Professor and Vice-Chair, Anatomy, UCSF
Member, Biomedical Sciences Program (BMS), Herbert Boyer Program in Biological Sciences (PIBS), and Immunology Graduate Program, UCSF
| CONTACT | |
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zena.werb@ucsf.edu Box 0452, UCSF; San Francisco, CA 94143-0452 |
additional websites: |
| EDUCATION | |
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University of Toronto, Toronto, Canada, B.Sc., 1966, Biochemistry
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| PROFESSIONAL EXPERIENCE | |
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1973-1975 |
Research Scientist, Strangeways Res. Lab., Cambridge, U.K. |
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1975-1976 |
Visiting Assistant Professor of Medicine, Dartmouth Medical School, Hanover, NH |
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1976-1980 |
Asst. Professor of Radiobiology, Radiology, Univ. of California, San Francisco |
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1979-1980 |
Asst. Professor of Anatomy, UCSF |
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1980-1983 |
Assoc. Professor of Anatomy and Radiology, UCSF |
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1983-present |
Professor of Anatomy, UCSF |
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1985-1986 |
Visiting Prof. (Lab. of N.J. Proudfoot), Sir William Dunn School of Pathology, Univ. of Oxford, U.K. |
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1998 |
Visiting Professor, Institut Curie Paris |
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1999-present |
Vice-chair, Dept of Anatomy, UCSF |
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2006-7 |
Visiting Professor, Max-Planck Institute for Biochemistry, Martinsried, Germany |
| HONORS & AWARDS | |
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(partial list) | |
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1971-1973 |
Fellow, Medical Research Council of Canada |
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1982 |
R.R. Bensley Memorial Lecturer of the American Association of Anatomists |
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1985-1986 |
Fellow, John Simon Guggenheim Foundation |
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1986 |
Muriel Trotter Lecturer, Washington University, St. Louis |
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1993-1994 |
Sigma Xi National Lecturer |
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1996 |
FASEB Excellence in Science Award |
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1997 |
Chitra Biswas Memorial Lecturer, Tufts Medical School |
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1998 |
Rothschild/Mayent Fellowship, Institut Curie, Paris |
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1998 |
Earl Benditt Distinguished Lecturer, University of Washington |
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1999 |
J.L. Melnick Lecturer, Baylor College of Medicine |
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1999 |
Biosciences Distinguished Lecturer, Lawrence Berkeley National Laboratory |
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2000 |
Gwendolyn J. Stewart Award, Temple University |
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2001 |
Charlotte Friend Lecturer, AACR |
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2001 |
44th Faculty Research Lecturer, UCSF |
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2001 |
H.B. Parker Lecture, Pacific Northwest National Laboratory |
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2002 |
elected Member, Institute of Medicine |
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2003 |
elected Fellow, American Academy of Arts and Sciences |
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2003 |
Doctor of Medicine (honoris causa), University of Copenhagen |
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2004 |
Schlessinger Lecture, Beth Israel Deaconess Medical Center, Harvard Medical School |
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2004 |
A. S. Wiener Lecture, New York Blood Center |
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2005 |
Maud L. Menten Lecturer, University of Pittsburgh |
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2006 |
Alexander von Humboldt Research Award. |
| SELECTED PUBLICATIONS | |
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(of more than 280 in Pubmed, 380 total full publications) | |
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Werb, Z., P.M. Tremble, O. Behrendtsen, E. Crowley & C.H. Damsky (1989). Signal transduction through the fibronectin receptor induces metalloproteinase gene expression. J. Cell Biol. 109: 877-889. PMID: 2547805 | |
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Sympson, C.J., R.S. Talhouk, et al. (1994). Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression. J. Cell Biol. 125: 681-693. PMID: 8175886 | |
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Vu, T. H., J. M. Shipley, et al. (1998). MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell. 93:411-422. PMID: 9590175 | |
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Sternlicht, M. D., A. Lochter, et al. (1999). The stromal proteinase MMP-3/stromelysin-1 promotes mammary carcinogenesis. Cell. 98: 137-146. PMID: 10428026 | |
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Bergers, G., R. Brekken, et al. (2000). Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nature Cell Biol. 2: 737-744. PMID: 11025665 | |
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Coussens, L. M., C. L. Tinkle, D. Hanahan & Z. Werb (2000). MMP-9 supplied by bone marrow-derived cells regulates skin carcinogenesis. Cell. 103: 481-490. PMID: 11081634 | |
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Coussens, L. M. & Z. Werb (2002). Inflammation and cancer. Nature 420:860-867. PMID: 12490959 | |
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Egeblad, M. & Z. Werb (2002). New functions for the matrix metalloproteinases in cancer progression. Nature Rev. Cancer 2: 163-176. PMID: 11990853 | |
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Heissig, B., K. Hattori, et al. (2002). Mobilization of stem cells from the bone marrow niche requires MMP-9-mediated release of Kit ligand. Cell. 109: 625-637. PMID: 12062105 | |
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Weaver, V. M., S. Lelivre, et al. (2002). ƒÀ4 Integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell. 2: 205-216. PMID: 12242153 | |
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Wiseman, B. & Z. Werb (2002). Stromal effects on mammary gland development and breast cancer. Science. 296:1046-1049. PMID: 12004111 | |
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Yan, Y., K. Shirakabe & Z. Werb (2002). The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G-protein coupled receptors.J. Cell Biol. 158:221-226.PMID: 12119356 | |
