Research Summary

Jeroen Roose, PhD, is Professor and Vice Chair of Anatomy at UCSF, where he leads a multidisciplinary research program focused on understanding the mechanisms that govern cancer cell fitness, tumor progression, and metastasis. His laboratory combines patient-derived organoids, advanced molecular profiling, computational analysis, and experimental models to define how tumor cells interact with immune cells and other components of the tumor microenvironment to drive disease progression and therapeutic response.

A central goal of his research is to understand the dynamic interactions between cancer cells and their surrounding cellular ecosystem. By developing human organoid and assembloid models that incorporate immune and stromal cells, his laboratory investigates how cell-cell communication regulates tumor evolution, metastatic spread, and responses to targeted and immune-based therapies.

Dr. Roose established the UCSF Disease-to-Biology Organoid Core to develop advanced patient-derived models for collaborative cancer research and co-led the Mark Foundation Endeavor Program, a multidisciplinary effort to understand and eliminate metastatic disease. His research integrates experimental biology with clinical partnerships and computational approaches to accelerate the discovery of new therapeutic strategies for cancer patients. His research has been continuously supported by the NIH, foundations, philanthropy, and industry collaborations.
 

Roose Laboratory – Research program, publications, and laboratory opportunities 

UCSF Disease-to-Biology Organoid Core – Organoid technologies and collaborative resources. General | Internal UCSF

LinkedIn – Professional profile and updates

Research Funding

  • April 1, 2023 - March 31, 2028 - Roles for Intracellular pH dynamics in cancer , PI . Sponsor: NIH/NCI, Sponsor Award ID: 2 R01 CA197855
  • May 1, 2022 - April 30, 2027 - Defining the unique properties of the distinct signaling machinery used by the TCR , Co-Lead/PI . Sponsor: NIH/NIAID, Sponsor Award ID: 3P01 AI091580
  • July 15, 2011 - April 30, 2027 - Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01AI091580
  • January 1, 2022 - December 30, 2026 - Molecular understanding of leukemic bone marrow cytokine-Ras signals and metabolic dependence , PI . Sponsor: NIH/NCI, Sponsor Award ID: 2R01 CA187318
  • August 1, 2022 - July 30, 2026 - Defining and re-engineering the DTC and metastatic cell surface to prevent lethal breast cancer metastasis , PI . Sponsor: DoD, Sponsor Award ID: W81XWH-22-2-0007 (BC210386P4)
  • December 1, 2020 - November 30, 2023 - Understand and Eliminate Metastatic Cancer , Co-Lead/PI . Sponsor: Mark Foundation for Cancer Research, Sponsor Award ID: A136299
  • March 1, 2014 - May 31, 2022 - Loss of Intrinsic Control in Autoimmune T Helper Cells with Signaling Variants , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R56AI104789
  • August 15, 2015 - April 30, 2021 - Balanced signaling cues to guide cell transitions in the blood lineage continuum , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HL120724
  • July 1, 2015 - June 30, 2020 - Molecular understanding of cytokine-Ras signals in leukemic bone marrow , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA187318
  • March 1, 2014 - February 28, 2019 - Loss of Intrinsic Control in Autoimmune T Helper Cells with Signaling Variants , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI104789

Education

University of Utrecht, The Netherlands, MS, 1993, Medical Biology
University of Utrecht, The Netherlands, PhD, 1999, Immunology/Transcription
University of Utrecht, The Netherlands, Fellowship, 1997-1999, Immunology/Transcription
University of California San Francisco, San Francisco, Fellowship, 1999-2004, Immunology/Signaling

Honors & Awards

  • 2012
    Gabrielle's Angel Foundation Award
  • 2013
    9th annual Mentoring award by the UCSF PSA (Postdoctoral Scholar’s Association)
  • 2014
     R01 Award (NIH; NIAID)
  • 2015
    R01 Award (NIH; NCI)
  • 2015
    Alex's Lemonade Stand Foundation Innovator Award
  • 2015
    R01 Award (NIH; NHLBI)
  • 2016
    Renewal P01 Award (NIH; NIAID)
  • 2020 -
    Endeavor Award (Mark Foundation for Cancer Research)
  • 2021
    Renewal R01 Award (NIH; NCI)
  • 2022
    Renewal P01 Award (NIH; NIAID)

