Despite the virtual format due to the coronavirus pandemic, UCSF once again had an impressive presence at this year's annual meeting of the American Society of Clinical Oncologists (ASCO). The program convened online Friday, May 29 through Sunday, May 31, with the theme, “Unite and Conquer: Accelerating Progress Together.”
Dozens of the HDFCCC’s 400+ members were represented in abstracts accepted for presentation, and ASCO provided investigators of all levels a chance to present and review research, confer with colleagues, and return with new ideas.
Highlights
Notable Honors- Chemtai Mungo, MD, MPH received a 2020 Conquer Cancer Young Investigator Award for her project, "Evaluation of the efficacy of thermal ablation for treatment of biopsy-confirmed cervical intraepithelial neoplasia grade 2 and 3."
- Rahul Banerjee, MD received a 2020 Conquer Cancer Young Investigator Award for his project, "Efficacy of digital life coaching to lower benzodiazepine usage and improve quality of life in multiple myeloma patients undergoing transplantation."
- Bridget Keenan, MD, PhD received a 2020 Conquer Cancer Young Investigator Award for her project, "Dissecting T cell states in advanced biliary cancer patients undergoing combination immunotherapy with GM-CSF and anti-PD-1."
- Rebecca DeBoer, MD, MA received a 2020 Conquer Cancer Young Investigator Award for her project, "Implementation and Adaptation of Evidence-Based Communication Skills Training for Oncology Providers at Butaro Hospital in Rwanda"
- Ana Velázquez Mañana, MD, MSc received an ASCO20 Virtual Scientific Program Merit Award.
We look forward to the @ConquerCancerFd awardees each year at @ASCO. Kudos to our @UCSF rising stars on the list #ASCO20: @ChemtaiMungo @RahulBanerjeeMD @bridgetMDPhD and Dr. Becky DeBoer #UCSFProud. See the full list: https://t.co/pkkTWwZow8 pic.twitter.com/SfdeGHvD3T
— UCSF Cancer Center (@UCSFCancer) May 29, 2020
Noteworthy Research
Prostate cancer: Eric Jay Small, MD, presented findings of a new subset of advanced prostate cancer. The research was conducted by the West Coast Prostate Cancer Dream Team, which is sponsored by the Prostate Cancer Foundation and Stand Up To Cancer. [View abstract]
- ASCO 2020: The Comprehensive Methylation Landscape of mCRPC Identifies New Phenotypic Subtypes: Results from the West Coast Prostate Cancer Dream Team
- ASCO 2020: Final Survival Results from SPARTAN, A Phase III Study of Apalutamide versus Placebo in Patients with Nonmetastatic Castration-Resistant Prostate Cancer From UroToday.com
Liver cancer: R. Kate Kelley, MD, presented findings on a Phase 2 study testing safety, efficacy and tolerability of tremelimumab added to durvalumab in patients with advanced hepatocellular carcinoma, a challenging form of cancer where patients have few treatment options. [View abstract]
Breast cancer: Hope S. Rugo, MD, presented data about a combination therapy with immunotherapy and chemotherapy for first-line treatment in a form of locally recurrent, inoperable or metastatic breast cancer. [View abstract]
Colorectal cancer: Mary Kathryn Abel presented "The increasing incidence of colorectal cancer in younger patients in the United States: Who, what, when, and where?" highlighting the changing demographics of colorectal cancer among nearly 1.9 million people, examining differences in age, race, region and tumor location. [View abstract]
- The results suggest that colon cancer is increasing in young patients, particularly among those 40–49, as well as in African American patients. Prior U.S. research has shown increased colorectal cancer among younger people, but few studies have evaluated health disparities in this population, especially in a large, national patient population. Co-authors include Katherine Van Loon, MD.
Highlights on Twitter
The modified virtual program offered some unexpected benefits with many abstracts and posters available on demand. The virtual format also moved most discussion and debate into the digital realm on Twitter and other social media platforms. We have included some highlights below.
Twitter Highlights: Day 1
Important work in trainee and workforce diversity in heme/onc presented by @anavmanana @UCSFCancer at #asco20.
— Daniel Kwon MD (@danielkwonmd) May 29, 2020
1️⃣10 yrs later, females and minorities continue to be underrepresented.