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Colnot, C., Z. Thompson, T. Miclau, Z. Werb & J. A. Helms (2003). Altered bone regeneration in the absence of MMP9. Development. 130: 4123-4133. PMID: 12874132 | |
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Hamano, H., M. Zeisberg, et al. (2003). Physiological levels of tumstatin, a fragment of collagen IV ƒ¿3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via ƒ¿VƒÀ integrin. Cancer Cell. 3:589-601. PMID: 12842087 | |
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Li, Y., B. Welm, et al. (2003). Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc. Natl. Acad. Sci. USA. 100: 15853-15858. PMID: 14668450 | |
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Parisi, T., A. R. Beck, et al. (2003). Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. EMBO J. 22: 4794-4803. PMID: 12970191 | |
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Wiseman, B.S., M. D. Sternlicht, et al. (2003). Site-specific positive and negative activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. J. Cell Biol. 162:1123-1133.PMID: 12975354 | |
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Chantrain, C. F., H. Shimada, et al. (2004). Stromal matrix metalloproteinase-9 (MMP-9) regulates the vascular architecture in neuroblastoma by promoting pericyte recruitment. Cancer Res. 64: 1675-1686. PMID: 14996727 | |
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Cases, S., P. Zhou, et al. (2004). Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues. Development. 131: 3047-3055. PMID: 15163627 | |
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Stickens, D., D. J. Behonick, et al. (2004). Altered endochondral bone formation in matrix metalloproteinase-13 deficient mice. Development. 131: 5883-5895. PMID: 15539485 | |
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Atabai K., R. Fernandez, et al. (2005). Mfge8 is critical for mammary gland remodeling during involution. Mol. Biol. Cell. 16:5528-5537. PMID: 16195353 | |
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Carlson, T. R., Y. Yan, et al. (2005). Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice. Proc. Nat. Acad. Sci. USA 102: 9884-9889. PMID: 15994223 | |
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Heissig, B., S. Rafii, et al. (2005). Low-dose irradiation promotes tissue revascularization through Kit-ligand mediated release of VEGF from mast cells and MMP-9 mediated mobilization of endothelial progenitors. J. Exp. Med. 202:739-750. PMID: 16157686 | |
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Littlepage, L.E., M. Egeblad & Z. Werb (2005). Coevolution of cancer and stromal cellular responses. Cancer Cell. 7:499-500. PMID: 15950897 | |
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Liu, Z., X. Zhou, L. A. Diaz, R. M. Senior & Z. Werb (2005). Synergy between a plasminogen cascade and MMP-9 in autoimmune disease. J. Clin. Invest. 115: 879-887. PMID: 15841177 | |
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Morimoto-Tomita, M., K. Uchimura, et al. (2005). Sulf-2, an extracellular heparan sulfate endosulfatase, is upregulated during breast cancer progression and is proangiogenic. Neoplasia. 7: 1001-1010. PMID: 16331886 | |
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Ortega, N., D. J. Behonick, C. Colnot, D. H. Cooper & Z. Werb (2005). Galectin-3 is a downstream regulator of MMP-9 function during endochondral bone formation. Mol. Biol. Cell. 16: 3028-3039. PMID: 15800063 | |
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Radisky, D. C., D. D. Levy, et al. (2005). Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature. 436:123-127. PMID: 16001073 | |
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Song, S., A. J. Ewald, W. Stallcup, Z. Werb & G. Bergers (2005). PDGFR+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nature Cell. Biol. 7: 870-879. PMID: 16113679 | |
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Sternlicht, M.D., S.W. Sunnarborg, H. Kouros-Mehr, Y. Yu, D. C. Lee & Z. Werb (2005). Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Development. 132:3923-3933. PMID: 16079154 | |
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Stickens, D., B. M. Zak, N. Rougier, J. D. Esko & Z. Werb (2005). Mice deficient in Ext2 lack heparan sulfate and develop exostoses. Development. 132:5055-5068. PMID: 16236767 | |
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Wall, S., E. Werner, Z. Werb & Y. A. DeClerck (2005). Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen. J. Biol. Chem. 280:40187-4019. PMID: 16186104 | |
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Greenlee, K., D. B. Corry, et al. (2006). Proteomics identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation. J. Immunol. 177: 7312-7321. PMID: 17082650 | |
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Hsu, J.-Y. C., R. McKeon, et al. (2006). Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury. J. Neurosci. 26 :9841-9850. PMID: 17005848 | |
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Kouros-Mehr, H. & Z. Werb (2006). Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis. Dev. Dyn. Oct 12; [Epub ahead of print] PMID: 17039550 | |
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Kouros-Mehr, H., E. M. Slorach, M. D. Sternlicht & Z. Werb (2006). GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell. In press. | |
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Lum, D.H., J. Tan, S. D. Rosen & Z. Werb (2006). Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase, Sulf2. Mol. Cell. Biol. In press. | |
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Lund, L.R., K. A. Green, et al. (2006). Plasminogen activation independent of uPA and tPA maintains skin wound healing in gene-deficient mice. EMBO J. 25:2686-2697. PMID: 16763560 | |
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Sternlicht, M.D., H. Kouros-Mehr, P. Lu & Z. Werb (2006). Hormonal and local control of mammary branching morphogenesis. Differentiation. 74:365-381. PMID: 16916375 | |
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Sternlicht, M. D., A. M. Dunning, et al. (2006). Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression. Canc. Epidemiol. Biomarkers. Prev. In press. | |
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Uchimura, K., M. Morimoto-Tomita, et al. (2006). HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1 and SDF-1. BMC Biochemistry. 7:2. PMID: 16417632 | |
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Zeisberg, M., M. Khurana, et al. (2006). Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. PLoS Med. 3:e100. PMID: 16509766 | |
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12/7/06 |
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