Research Funding

  • July 9, 2010 - May 31, 2017 - The Role of Cul4A in Genome Stability and Cancer Development , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA140654
  • July 9, 2010 - May 31, 2017 - The Role of Cul4A in Genome Stability and Cancer Development , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA140654
  • July 9, 2010 - May 31, 2017 - The Role of Cul4A in Genome Stability and Cancer Development , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA140654

Education

  • Jinzhou Medical College, PRC, M.D., 1987, Medicine
  • Medical College of Ohio, Toledo, OH, Ph.D., 1994, Pathology Lung cancer
  • National Cancer Institute, NIH, MD, Post-doc, 1996, Lung cancer
  • Lawrence Berkeley National Laboratory, CA, Post-doc, 1997, Cancer genetics

Honors & Awards

  • 1988
    Fellowship, Medical College of Ohio, Toledo, OH
  • 1994
    NIH Intramural Research Training Award (IRTA), National Cancer Institute, NIH
  • 1999
    Outstanding Performance Award, UCSF
  • 2001
    Outstanding Performance Award, Arcturus, CA
  • 2005
    Visiting Professor and Special Consultant to Beijing Lung Cancer Center, Beijing, PRC
  • 2007
    The David Jablons “Asclepios” Award, The Bonnie J. Addario Lung Cancer Foundation, CA
  • 2007
    The Barbara Isackson Thoracic Oncology Research Award, UCSF, CA