Selected Publications

  1. Karra L, Finger AM, Shechtman LA, Krush M, Meng-Yao Huang R, Prinz M, Tennvooren I, Bahl K, Hysienaj L, Garcia-Gonzalez P, Combes AJ, Gonzalez H, Argüello RJ, Spitzer MH, Roose JP. Single cell proteomics characterization of bone marrow hematopoiesis with distinct Ras pathway lesions. View on PubMed
  2. Mondal G, Gonzalez H, Marsh T, Leidal AM, Vlahakis A, Phadatare PR, Bustamante Eguiguren S, Bruck M, Naik A, Magbanua MJM, Huppert LA, Wiita AP, Roose JP, Rosenbluth JM, Debnath J. Autophagy-targeted NBR1-p62/SQSTM1 complexes promote breast cancer metastasis by sequestering ITCH. Nat Cell Biol. 2025 Jul; 27(7):1098-1113. View on PubMed
  3. Hendley AM, Ashe S, Urano A, Ng M, Phu TA, Peng XL, Luan C, Finger AM, Jang GH, Kerper NR, Berrios DI, Jin D, Lee J, Riahi IR, Gbenedio OM, Chung C, Roose JP, Yeh JJ, Gallinger S, Biankin AV, O'Kane GM, Ntranos V, Chang DK, Dawson DW, Kim GE, Weaver VM, Raffai RL, Hebrok M. nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer. bioRxiv. 2024 Sep 25. View on PubMed
  4. Audrey M Hendley, Sudipta Ashe, Atsushi Urano, Martin Ng, Tuan A Phu, Xianlu Laura Peng, Changfei Luan, Anna-Marie Finger, Gun Ho Jang, Natanya R Kerper, David I Berrios, David Jin, Jonghyun Lee, Irene R Riahi, Oghenekevwe M Gbenedio, Christina Chung, Jeroen P Roose, Jen Jen Yeh, Steven Gallinger, Andrew V Biankin, Grainne M O’Kane, Vasilis Ntranos, David K Chang, David W Dawson, Grace E Kim, Valerie M Weaver, Robert L Raffai, Matthias Hebrok. Abstract A066: nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer. Cancer Research. 2024 Sep 15; 84(17_Supplement_2):a066-a066. View on PubMed
  5. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Bernard O, Simoneau CR, Hysenaj L, Hu KH, Maishan M, Conrad C, Gbenedio OM, Samad B, Consortium TUC, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Immediate myeloid depot for SARS-CoV-2 in the human lung. Sci Adv. 2024 Aug 02; 10(31):eadm8836. View on PubMed
  6. Simoneau CR, Chen PY, Xing GK, Hayashi JM, Chen IP, Khalid MM, Meyers NL, Taha TY, Leon KE, Suryawanshi RK, McCavitt-Malvido M, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, Fang X, Maishan M, Schultz S, Roose JP, Matthay MA, Sil A, Arjomandi M, Yosef N, Ott M. NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids. Sci Rep. 2024 07 04; 14(1):15351. View on PubMed
  7. Haderk F, Chou YT, Cech L, Fernández-Méndez C, Yu J, Olivas V, Meraz IM, Barbosa Rabago D, Kerr DL, Gomez C, Allegakoen DV, Guan J, Shah KN, Herrington KA, Gbenedio OM, Nanjo S, Majidi M, Tamaki W, Pourmoghadam YK, Rotow JK, McCoach CE, Riess JW, Gutkind JS, Tang TT, Post L, Huang B, Santisteban P, Goodarzi H, Bandyopadhyay S, Kuo CJ, Roose JP, Wu W, Blakely CM, Roth JA, Bivona TG. Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer. Nat Commun. 2024 May 03; 15(1):3741. View on PubMed
  8. Lisa Miller-Phillips, Imene Boukhalfa Hanafi, Alexis J. Combes, Shabana Bano, Lisiena Hysenaj, Jeroen P. Roose, Adam Olshen, Ashley Kiemen, Sarah Umetsu, Man-Tzu Wang, Eric A. Collisson. Abstract 7465: Leukemia inhibitory factor creates an immune suppressive tumor microenvironment and fosters tumor growth in KRAS-driven pancreatic ductal adenocarcinoma. Cancer Research. 2024 Mar 22; 84(6_Supplement):7465-7465. View on PubMed
  9. Audrey M. Hendley, Atsushi Urano, Xianlu L. Peng, Sudipta Ashe, Tuan A. Phu, Martin Ng, Natanya R. Kerper, David I. Berrios, Jonghyun Lee, David Jin, Gun H. Jang, Oghenekevwe M. Gbenedio, Jeroen P. Roose, Jen J. Yeh, Steven Gallinger, Andrew V. Biankin, Vasilis Ntranos, David K. Chang, David W. Dawson, Grace E. Kim, Valerie M. Weaver, Robert L. Raffai, Matthias Hebrok. Abstract A046: nSMase2-generated ceramide promotes PDA aggression through exosome reprogramming of the stroma. Cancer Research. 2024 Jan 16; 84(2_Supplement):a046-a046. View on PubMed
