University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Jeffry P. Simko, MD, PhD

Jeffry P. Simko, MD, PhD

Associate Clinical Professor, Department of Pathology, UCSF

Cancer Center Program Memberships

Prostate Cancer

Education

University of Delaware, Newark, Delaware, BS, 1985, Chemistry
University of North Carolina at Chapel Hill, PhD, 1990, Analytical Chemistry/ Materials Science
University of North Carolina School of Medicine, MD, 1992-1996, Medicine
University of California, San Francisco, CA Resident, 1996-00, Pathology/ Laboratory Medicine
Brigham and Womens Hospital and Harvard Medical School, Boston, MA, Clinical Fellow, 2000-01, Molecular Pathology
University of California, San Francisco, CA, Clinical Fellow, 2001-02, Surgical Pathology


Professional Experience

  • 1983-1985
    Student Employee, E.I. duPont de Nemours Inc., Pioneering Research Laboratory, Experimental Station, Wilmington, Delaware
  • 5/88-2/90
    Visiting Engineer, IBM T.J. Watson Research Center, Yorktown Hts., NY
  • 1986-1990
    Research Assistant, University of North Carolina Chemistry Department
  • 1991-7/92
    Research Associate, Frontier Research Program, RIKEN, The Institute of Physical and Chemical Research, Wakou-shi, Saitama, Japan
  • 1993
    Student Researcher, Department of Biochemistry, UNC School of Medicine
  • 1993-1994
    Student Researcher, Department of Maternal and Fetal Medicine, UNC School of Medicine
  • 9/94-12/94
    Visiting Scientist, Department of Biophysics, Beijing Medical University, Beijing, People's Republic of China
  • 1996-2000
    Resident, Department of Pathology/Laboratory Medicine, UCSF, San Francisco
  • 2000-2001
    Clinical Fellow, Department of Molecular Pathology, Brigham & Women's Hospital and Harvard Medical School, Boston
  • 2001-2002
    Clinical Fellow, Department of Surgical Pathology, UCSF, San Francisco
  • 2002-2003
    Assistant Clinical Professor, Department of Anatomic Pathology, UCSF, San Francisco
  • 2003-2007
    Assistant Professor, Department of Anatomic Pathology, UCSF, San Francisco
  • 2007-present
    Associate Professor, Department of Anatomic Pathology, UCSF, San Francisco

Honors & Awards

  • 1984
    American Chemical Society, U. of Delaware Analytical Chemistry Award
  • 1994
    Howard Hughes Trust Fund Fellowship
  • 1994
    UNC School of Medicine Foreign Fellowship
  • 1994
    Medical Alumni Association Research Fellowship
  • 10/97-12/97
    Chief Resident, Department of Pathology, S.F. VA Medical Center
  • 4/98-6/98
    Chief Resident, Department of Pathology, S.F. General Hospital
  • 3/00-6/00
    Chief Resident, Department of Lab Medicine, S.F. General Hospital
  • 2002
    College of American Pathology Travel Award: Strategic Science Seminar Series, HER2/neu Testing of Breast Care Patients

