Research Summary

Dr. Elizabeth Young, who goes by Betsy, is a pediatric hematologist-oncologist who cares for children with cancer. She specializes in treating solid tumors, including sarcomas, a type of cancer that originates in bone or soft tissue.

In research, Young studies ways to improve immunotherapy for osteosarcoma, an aggressive bone cancer. She focuses on harnessing osteosarcoma's capacity to activate the immune system and developing research models that illuminate the relationship between pediatric sarcomas and the immune system.

Education

  • Yale University, B.S., 2012, Biology
  • Weill Cornell Medical College, M.D., 2016, Medicine
  • Baylor College of Medicine/Texas Children's Hospital, 2019, Pediatrics Residency, Research Track
  • UCSF/Benioff Children's Hospital, 2022, Pediatric Hematology/ Oncology Fellowship

Honors & Awards

  • 2021
    Chief Fellow, UCSF Pediatric Hematology/Oncology Fellowship Program
  • 2020
    Chan Zuckerberg Biohub Physician Scientist Fellowship Recipient
  • 2019
    Gold Humanism Honor Society Member
  • 2017
    The Reba Michaels Hill Award
  • 2016
    The George S. Meister Prize in Pediatrics
  • 2013
    Memorial Sloan Kettering Cancer Center Medical Student Summer Fellowship
  • 2013
    The Henry C. and Anne Hayworth First Honor Prize
  • 2012
    Yale College Edwin Foster Blair Prize
  • 2010
    Michael Manzella Foundation Summer Fellowship

Selected Publications

  1. Schott CR, Koehne AL, Sayles LC, Young EP, Luck C, Yu K, Lee AG, Breese MR, Leung SG, Xu H, Shah AT, Liu HY, Spillinger A, Behroozfard IH, Marini KD, Dinh PT, Pons Ventura MV, Vanderboon EN, Hazard FK, Cho SJ, Avedian RS, Mohler DG, et al. Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach. Clin Cancer Res. 2024 Feb 16;30(4):849-864.
  2. Solomon PE, Bracken CJ, Carozza JA, Wang H, Young EP, Wellner A, Liu CC, Sweet-Cordero EA, Li L, Wells JA. Discovery of VH domains that allosterically inhibit ENPP1. Nat Chem Biol. 2024 Jan;20(1):30-41. doi: 10.1038/s41589-023-01368-5. Epub 2023 Jul 3.
  3. Kirk SE, Young E, Ray A, Dzurik Y, Elghetany T, Sasa G. Transient Pancytopenia Subsequently Diagnosed With Acute Leukemia: A Report of 4 Cases of Acute Lymphoblastic Leukemia and Acute Myeloid Leukemia. J Pediatr Hematol Oncol. 2021 Jul 1;43(5):e715-e717.
  4. Behnert A, Lee AG, Young EP, Breese MR, Leung SG, Behroozfard I, Maruffi M, Sweet-Cordero EA, Dvorak CC, Chu J, Stieglitz E. NUP98-NSD1 Driven MDS/MPN in Childhood Masquerading as JMML. J Pediatr Hematol Oncol. 2021 Aug 1;43(6):e808-e811.
  5. Young EP, Cheng WS, Bernhardt MB, Wang LL, Rainusso N, Foster JH. Risk factors associated with delayed methotrexate clearance and increased toxicity in pediatric patients with osteosarcoma. Pediatr Blood Cancer. 2020 Apr;67(4):e28123.
  6. Cowell E, Patel K, Heczey A, Finegold M, Venkatramani R, Wu H, López-Terrada D, Miloh T. Predisposing Conditions to Pediatric Hepatocellular Carcinoma and Association With Outcomes: Single-center Experience. J Pediatr Gastroenterol Nutr. 2019 May;68(5):695-699. 
  7. Yaeger R, Cowell E, Chou JF, Gewirtz AN, Borsu L, Vakiani E, Solit DB, Rosen N, Capanu M, Ladanyi M, Kemeny N. RAS mutations affect pattern of metastatic spread and increase propensity for brain metastasis in colorectal cancer. Cancer. 2015 Apr 15;121(8):1195-203. doi: 10.1002/cncr.29196. Epub 2014 Dec 9.
  8. Breindel JL, Haskins JW, Cowell EP, Zhao M, Nguyen DX, Stern DF. EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis. Cancer Res. 2013 Aug 15;73(16):5053-65. doi: 10.1158/0008-5472.CAN-12-3775. Epub 2013 Jun 21.

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