University of California San Francisco
Helen Diller Family Comprehensive Cancer Center

About SPOREs

NCI Specialized Programs of Research Excellence (SPORE) at UCSF

The NCI currently funds 52 Specialized Programs of Research Excellence (SPORE) grants which are located at 52 academic centers in 21 states across the United States, including the following at UCSF:

Brain Tumor SPORE

The Brain Tumor SPORE represents the translational research component of the Cancer Center’s Neurologic Oncology Program, which brings together neurosurgeons, neuro-oncologists, and basic scientists with the shared goal of improving the therapy of brain tumors.

The SPORE focuses primarily on the development of new therapeutic approaches to brain tumor treatment and prevention using molecular insights gained from the wealth of basic cancer research ongoing at the University of California, San Francisco. The SPORE is organized into four projects, two developmental research programs, two career development programs and four supporting cores.
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The DHART SPORE represents the translational research component of the Cancer Center’s Pediatric Malignancies Program, which brings together basic and clinical researchers with the shared goal of improving the outcome for children with cancer.

The overall goal of the SPORE is to implement effective new targeted treatments for tumors characterized by mutations of the NF1 tumor suppressor gene. The collaborating researchers are pursuing this goal by conducting integrated, mechanistically based translational research. In contrast to most other SPORE efforts supported by the NCI, the DHART SPORE does not focus on a particular type of cancer. Instead, the strategy is to implement new treatments for tumors that develop in different tissues due to NF1 mutations.
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About the NCI Specialized Programs of Research Excellence (SPORE)

NCI Translation Research ProgramThe Translational Research Program (TRP) is the home of the SPOREs — the Specialized Programs of Research Excellence — a cornerstone of NCI’s efforts to promote collaborative, interdisciplinary translational cancer research. SPORE grants involve both basic and clinical/applied scientists working together and support projects that will result in new and diverse approaches to the prevention, early detection, diagnosis and treatment of human cancers.


Each SPORE is focused on a specific organ site, such as breast or lung cancer, on a group of highly related cancers, such as gastrointestinal cancers and sarcomas, or on a common pathway or theme that ties together the cancers under study. SPOREs are designed to enable the rapid and efficient movement of basic scientific findings into clinical settings, as well as to determine the biological basis for observations made in individuals with cancer or in populations at risk for cancer. 
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