University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Laura Fejerman, PhD

Laura Fejerman, PhD

Assistant Professor, Dept. Medicine, UCSF

Cancer Center Program Memberships

Cancer Control

Research Summary

Dr. Fejerman’s research focuses on the discovery of genetic and non-genetic factors that contribute to breast cancer risk and prognosis in Latinas. Her past work established a relationship between genetic ancestry and breast cancer risk, where higher European ancestry in U.S. and Mexican Latinas was associated with an increased risk. Her subsequent research has built upon this observation, exploring genetic variants, through admixture mapping and genome-wide association approaches, as well as the possible environmental and lifestyle related factors, and ancestry-gene interactions. Additional work explores disparities in breast cancer prognosis in Latinas and its potential causes, including access to information, screening and care.

Dr. Fejerman is the 2019-2020 Chair of the AACR Minorities in Cancer Research (MICR) Council.

Education

University of Buenos Aires, Argentina Licentiate 03/1992-12/1997 Anthropology
University of Oxford, England M.Sc. 09/1998-08/1999 Human Biology
University of Oxford, England Ph.D. 09/1999-10/2005 Biological Anthropology
University of California San Francisco Postdoctoral 11/2006-1/2011 Genetic Epidemiology
University of California San Francisco Certificate 09/2011-05/2012 Clinical Research


Professional Experience

  • 2006-2011
    University of California San Francisco, Postdoctoral Fellow, Dept. Medicine
  • 2011-present
    University of California San Francisco, Assistant Professor, Dept. Medicine

Honors & Awards

  • 1997 Licentiate Honor Diploma, University of Buenos Aires
  • 1999 M.Sc. in Human Biology Distinction Award, University of Oxford
  • 2007 Best Early Detection & Prevention Poster, Breast Oncology Program Retreat, UCSF
  • 2009 Best Early Detection & Prevention Poster, Breast Oncology Program Retreat, UCSF
  • 2011 Best Early Detection & Prevention Poster, Breast Oncology Program Retreat, UCSF
  • 2011 BIRCWH K12 Program Award, University of California San Francisco
  • 2011 K01 Mentored Research Scientist Career Development Award, National Cancer Institute (NIH)
  • 2013 California Breast Cancer Research Program (CBCRP) IDEA Award
  • 2014 Best Early Detection & Prevention Poster, Breast Oncology Program Retreat, UCSF

