David P. Toczyski, PhD

David P. Toczyski, PhD

Professor, Department of Biochemistry and Biophysics, UCSF


Phone: (415) 502-1301 (voice)
Box 0128, UCSF
San Francisco, CA 94143-0128

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Cancer Center Membership

Program Member » Non-aligned

Additional Websites


State University of New York/Buffalo, B.S., 1987, Biology
Yale University, M.Phil., 1990, Biophysics & Biochem
Yale University, Ph.D., 1992, Biophysics & Biochem

Professional Experience

  • 1984-1986
    State University New York - Buffalo, Undergrad Research
  • 1987-1992
    Yale University, Graduate Student
  • 1993-1998
    University of Washington/FHCRC, Postdoctoral Associate
  • 1998-2005
    UCSF Biochemistry & Biophysics/CRI, Assistant Professor
  • 2005-2010
    UCSF Biochemistry & Biophysics/CRI, Associate Professor
  • 2010-present
    UCSF Biochemistry & Biophysics/CRI,  Professor

Honors & Awards

  • 1993-1996
    Jane Coffin Childs Fellow
  • 2003-2009
    Leukemia and Lymphoma Society Scholar
  • 2005-present
    NDT study section, permanent member
  • 2009
    Keynote address, NIH Cell Cycle meeting

Selected Publications

  1. Mark KG, Meza-Gutierrez F, Johnson JR, Newton BW, Krogan NJ, Toczyski DP. Prb1 Protease Activity Is Required for Its Recognition by the F-Box Protein Saf1. Biochemistry. 2015 Jul 28; 54(29):4423-6.
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  2. Loveless TB, Topacio BR, Vashisht AA, Galaang S, Ulrich KM, Young BD, Wohlschlegel JA, Toczyski DP. DNA Damage Regulates Translation through ß-TRCP Targeting of CReP. PLoS Genet. 2015 Jun; 11(6):e1005292.
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  3. Edenberg ER, Mark KG, Toczyski DP. Ndd1 Turnover by SCFGrr1 Is Inhibited by the DNA Damage Checkpoint in Saccharomyces cerevisiae. PLoS Genet. 2015 Apr; 11(4):e1005162.
    View on PubMed
  4. Downey M, Johnson JR, Davey NE, Newton BW, Johnson TL, Galaang S, Seller CA, Krogan N, Toczyski DP. Acetylome profiling reveals overlap in the regulation of diverse processes by sirtuins, gcn5, and esa1. Mol Cell Proteomics. 2015 Jan; 14(1):162-76.
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  5. Edenberg ER, Downey M, Toczyski D. Polymerase stalling during replication, transcription and translation. Curr Biol. 2014 May 19; 24(10):R445-52.
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  6. Edenberg ER, Vashisht AA, Topacio BR, Wohlschlegel JA, Toczyski DP. Hst3 is turned over by a replication stress-responsive SCF(Cdc4) phospho-degron. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):5962-7.
    View on PubMed
  7. Mark KG, Simonetta M, Maiolica A, Seller CA, Toczyski DP. Ubiquitin ligase trapping identifies an SCF(Saf1) pathway targeting unprocessed vacuolar/lysosomal proteins. Mol Cell. 2014 Jan 9; 53(1):148-61.
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  8. Edenberg ER, Vashisht A, Benanti JA, Wohlschlegel J, Toczyski DP. Rad53 downregulates mitotic gene transcription by inhibiting the transcriptional activator Ndd1. Mol Cell Biol. 2014 Feb; 34(4):725-38.
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  9. Downey M, Knight B, Vashisht AA, Seller CA, Wohlschlegel JA, Shore D, Toczyski DP. Gcn5 and sirtuins regulate acetylation of the ribosomal protein transcription factor Ifh1. Curr Biol. 2013 Sep 9; 23(17):1638-48.
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  10. Landry BD, Doyle JP, Toczyski DP, Benanti JA. F-box protein specificity for g1 cyclins is dictated by subcellular localization. PLoS Genet. 2012; 8(7):e1002851.
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  11. Foe IT, Toczyski DP. Ubiquitin ligases: Taming the APC. Nat Chem Biol. 2012 Apr; 8(4):323-4.
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  12. Berens TJ, Toczyski DP. Keeping it together in times of stress: checkpoint function at stalled replication forks. Mol Cell. 2012 Mar 9; 45(5):585-6.
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  13. Berens TJ, Toczyski DP. Colocalization of Mec1 and Mrc1 is sufficient for Rad53 phosphorylation in vivo. Mol Biol Cell. 2012 Mar; 23(6):1058-67.
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  14. Foe IT, Foster SA, Cheung SK, DeLuca SZ, Morgan DO, Toczyski DP. Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism. Curr Biol. 2011 Nov 22; 21(22):1870-7.
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  15. Foe I, Toczyski D. Structural biology: a new look for the APC. Nature. 2011 Feb 10; 470(7333):182-3.
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  16. Kapitzky L, Beltrao P, Berens TJ, Gassner N, Zhou C, Wüster A, Wu J, Babu MM, Elledge SJ, Toczyski D, Lokey RS, Krogan NJ. Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol. 2010 Dec 21; 6:451.
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  17. Lopez-Mosqueda J, Vidanes GM, Toczyski DP. Cdc5 blocks in vivo Rad53 activity, but not in situ activity (ISA). Cell Cycle. 2010 Nov 1; 9(21):4266-8.
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  18. Lopez-Mosqueda J, Maas NL, Jonsson ZO, Defazio-Eli LG, Wohlschlegel J, Toczyski DP. Damage-induced phosphorylation of Sld3 is important to block late origin firing. Nature. 2010 Sep 23; 467(7314):479-83.
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  19. Downey M, Edenberg ER, Toczyski DP. Repair scaffolding reaches new heights at blocked replication forks. Mol Cell. 2010 Jul 30; 39(2):162-4.
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  20. Vidanes GM, Sweeney FD, Galicia S, Cheung S, Doyle JP, Durocher D, Toczyski DP. CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation. PLoS Biol. 2010 Jan; 8(1):e1000286.
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