University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Li Zhang, PhD

Li Zhang, PhD

Associate Professor, Medicine, UCSF

Cancer Center Program Memberships



Southeast University, China, B. Eng, 1999, Civil Engineering
University of Florida, M.Stat, 2003, Statistics
University of Florida, Ph.D., 2006, Statistics

Honors & Awards

  • 2004
    Mu Sigma Rho Prize (The National Statistical Honor Fraternity)
  • 2005
    Keene Dissertation Fellowship Award, College of Liberal Arts & Sciences, University of Florida
  • 2005
    Cancer Research Training Award, National Cancer Institute, NIH
  • 2012
    Innovator Award - Genomic Biomarkers of Lung Cancer Risk, Cleveland Clinic
  • 2014
    The Safeway Foundation-PCF Challenge Award – The NEXT Project: Network Enriched Crossover Trial, Prostate Cancer Foundation
  • 2016
    UCSF Global Oncology Pilot Project Award
  • 2016
    UCSF Research Allocation Program Award

Selected Publications

  1. Download TCR3D
  2. Zhang L, Johnson J, Gottschalk AR, Chang AJ, Hsu IC, Roach M, and Seymour ZA. Receiver Operating Curves and Dose-Volume Analysis of Late Toxicity for with Stereotactic Body Radiotherapy for Prostate Cancer. Practical Radiation Oncology doi:10.1016/j.prro.2016.07.004
  3. Sheikh NA, Cham J, Zhang L, DeVries T, Letarte S, Pufnock J, Hamm D, Trager JB, Fong L. Clonotypic Diversification of Intratumoral T Cells Following Sipuleucel-T Treatment in Prostate Cancer Subjects. Cancer Res. 2016 Jul 1; 76(13):3711-8. PMID: 27216195.
  4. Kwek SS, Lewis J, Zhang L, Weinberg V, Greaney SK, Harzstark AL, Lin AM, Ryan CJ, Small EJ, Fong L. Preexisting Levels of CD4 T Cells Expressing PD-1 Are Related to Overall Survival in Prostate Cancer Patients Treated with Ipilimumab. Cancer Immunol Res. 2015 Sep; 3(9):1008-16. PMID: 25968455; PMCID: PMC4561203 [Available on 09/01/16].
  5. Seymour ZA, Chang AJ, Zhang L, Kirby N, Descovich M, Roach M, Hsu IC, Gottschalk AR. Dose-volume analysis and the temporal nature of toxicity with stereotactic body radiation therapy for prostate cancer. Pract Radiat Oncol. 2015 Sep-Oct; 5(5):e465-72. PMID: 25795252.
  6. Cheng ML, Zhang L, Borok M, Chokunonga E, Dzamamala C, Korir A, Wabinga HR, Hiatt RA, Parkin DM, Van Loon K. The incidence of oesophageal cancer in Eastern Africa: identification of a new geographic hot spot? Cancer Epidemiol. 2015 Apr; 39(2):143-9. PMID: 25662402; PMCID: PMC4470609 [Available on 04/01/16].
  7. Serena S. Kwek, James Kahn, Samantha K. Greaney, Jera Lewis, Edward Cha, Li Zhang, Robert Weber, Lonnie Leonard, Svetomir N. Markovic, Lawrence Fong, and Lynn E. Spitler. . GM-CSF and Ipilimumab Therapy in Metastatic Melanoma: Clinical Outcomes and Immunologic Responses. Oncoimmunology. 2015.
  8. V. Visconte, A. Tabarroki, L. Zhang, A.T. Gerds, H.J. Rogers, Y. Han, J. Barnard, V. Shivarov, J. Carew, R.V. Tiu . . Somatic wiskott-aldrich syndrome protein family member 3 (WASF3) mutations in myelodysplastic syndromes and related myeloid malignancies. Leukemia Research. 2015; 39:S85-S86.
