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Zena Werb, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
werb_zena

Professor and Vice-Chair, Department of Anatomy, UCSF
Co-Leader, Cancer, Immunity, and Microenvironment Program, UCSF Helen Diller Family Comprehensive Cancer Center

zena.werb@ucsf.edu

Phone: (415) 476-4622, (415) 476-4758, (415) 476-4564 (voice)
Box 0452, UCSF
San Francisco, CA 94143-0452

View on UCSF Profiles


Additional Websites


Education

University of Toronto, Toronto, Canada, B.Sc., 1966, Biochemistry
Rockefeller University, New York, NY, Ph.D., 1971, Cell Biology
Strangeways Research. Laboratory, Cambridge, U.K., Postdoc., 1971-73, Protein Chemistry


Professional Experience

  • 1973-1975
    Research Scientist, Strangeways Res. Lab., Cambridge, U.K.
  • 1975-1976
    Visiting Assistant Professor of Medicine, Dartmouth Medical School, Hanover, NH
  • 1976-1980
    Asst. Professor of Radiobiology, Radiology, Univ. of California, San Francisco
  • 1979-1980
    Asst. Professor of Anatomy, UCSF
  • 1980-1983
    Assoc. Professor of Anatomy and Radiology, UCSF
  • 1983-present
    Professor of Anatomy, UCSF
  • 1985-1986
    Visiting Prof. (Lab. of N.J. Proudfoot), Sir William Dunn School of Pathology, Univ. of Oxford, U.K.
  • 1998
    Visiting Professor, Institut Curie Paris
  • 1999-present
    Vice-chair, Dept of Anatomy, UCSF
  • 2006-2007
    Visiting Professor, Max-Planck Institute for Biochemistry, Martinsried, Germany

Honors & Awards

  • 1971-1973
    Fellow, Medical Research Council of Canada
  • 1982
    R.R. Bensley Memorial Lecturer of the American Association of Anatomists
  • 1985-1986
    Fellow, John Simon Guggenheim Foundation
  • 1986
    Muriel Trotter Lecturer, Washington University, St. Louis
  • 1993-1994
    Sigma Xi National Lecturer
  • 1996
    FASEB Excellence in Science Award
  • 1997
    Chitra Biswas Memorial Lecturer, Tufts Medical School
  • 1998
    Rothschild/Mayent Fellowship, Institut Curie, Paris
  • 1998
    Earl Benditt Distinguished Lecturer, University of Washington
  • 1999
    J.L. Melnick Lecturer, Baylor College of Medicine
  • 1999
    Biosciences Distinguished Lecturer, Lawrence Berkeley National Laboratory
  • 2000
    Gwendolyn J. Stewart Award, Temple University
  • 2001
    Charlotte Friend Lecturer, AACR
  • 2001
    44th Faculty Research Lecturer, UCSF
  • 2001
    H.B. Parker Lecture, Pacific Northwest National Laboratory
  • 2002
    Elected Member, Institute of Medicine
  • 2003
    Elected Fellow, American Academy of Arts and Sciences
  • 2003
    Doctor of Medicine (honoris causa), University of Copenhagen
  • 2004
    Schlessinger Lecture, Beth Israel Deaconess Medical Center, Harvard Medical School
  • 2004
    A. S. Wiener Lecture, New York Blood Center
  • 2005
    Maud L. Menten Lecturer, University of Pittsburgh
  • 2006
    Alexander von Humboldt Research Award
  • 2007
    E.B. Wilson Medal, American Society for Cell Biology
  • 2009
    Colin Thomson Memorial Medal, Association for International Cancer Research
  • 2010
    Elected Member, National Academy of Sciences
  • 2010
    American Society for Cell Biology, Women in Cell Biology Senior Award
  • 2011
    Zero Breast Cancer 2011 Community Breast Cancer Research Award