Selected Publications

  1. Friedlander TW, Welty C, Anantharaman A, Schonhoft JD, Jendrisak A, Lee J, Li P, Hough J, Stromlund A, Kobayashi Y, Simko J, Farrokhian N, Lindquist K, Greene S, Ontiveros P, Graf R, Rodriquez A, Suraneni M, Wang Y, Landers M, Carroll P, Cooperberg MR, Dittamore R, Paris PL. Identification and Characterization of Circulating Tumor Cells in Men Who Have Undergone Prostatectomy for Clinically Localized, High - Risk Prostate Cancer. J Urol. 2019 Jun 19; 101097JU0000000000000393.
    View on PubMed
  2. Sirohi D, Devine P, Grenert JP, van Ziffle J, Simko JP, Stohr BA. TP53 structural variants in metastatic prostatic carcinoma. PLoS One. 2019; 14(6):e0218618.
    View on PubMed
  3. Kornberg Z, Cooperberg MR, Cowan JE, Chan JM, Shinohara K, Simko JP, Tenggara I, Carroll PR. A 17-Gene Genomic Prostate Score as a Predictor of Adverse Pathology for Men on Active Surveillance. J Urol. 2019 Apr 26; 101097JU0000000000000290.
    View on PubMed
  4. Greenland NY, Zhang L, Cowan JE, Carroll PR, Stohr BA, Simko JP. Correlation of a Commercial Genomic Risk Classifier with Histological Patterns in Prostate Cancer. J Urol. 2019 Feb 15; 101097JU0000000000000175.
    View on PubMed
  5. Behr SC, Aggarwal R, Van Brocklin HF, Flavell RR, Geo K, Small EJ, Blecha J, Jivan S, Hope TA, Simko JP, Kurhanewicz J, Noworolski SM, Korn NJ, De Los Santos R, Cooperberg MR, Carroll PR, Nguyen HG, Greene KL, Langton-Webster B, Berkman CE, Seo Y. First-in-Human Phase I study of CTT1057, a Novel 18F Labeled Imaging Agent with Phosphoramidate Core Targeting Prostate Specific Membrane Antigen in Prostate Cancer. J Nucl Med. 2018 Nov 21.
    View on PubMed
  6. Hagihara K, Chan S, Zhang L, Oh DY, Wei XX, Simko J, Fong L. Neoadjuvant sipuleucel-T induces both Th1 activation and immune regulation in localized prostate cancer. Oncoimmunology. 2019; 8(1):e1486953.
    View on PubMed
  7. Hicks RM, Simko JP, Westphalen AC, Nguyen HG, Greene KL, Zhang L, Carroll PR, Hope TA. Diagnostic Accuracy of 68Ga-PSMA-11 PET/MRI Compared with Multiparametric MRI in the Detection of Prostate Cancer. Radiology. 2018 Dec; 289(3):730-737.
    View on PubMed
  8. Su Y, Liu Y, Behrens CR, Bidlingmaier S, Lee NK, Aggarwal R, Sherbenou DW, Burlingame AL, Hann BC, Simko JP, Premasekharan G, Paris PL, Shuman MA, Seo Y, Small EJ, Liu B. Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer. JCI Insight. 2018 Sep 06; 3(17).
    View on PubMed
  9. Leapman MS, Nguyen HG, Cowan JE, Xue L, Stohr B, Simko J, Cooperberg MR, Carroll PR. Comparing Prognostic Utility of a Single-marker Immunohistochemistry Approach with Commercial Gene Expression Profiling Following Radical Prostatectomy. Eur Urol. 2018 11; 74(5):668-675.
    View on PubMed
  10. Lelo A, Prip F, Harris BT, Solomon D, Berry DL, Chaldekas K, Kumar A, Simko J, Jensen JB, Bhattacharyya P, Mannion C, Kim JS, Philips G, Dyrskjøt L, Waldman T. STAG2 Is a Biomarker for Prediction of Recurrence and Progression in Papillary Non-Muscle-Invasive Bladder Cancer. Clin Cancer Res. 2018 Sep 01; 24(17):4145-4153.
    View on PubMed
  11. Cooperberg MR, Erho N, Chan JM, Feng FY, Fishbane N, Zhao SG, Simko JP, Cowan JE, Lehrer J, Alshalalfa M, Kolisnik T, Chelliserry J, Margrave J, Aranes M, Plessis MD, Buerki C, Tenggara I, Davicioni E, Carroll PR. The Diverse Genomic Landscape of Clinically Low-risk Prostate Cancer. Eur Urol. 2018 10; 74(4):444-452.
    View on PubMed
  12. Sirohi D, Vaske C, Sanborn Z, Smith SC, Don MD, Lindsey KG, Federman S, Vankalakunti M, Koo J, Bose S, Peralta-Venturina M, Ziffle JV, Grenert JP, Miller S, Chiu C, Amin MB, Simko JP, Stohr BA, Luthringer DJ. Polyoma virus-associated carcinomas of the urologic tract: a clinicopathologic and molecular study. Mod Pathol. 2018 09; 31(9):1429-1441.
    View on PubMed
  13. Tzou DT, Cadwell C, Simko JP, Chi T, Stoller ML. Management of Inverted Papilloma During Holmium Laser Enucleation of the Prostate. Urology. 2018 Jun; 116:e5-e6.
    View on PubMed
  14. Sirohi D, Garg K, Simko JP, Grenert JP. Renal NUT carcinoma: a case report. Histopathology. 2018 02; 72(3):528-530.
    View on PubMed
  15. Lawrence YR, Moughan J, Magliocco AM, Klimowicz AC, Regine WF, Mowat RB, DiPetrillo TA, Small W, Simko JP, Golan T, Winter KA, Guha C, Crane CH, Dicker AP. Expression of the DNA repair gene MLH1 correlates with survival in patients who have resected pancreatic cancer and have received adjuvant chemoradiation: NRG Oncology RTOG Study 9704. Cancer. 2018 Feb 01; 124(3):491-498.
    View on PubMed
  16. Starobinets O, Simko JP, Kuchinsky K, Kornak J, Carroll PR, Greene KL, Kurhanewicz J, Noworolski SM. Characterization and stratification of prostate lesions based on comprehensive multiparametric MRI using detailed whole-mount histopathology as a reference standard. NMR Biomed. 2017 Dec; 30(12).
    View on PubMed
  17. Sirohi D, Smith SC, Epstein JI, Balzer BL, Simko JP, Balitzer D, Benhamida J, Kryvenko ON, Gupta NS, Paluru S, da Cunha IW, Leal DN, Williamson SR, de Peralta-Venturina M, Amin MB. Pericytic tumors of the kidney-a clinicopathologic analysis of 17 cases. Hum Pathol. 2017 06; 64:106-117.
    View on PubMed
  18. Leapman MS, Cowan JE, Simko J, Roberge G, Stohr BA, Carroll PR, Cooperberg MR. Application of a Prognostic Gleason Grade Grouping System to Assess Distant Prostate Cancer Outcomes. Eur Urol. 2017 05; 71(5):750-759.
    View on PubMed
  19. Emami NC, Leong L, Wan E, Van Blarigan EL, Cooperberg MR, Tenggara I, Carroll PR, Chan JM, Witte JS, Simko JP. Tissue Sources for Accurate Measurement of Germline DNA Genotypes in Prostate Cancer Patients Treated With Radical Prostatectomy. Prostate. 2017 03; 77(4):425-434.
    View on PubMed
  20. Wei XX, Chan S, Kwek S, Lewis J, Dao V, Zhang L, Cooperberg MR, Ryan CJ, Lin AM, Friedlander TW, Rini B, Kane C, Simko JP, Carroll PR, Small EJ, Fong L. Systemic GM-CSF Recruits Effector T Cells into the Tumor Microenvironment in Localized Prostate Cancer. Cancer Immunol Res. 2016 11; 4(11):948-958.
    View on PubMed

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