Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: thymidylate synthase mutagenesis, function, and structure. Read more about Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: thymidylate synthase mutagenesis, function, and structure.
Conformational dynamics along an enzymatic reaction pathway: thymidylate synthase, "the movie". Read more about Conformational dynamics along an enzymatic reaction pathway: thymidylate synthase, "the movie".
Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. Read more about Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases.
P52rIPK regulates the molecular cochaperone P58IPK to mediate control of the RNA-dependent protein kinase in response to cytoplasmic stress. Read more about P52rIPK regulates the molecular cochaperone P58IPK to mediate control of the RNA-dependent protein kinase in response to cytoplasmic stress.
Peptides derived from BH3 domains of Bcl-2 family members: a comparative analysis of inhibition of Bcl-2, Bcl-x(L) and Bax oligomerization, induction of cytochrome c release, and activation of cell death. Read more about Peptides derived from BH3 domains of Bcl-2 family members: a comparative analysis of inhibition of Bcl-2, Bcl-x(L) and Bax oligomerization, induction of cytochrome c release, and activation of cell death.
Role of aromatic transmembrane residues of the organic anion transporter, rOAT3, in substrate recognition. Read more about Role of aromatic transmembrane residues of the organic anion transporter, rOAT3, in substrate recognition.
The pro region N-terminal domain provides specific interactions required for catalysis of alpha-lytic protease folding. Read more about The pro region N-terminal domain provides specific interactions required for catalysis of alpha-lytic protease folding.
Selective inhibition of the collagenolytic activity of human cathepsin K by altering its S2 subsite specificity. Read more about Selective inhibition of the collagenolytic activity of human cathepsin K by altering its S2 subsite specificity.
Molecular targeting of inhibitor of apoptosis proteins based on small molecule mimics of natural binding partners. Read more about Molecular targeting of inhibitor of apoptosis proteins based on small molecule mimics of natural binding partners.
Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access. Read more about Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access.
