BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2. Read more about BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.
Colloidal aggregators in biochemical SARS-CoV-2 repurposing screens. Read more about Colloidal aggregators in biochemical SARS-CoV-2 repurposing screens.
Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant. Read more about Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant.
SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator. Read more about SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator.
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. Read more about CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells. Read more about A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells.
Rapid decay of host basal mRNAs during SARS-CoV-2 infection perturbs host antiviral mRNA biogenesis and export. Read more about Rapid decay of host basal mRNAs during SARS-CoV-2 infection perturbs host antiviral mRNA biogenesis and export.
Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2. Read more about Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2.
Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19: Anti-IFN antibodies in critical COVID-19 correlate with poor ISG response and upregulation of LAIR1 surface prot Read more about Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19: Anti-IFN antibodies in critical COVID-19 correlate with poor ISG response and upregulation of LAIR1 surface prot
Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant. Read more about Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant.