Selected Publications

  1. Cheung KJ, Gabrielson E, Werb Z, Ewald AJ. Collective invasion in breast cancer requires a conserved Basal epithelial program. Cell. 2013 Dec 19; 155(7):1639-51.
    View on PubMed
  2. Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, Bainton RJ, Werb Z, Roth BL, Shoichet BK, Ashrafi K. In Silico Molecular Comparisons of C. elegans and Mammalian Pharmacology Identify Distinct Targets That Regulate Feeding. PLoS Biol. 2013 Nov; 11(11):e1001712.
    View on PubMed
  3. Plaks V, Koopman CD, Werb Z. Cancer. Circulating tumor cells. Science. 2013 Sep 13; 341(6151):1186-8.
    View on PubMed
  4. Brabletz T, Lyden D, Steeg PS, Werb Z. Roadblocks to translational advances on metastasis research. Nat Med. 2013 Sep; 19(9):1104-9.
    View on PubMed
  5. Chou J, Shahi P, Werb Z. microRNA-mediated regulation of the tumor microenvironment. Cell Cycle. 2013 Oct 15; 12(20):3262-71.
    View on PubMed
  6. Kessenbrock K, Dijkgraaf GJ, Lawson DA, Littlepage LE, Shahi P, Pieper U, Werb Z. A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell. 2013 Sep 5; 13(3):300-13.
    View on PubMed
  7. Chan MF, Li J, Bertrand A, Casbon AJ, Lin JH, Maltseva I, Werb Z. Protective effects of matrix metalloproteinase-12 following corneal injury. J Cell Sci. 2013 Sep 1; 126(Pt 17):3948-60.
    View on PubMed
  8. Plaks V, Rinkenberger J, Dai J, Flannery M, Sund M, Kanasaki K, Ni W, Kalluri R, Werb Z. Matrix metalloproteinase-9 deficiency phenocopies features of preeclampsia and intrauterine growth restriction. Proc Natl Acad Sci U S A. 2013 Jul 2; 110(27):11109-14.
    View on PubMed
  9. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6.
    View on PubMed
  10. Chou J, Lin JH, Brenot A, Kim JW, Provot S, Werb Z. GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. Nat Cell Biol. 2013 Feb; 15(2):201-13.
    View on PubMed
  11. Plaks V, Brenot A, Lawson DA, Linnemann JR, Van Kappel EC, Wong KC, de Sauvage F, Klein OD, Werb Z. Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Rep. 2013 Jan 31; 3(1):70-8.
    View on PubMed
  12. Chou J, Werb Z. MicroRNAs play a big role in regulating ovarian cancer-associated fibroblasts and the tumor microenvironment. Cancer Discov. 2012 Dec; 2(12):1078-80.
    View on PubMed
  13. Wang X, Yu YY, Lieu S, Yang F, Lang J, Lu C, Werb Z, Hu D, Miclau T, Marcucio R, Colnot C. MMP9 regulates the cellular response to inflammation after skeletal injury. Bone. 2013 Jan; 52(1):111-9.
    View on PubMed
  14. Nguyen-Ngoc KV, Cheung KJ, Brenot A, Shamir ER, Gray RS, Hines WC, Yaswen P, Werb Z, Ewald AJ. ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium. Proc Natl Acad Sci U S A. 2012 Sep 25; 109(39):E2595-604.
    View on PubMed
  15. Caudrillier A, Kessenbrock K, Gilliss BM, Nguyen JX, Marques MB, Monestier M, Toy P, Werb Z, Looney MR. Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest. 2012 Jul 2; 122(7):2661-71.
    View on PubMed
  16. Littlepage LE, Adler AS, Kouros-Mehr H, Huang G, Chou J, Krig SR, Griffith OL, Korkola JE, Qu K, Lawson DA, Xue Q, Sternlicht MD, Dijkgraaf GJ, Yaswen P, Rugo HS, Sweeney CA, Collins CC, Gray JW, Chang HY, Werb Z. The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression. Cancer Discov. 2012 Jul; 2(7):638-51.
    View on PubMed
  17. Nakasone ES, Askautrud HA, Kees T, Park JH, Plaks V, Ewald AJ, Fein M, Rasch MG, Tan YX, Qiu J, Park J, Sinha P, Bissell MJ, Frengen E, Werb Z, Egeblad M. Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell. 2012 Apr 17; 21(4):488-503.
    View on PubMed
  18. Engelhardt JJ, Boldajipour B, Beemiller P, Pandurangi P, Sorensen C, Werb Z, Egeblad M, Krummel MF. Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer Cell. 2012 Mar 20; 21(3):402-17.
    View on PubMed
  19. Lu P, Weaver VM, Werb Z. The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol. 2012 Feb 20; 196(4):395-406.
    View on PubMed
  20. Ewald AJ, Huebner RJ, Palsdottir H, Lee JK, Perez MJ, Jorgens DM, Tauscher AN, Cheung KJ, Werb Z, Auer M. Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium. J Cell Sci. 2012 Jun 1; 125(Pt 11):2638-54.
    View on PubMed

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