Pediatric Malignancies

The Pediatric Malignancies Program includes 23 members from 9 academic departments from the UCSF Schools of Dentistry and Medicine. The overarching goal of the Program is to improve the outcome for children with cancer by investigating links between normal development and the aberrant signaling networks of childhood malignancies, and to leverage these genetic networks to identify new therapeutic targets that we integrate into innovative clinical trials. 
 
The Pediatric Malignancies Program conducts research under four themes:
  • Theme 1: Neuroblastoma
  • Theme 2: Brain Tumors
  • Theme 3: Leukemia
  • Theme 4: Sarcomas and Developmental Therapeutics for Pediatric Solid Tumors

Pediatric cancers are unique in their morphology, tissues of origin, and behavior. They provide an opportunity to understand the link between normal development and the aberrant signaling networks of childhood malignancy; to discover through these genetic networks new therapeutic targets; and then integrate these into innovative clinical trials. These molecular studies can lead to a new understanding of the interactions of genetics and environment in cancer development and the late effects of treatment, thus improving the outcome for survivors of pediatric cancer. The Program’s efforts will also affect future advances through our excellent physician scientist training programs and our outreach and education of the public.