Cancer Genetics Program

A.Balmain J.Witte
Program Leader: John Witte, PhD
Program Co-Leader: Allan Balmain, PhD

Latest News

April 30, 2015
Dr. Allan Balmain, an internationally known expert in cancer genetics, has been elected a Fellow of The Royal Society, the oldest continuously operating scientific society in the world.
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The Cancer Genetics Program includes 25 members from 17 academic departments in the UCSF Schools of Medicine, Nursing, and Pharmacy. The overarching goal of the Program is to elucidate the genetics of tumor susceptibility, tumorigenesis, and progression; and to use this information clinically to improve cancer management.

The Cancer Genetics Program conducts research under four themes:

  • Theme 1: Genetics of Cancer Susceptibility, Progression, and Response
  • Theme 2: Cancer Genome and Epigenome
  • Theme 3: Functional Genomics
  • Theme 4: Systems Genetics of Cancer

Cancer is a complex disease with a range of genetic, genomic, and environmental factors that can impact disease development, progression, and response to therapy. These factors exhibit broad heterogeneity: large variations are seen between individuals in germline DNA sequence, tumor genetics, or histological subtypes, and environmental exposures. A high level of complexity is seen in the patterns of inherited genetic variants (SNPs) in the normal host DNA, and in the combinations of somatic genetic events and gene expression changes in tumors. In addition, complex interactions exist between the genetics of the host and environmental exposures that contribute to tumor susceptibility.

Ultimately the Program aims to encourage and support crosscutting research that encompasses both germline and somatic approaches to deciphering the genetic basis of cancer.

The Cancer Genetics Program brings together experts in the application of advanced genomic and genetic analysis tools to identify abnormalities that contribute to cancer genesis and progression by utilizing the outstanding mouse and human genetic resources at UCSF. Program members are fully integrated into the organ site-specific programs, and participate broadly in seminars, and discussion groups organized by the Program; and in conjunction with other research programs (e.g., the Cancer Genetics Risk Program, and the Human Genetics Program).