Research Summary

I have studied natural killer (NK) cells in humans and mice since 1981. My lab has identified many of the activating and inhibitory NK receptors, their ligands, and signaling pathways and defined their role in innate and adaptive immune responses to pathogens and cancer.

Research Funding

  • August 1, 2018 - June 30, 2022 - Hypo-immunogenic cardiomyocytes for myocardial repair, Co-Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: R01HL140236
  • June 16, 2014 - May 31, 2016 - Human natural killer cell recognition of cytomegalovirus, Principal Investigator. Sponsor: NIH/NIAID, Sponsor Award ID: R21AI108860
  • March 1, 2001 - February 29, 2016 - NK and T Cell Costimulation by NKG2D/DAP10, Principal Investigator. Sponsor: NIH/NIAID, Sponsor Award ID: R37AI066897
  • January 9, 2001 - November 30, 2015 - NK Memory, Principal Investigator. Sponsor: NIH/NIAID, Sponsor Award ID: R01AI068129

Education

Virginia Polytechnic Institute & State U., Blacksburg, VA, B.S. (honors), 1975, Microbiology
Univ. North Carolina - Chapel Hill, NC, Ph.D., 1978, Immunology
Univ. North Carolina - Chapel Hill, NC, Postdoc, 1978-79, Immunology
Univ. New Mexico Med Sch, Albuquerque, NM, Postdoc, 1979-81, Immunology

Honors & Awards

  • 1971
    Virginia Polytechnic Institute and State University Freshman Science Scholarship
  • 1978-1979
    National Research Service Award Fellowship, University of North Carolina School of Medicine at Chapel Hill Cancer Research Center
  • 1979-1981
    Damon Runyon - Walter Winchell Cancer Fund Postdoctoral Fellowship
  • 2001
    American Association of Immunologists Distinguished Service Award
  • 2002
    William B Coley Award for Distinguished Research in Basic and Tumor Immunology, Cancer Research Institute, New York
  • 2003
    American Cancer Society Research Professorship
  • 2005
    American Society for Histocompatibility and Immunogenetics Rose Payne Award
  • 2006
    NIH Merit Grant Award
  • 2010
    Member, National Academy of Sciences
  • 2011
    Member, National Academy of Arts and Sciences
  • 2011
    Fellow, American Academy of Microbiology
  • 2013
    J. Michael Bishop Distinguished Professor of Microbiology and Immunology
  • 2017
    American Association of Immunologists Excellence in Mentoring Award