  10. Karra L, Finger AM, Shechtman L, Krush M, Huang RM, Prinz M, Tennvooren I, Bahl K, Hysienaj L, Gonzalez PG, Combes AJ, Gonzalez H, Argüello RJ, Spitzer MH, Roose JP. Single cell proteomics characterization of bone marrow hematopoiesis with distinct Ras pathway lesions. bioRxiv. 2023 Dec 20. View on PubMed
  11. Chang Y, Manivannan P, Doosti A, Lapinski PE, Chen D, Roose JP, King PD. Cutting Edge: Induced Loss of Rasgrp1 in Peripheral CD4+ T Cells of Conditional Rasgrp1-Deficient Mice Reveals an Essential Role for Rasgrp1 in TCR/CD28-Induced Ras-MAPK Signaling. J Immunol. 2023 09 15; 211(6):917-922. View on PubMed
  12. Jana S, Brahma S, Arora S, Wladyka CL, Hoang P, Blinka S, Hough R, Horn JL, Liu Y, Wang LJ, Depeille P, Smith E, Montgomery RB, Lee JK, Haffner MC, Vakar-Lopez F, Grivas P, Wright JL, Lam HM, Black PC, Roose JP, Ryazanov AG, Subramaniam AR, Henikoff S, Hsieh AC. Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression. Cancer Cell. 2023 05 08; 41(5):853-870.e13. View on PubMed
  13. Hysenaj L, Little S, Kulhanek K, Magnen M, Bahl K, Gbenedio OM, Prinz M, Rodriguez L, Andersen C, Rao AA, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Mick E, Khalid MM, Taha TY, Kumar R, Li JZ, Ding VW, Matsumoto S, Maishan M, Sreekumar B, Simoneau C, Nazarenko I, Tomlinson MG, Khan K, von Gottberg A, Sigal A, Looney MR, Fragiadakis GK, Jablons DM, Langelier CR, Matthay M, Krummel M, Erle DJ, Combes AJ, Sil A, Ott M, Kratz JR, Roose JP. SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants. Stem Cell Reports. 2023 03 14; 18(3):636-653. View on PubMed
  14. Hugo Gonzalez, Wenbin Mei, Isabella Robles, Catharina Hagerling, Breanna Allen, Trine Hauge Okholm, Ankitha Nanjaraj, Tamara Verbeek, Sandhya Kalavacherla, Merel van Gogh, Stephen Georgiou, Mariza Daras, Joanna J. Phillips, Matthew H. Spitzer, Jeroen P. Roose, Zena Werb. Abstract IA022: Cell archetypes in human brain metastases: Connecting programs in tumor cells with the microenvironment. Cancer Research. 2023 Jan 15; 83(2_Supplement_2):ia022-ia022. View on PubMed
  15. Simoneau CR, Chen PY, Xing GK, Khalid MM, Meyers NL, Hayashi JM, Taha TY, Leon KE, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, Fang X, Maishan M, Schultz S, Roose J, Matthay MA, Sil A, Arjomandi M, Yosef N, Ott M. NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids. bioRxiv. 2022 Aug 02. View on PubMed
  16. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Immediate myeloid depot for SARS-CoV-2 in the human lung. Res Sq. 2022 May 17. View on PubMed
  17. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Immediate myeloid depot for SARS-CoV-2 in the human lung. bioRxiv. 2022 May 11. View on PubMed
  18. Wen Z, Finn R, Gao X, Li L, Hebert A, Ranheim EA, Zhou Y, Yun G, Roose JP, Coon JJ, Shiang R, Wen R, Yu M, Wang D, Zhang J. Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in NrasQ61R/+ mice. Leukemia. 2022 04; 36(4):1167-1170. View on PubMed
  19. Gonzalez H, Mei W, Robles I, Hagerling C, Allen BM, Hauge Okholm TL, Nanjaraj A, Verbeek T, Kalavacherla S, van Gogh M, Georgiou S, Daras M, Phillips JJ, Spitzer MH, Roose JP, Werb Z. Cellular architecture of human brain metastases. Cell. 2022 02 17; 185(4):729-745.e20. View on PubMed
  20. Roose J, Barton G. Editorial overview: Communities in immune cell signaling. Curr Opin Immunol. 2021 12; 73:iii-iv. View on PubMed

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