Selected Publications

  1. Dai Y, Kyoyama H, Yang YL, Wang Y, Liu S, Wang Y, Mao JH, Xu Z, Uematsu K, Jablons DM, You L. A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells. Oncotarget. 2021 Feb 02; 12(3):173-184.  View on PubMed
  2. Hsu PC, Yang CT, Jablons DM, You L. The Crosstalk between Src and Hippo/YAP Signaling Pathways in Non-Small Cell Lung Cancer (NSCLC). Cancers (Basel). 2020 May 26; 12(6).  View on PubMed
  3. Miao J, Kyoyama H, Liu L, Chan G, Wang Y, Urisman A, Yang YL, Liu S, Xu Z, Bin H, Li H, Jablons DM, You L. Inhibition of cyclin-dependent kinase 7 down-regulates yes-associated protein expression in mesothelioma cells. J Cell Mol Med. 2020 01; 24(1):1087-1098.  View on PubMed
  4. Hsu PC, Jablons DM, Yang CT, You L. Epidermal Growth Factor Receptor (EGFR) Pathway, Yes-Associated Protein (YAP) and the Regulation of Programmed Death-Ligand 1 (PD-L1) in Non-Small Cell Lung Cancer (NSCLC). Int J Mol Sci. 2019 Aug 05; 20(15).  View on PubMed
  5. Agnew C, Liu L, Liu S, Xu W, You L, Yeung W, Kannan N, Jablons D, Jura N. The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region. J Biol Chem. 2019 09 13; 294(37):13545-13559.  View on PubMed
  6. Hsu PC, Tian B, Yang YL, Wang YC, Liu S, Urisman A, Yang CT, Xu Z, Jablons DM, You L. Cucurbitacin E inhibits the Yes‑associated protein signaling pathway and suppresses brain metastasis of human non‑small cell lung cancer in a murine model. Oncol Rep. 2019 Aug; 42(2):697-707.  View on PubMed
  7. Hung MS, Chen YC, Lin P, Li YC, Hsu CC, Lung JH, You L, Xu Z, Mao JH, Jablons DM, Yang CT. Cul4A Modulates Invasion and Metastasis of Lung Cancer Through Regulation of ANXA10. Cancers (Basel). 2019 May 02; 11(5).  View on PubMed
  8. Hsu PC, Yang CT, Jablons DM, You L. The Role of Yes-Associated Protein (YAP) in Regulating Programmed Death-Ligand 1 (PD-L1) in Thoracic Cancer. Biomedicines. 2018 Dec 07; 6(4).  View on PubMed
  9. Hsu PC, Miao J, Wang YC, Zhang WQ, Yang YL, Wang CW, Yang CT, Huang Z, You J, Xu Z, Jablons DM, You L. Inhibition of yes-associated protein down-regulates PD-L1 (CD274) expression in human malignant pleural mesothelioma. J Cell Mol Med. 2018 06; 22(6):3139-3148.  View on PubMed
  10. Hsu PC, Miao J, Huang Z, Yang YL, Xu Z, You J, Dai Y, Yeh CC, Chan G, Liu S, Urisman A, Yang CT, Jablons DM, You L. Inhibition of yes-associated protein suppresses brain metastasis of human lung adenocarcinoma in a murine model. J Cell Mol Med. 2018 06; 22(6):3073-3085.  View on PubMed
  11. Miao J, Hsu PC, Yang YL, Xu Z, Dai Y, Wang Y, Chan G, Huang Z, Hu B, Li H, Jablons DM, You L. YAP regulates PD-L1 expression in human NSCLC cells. Oncotarget. 2017 Dec 29; 8(70):114576-114587.  View on PubMed
  12. Dai Y, Jablons D, You L. Hippo pathway in lung development. J Thorac Dis. 2017 Aug; 9(8):2246-2250.  View on PubMed
  13. Woodard GA, Yang YL, You L, Jablons DM. Drug development against the hippo pathway in mesothelioma. Transl Lung Cancer Res. 2017 Jun; 6(3):335-342.  View on PubMed
  14. Wang H, Dai YY, Zhang WQ, Hsu PC, Yang YL, Wang YC, Chan G, Au A, Xu ZD, Jiang SJ, Wang W, Jablons DM, You L. DCLK1 is correlated with MET and ERK5 expression, and associated with prognosis in malignant pleural mesothelioma. Int J Oncol. 2017 Jul; 51(1):91-103.  View on PubMed
  15. Zhang WQ, Dai YY, Hsu PC, Wang H, Cheng L, Yang YL, Wang YC, Xu ZD, Liu S, Chan G, Hu B, Li H, Jablons DM, You L. Targeting YAP in malignant pleural mesothelioma. J Cell Mol Med. 2017 Nov; 21(11):2663-2676.  View on PubMed
  16. Dai Y, Liu S, Zhang WQ, Yang YL, Hang P, Wang H, Cheng L, Hsu PC, Wang YC, Xu Z, Jablons DM, You L. YAP1 regulates ABCG2 and cancer cell side population in human lung cancer cells. Oncotarget. 2017 Jan 17; 8(3):4096-4109.  View on PubMed
  17. Hsu PC, You B, Yang YL, Zhang WQ, Wang YC, Xu Z, Dai Y, Liu S, Yang CT, Li H, Hu B, Jablons DM, You L. YAP promotes erlotinib resistance in human non-small cell lung cancer cells. Oncotarget. 2016 Aug 09; 7(32):51922-51933.  View on PubMed
  18. Hung MS, Chen IC, You L, Jablons DM, Li YC, Mao JH, Xu Z, Lung JH, Yang CT, Liu ST. Knockdown of cullin 4A inhibits growth and increases chemosensitivity in lung cancer cells. J Cell Mol Med. 2016 07; 20(7):1295-306.  View on PubMed
  19. Hung MS, Chen IC, You L, Jablons DM, Li YC, Mao JH, Xu Z, Hsieh MJ, Lin YC, Yang CT, Liu ST, Tsai YH. Knockdown of Cul4A increases chemosensitivity to gemcitabine through upregulation of TGFBI in lung cancer cells. Oncol Rep. 2015 Dec; 34(6):3187-95.  View on PubMed
  20. Yang YL, Ni J, Hsu PC, Mao JH, Hsieh D, Xu A, Chan G, Au A, Xu Z, Jablons DM, You L. Cul4A overexpression associated with Gli1 expression in malignant pleural mesothelioma. J Cell Mol Med. 2015 Oct; 19(10):2385-96.  View on PubMed

Go to UCSF Profiles, powered by CTSI