2️⃣trends across med school to practice continuum identify targets for intervention. Abst 11000
"This was very much a study of an active agent (apalutamide) early versus an active agent later, and earlier leads to improved survival,” Dr. Eric Small @UCSFUrology reporting on SPARTAN trial on Nonmetastatic #ProstateCancer, via @ASCOPost #ASCO20 https://t.co/pIbZlr1D9c pic.twitter.com/cSZ61WpHqb
— UCSF Cancer Center (@UCSFCancer) May 29, 2020
If geriatric assessment-driven intervention was a drug, it would be FDA approved and implemented in all cancer clinics to improve the care of older adults. Congrats to the both research teams! @rochgerionc @DanengLi @WilliamDale_MD #ASCO20 #gerionc #DrHurriasLight pic.twitter.com/xVIhZ1eb7v
— Melisa Wong, MD, MAS (@melisawongmd) May 29, 2020
Proud of my friend @anavmanana and happy to be part of this project created #ASCO2020. Yet another example highlighting the lack of #diversity and #representation among cancer centers. #representationmatters #latinasinmedicine @BernabeCarolina https://t.co/X0wc0s6iB9
— Coral Olazagasti, MD (@COlazagasti) May 29, 2020
Get ORVA it! Orva-cel BCMA CAR T in RRMM: doses of 300, 450, 600 reported; n=62, ORR 92%, >VGPR 68%. Highly refractory population. FU too short to estimate duration. Shout out to @SandyWong02111 for leading the @UCSFCancer effort on this! #mmsm #ASCO20 pic.twitter.com/GMDjW59UuD
— Nina Shah (@ninashah33) May 29, 2020
Thanks @ASCO for featuring our study using #designthinking to improve #bonemarrowbiopsy #training for #fellows as part of a #posterdiscussion! @UCSFCancer pic.twitter.com/7dpT7KpGHv
— Sam Brondfield, MD, MAEd (@s_brond) May 29, 2020
Real-time Conversations
YES! 🙌 #ASCO20 We need to invest in solutions to reach, engage, motivate, and #mentor young #minorities #URM to seek careers in #healthcare #medicine #hemeonc
— Ana Velázquez Mañana MD MSc (@anavmanana) May 29, 2020
Glad to have (still few) #rolemodels who look like me & excited to be one in the future! @LatinasInMed @NarjustDumaMD https://t.co/9q7HrA4wbG
As fellowship PD @LoyolaOnc I was esp drawn to work by @anavmanana et al. Good reminder that mentorship & visibility can help ensure success for our URM/female trainees (likely applies to LGBTQ+ though not studied here) #ASCO20 #OncMedEd 💪 https://t.co/YFMVJuN8TF
— Liza Henry McDonald (@DocLHenry) May 30, 2020
“Higher love!” Meta-analysis shows dara benefits pts with high risk #myeloma. Kinda confused bc original data with different HR data (ex. NEJM MAIA) than seen in table (thoughts @End_myeloma?) But very useful analysis & practice-guiding #mmsm #ASCO20 https://t.co/aGjXT5Cf50 pic.twitter.com/wl5NVz4vvf
— Nina Shah (@ninashah33) May 29, 2020
Twitter Highlights: Day 2
Fantastic overview from @TomBmt133 @UCSFCancer on BCMA directed therapies in development #mmsm #ASCO2020 @ASCO — @ninashah33 what do you think? pic.twitter.com/RI9CGbXefh
— Saad Usmani (@szusmani) May 30, 2020
Apalutimide Plus ADT Leads to Significantly Improved Outcomes in Patients With nmCRPC @UCSFCancer @ASCO #ASCO20 #pcsm https://t.co/T5kibwTEIx
— OncLive.com (@OncLive) May 30, 2020
CONGRESS | #ASCO20 | 'Immunotherapy is here to stay if we can afford it, and we can afford it if it means a cure' @TomBmt133, @UCSFCancer on bispecific antibodies for multiple #myeloma 👏. #mmsm @szusmani pic.twitter.com/2ZKN1QaNKx
— Multiple Myeloma Hub (@MM_Hub) May 30, 2020
#btsm #asco Team at @NeurosurgUCSF @UCSFCancer presented a project using WES of 82 pts undergoing re-op to evaluate prevalence & clinical implications of hypermutation. 🧬Hypermutation was id'ed at transformation in 57% of recurrent gliomas s/p TMZ. 94% went to higher WHO grades.
— Ashley Love Sumrall, MD, FACP (@AshleySumrallMD) May 30, 2020
Twitter Highlights: Day 3
Outstanding poster discussion by Dr. Katie Kelley...head spinning gleefully with all of the advancements in hepaobiliary cancers! @UCSFCancer @Sahaiz @rachnatshroff @autumnmcree @ShaalanBeg @DocDustyD @KristenCiombor @CardinMD @RajivAgarwalMD @nanudasmd @VUMC_Cancer pic.twitter.com/5HQN9FQOQc
— Laura Goff (@drlauragoff) May 31, 2020
Despite multiple efforts we continue to struggle with the lack of diversity in our hematology oncology workforce.
— Narjust Duma, M.D. (@NarjustDumaMD) May 31, 2020
Dr. @anavmanana breaks down the findings from her study looking at H/O fellowships. #ASCO20 Abstract: https://t.co/g2DF4mOyyY@OncoAlert @s_brond @COlazagasti pic.twitter.com/Cw4DcPizmC
RTOG 3506 (STEEL): Salvage RT ±Enzalutamide in Recurrent Prostate Ca #ASCO20 #OncoAlert #pcsm
— Nat Lester-Coll, MD (@DrLesterColl) May 31, 2020
👉 Post-RP, PSA≥0.2
👉 SRT 66-70.2 Gy +24 mos GnRH analog ±24 mos enzalutamide; optional nodal RT, boost
👉 Stratify: GS, nodes, SVI, +PSA after RP, PSA>0.7
Outcomes to clarify sys tx! pic.twitter.com/Q1PWIr7dRW
ASCO 2020 Updates on YouTube