Selected Publications

  1. Shieh Y, Fejerman L, Lott PC, Marker K, Sawyer SD, Hu D, Huntsman S, Torres J, Echeverry M, Bohorquez ME, Martínez-Chéquer JC, Polanco-Echeverry G, Estrada-Florez AP. A polygenic risk score for breast cancer in U.S. Latinas and Latin-American women. J Natl Cancer Inst. 2019 Sep 25.
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  2. Guan A, Lichtensztajn DY, Oh D, Jain J, Tao L, Hiatt RA, Gomez SL, Fejerman L. Breast Cancer in San Francisco: Disentangling Disparities at the Neighborhood Level. Cancer Epidemiol Biomarkers Prev. 2019 Sep 23.
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  3. Rey-Vargas L, Sanabria-Salas MC, Fejerman L, Serrano-Gómez SJ. Risk Factors for Triple-Negative Breast Cancer among Latina Women. Cancer Epidemiol Biomarkers Prev. 2019 Nov; 28(11):1771-1783.
    View on PubMed
  4. Sanchez SS, Tachachartvanich P, Stanczyk FZ, Gomez SL, John EM, Smith MT, Fejerman L. Estrogenic activity, race/ethnicity, and Indigenous American ancestry among San Francisco Bay Area women. PLoS One. 2019; 14(3):e0213809.
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  5. Zavala VA, Serrano-Gomez SJ, Dutil J, Fejerman L. Genetic Epidemiology of Breast Cancer in Latin America. Genes (Basel). 2019 02 18; 10(2).
    View on PubMed
  6. Hoffman J, Fejerman L, Hu D, Huntsman S, Li M, John EM, Torres-Mejia G, Kushi L, Ding YC, Weitzel J, Neuhausen SL, Lott P, Echeverry M, Carvajal-Carmona L, Burchard E, Eng C, Long J, Zheng W, Olopade O, Huo D, Haiman C, Ziv E. Identification of novel common breast cancer risk variants at the 6q25 locus among Latinas. Breast Cancer Res. 2019 01 14; 21(1):3.
    View on PubMed
  7. Tamayo LI, Vidaurre T, Navarro Vásquez J, Casavilca S, Aramburu Palomino JI, Calderon M, Abugattas JE, Gomez HL, Castaneda CA, Song S, Cherry D, Rauscher GH, Fejerman L. Breast cancer subtype and survival among Indigenous American women in Peru. PLoS One. 2018; 13(9):e0201287.
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  8. Hiatt RA, Sibley A, Fejerman L, Glantz S, Nguyen T, Pasick R, Palmer N, Perkins A, Potter MB, Somsouk M, Vargas RA, van 't Veer LJ, Ashworth A. The San Francisco Cancer Initiative: A Community Effort To Reduce The Population Burden Of Cancer. Health Aff (Millwood). 2018 01; 37(1):54-61.
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  9. Serrano-Gómez SJ, Fejerman L, Zabaleta J. Breast Cancer in Latinas: A Focus on Intrinsic Subtypes Distribution. Cancer Epidemiol Biomarkers Prev. 2018 01; 27(1):3-10.
    View on PubMed
  10. Engmann NJ, Ergas IJ, Yao S, Kwan ML, Roh JM, Ambrosone CB, Kushi LH, Fejerman L. Genetic Ancestry Is not Associated with Breast Cancer Recurrence or Survival in U.S. Latina Women Enrolled in the Kaiser Permanente Pathways Study. Cancer Epidemiol Biomarkers Prev. 2017 09; 26(9):1466-1469.
    View on PubMed
  11. Serrano-Gómez SJ, Sanabria-Salas MC, Garay J, Baddoo MC, Hernández-Suarez G, Mejía JC, García O, Miele L, Fejerman L, Zabaleta J. Ancestry as a potential modifier of gene expression in breast tumors from Colombian women. PLoS One. 2017; 12(8):e0183179.
    View on PubMed
  12. Sanabria-Salas MC, Hernández-Suárez G, Umaña-Pérez A, Rawlik K, Tenesa A, Serrano-López ML, Sánchez de Gómez M, Rojas MP, Bravo LE, Albis R, Plata JL, Green H, Borgovan T, Li L, Majumdar S, Garai J, Lee E, Ashktorab H, Brim H, Li L, Margolin D, Fejerman L, Zabaleta J. IL1B-CGTC haplotype is associated with colorectal cancer in admixed individuals with increased African ancestry. Sci Rep. 2017 02 03; 7:41920.
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  13. Santiago-Torres M, De Dieu Tapsoba J, Kratz M, Lampe JW, Breymeyer KL, Levy L, Song X, Villaseñor A, Wang CY, Fejerman L, Neuhouser ML, Carlson CS. Genetic ancestry in relation to the metabolic response to a US versus traditional Mexican diet: a randomized crossover feeding trial among women of Mexican descent. Eur J Clin Nutr. 2017 03; 71(3):395-401.
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  14. Hines LM, Sedjo RL, Byers T, John EM, Fejerman L, Stern MC, Baumgartner KB, Giuliano AR, Torres-Mejia G, Wolff RK, Harrall KK, Slattery ML. The Interaction between Genetic Ancestry and Breast Cancer Risk Factors among Hispanic Women: The Breast Cancer Health Disparities Study. Cancer Epidemiol Biomarkers Prev. 2017 05; 26(5):692-701.
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  15. Lynce F, Graves KD, Jandorf L, Ricker C, Castro E, Moreno L, Augusto B, Fejerman L, Vadaparampil ST. Genomic Disparities in Breast Cancer Among Latinas. Cancer Control. 2016 Oct; 23(4):359-372.
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  16. Fejerman L, Sanchez SS, Thomas R, Tachachartvanich P, Riby J, Gomez SL, John EM, Smith MT. Association of lifestyle and demographic factors with estrogenic and glucocorticogenic activity in Mexican American women. Carcinogenesis. 2016 09; 37(9):904-911.
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  17. Stern MC, Fejerman L, Das R, Setiawan VW, Cruz-Correa MR, Perez-Stable EJ, Figueiredo JC. Variability in Cancer Risk and Outcomes Within US Latinos by National Origin and Genetic Ancestry. Curr Epidemiol Rep. 2016; 3:181-190.
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  18. Serrano-Gomez SJ, Sanabria-Salas MC, Hernández-Suarez G, García O, Silva C, Romero A, Mejía JC, Miele L, Fejerman L, Zabaleta J. High prevalence of luminal B breast cancer intrinsic subtype in Colombian women. Carcinogenesis. 2016 07; 37(7):669-676.
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  19. Kim AE, Lundgreen A, Wolff RK, Fejerman L, John EM, Torres-Mejía G, Ingles SA, Boone SD, Connor AE, Hines LM, Baumgartner KB, Giuliano A, Joshi AD, Slattery ML, Stern MC. Red meat, poultry, and fish intake and breast cancer risk among Hispanic and Non-Hispanic white women: The Breast Cancer Health Disparities Study. Cancer Causes Control. 2016 Apr; 27(4):527-43.
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  20. Ziv E, Dean E, Hu D, Martino A, Serie D, Curtin K, Campa D, Aftab B, Bracci P, Buda G, Zhao Y, Caswell-Jin J, Diasio R, Dumontet C, Dudzinski M, Fejerman L, Greenberg A, Huntsman S, Jamroziak K, Jurczyszyn A, Kumar S, Atanackovic D, Glenn M, Cannon-Albright LA, Jones B, Lee A, Marques H, Martin T, Martinez-Lopez J, Rajkumar V, Sainz J, Juul Vangsted A, Watek M, Wolf J, Slager S, Camp NJ, Canzian F, Vachon C. Corrigendum: Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients. Nat Commun. 2015 Dec 09; 6:10203.
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