Selected Publications

  1. Deuse T, Hu X, Agbor-Enoh S, Jang MK, Alawi M, Saygi C, Gravina A, Tediashvili G, Nguyen VQ, Liu Y, Valantine H, Lanier LL, Schrepfer S The SIRPα-CD47 immune checkpoint in NK cells.  View on PubMed
  2. Adams NM, Diaz-Salazar C, Dang C, Lanier LL, Sun JC Cutting Edge: Heterogeneity in Cell Age Contributes to Functional Diversity of NK Cells.  View on PubMed
  3. Calabrese DR, Aminian E, Mallavia B, Liu F, Cleary SJ, Aguilar OA, Wang P, Hoover J, Singer JP, Hays SR, Golden JA, Kukreja J, Dugger DT, Nakamura M, Lanier LL, Looney MR, Greenland JR Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury.  View on PubMed
  4. Casanova JL, Holtzman DM, Kaech SM, Lanier LL, Nathan CF, Rudensky AY, Tuveson D, Wolchok JD Immigration in science.  View on PubMed
  5. Su Y, Chen D, Yuan D, Lausted C, Choi J, Dai CL, Voillet V, Duvvuri VR, Scherler K, Troisch P, Baloni P, Qin G, Smith B, Kornilov SA, Rostomily C, Xu A, Li J, Dong S, Rothchild A, Zhou J, Murray K, Edmark R, Hong S, Heath JE, Earls J, Zhang R, Xie J, Li S, Roper R, Jones L, Zhou Y, Rowen L, Liu R, Mackay S, O'Mahony DS, Dale CR, Wallick JA, Algren HA, Zager MA, Wei W, Price ND, Huang S, Subramanian N, Wang K, Magis AT, Hadlock JJ, Hood L, Aderem A, Bluestone JA, Lanier LL, Greenberg PD, Gottardo R, Davis MM, Goldman JD, Heath JR Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19.  View on PubMed
  6. Aguilar OA, Tanaka M, Balaji GR, Berry R, Rossjohn J, Lanier LL, Carlyle JR Tetramer Immunization and Selection Followed by CELLISA Screening to Generate Monoclonal Antibodies against the Mouse Cytomegalovirus m12 Immunoevasin.  View on PubMed
  7. Su Y, Chen D, Lausted C, Yuan D, Choi J, Dai C, Voillet V, Scherler K, Troisch P, Duvvuri VR, Baloni P, Qin G, Smith B, Kornilov S, Rostomily C, Xu A, Li J, Dong S, Rothchild A, Zhou J, Murray K, Edmark R, Hong S, Jones L, Zhou Y, Roper R, Mackay S, O'Mahony DS, Dale CR, Wallick JA, Algren HA, Michael ZA, Magis A, Wei W, Price ND, Huang S, Subramanian N, Wang K, Hadlock J, Hood L, Aderem A, Bluestone JA, Lanier LL, Greenberg P, Gottardo R, Davis MM, Goldman JD, Heath JR Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories.  View on PubMed
  8. Guerra N, Lanier LL Editorial: Emerging Concepts on the NKG2D Receptor-Ligand Axis in Health and Diseases.  View on PubMed
  9. Dogra P, Rancan C, Ma W, Toth M, Senda T, Carpenter DJ, Kubota M, Matsumoto R, Thapa P, Szabo PA, Li Poon MM, Li J, Arakawa-Hoyt J, Shen Y, Fong L, Lanier LL, Farber DL Tissue Determinants of Human NK Cell Development, Function, and Residence.  View on PubMed
  10. Zammit NW, Siggs OM, Gray PE, Horikawa K, Langley DB, Walters SN, Daley SR, Loetsch C, Warren J, Yap JY, Cultrone D, Russell A, Malle EK, Villanueva JE, Cowley MJ, Gayevskiy V, Dinger ME, Brink R, Zahra D, Chaudhri G, Karupiah G, Whittle B, Roots C, Bertram E, Yamada M, Jeelall Y, Enders A, Clifton BE, Mabbitt PD, Jackson CJ, Watson SR, Jenne CN, Lanier LL, Wiltshire T, Spitzer MH, Nolan GP, Schmitz F, Aderem A, Porebski BT, Buckle AM, Abbott DW, Ziegler JB, Craig ME, Benitez-Aguirre P, Teo J, Tangye SG, King C, Wong M, Cox MP, Phung W, Tang J, Sandoval W, Wertz IE, Christ D, Goodnow CC, Grey ST Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity.  View on PubMed
  11. Lee BH, Kelly G, Bradford S, Davila M, Guo XV, Amir ED, Thrash EM, Solga MD, Lannigan J, Sellers B, Candia J, Tsang J, Montgomery RR, Tamaki SJ, Sigdel TK, Sarwal MM, Lanier LL, Tian Y, Kim C, Hinz D, Peters B, Sette A, Rahman AH A Modified Injector and Sample Acquisition Protocol Can Improve Data Quality and Reduce Inter-Instrument Variability of the Helios Mass Cytometer.  View on PubMed
  12. McKechnie JL, Beltrán D, Pitti A, Saenz L, Araúz AB, Vergara R, Harris E, Lanier LL, Blish CA, López-Vergès S HLA Upregulation During Dengue Virus Infection Suppresses the Natural Killer Cell Response.  View on PubMed
  13. Lanier LL Plastic fantastic innate lymphoid cells.  View on PubMed
  14. Lam VC, Folkersen L, Aguilar OA, Lanier LL KLF12 Regulates Mouse NK Cell Proliferation.  View on PubMed
  15. Feng Y, Daley-Bauer LP, Roback L, Guo H, Koehler HS, Potempa M, Lanier LL, Mocarski ES Caspase-8 restricts antiviral CD8 T cell hyperaccumulation.  View on PubMed
  16. Feng Y, Daley-Bauer LP, Roback L, Potempa M, Lanier LL, Mocarski ES Caspase-8 restricts natural killer cell accumulation during MCMV Infection.  View on PubMed
  17. Das J, Lanier LL Data analysis to modeling to building theory in NK cell biology and beyond: How can computational modeling contribute?  View on PubMed
  18. Calabrese DR, Chong T, Wang A, Singer JP, Gottschall M, Hays SR, Golden JA, Kukreja J, Lanier LL, Tang Q, Greenland JR NKG2C Natural Killer Cells in Bronchoalveolar Lavage Are Associated With Cytomegalovirus Viremia and Poor Outcomes in Lung Allograft Recipients.  View on PubMed
  19. Deuse T, Hu X, Gravina A, Wang D, Tediashvili G, De C, Thayer WO, Wahl A, Garcia JV, Reichenspurner H, Davis MM, Lanier LL, Schrepfer S Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients.  View on PubMed
  20. Balaji GR, Aguilar OA, Tanaka M, Shingu-Vazquez MA, Fu Z, Gully BS, Lanier LL, Carlyle JR, Rossjohn J, Berry R Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition.  View on PubMed

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