  9. Visconte V, Tabarroki A, Zhang L, Parker Y, Hasrouni E, Mahfouz R, Isono K, Koseki H, Sekeres MA, Saunthararajah Y, Barnard J, Lindner D, Rogers HJ, Tiu RV. Splicing factor 3b subunit 1 (Sf3b1) haploinsufficient mice display features of low risk Myelodysplastic syndromes with ring sideroblasts. J Hematol Oncol. 2014; 7:89. PMID: 25481243; PMCID: PMC4266210.
  10. Van Loon K, Zhang L, Keiser J, Carrasco C, Glass K, Ramirez MT, Bobiak S, Nakakura EK, Venook AP, Shah MH, Bergsland EK. Bone metastases and skeletal-related events from neuroendocrine tumors. Endocr Connect. 2015 Mar; 4(1):9-17. PMID: 25430999; PMCID: PMC4285767.
  11. Kim W, Zhang L, Wilton JH, Fetterly G, Mohler JL, Weinberg V, Morse A, Szmulewitz RZ, Friedlander TW,Fong L, Lin AM, Harzstark AL, Molina A, Small EJ, Ryan CJ. Sequential use of the androgen synthesis inhibitors ketoconazole and abiraterone acetate in castration-resistant prostate cancer and the predictive value of circulating androgens. Clin Cancer Res. 2014 Dec 15; 20(24):6269-76. PMID: 25336698
  12. Visconte V, Tabarroki A, Zhang L, Hasrouni E, Gerace C, Frum R, Ai J, Advani AS, Duong HK, Kalaycio M, Saunthararajah Y, Sekeres MA, His ED, Shetty S, Rogers HJ, Tiu RV. Clinicopathologic and molecular characterization of myeloid neoplasms harboring isochromosome 17(q10). Am J Hematol. 2014 Aug; 89(8):862. PMID: 24796269.
  13. Timur AA, Murugesan G, Zhang L, Barnard J, Bhatt DL, Kottke-Marchant K. Multi-parameter assessment of platelet inhibition and its stability during aspirin and clopidogrel therapy. Thromb Res. 2014 Jul; 134(1):96-104. PMID: 24852729
  14. Zhang L, Orloff MS, Reber S, Li S, Zhao Y, Eng C. cgaTOH: extended approach for identifying tracts of homozygosity. PLoS One. 2013; 8(3):e57772. PMID: 23469237; PMCID: PMC3585782.
  15. Zhang L, Liu R, Wang Z, Culver DA, Wu R. Modeling haplotype-haplotype interactions in case-control genetic association studies. Front Genet. 2012; 3:2. PMID: 22303409; PMCID: PMC3260479.
  16. Zhang L, Mukherjee B, Hu B, Moreno V, Cooney KA. Semiparametric Bayesian modeling of random genetic effects in family-based association studies. Stat Med. 2009 Jan 15; 28(1):113-39. PMID: 18792083; PMCID: PMC2684653.
  17. Zhang L, Mukherjee B, Ghosh M, Gruber S, Moreno V. Accounting for error due to misclassification of exposures in case-control studies of gene-environment interaction. Stat Med. 2008 Jul 10; 27(15):2756-83. PMID: 17879261.
  18. Bong-Rae Kim, Li Zhang, Arthur Berg, Jianqing Fan and Rongling Wu. . A Computational Approach to the Functional Clustering of Periodic Gene Expression Profiles. Genetics. 2008; (180):1-14.
  19. Patocs A, Zhang L, Xu Y, Weber F, Caldes T, Mutter GL, Platzer P, Eng C. Breast-cancer stromal cells with TP53 mutations and nodal metastases. N Engl J Med. 2007 Dec 20; 357(25):2543-51. PMID: 18094375.
  20. Bhramar Mukherjee, Li Zhang, Malay Ghosh and Samiran Sinha. . Semiparametric Bayesian Analysis of Case-Control Data under Conditional Gene-Environment Independence. Biometrics. 2007; (63):834-844.
  21. Li Zhang, Bhramar Mukherjee, Malay Ghosh and Rongling Wu. . . A Bayesian Framework for Genetic Association in Case-Control Studies: Accounting for Unknown Population Substructure. Statistical Modeling. 2006; (6):352-372.