riparip LK, Jones T, Campbell-Beachler M, Nelson G, Rosi S. Author Correction: Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits. Sci Rep. 2018 Jul 03; 8(1):10297.
    View on PubMed
  9. Nolan A, Hennessy E, Krukowski K, Guglielmetti C, Chaumeil MM, Sohal VS, Rosi S. Repeated Mild Head Injury Leads to Wide-Ranging Deficits in Higher-Order Cognitive Functions Associated with the Prefrontal Cortex. J Neurotrauma. 2018 Oct 15; 35(20):2425-2434.
    View on PubMed
  10. Chou A, Krukowski K, Morganti JM, Riparip LK, Rosi S. Persistent Infiltration and Impaired Response of Peripherally-Derived Monocytes after Traumatic Brain Injury in the Aged Brain. Int J Mol Sci. 2018 May 30; 19(6).
    View on PubMed
  11. Krukowski K, Jones T, Campbell-Beachler M, Nelson G, Rosi S. Peripheral T Cells as a Biomarker for Oxygen-Ion-Radiation-Induced Social Impairments. Radiat Res. 2018 08; 190(2):186-193.
    View on PubMed
  12. Krukowski K, Feng X, Paladini MS, Chou A, Sacramento K, Grue K, Riparip LK, Jones T, Campbell-Beachler M, Nelson G, Rosi S. Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits. Sci Rep. 2018 May 18; 8(1):7857.
    View on PubMed
  13. Guglielmetti C, Chou A, Krukowski K, Najac C, Feng X, Riparip LK, Rosi S, Chaumeil MM. In vivo metabolic imaging of Traumatic Brain Injury. Sci Rep. 2017 Dec 13; 7(1):17525.
    View on PubMed
  14. Rosi S. Colony stimulating factor-1 receptor as a treatment for cognitive deficits postfractionated whole-brain irradiation. Brain Circ. 2017 Jul-Sep; 3(3):180-182.
    View on PubMed
  15. Impey S, Jopson T, Pelz C, Tafessu A, Fareh F, Zuloaga D, Marzulla T, Riparip LK, Stewart B, Rosi S, Turker MS, Raber J. Bi-directional and shared epigenomic signatures following proton and 56Fe irradiation. Sci Rep. 2017 08 31; 7(1):10227.
    View on PubMed
  16. Chou A, Krukowski K, Jopson T, Zhu PJ, Costa-Mattioli M, Walter P, Rosi S. Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury. Proc Natl Acad Sci U S A. 2017 08 01; 114(31):E6420-E6426.
    View on PubMed
  17. Feng X, Krukowski K, Jopson T, Rosi S. Delayed-matching-to-place Task in a Dry Maze to Measure Spatial Working Memory in Mice. Bio Protoc. 2017 Jul 05; 7(13).
    View on PubMed
  18. Vonder Haar C, Martens KM, Riparip LK, Rosi S, Wellington CL, Winstanley CA. Frontal Traumatic Brain Injury Increases Impulsive Decision Making in Rats: A Potential Role for the Inflammatory Cytokine Interleukin-12. J Neurotrauma. 2017 10 01; 34(19):2790-2800.
    View on PubMed
  19. Klein RS, Voskuhl R, Segal BM, Dittel BN, Lane TE, Bethea JR, Carson MJ, Colton C, Rosi S, Anderson A, Piccio L, Goverman JM, Benveniste EN, Brown MA, Tiwari-Woodruff SK, Harris TH, Cross AH. Speaking out about gender imbalance in invited speakers improves diversity. Nat Immunol. 2017 04 18; 18(5):475-478.
    View on PubMed
  20. Feng X, Rosi S. Targeting colony stimulating factor 1 receptor to prevent cognitive deficits induced by fractionated whole-brain irradiation. Neural Regen Res. 2017 Mar; 12(3):399-400.
    View on PubMed

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